HRP950052B1 - Use of anti-tnf antibodies as drugs in treating diseases involving elevated interleukin-6 serum levels - Google Patents

Use of anti-tnf antibodies as drugs in treating diseases involving elevated interleukin-6 serum levels

Info

Publication number
HRP950052B1
HRP950052B1 HRP4409513.9A HRP950052A HRP950052B1 HR P950052 B1 HRP950052 B1 HR P950052B1 HR P950052 A HRP950052 A HR P950052A HR P950052 B1 HRP950052 B1 HR P950052B1
Authority
HR
Croatia
Prior art keywords
drugs
serum levels
treating diseases
diseases involving
tnf antibodies
Prior art date
Application number
HRP4409513.9A
Other languages
English (en)
Inventor
Roswitha Stenzel
Martin Kaul
Lothar Daum
Joachim Kempeni
Christa Raab
Sibylle Schaefer
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25933592&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP950052(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4409513A external-priority patent/DE4409513C1/de
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of HRP950052A2 publication Critical patent/HRP950052A2/hr
Publication of HRP950052B1 publication Critical patent/HRP950052B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HRP4409513.9A 1994-02-07 1995-02-06 Use of anti-tnf antibodies as drugs in treating diseases involving elevated interleukin-6 serum levels HRP950052B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4403669 1994-02-07
DE4409513A DE4409513C1 (de) 1994-02-07 1994-03-19 Verwendung von anti-TNF-Antikörpern als Arzneimittel zur Behandlung von Erkrankungen mit einem erhöhten Interleukin-6 Serumspiegel

Publications (2)

Publication Number Publication Date
HRP950052A2 HRP950052A2 (en) 1997-10-31
HRP950052B1 true HRP950052B1 (en) 2000-04-30

Family

ID=25933592

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP4409513.9A HRP950052B1 (en) 1994-02-07 1995-02-06 Use of anti-tnf antibodies as drugs in treating diseases involving elevated interleukin-6 serum levels

Country Status (20)

Country Link
US (2) US6235281B1 (cs)
EP (1) EP0804236B1 (cs)
JP (1) JPH09509411A (cs)
CN (1) CN1140414A (cs)
AT (1) ATE235917T1 (cs)
AU (1) AU1520195A (cs)
BR (1) BR9506741A (cs)
CA (1) CA2182723A1 (cs)
CZ (1) CZ290843B6 (cs)
DK (1) DK0804236T3 (cs)
ES (1) ES2197912T3 (cs)
FI (1) FI963101A7 (cs)
HR (1) HRP950052B1 (cs)
HU (1) HU220995B1 (cs)
IL (1) IL112427A (cs)
NO (1) NO963280L (cs)
NZ (1) NZ278607A (cs)
PT (1) PT804236E (cs)
TW (1) TW403656B (cs)
WO (1) WO1995020978A1 (cs)

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JP4914008B2 (ja) * 2002-11-21 2012-04-11 ジェンザイム・コーポレーション 免疫寛容を誘導するためのジアミド誘導体と免疫抑制剤との組み合わせ
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US7435799B2 (en) * 2004-01-08 2008-10-14 Applied Molecular Evolution TNF-α binding molecules
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US20060083741A1 (en) * 2004-10-08 2006-04-20 Hoffman Rebecca S Treatment of respiratory syncytial virus (RSV) infection
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US20070041905A1 (en) * 2005-08-19 2007-02-22 Hoffman Rebecca S Method of treating depression using a TNF-alpha antibody
EP1864692A1 (en) * 2006-06-07 2007-12-12 Biotempt B.V. Use of peptides for the control of radiation injury
RU2309732C1 (ru) 2006-03-13 2007-11-10 Олег Ильич Эпштейн Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата
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US20080118496A1 (en) * 2006-04-10 2008-05-22 Medich John R Uses and compositions for treatment of juvenile rheumatoid arthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
US9399061B2 (en) * 2006-04-10 2016-07-26 Abbvie Biotechnology Ltd Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis
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US20090317399A1 (en) * 2006-04-10 2009-12-24 Pollack Paul F Uses and compositions for treatment of CROHN'S disease
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
ES2456333T3 (es) * 2007-02-12 2014-04-22 Biotempt B.V. Tratamiento de hemorragia traumática con oligopéptidos cortos
US8062864B2 (en) * 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
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US7906117B2 (en) * 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
NZ581418A (en) * 2007-05-21 2012-08-31 Alderbio Holdings Llc Novel rabbit antibody humanization methods and humanized rabbit antibodies
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US8999337B2 (en) * 2007-06-11 2015-04-07 Abbvie Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis by inhibition of TNFα
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
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Also Published As

Publication number Publication date
ES2197912T3 (es) 2004-01-16
DK0804236T3 (da) 2003-07-21
CZ290843B6 (cs) 2002-10-16
HUT76875A (en) 1997-12-29
WO1995020978A1 (de) 1995-08-10
NO963280L (no) 1996-10-04
ATE235917T1 (de) 2003-04-15
JPH09509411A (ja) 1997-09-22
EP0804236A1 (de) 1997-11-05
FI963101L (fi) 1996-08-06
HU9602169D0 (en) 1996-10-28
HU220995B1 (hu) 2002-07-29
US6235281B1 (en) 2001-05-22
BR9506741A (pt) 1997-10-21
IL112427A0 (en) 1995-03-30
NZ278607A (en) 1999-05-28
AU1520195A (en) 1995-08-21
HRP950052A2 (en) 1997-10-31
NO963280D0 (no) 1996-08-06
IL112427A (en) 1998-12-06
EP0804236B1 (de) 2003-04-02
FI963101A0 (fi) 1996-08-06
PT804236E (pt) 2003-08-29
TW403656B (en) 2000-09-01
FI963101A7 (fi) 1996-08-06
CA2182723A1 (en) 1995-08-10
CN1140414A (zh) 1997-01-15
CZ232296A3 (en) 1997-03-12
US20010010819A1 (en) 2001-08-02

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