HRP980040B1 - Single pot process for producing (z)-azabicyclo oxime ethers - Google Patents

Single pot process for producing (z)-azabicyclo oxime ethers

Info

Publication number
HRP980040B1
HRP980040B1 HR980040A HRP980040A HRP980040B1 HR P980040 B1 HRP980040 B1 HR P980040B1 HR 980040 A HR980040 A HR 980040A HR P980040 A HRP980040 A HR P980040A HR P980040 B1 HRP980040 B1 HR P980040B1
Authority
HR
Croatia
Prior art keywords
producing
pot process
single pot
oxime ethers
azabicyclo
Prior art date
Application number
HR980040A
Other languages
English (en)
Inventor
Mark Alan Schwindt
Charles Franklin Lloyd
Tecle Haile
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HRP980040A2 publication Critical patent/HRP980040A2/hr
Publication of HRP980040B1 publication Critical patent/HRP980040B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR980040A 1997-01-27 1998-01-27 Single pot process for producing (z)-azabicyclo oxime ethers HRP980040B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3597797P 1997-01-27 1997-01-27

Publications (2)

Publication Number Publication Date
HRP980040A2 HRP980040A2 (en) 1998-10-31
HRP980040B1 true HRP980040B1 (en) 2002-10-31

Family

ID=21885887

Family Applications (1)

Application Number Title Priority Date Filing Date
HR980040A HRP980040B1 (en) 1997-01-27 1998-01-27 Single pot process for producing (z)-azabicyclo oxime ethers

Country Status (21)

Country Link
US (1) US6121459A (pt)
EP (1) EP1021446A1 (pt)
JP (1) JP2001511127A (pt)
KR (1) KR20000070464A (pt)
AR (1) AR011775A1 (pt)
AU (1) AU741566B2 (pt)
BR (1) BR9714469A (pt)
CA (1) CA2270884A1 (pt)
CO (1) CO5011092A1 (pt)
GT (1) GT199800019A (pt)
HR (1) HRP980040B1 (pt)
IL (1) IL129793A (pt)
MY (1) MY132840A (pt)
NZ (1) NZ335784A (pt)
PA (1) PA8445601A1 (pt)
PE (1) PE75499A1 (pt)
SV (1) SV1998000003A (pt)
TW (1) TW533215B (pt)
UY (1) UY24857A1 (pt)
WO (1) WO1998032758A1 (pt)
ZA (1) ZA98618B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2932121A1 (en) * 2007-11-30 2009-06-11 Newlink Genetics Corporation Ido inhibitors
FR2938534B1 (fr) 2008-11-14 2012-10-26 Sanofi Aventis Procede de preparation de l'hemifumarate d'eplivanserine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4158015A (en) * 1978-08-16 1979-06-12 Mobil Oil Corporation Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes
US5306718A (en) * 1990-03-06 1994-04-26 Warner-Lambert Company Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment
US5346911A (en) * 1990-03-06 1994-09-13 Warner-Lambert Company Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
IL97266A0 (en) * 1990-03-06 1992-05-25 Warner Lambert Co Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them
WO1993008191A1 (en) * 1991-10-15 1993-04-29 Warner-Lambert Company Azabicyclo oxime and amine cholinergic agents and methods of treatment
DE4203170A1 (de) * 1992-02-05 1993-08-12 Basf Ag Verfahren zur herstellung von e-oximethern von phenylglyoxylsaeureestern
IL107881A0 (en) * 1992-12-05 1994-04-12 Fisons Corp Furanone derivatives and pharmaceutical compositions containing them
US5514812A (en) * 1994-06-10 1996-05-07 Warner-Lambert Company Preparation of stereochemically pure oximes with muscarinic activity

Also Published As

Publication number Publication date
CO5011092A1 (es) 2001-02-28
TW533215B (en) 2003-05-21
AU5806598A (en) 1998-08-18
MY132840A (en) 2007-10-31
EP1021446A1 (en) 2000-07-26
BR9714469A (pt) 2000-05-16
US6121459A (en) 2000-09-19
HRP980040A2 (en) 1998-10-31
AR011775A1 (es) 2000-09-13
KR20000070464A (ko) 2000-11-25
UY24857A1 (es) 1998-06-25
SV1998000003A (es) 1998-08-13
CA2270884A1 (en) 1998-07-30
AU741566B2 (en) 2001-12-06
ZA98618B (en) 1998-07-30
IL129793A (en) 2003-01-12
PA8445601A1 (es) 2000-05-24
NZ335784A (en) 2000-12-22
PE75499A1 (es) 1999-08-20
WO1998032758A1 (en) 1998-07-30
JP2001511127A (ja) 2001-08-07
IL129793A0 (en) 2000-02-29
GT199800019A (es) 1999-07-20

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20021113

Year of fee payment: 6

PBON Lapse due to non-payment of renewal fee

Effective date: 20040128