GT199800019A - Proceso para producir eters de oxima ( z ) -azabiciclo en un unico recipiente. - Google Patents
Proceso para producir eters de oxima ( z ) -azabiciclo en un unico recipiente.Info
- Publication number
- GT199800019A GT199800019A GT199800019A GT199800019A GT199800019A GT 199800019 A GT199800019 A GT 199800019A GT 199800019 A GT199800019 A GT 199800019A GT 199800019 A GT199800019 A GT 199800019A GT 199800019 A GT199800019 A GT 199800019A
- Authority
- GT
- Guatemala
- Prior art keywords
- azabicycle
- separation
- isomer
- oxima
- eters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Abstract
ES POSIBLE AISLAR EN FORMA SIMPLE LAS OXIMAS AZABICICLO OSUBSTITUIDAS BIOLOGICAMENTE ACTIVAS QUE POSEEN LA CONFIGURACION Z, SIN NECESIDAD DE EFECTUAR UNA SEPARACION POR CROMATOGRAFIA, Y OBTENER ALTOS RENDIMIENTOS Y PUREZA E/Z MEDIANTE LA UNION DE UN 1AZABICICLO3UNO CON UNA HIDROXILAMINA OSUSTITUIDA EN SOLUCION ACUOSA ACIDICA. DEL MISMO MODO, SE PUEDE EFECTUAR LA CONVERSION DE UN ISOMERO CONFIGURADO E A UN ISOMERO Z SIN NECESIDAD DE REALIZAR UNA PURIFICACION O SEPARACION. LA NEUTRALIZACION Y LA SUBSIGUIENTE AISLACION DE LA BASE LIBRE, SEGUIDA POR LA PRECIPITACION DE LA SAL, PERMITE LA SEPARACION DEL ISOMERO Z CON ALTA PUREZA Z/E.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3597797P | 1997-01-27 | 1997-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT199800019A true GT199800019A (es) | 1999-07-20 |
Family
ID=21885887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT199800019A GT199800019A (es) | 1997-01-27 | 1998-01-26 | Proceso para producir eters de oxima ( z ) -azabiciclo en un unico recipiente. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6121459A (es) |
| EP (1) | EP1021446A1 (es) |
| JP (1) | JP2001511127A (es) |
| KR (1) | KR20000070464A (es) |
| AR (1) | AR011775A1 (es) |
| AU (1) | AU741566B2 (es) |
| BR (1) | BR9714469A (es) |
| CA (1) | CA2270884A1 (es) |
| CO (1) | CO5011092A1 (es) |
| GT (1) | GT199800019A (es) |
| HR (1) | HRP980040B1 (es) |
| IL (1) | IL129793A (es) |
| MY (1) | MY132840A (es) |
| NZ (1) | NZ335784A (es) |
| PA (1) | PA8445601A1 (es) |
| PE (1) | PE75499A1 (es) |
| SV (1) | SV1998000003A (es) |
| TW (1) | TW533215B (es) |
| UY (1) | UY24857A1 (es) |
| WO (1) | WO1998032758A1 (es) |
| ZA (1) | ZA98618B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2932121A1 (en) * | 2007-11-30 | 2009-06-11 | Newlink Genetics Corporation | Ido inhibitors |
| FR2938534B1 (fr) | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Procede de preparation de l'hemifumarate d'eplivanserine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4158015A (en) * | 1978-08-16 | 1979-06-12 | Mobil Oil Corporation | Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes |
| US5346911A (en) * | 1990-03-06 | 1994-09-13 | Warner-Lambert Company | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment |
| US5306718A (en) * | 1990-03-06 | 1994-04-26 | Warner-Lambert Company | Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment |
