HU185938B - Process for the preparation of 4,5-diaryl-alfa-1h-imidazol-2-alfa-polyhalogen-alkyl-methanamine derivatives and pharmaceutical compositions containing said compounds - Google Patents

Process for the preparation of 4,5-diaryl-alfa-1h-imidazol-2-alfa-polyhalogen-alkyl-methanamine derivatives and pharmaceutical compositions containing said compounds Download PDF

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Publication number
HU185938B
HU185938B HU812114A HU211481A HU185938B HU 185938 B HU185938 B HU 185938B HU 812114 A HU812114 A HU 812114A HU 211481 A HU211481 A HU 211481A HU 185938 B HU185938 B HU 185938B
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HU
Hungary
Prior art keywords
formula
group
hydrogen
alkyl
preparation
Prior art date
Application number
HU812114A
Other languages
English (en)
Hungarian (hu)
Inventor
Joel G Whitney
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of HU185938B publication Critical patent/HU185938B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU812114A 1980-07-21 1981-07-20 Process for the preparation of 4,5-diaryl-alfa-1h-imidazol-2-alfa-polyhalogen-alkyl-methanamine derivatives and pharmaceutical compositions containing said compounds HU185938B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17087180A 1980-07-21 1980-07-21
US06/271,276 US4348404A (en) 1980-07-21 1981-06-15 Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines

Publications (1)

Publication Number Publication Date
HU185938B true HU185938B (en) 1985-04-28

Family

ID=26866505

Family Applications (1)

Application Number Title Priority Date Filing Date
HU812114A HU185938B (en) 1980-07-21 1981-07-20 Process for the preparation of 4,5-diaryl-alfa-1h-imidazol-2-alfa-polyhalogen-alkyl-methanamine derivatives and pharmaceutical compositions containing said compounds

Country Status (16)

Country Link
US (1) US4348404A (en, 2012)
EP (1) EP0044486B1 (en, 2012)
AU (1) AU7312581A (en, 2012)
CA (1) CA1144552A (en, 2012)
DE (1) DE3166949D1 (en, 2012)
DK (1) DK323981A (en, 2012)
ES (1) ES504121A0 (en, 2012)
FI (1) FI812270A7 (en, 2012)
GR (1) GR76541B (en, 2012)
HU (1) HU185938B (en, 2012)
IL (1) IL63368A0 (en, 2012)
NO (1) NO812484L (en, 2012)
NZ (1) NZ197762A (en, 2012)
PH (1) PH16513A (en, 2012)
PT (1) PT73388B (en, 2012)
YU (1) YU180181A (en, 2012)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA826501B (en) * 1982-09-06 1984-04-25 Du Pont Anti-hypertensive imidazole derivative
US4478845A (en) * 1983-01-19 1984-10-23 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic imidazoimidazoles
US4632930A (en) * 1984-11-30 1986-12-30 E. I. Du Pont De Nemours And Company Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives
NZ238688A (en) * 1990-06-28 1992-05-26 Smithkline Beecham Corp Substituted histidines: pharmaceutical compositions, preparation and uses thereof
US6426360B1 (en) * 1994-07-28 2002-07-30 G D Searle & Co. 4,5-substituted imidazolyl compounds for the treatment of inflammation
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
EP0994858A1 (en) * 1997-06-30 2000-04-26 Ortho-McNeil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
US5840721A (en) * 1997-07-09 1998-11-24 Ontogen Corporation Imidazole derivatives as MDR modulators
AU760527C (en) 1998-05-22 2004-05-06 Smithkline Beecham Corporation Novel 2-alkyl substituted imidazole compounds
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
TR200201364T2 (tr) 1999-11-22 2002-10-21 Smithkline Beecham P. L. C. Yeni bileşikler.
BR0016463A (pt) * 1999-12-17 2002-08-27 Procter & Gamble Compostos de n-(1-feniletil)-5-fenil-imidazol-2-amina, suas composições e usos
US6596739B2 (en) 2000-03-29 2003-07-22 The Procter & Gamble Company N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses
GB0112348D0 (en) * 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
EP1432703A1 (en) * 2001-09-05 2004-06-30 Smithkline Beecham Plc Heterocycle-carboxamide derivatives as raf kinase inhibitors
EP1394043B1 (en) 2002-08-30 2006-04-26 Ishida Co., Ltd. Display strip

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2532547A (en) * 1950-12-05 Z-aminoalkyl-glyoxaline derivatives
US3197480A (en) * 1962-12-12 1965-07-27 Du Pont 2 and 2, 4-(alpha hydroxypolyperhalocycloalkyl)-thiophenes, pyrroles, and furans; 2 and 2, 4-[(alpha hydroxyalpha, alpha dipolyperhalo hydrocarbon) methyl]-thiophenes, pyrroles and furans and process for making them
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
BE793407A (fr) 1971-12-28 1973-06-28 Hoechst Ag Imidazolyl - (2) -carbinols ayant une activite hypolipidemique et leur procede de preparation
US4190666A (en) * 1975-08-11 1980-02-26 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones
US4159338A (en) * 1977-02-09 1979-06-26 E. I. Du Pont De Nemours And Company Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
EP0005219B1 (en) * 1978-04-24 1981-07-22 A/S Dumex (Dumex Ltd.) Arylimidazoles, their synthesis and pharmaceutical or veterinary preparations containing them
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles

Also Published As

Publication number Publication date
GR76541B (en, 2012) 1984-08-10
DE3166949D1 (de) 1984-12-06
PT73388A (en) 1981-08-01
NZ197762A (en) 1984-09-28
PT73388B (en) 1983-09-14
US4348404A (en) 1982-09-07
ES8301218A1 (es) 1982-12-01
IL63368A0 (en) 1981-10-30
NO812484L (no) 1982-01-22
AU7312581A (en) 1982-01-28
ES504121A0 (es) 1982-12-01
CA1144552A (en) 1983-04-12
PH16513A (en) 1983-11-08
DK323981A (da) 1982-01-22
EP0044486A1 (en) 1982-01-27
FI812270L (fi) 1982-01-22
FI812270A7 (fi) 1982-01-22
EP0044486B1 (en) 1984-10-31
YU180181A (en) 1984-02-29

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