HRP940842B1 - Crystalline acid addition salts of both diasttereomers of the 1-(2,2-dimethylpropionyloxy)-ethylester of 3-cephem-4-carboxylic acid - Google Patents
Crystalline acid addition salts of both diasttereomers of the 1-(2,2-dimethylpropionyloxy)-ethylester of 3-cephem-4-carboxylic acidInfo
- Publication number
- HRP940842B1 HRP940842B1 HRP940842A HRP940842B1 HR P940842 B1 HRP940842 B1 HR P940842B1 HR P940842 A HRP940842 A HR P940842A HR P940842 B1 HRP940842 B1 HR P940842B1
- Authority
- HR
- Croatia
- Prior art keywords
- cephem
- dimethylpropionyloxy
- addition salts
- carboxylic acid
- diasttereomers
- Prior art date
Links
- IKWLIQXIPRUIDU-ZCFIWIBFSA-N (6r)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound OC(=O)C1=CCS[C@@H]2CC(=O)N12 IKWLIQXIPRUIDU-ZCFIWIBFSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000001782 cephems Chemical class 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- -1 1-(2,2-dimethylpropionyloxy)ethyl Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000007519 polyprotic acids Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4116937 | 1991-05-24 | ||
YU33592A YU48484B (sh) | 1991-05-24 | 1992-03-30 | Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP940842A2 HRP940842A2 (en) | 1997-02-28 |
HRP940842B1 true HRP940842B1 (en) | 2001-02-28 |
Family
ID=6432313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP-335/92 HRP940842B1 (en) | 1991-05-24 | 1994-10-26 | Crystalline acid addition salts of both diasttereomers of the 1-(2,2-dimethylpropionyloxy)-ethylester of 3-cephem-4-carboxylic acid |
Country Status (29)
Country | Link |
---|---|
US (2) | US5594133A (el) |
EP (1) | EP0514791B1 (el) |
JP (1) | JPH0680065B2 (el) |
KR (1) | KR100198908B1 (el) |
CN (1) | CN1037608C (el) |
AT (1) | ATE164377T1 (el) |
AU (1) | AU652635B2 (el) |
BR (1) | BR9201939A (el) |
CA (1) | CA2069200C (el) |
CZ (1) | CZ282299B6 (el) |
DE (1) | DE59209246D1 (el) |
DK (1) | DK0514791T3 (el) |
EG (1) | EG20121A (el) |
ES (1) | ES2115625T3 (el) |
FI (1) | FI108435B (el) |
GR (1) | GR3026625T3 (el) |
HR (1) | HRP940842B1 (el) |
HU (1) | HU220065B (el) |
IE (1) | IE921660A1 (el) |
IL (1) | IL101970A (el) |
MA (1) | MA22532A1 (el) |
MX (1) | MX9202460A (el) |
NO (1) | NO301982B1 (el) |
PH (1) | PH31070A (el) |
PL (3) | PL170403B1 (el) |
RU (1) | RU2073680C1 (el) |
SK (1) | SK280291B6 (el) |
UY (1) | UY23418A1 (el) |
YU (1) | YU48484B (el) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW212181B (el) * | 1992-02-14 | 1993-09-01 | Hoechst Ag | |
ES2117066T3 (es) * | 1992-05-21 | 1998-08-01 | Hoechst Ag | Procedimiento para la disociacion de esteres profarmacos de cefalosporina para dar acido 7-amino-3-metoximetil-cef-3-em-4-carboxilico. |
AT401651B (de) * | 1994-06-14 | 1996-11-25 | Biochemie Gmbh | 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4- |
AT408226B (de) * | 1999-05-05 | 2001-09-25 | Biochemie Gmbh | Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2 |
WO2004056834A1 (en) * | 2002-12-20 | 2004-07-08 | Lupin Limited | A process for the preparation of cefpodoxime proxetil |
AU2003303657A1 (en) * | 2003-01-06 | 2004-07-29 | Lupin Limited | A process for the manufacture of cefpodoxime proxetil |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
US4203899A (en) * | 1974-12-19 | 1980-05-20 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido compounds |
US4668783A (en) * | 1974-12-19 | 1987-05-26 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido cephalosporin compounds |
JPS5760345B2 (el) * | 1974-12-19 | 1982-12-18 | Takeda Chemical Industries Ltd | |
US4298606A (en) * | 1974-12-19 | 1981-11-03 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido compounds |
DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
