HU187471B - Process for preparing n-acyl-triptamine derivatives and pharmaceutical compositions containing them as active agents - Google Patents

Process for preparing n-acyl-triptamine derivatives and pharmaceutical compositions containing them as active agents Download PDF

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Publication number
HU187471B
HU187471B HU339881A HU339881A HU187471B HU 187471 B HU187471 B HU 187471B HU 339881 A HU339881 A HU 339881A HU 339881 A HU339881 A HU 339881A HU 187471 B HU187471 B HU 187471B
Authority
HU
Hungary
Prior art keywords
tryptamine
methoxy
acid
formula
chlorobenzoyl
Prior art date
Application number
HU339881A
Other languages
English (en)
Hungarian (hu)
Inventor
Marian Eckstein
Stanislaw Misztal
Barbara Sienkiewicz
Andrzej Roszkowski
Original Assignee
Krakowskie Zaklady Farmaceutyczne "Polfa",Pl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krakowskie Zaklady Farmaceutyczne "Polfa",Pl filed Critical Krakowskie Zaklady Farmaceutyczne "Polfa",Pl
Publication of HU187471B publication Critical patent/HU187471B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
HU339881A 1980-11-13 1981-11-13 Process for preparing n-acyl-triptamine derivatives and pharmaceutical compositions containing them as active agents HU187471B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL22786080A PL131389B1 (en) 1980-11-13 1980-11-13 Method of obtaining n-acyl derivatives of triptamines

Publications (1)

Publication Number Publication Date
HU187471B true HU187471B (en) 1986-01-28

Family

ID=20005887

Family Applications (1)

Application Number Title Priority Date Filing Date
HU339881A HU187471B (en) 1980-11-13 1981-11-13 Process for preparing n-acyl-triptamine derivatives and pharmaceutical compositions containing them as active agents

Country Status (3)

Country Link
HU (1) HU187471B (nl)
NL (1) NL189964C (nl)
PL (1) PL131389B1 (nl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
EP1744747A4 (en) 2004-04-26 2009-12-02 Univ Vanderbilt INDIC ACID AND INDULECTIC ACID DERIVATIVES AS THERAPEUTIC ACTIVITIES WITH REDUCED GASTROINTESTINAL TOXICITY
WO2007149456A2 (en) 2006-06-19 2007-12-27 Vanderbilt University Methods and compositions for diagnostic and therapeutic targeting of cox-2
EP3078374B1 (en) 2011-10-17 2019-06-19 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1453808A (fr) * 1964-04-20 1966-07-22 Nouveaux aminoacétyl-3-indoles n'-monosubstitués et leur procédé de préparation
CH444160A (de) * 1964-07-02 1967-09-30 Sandoz Ag Verfahren zur Herstellung von neuen Indolderivaten

Also Published As

Publication number Publication date
NL189964C (nl) 1993-09-16
NL189964B (nl) 1993-04-16
NL8105139A (nl) 1982-06-01
PL131389B1 (en) 1984-11-30
PL227860A1 (nl) 1982-06-21

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee