PA8445601A1 - Proceso para producir eters de oxima (z)-azabiciclo en un unico recipiente - Google Patents
Proceso para producir eters de oxima (z)-azabiciclo en un unico recipienteInfo
- Publication number
- PA8445601A1 PA8445601A1 PA19988445601A PA8445601A PA8445601A1 PA 8445601 A1 PA8445601 A1 PA 8445601A1 PA 19988445601 A PA19988445601 A PA 19988445601A PA 8445601 A PA8445601 A PA 8445601A PA 8445601 A1 PA8445601 A1 PA 8445601A1
- Authority
- PA
- Panama
- Prior art keywords
- separation
- isomer
- oxima
- azabicycle
- eters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Abstract
ES POSIBLE AISLAR EN FORMA SIMPLE LAS OXIMAS AZABICICLO O-SUSTITUIDAS BIOLOGICAMENTE ACTIVAS QUE POSEEN LA CONFIGURACION Z, SIN NECESIDAD DE EFECTUAR UNA SEPARACION POR CROMATOGRAFIA, Y OBTENER RENDIMIENTO Y PUREZA E/Z MEDIANTE LA UNION DE UN 1-AZABICICLO-3-UNO CON UNA HIDROXILAMINA O-SUSTITUIDA EN SOLUCION ACUOSA ACIDICA. DEL MISMO MODO, SE PUEDE EFECTUAR LA CONVERSION DE UN ISOMERO CONFIGURADO E A UN ISOMERO Z SIN NECESIDAD DE REALIZAR UNA PURIFICACION O SEPARACION. LA NEUTRALIZACION Y LA SUBSIGUIENTE AISLACIÓN DE LA BASE LIBRE, SEGUIDA POR LA PRECIPITACIÓN DE LA SAL, PERMITE LA SEPARACION DEL ISOMERO Z CON ALTA PUREZA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3597797P | 1997-01-27 | 1997-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8445601A1 true PA8445601A1 (es) | 2000-05-24 |
Family
ID=21885887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA19988445601A PA8445601A1 (es) | 1997-01-27 | 1998-01-26 | Proceso para producir eters de oxima (z)-azabiciclo en un unico recipiente |
Country Status (21)
Country | Link |
---|---|
US (1) | US6121459A (es) |
EP (1) | EP1021446A1 (es) |
JP (1) | JP2001511127A (es) |
KR (1) | KR20000070464A (es) |
AR (1) | AR011775A1 (es) |
AU (1) | AU741566B2 (es) |
BR (1) | BR9714469A (es) |
CA (1) | CA2270884A1 (es) |
CO (1) | CO5011092A1 (es) |
GT (1) | GT199800019A (es) |
HR (1) | HRP980040B1 (es) |
IL (1) | IL129793A (es) |
MY (1) | MY132840A (es) |
NZ (1) | NZ335784A (es) |
PA (1) | PA8445601A1 (es) |
PE (1) | PE75499A1 (es) |
SV (1) | SV1998000003A (es) |
TW (1) | TW533215B (es) |
UY (1) | UY24857A1 (es) |
WO (1) | WO1998032758A1 (es) |
ZA (1) | ZA98618B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2227233B1 (en) * | 2007-11-30 | 2013-02-13 | Newlink Genetics | Ido inhibitors |
FR2938534B1 (fr) | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Procede de preparation de l'hemifumarate d'eplivanserine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4158015A (en) * | 1978-08-16 | 1979-06-12 | Mobil Oil Corporation | Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes |
US5306718A (en) * | 1990-03-06 | 1994-04-26 | Warner-Lambert Company | Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment |
IL97266A0 (en) * | 1990-03-06 | 1992-05-25 | Warner Lambert Co | Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them |
