HU181745B - Process for producing new vinblastin and leurosidin derivatives - Google Patents

Process for producing new vinblastin and leurosidin derivatives Download PDF

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Publication number
HU181745B
HU181745B HU802562A HU256280A HU181745B HU 181745 B HU181745 B HU 181745B HU 802562 A HU802562 A HU 802562A HU 256280 A HU256280 A HU 256280A HU 181745 B HU181745 B HU 181745B
Authority
HU
Hungary
Prior art keywords
vinblastine
formula
group
addition salt
acid addition
Prior art date
Application number
HU802562A
Other languages
English (en)
Hungarian (hu)
Inventor
Lajos Dancsi
Tibor Keve
Gyoergy Fekete
Eszter Dezseri
Sandor Goeroeg
Tibor Acs
Csaba Szantay
Lajos Szabo
Katalin Honty
Sandor Eckhardt
Ivan Hindi
Sandor Kerpel-Fronius
Peterne Relle
Zsuzsanna Somfai
Janos Sugar
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to HU802562A priority Critical patent/HU181745B/hu
Priority to SE8104877A priority patent/SE442116B/sv
Priority to CH5313/81A priority patent/CH648320A5/de
Priority to FR8115835A priority patent/FR2492384B1/fr
Priority to CA000383978A priority patent/CA1174672A/en
Priority to NL8103844A priority patent/NL8103844A/nl
Priority to BE0/205691A priority patent/BE889989A/fr
Priority to DE3132476A priority patent/DE3132476A1/de
Priority to IL63593A priority patent/IL63593A0/xx
Priority to SU813320101A priority patent/SU1053757A3/ru
Priority to IT23540/81A priority patent/IT1138154B/it
Priority to AT0358681A priority patent/AT376678B/de
Priority to ES505310A priority patent/ES8300777A1/es
Priority to GB8125029A priority patent/GB2086378B/en
Priority to JP56128642A priority patent/JPS5772992A/ja
Publication of HU181745B publication Critical patent/HU181745B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU802562A 1980-10-22 1980-10-22 Process for producing new vinblastin and leurosidin derivatives HU181745B (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
HU802562A HU181745B (en) 1980-10-22 1980-10-22 Process for producing new vinblastin and leurosidin derivatives
SE8104877A SE442116B (sv) 1980-10-22 1981-08-17 Sett att framstella cytostatiska foreningar innefattande derivat av vinblastin och leurosidin jemte farmaceutiska beredningar derav
CH5313/81A CH648320A5 (de) 1980-10-22 1981-08-17 Cytostatische verbindungen, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel.
FR8115835A FR2492384B1 (fr) 1980-10-22 1981-08-17 Procede de preparation de nouveaux composes cytostatiques et compositions pharmaceutiques les contenant
CA000383978A CA1174672A (en) 1980-10-22 1981-08-17 Process for the preparation of new vinblastine cytostatic compounds
NL8103844A NL8103844A (nl) 1980-10-22 1981-08-17 Werkwijze voor de bereiding van nieuwe cytostatische verbindingen, alsmede deze verbindingen bevattende farmaceutische samenstellingen.
BE0/205691A BE889989A (fr) 1980-10-22 1981-08-17 Procede de preparation de nouveaux composes cytostatiques et compositions pharmaceutiques les contenant
DE3132476A DE3132476A1 (de) 1980-10-22 1981-08-17 Neue cytostatische verbindungen und verfahren zu ihrer herstellung
IL63593A IL63593A0 (en) 1980-10-22 1981-08-17 Process for the preparation of new cytostatic compounds and pharmaceutical compositions containing them
SU813320101A SU1053757A3 (ru) 1980-10-22 1981-08-17 Способ получени производных винбластина
IT23540/81A IT1138154B (it) 1980-10-22 1981-08-17 Procedimento per la preparazione di composti citostatici e composizioni farmaceutiche contenenti gli stessi
AT0358681A AT376678B (de) 1980-10-22 1981-08-17 Verfahren zur herstellung von neuen cytostatischen verbindungen
ES505310A ES8300777A1 (es) 1980-10-22 1981-08-17 Metodo de obtener nuevos compuestos citostaticos del tipo de la vinblastina y similares.
GB8125029A GB2086378B (en) 1980-10-22 1981-08-17 Process for the preparation of cytostatic compounds
JP56128642A JPS5772992A (en) 1980-10-22 1981-08-17 Manufacture of cell propagation controlling compound and medicinal composition containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU802562A HU181745B (en) 1980-10-22 1980-10-22 Process for producing new vinblastin and leurosidin derivatives

Publications (1)

Publication Number Publication Date
HU181745B true HU181745B (en) 1983-11-28

Family

ID=10960005

Family Applications (1)

Application Number Title Priority Date Filing Date
HU802562A HU181745B (en) 1980-10-22 1980-10-22 Process for producing new vinblastin and leurosidin derivatives

Country Status (15)

Country Link
JP (1) JPS5772992A (xx)
AT (1) AT376678B (xx)
BE (1) BE889989A (xx)
CA (1) CA1174672A (xx)
CH (1) CH648320A5 (xx)
DE (1) DE3132476A1 (xx)
ES (1) ES8300777A1 (xx)
FR (1) FR2492384B1 (xx)
GB (1) GB2086378B (xx)
HU (1) HU181745B (xx)
IL (1) IL63593A0 (xx)
IT (1) IT1138154B (xx)
NL (1) NL8103844A (xx)
SE (1) SE442116B (xx)
SU (1) SU1053757A3 (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193318B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing new bis- indol derivatives
HU198074B (en) * 1985-06-12 1989-07-28 Richter Gedeon Vegyeszet Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds
JPH0321210U (xx) * 1989-07-11 1991-03-01

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899493A (en) * 1972-12-29 1975-08-12 Richter Gedeon Vegyeszet Chromic acid oxidation of vinblastine sulfate to form vincristine
HU178706B (en) * 1979-04-23 1982-06-28 Richter Gedeon Vegyeszet Process for preparing bis-indole alkaloids and acid addition salts thereof
JPS56128643A (en) * 1980-03-13 1981-10-08 Sintokogio Ltd Vertical flaskless type molding machine

Also Published As

Publication number Publication date
ES505310A0 (es) 1982-12-01
CA1174672A (en) 1984-09-18
GB2086378A (en) 1982-05-12
JPH0161118B2 (xx) 1989-12-27
ATA358681A (de) 1984-05-15
FR2492384B1 (fr) 1986-04-04
IL63593A0 (en) 1981-11-30
NL8103844A (nl) 1982-05-17
ES8300777A1 (es) 1982-12-01
AT376678B (de) 1984-12-27
SE442116B (sv) 1985-12-02
IT8123540A0 (it) 1981-08-17
CH648320A5 (de) 1985-03-15
FR2492384A1 (fr) 1982-04-23
JPS5772992A (en) 1982-05-07
SE8104877L (sv) 1982-04-23
DE3132476A1 (de) 1982-06-09
GB2086378B (en) 1984-07-25
BE889989A (fr) 1982-02-17
DE3132476C2 (xx) 1991-04-18
SU1053757A3 (ru) 1983-11-07
IT1138154B (it) 1986-09-17

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee