HU179018B - Process for producing new 5h-2,3-benzodiazepine derivatives - Google Patents
Process for producing new 5h-2,3-benzodiazepine derivativesInfo
- Publication number
- HU179018B HU179018B HU78GO1426A HUGO001426A HU179018B HU 179018 B HU179018 B HU 179018B HU 78GO1426 A HU78GO1426 A HU 78GO1426A HU GO001426 A HUGO001426 A HU GO001426A HU 179018 B HU179018 B HU 179018B
- Authority
- HU
- Hungary
- Prior art keywords
- producing new
- benzodiazepine derivatives
- benzodiazepine
- derivatives
- producing
- Prior art date
Links
- YVOHCRLDUPTKOH-UHFFFAOYSA-N 5h-2,3-benzodiazepine Chemical class C1C=NN=CC2=CC=CC=C12 YVOHCRLDUPTKOH-UHFFFAOYSA-N 0.000 title 1
Classifications
- 
        - C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
 
- 
        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
 
- 
        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
 
- 
        - C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
 
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| HU78GO1426A HU179018B (en) | 1978-10-19 | 1978-10-19 | Process for producing new 5h-2,3-benzodiazepine derivatives | 
| YU2410/79A YU41887B (en) | 1978-10-19 | 1979-10-03 | Process for obtaining new 5-h-2,3-benzodiazepine derivative | 
| AT0647279A AT373589B (de) | 1978-10-19 | 1979-10-04 | Verfahren zur herstellung von neuen 5h-2,3benzodiazepin-derivaten und deren saeureadditions- salzen | 
| DE19792940483 DE2940483A1 (de) | 1978-10-19 | 1979-10-05 | 5h-2,3-benzodiazepinderivate, verfahren zur herstellung derselben und diese enthaltende arzneimittel | 
| SE7908481A SE439919B (sv) | 1978-10-19 | 1979-10-12 | 5h-2,3-bensodiazepinderivat | 
| BE1/9569A BE879404A (fr) | 1978-10-19 | 1979-10-15 | Nouveaux derives de la 5h-2,3-benzodiazepine et procede pour la preparation de ces derives | 
| AU51817/79A AU532079B2 (en) | 1978-10-19 | 1979-10-16 | 5h-2,3-benzodiazepine derivatives | 
| FR7925698A FR2439189A1 (fr) | 1978-10-19 | 1979-10-16 | Nouveaux derives de la 5h-2,3-benzodiazepine et procede pour la preparation de ces derives et compositions pharmaceutiques les contenant | 
| FI793209A FI66604C (fi) | 1978-10-19 | 1979-10-16 | Foerfarande foer framstaellning av nya 5h-2,3-bensodiazepinderivat med inverkan pao det centrala nervsystemet | 
| CH929279A CH643835A5 (de) | 1978-10-19 | 1979-10-16 | 5h-2,3-benzodiazepin-derivate und verfahren zu ihrer herstellung. | 
| CS797020A CS236456B2 (en) | 1978-10-19 | 1979-10-16 | Method of 5h-2,3-benzodiazepine derivative production | 
| GR60290A GR74034B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-10-19 | 1979-10-17 | |
| DD79216290A DD146596A5 (de) | 1978-10-19 | 1979-10-17 | Verfahren zur herstellung neuer 5 h-2,3-benzodiazepin-derivate | 
| JP13471879A JPS5592377A (en) | 1978-10-19 | 1979-10-18 | Novel benzodiazepin derivative | 
| PL1979219034A PL124063B1 (en) | 1978-10-19 | 1979-10-18 | Process for preparing novel derivatives of 5h-2,3-benzodiazepine | 
| ES485163A ES485163A1 (es) | 1978-10-19 | 1979-10-18 | Procedimiento de preparacion de un nuevo derivado 5h-2,3- benzodiazepinos o de una sal de adicion acida | 
| CA337,955A CA1125749A (en) | 1978-10-19 | 1979-10-18 | 5h-2,3-benzodiazepine derivatives and a process for the preparation thereof | 
| DK440179A DK155327C (da) | 1978-10-19 | 1979-10-18 | Analogifremgangsmaade til fremstilling af 5h-2,3-benzodiazepinderivater eller et farmaceutisk acceptabelt syreadditionssalt deraf | 
| NLAANVRAGE7907692,A NL190552C (nl) | 1978-10-19 | 1979-10-18 | 1-Fenyl-4-alkyl-7,8-dialkoxy-5H-2,3-benzodiazepinederivaten en farmaceutische preparaten, die deze bevatten. | 
| GB7936185A GB2034706B (en) | 1978-10-19 | 1979-10-18 | Benzodiazepines | 
| SU792832177A SU1402258A3 (ru) | 1978-10-19 | 1979-10-18 | Способ получени производных 5Н-2,3-бензодиазепина или их солей присоединени кислот | 
| BG45206A BG60270B2 (bg) | 1978-10-19 | 1979-10-18 | Метод за получаване на 5н-2,3-бензодиазепинови производни | 
| NO793349A NO152048C (no) | 1978-10-19 | 1979-10-18 | Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive 5h-2,3-benzodiazepinderivater | 
| IT7926579A IT1220947B (it) | 1978-10-19 | 1979-10-18 | Nuovi derivati della 5h-2,3-benzodiazepina e procedimento per la loro preparazione | 
| US06/191,811 US4322346A (en) | 1978-10-19 | 1980-09-26 | 5H-2,3-Benzodiazepine derivatives | 
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| HU78GO1426A HU179018B (en) | 1978-10-19 | 1978-10-19 | Process for producing new 5h-2,3-benzodiazepine derivatives | 
Publications (1)
| Publication Number | Publication Date | 
|---|---|
| HU179018B true HU179018B (en) | 1982-08-28 | 
Family
ID=10996876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| HU78GO1426A HU179018B (en) | 1978-10-19 | 1978-10-19 | Process for producing new 5h-2,3-benzodiazepine derivatives | 
Country Status (25)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| BG65405B1 (bg) * | 1999-07-07 | 2008-06-30 | Egis Gyogyszergyar Rt. | 2,3-бензодиазепинови производни, метод за тяхнотополучаване, фармацевтични състави, които ги съдържат, и тяхното използване | 
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| HU186760B (en) * | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives | 
| HU191702B (en) * | 1984-06-27 | 1987-03-30 | Gyogyszerkutato Intezet | New process for preparing 1-aryl-5 h-2,3-benzodiazepines | 
| HU191698B (en) * | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines | 
| HU195788B (en) * | 1986-05-21 | 1988-07-28 | Gyogyszerkutato Intezet | Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them | 
| JPH01311400A (ja) * | 1988-06-09 | 1989-12-15 | Kyocera Corp | 発光標識体の点灯方法 | 
| JPH0251568U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1988-10-07 | 1990-04-11 | ||
| JPH0324693U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1989-07-18 | 1991-03-14 | ||
| HU207055B (en) * | 1990-10-17 | 1993-03-01 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same | 
| HU208429B (en) * | 1991-05-03 | 1993-10-28 | Gyogyszerkutato Intezet | Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity | 
| ES2190428T3 (es) * | 1991-06-28 | 2003-08-01 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogeno. | 
| US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists | 
| US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists | 
| SK283859B6 (sk) * | 1995-02-09 | 2004-03-02 | Egis Gy�Gyszergy�R Rt. | 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie | 
| EP0726256A1 (en) * | 1995-02-09 | 1996-08-14 | Egis Gyogyszergyar Rt. | 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders | 
| HU224435B1 (hu) * | 1995-02-09 | 2005-10-28 | EGIS Gyógyszergyár Rt. | Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények | 
| US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity | 
| DE19604920A1 (de) * | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel | 
| DE19604919A1 (de) * | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel | 
| ES2111493B1 (es) * | 1996-02-08 | 1999-08-01 | Egyt Gyogyszervegyeszeti Gyar | Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes. | 
| ZA972746B (en) * | 1996-04-04 | 1998-10-09 | Egyt Gyogyszervegyeszeti Gyar | Novel 2,3-benzodiazepine derivatives | 
| HU9600871D0 (en) * | 1996-04-04 | 1996-05-28 | Gyogyszerkutato Intezet | New 2,3-benzodiazepine derivatives | 
| HUP9701284A3 (en) * | 1997-07-24 | 2005-11-28 | Egyt Gyogyszervegyeszeti Gyar | Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system | 
| FR2824065A1 (fr) * | 2001-04-26 | 2002-10-31 | Neuro3D | Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations | 
| US6649607B2 (en) | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures | 
| ATE358488T1 (de) * | 2002-09-13 | 2007-04-15 | Motac Neuroscience Ltd | Behandlung von dyskinesie mit 2,3-benzodiazepinen | 
| ES2286453T3 (es) * | 2002-09-17 | 2007-12-01 | Motac Neuroscience Limited | Tratamiento de la discinesia. | 
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines | 
| JP2006514084A (ja) * | 2002-12-03 | 2006-04-27 | ヴェラ ファーマスーティカルズ インコーポレイテッド | 1−(3−ヒドロキシ−4−メトキシフェニル)−4−メチル−5−エチル−7,8−ジメトキシ−5h−2,3−ベンゾジアゼピンの製薬組成物及びその用途 | 
| JP2006510634A (ja) * | 2002-12-03 | 2006-03-30 | ヴェラ ファーマスーティカルズ インコーポレイテッド | 1−(3,4−ジメトキシフェニル)−4−メチル−5−エチル−7−メトキシ−8−ヒドロキシ−5h−2,3−ベンゾジアゼピンの製薬組成物及びその用途 | 
| US6638928B1 (en) | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines | 
| US7022700B2 (en) * | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines | 
| US20040162284A1 (en) * | 2003-02-19 | 2004-08-19 | Harris Herbert W. | Method of lowering body temperature with (S) tofisopam | 
| US20040224943A1 (en) * | 2003-02-19 | 2004-11-11 | Leventer Steven M. | Method of lowering body temperature with (R) - 2,3-benzodiazepines | 
| US20070021412A1 (en) * | 2003-05-16 | 2007-01-25 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine | 
| US20040229867A1 (en) * | 2003-05-16 | 2004-11-18 | Kucharik Robert F. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (R) 2,3-benzodiazepine | 
| US20040254173A1 (en) * | 2003-06-13 | 2004-12-16 | Leventer Steven M. | Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines | 
| HUP0302449A3 (en) * | 2003-08-04 | 2005-06-28 | Egis Gyogyszergyar Nyilvanosan | 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them | 
| US7541355B2 (en) * | 2005-05-23 | 2009-06-02 | Vela Acquisition Corporation | Conversion process for 2,3-benzodiazepine enantiomers | 
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| DK118660B (da) * | 1966-12-09 | 1970-09-21 | Egyt Gyogyszervegyeszeti Gyar | Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid. | 
| USRE30014E (en) | 1966-12-09 | 1979-05-29 | Egyesult Gyogyazer-es Tapozergyar | 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine | 
| GB1202579A (en) * | 1966-12-09 | 1970-08-19 | Egyt Gyogyszervegyeszeti Gyar | Pharmacologically active new isoquinoline derivative and process for preparing same | 
| ZA712798B (en) * | 1970-11-06 | 1972-02-23 | Egyt Gyogyszervegyeszeti Gyar | New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same | 
- 
        1978
        - 1978-10-19 HU HU78GO1426A patent/HU179018B/hu not_active IP Right Cessation
 
- 
        1979
        - 1979-10-03 YU YU2410/79A patent/YU41887B/xx unknown
- 1979-10-04 AT AT0647279A patent/AT373589B/de not_active IP Right Cessation
- 1979-10-05 DE DE19792940483 patent/DE2940483A1/de active Granted
- 1979-10-12 SE SE7908481A patent/SE439919B/sv not_active IP Right Cessation
- 1979-10-15 BE BE1/9569A patent/BE879404A/fr not_active IP Right Cessation
- 1979-10-16 CS CS797020A patent/CS236456B2/cs unknown
- 1979-10-16 AU AU51817/79A patent/AU532079B2/en not_active Ceased
- 1979-10-16 FR FR7925698A patent/FR2439189A1/fr active Granted
- 1979-10-16 FI FI793209A patent/FI66604C/fi not_active IP Right Cessation
- 1979-10-16 CH CH929279A patent/CH643835A5/de not_active IP Right Cessation
- 1979-10-17 GR GR60290A patent/GR74034B/el unknown
- 1979-10-17 DD DD79216290A patent/DD146596A5/de not_active IP Right Cessation
- 1979-10-18 GB GB7936185A patent/GB2034706B/en not_active Expired
- 1979-10-18 BG BG45206A patent/BG60270B2/bg unknown
- 1979-10-18 DK DK440179A patent/DK155327C/da not_active IP Right Cessation
- 1979-10-18 CA CA337,955A patent/CA1125749A/en not_active Expired
- 1979-10-18 NO NO793349A patent/NO152048C/no unknown
- 1979-10-18 NL NLAANVRAGE7907692,A patent/NL190552C/xx not_active IP Right Cessation
- 1979-10-18 SU SU792832177A patent/SU1402258A3/ru active
- 1979-10-18 JP JP13471879A patent/JPS5592377A/ja active Granted
- 1979-10-18 PL PL1979219034A patent/PL124063B1/pl unknown
- 1979-10-18 ES ES485163A patent/ES485163A1/es not_active Expired
- 1979-10-18 IT IT7926579A patent/IT1220947B/it active
 
- 
        1980
        - 1980-09-26 US US06/191,811 patent/US4322346A/en not_active Expired - Lifetime
 
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| BG65405B1 (bg) * | 1999-07-07 | 2008-06-30 | Egis Gyogyszergyar Rt. | 2,3-бензодиазепинови производни, метод за тяхнотополучаване, фармацевтични състави, които ги съдържат, и тяхното използване | 
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Legal Events
| Date | Code | Title | Description | 
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HQB4 | Licence granted & registered | Free format text: EGIS GYOGYSZERGYAR, HU | |
| HMM4 | Cancellation of final prot. due to non-payment of fee |