US5346911A (en) * | 1990-03-06 | 1994-09-13 | Warner-Lambert Company | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment |
AU2782792A (en) * | 1991-10-15 | 1993-05-21 | Warner-Lambert Company | Azabicyclo oxime and amine cholinergic agents and methods of treatment |
DE4203170A1 (de) * | 1992-02-05 | 1993-08-12 | Basf Ag | Verfahren zur herstellung von e-oximethern von phenylglyoxylsaeureestern |
IL107881A0 (en) * | 1992-12-05 | 1994-04-12 | Fisons Corp | Furanone derivatives and pharmaceutical compositions containing them |
US5514812A (en) * | 1994-06-10 | 1996-05-07 | Warner-Lambert Company | Preparation of stereochemically pure oximes with muscarinic activity |
-
1997
- 1997-12-29 IL IL12979397A patent/IL129793A/xx active IP Right Grant
- 1997-12-29 AU AU58065/98A patent/AU741566B2/en not_active Ceased
- 1997-12-29 KR KR1019997006702A patent/KR20000070464A/ko not_active Application Discontinuation
- 1997-12-29 WO PCT/US1997/023872 patent/WO1998032758A1/en not_active Application Discontinuation
- 1997-12-29 EP EP97954232A patent/EP1021446A1/en not_active Withdrawn
- 1997-12-29 US US09/355,227 patent/US6121459A/en not_active Expired - Fee Related
- 1997-12-29 BR BR9714469-0A patent/BR9714469A/pt not_active IP Right Cessation
- 1997-12-29 CA CA002270884A patent/CA2270884A1/en not_active Abandoned
- 1997-12-29 NZ NZ335784A patent/NZ335784A/xx unknown
- 1997-12-29 JP JP53198098A patent/JP2001511127A/ja active Pending
-
1998
- 1998-01-12 MY MYPI98000130A patent/MY132840A/en unknown
- 1998-01-14 SV SV1998000003A patent/SV1998000003A/es active IP Right Grant
- 1998-01-26 ZA ZA98618A patent/ZA98618B/xx unknown
- 1998-01-26 PE PE1998000052A patent/PE75499A1/es not_active Application Discontinuation
- 1998-01-26 GT GT199800019A patent/GT199800019A/es unknown
- 1998-01-26 CO CO98003337A patent/CO5011092A1/es unknown
- 1998-01-26 UY UY24857A patent/UY24857A1/es not_active IP Right Cessation
- 1998-01-26 PA PA19988445601A patent/PA8445601A1/es unknown
- 1998-01-26 AR ARP980100342A patent/AR011775A1/es not_active Application Discontinuation
- 1998-01-27 HR HR980040A patent/HRP980040B1/xx not_active IP Right Cessation
- 1998-02-17 TW TW087101120A patent/TW533215B/zh active
Also Published As
Publication number | Publication date |
---|---|
SV1998000003A (es) | 1998-08-13 |
HRP980040B1 (en) | 2002-10-31 |
CA2270884A1 (en) | 1998-07-30 |
CO5011092A1 (es) | 2001-02-28 |
TW533215B (en) | 2003-05-21 |
EP1021446A1 (en) | 2000-07-26 |
US6121459A (en) | 2000-09-19 |
AU5806598A (en) | 1998-08-18 |
IL129793A0 (en) | 2000-02-29 |
AU741566B2 (en) | 2001-12-06 |
BR9714469A (pt) | 2000-05-16 |
UY24857A1 (es) | 1998-06-25 |
KR20000070464A (ko) | 2000-11-25 |
MY132840A (en) | 2007-10-31 |
JP2001511127A (ja) | 2001-08-07 |
PE75499A1 (es) | 1999-08-20 |
ZA98618B (en) | 1998-07-30 |
WO1998032758A1 (en) | 1998-07-30 |
IL129793A (en) | 2003-01-12 |
HRP980040A2 (en) | 1998-10-31 |
GT199800019A (es) | 1999-07-20 |
AR011775A1 (es) | 2000-09-13 |
NZ335784A (en) | 2000-12-22 |
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