| IL97266A0 (en) * | 1990-03-06 | 1992-05-25 | Warner Lambert Co | Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them |
| AU2782792A (en) * | 1991-10-15 | 1993-05-21 | Warner-Lambert Company | Azabicyclo oxime and amine cholinergic agents and methods of treatment |
| DE4203170A1 (de) * | 1992-02-05 | 1993-08-12 | Basf Ag | Verfahren zur herstellung von e-oximethern von phenylglyoxylsaeureestern |
| IL107881A0 (en) * | 1992-12-05 | 1994-04-12 | Fisons Corp | Furanone derivatives and pharmaceutical compositions containing them |
| US5514812A (en) * | 1994-06-10 | 1996-05-07 | Warner-Lambert Company | Preparation of stereochemically pure oximes with muscarinic activity |
-
1997
- 1997-12-29 NZ NZ335784A patent/NZ335784A/xx unknown
- 1997-12-29 IL IL12979397A patent/IL129793A/xx active IP Right Grant
- 1997-12-29 BR BR9714469-0A patent/BR9714469A/pt not_active IP Right Cessation
- 1997-12-29 KR KR1019997006702A patent/KR20000070464A/ko not_active Application Discontinuation
- 1997-12-29 AU AU58065/98A patent/AU741566B2/en not_active Ceased
- 1997-12-29 JP JP53198098A patent/JP2001511127A/ja active Pending
- 1997-12-29 EP EP97954232A patent/EP1021446A1/en not_active Withdrawn
- 1997-12-29 US US09/355,227 patent/US6121459A/en not_active Expired - Fee Related
- 1997-12-29 CA CA002270884A patent/CA2270884A1/en not_active Abandoned
- 1997-12-29 WO PCT/US1997/023872 patent/WO1998032758A1/en not_active Application Discontinuation
-
1998
- 1998-01-12 MY MYPI98000130A patent/MY132840A/en unknown
- 1998-01-14 SV SV1998000003A patent/SV1998000003A/es active IP Right Grant
- 1998-01-26 ZA ZA98618A patent/ZA98618B/xx unknown
- 1998-01-26 GT GT199800019A patent/GT199800019A/es unknown
- 1998-01-26 PA PA19988445601A patent/PA8445601A1/es unknown
- 1998-01-26 CO CO98003337A patent/CO5011092A1/es unknown
- 1998-01-26 AR ARP980100342A patent/AR011775A1/es not_active Application Discontinuation
- 1998-01-26 PE PE1998000052A patent/PE75499A1/es not_active Application Discontinuation
- 1998-01-26 UY UY24857A patent/UY24857A1/es not_active IP Right Cessation
- 1998-01-27 HR HR980040A patent/HRP980040B1/xx not_active IP Right Cessation
- 1998-02-17 TW TW087101120A patent/TW533215B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| AU741566B2 (en) | 2001-12-06 |
| EP1021446A1 (en) | 2000-07-26 |
| PE75499A1 (es) | 1999-08-20 |
| WO1998032758A1 (en) | 1998-07-30 |
| CA2270884A1 (en) | 1998-07-30 |
| AR011775A1 (es) | 2000-09-13 |
| IL129793A (en) | 2003-01-12 |
| TW533215B (en) | 2003-05-21 |
| BR9714469A (pt) | 2000-05-16 |
| ZA98618B (en) | 1998-07-30 |
| PA8445601A1 (es) | 2000-05-24 |
| AU5806598A (en) | 1998-08-18 |
| IL129793A0 (en) | 2000-02-29 |
| CO5011092A1 (es) | 2001-02-28 |
| MY132840A (en) | 2007-10-31 |
| UY24857A1 (es) | 1998-06-25 |
| JP2001511127A (ja) | 2001-08-07 |
| KR20000070464A (ko) | 2000-11-25 |
| NZ335784A (en) | 2000-12-22 |
| SV1998000003A (es) | 1998-08-13 |
| US6121459A (en) | 2000-09-19 |
| HRP980040B1 (en) | 2002-10-31 |
| HRP980040A2 (en) | 1998-10-31 |
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