JPS6011713B2 (ja) * | 1976-09-08 | 1985-03-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
FR2476087A1 (fr) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
US4486425A (en) * | 1980-09-30 | 1984-12-04 | Sankyo Company Limited | 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates |
JPS5759894A (en) * | 1980-09-30 | 1982-04-10 | Sankyo Co Ltd | Cephalosporin for oral administration |
DE3804841A1 (de) * | 1988-02-17 | 1989-08-31 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
DE3919259A1 (de) * | 1989-06-13 | 1990-12-20 | Hoechst Ag | Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
-
1992
- 1992-03-30 YU YU33592A patent/YU48484B/sh unknown
- 1992-05-12 PH PH44394A patent/PH31070A/en unknown
- 1992-05-15 EP EP92108252A patent/EP0514791B1/de not_active Expired - Lifetime
- 1992-05-15 AT AT92108252T patent/ATE164377T1/de active
- 1992-05-15 DK DK92108252T patent/DK0514791T3/da active
- 1992-05-15 ES ES92108252T patent/ES2115625T3/es not_active Expired - Lifetime
- 1992-05-15 DE DE59209246T patent/DE59209246D1/de not_active Expired - Lifetime
- 1992-05-21 FI FI922310A patent/FI108435B/fi not_active IP Right Cessation
- 1992-05-21 EG EG26792A patent/EG20121A/xx active
- 1992-05-21 UY UY23418A patent/UY23418A1/es not_active IP Right Cessation
- 1992-05-22 BR BR929201939A patent/BR9201939A/pt not_active Application Discontinuation
- 1992-05-22 CA CA002069200A patent/CA2069200C/en not_active Expired - Lifetime
- 1992-05-22 PL PL92311554A patent/PL170403B1/pl unknown
- 1992-05-22 PL PL92294651A patent/PL170798B1/pl unknown
- 1992-05-22 PL PL92311553A patent/PL170962B1/pl unknown
- 1992-05-22 MX MX9202460A patent/MX9202460A/es unknown
- 1992-05-22 HU HU9201716A patent/HU220065B/hu unknown
- 1992-05-22 SK SK1547-92A patent/SK280291B6/sk not_active IP Right Cessation
- 1992-05-22 CZ CS921547A patent/CZ282299B6/cs not_active IP Right Cessation
- 1992-05-22 JP JP4130688A patent/JPH0680065B2/ja not_active Expired - Lifetime
- 1992-05-22 IL IL10197092A patent/IL101970A/en not_active IP Right Cessation
- 1992-05-22 KR KR1019920008671A patent/KR100198908B1/ko not_active IP Right Cessation
- 1992-05-22 RU SU925011790A patent/RU2073680C1/ru active
- 1992-05-22 AU AU17062/92A patent/AU652635B2/en not_active Expired
- 1992-05-22 NO NO922023A patent/NO301982B1/no not_active IP Right Cessation
- 1992-05-22 MA MA22819A patent/MA22532A1/fr unknown
- 1992-05-23 CN CN92103911A patent/CN1037608C/zh not_active Expired - Lifetime
- 1992-07-01 IE IE166092A patent/IE921660A1/en not_active IP Right Cessation
-
1994
- 1994-10-26 HR HRP-335/92 patent/HRP940842B1/xx not_active IP Right Cessation
-
1995
- 1995-05-22 US US08/447,045 patent/US5594133A/en not_active Expired - Lifetime
- 1995-05-23 US US08/447,635 patent/US5556850A/en not_active Expired - Lifetime
-
1998
- 1998-04-14 GR GR980400821T patent/GR3026625T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA891162B (en) | Cephalosporin derivatives and processes for their preparation | |
EG20121A (en) | Process for preparing of crystalline acid addition salts of the diastereomers of 1-(2,2-dimethylpromonyloxy) ethyl3-cephem-4-carboxylate | |
IE880503L (en) | Crystallized cephem-acid addition salts, and a process for the preparation thereof | |
HUT56375A (en) | Process for producing crystalline acid-addition salts of cefem carboxylic acid | |
ZA868518B (en) | Cephalosporin derivatives and a process for their preparation | |
GR3020519T3 (en) | Polar cephalosporin derivatives and process for their preparation | |
HUT53654A (en) | Process for producing cefemcarboxylic acid compounds and pharmaceutical compositions comprising such compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1OB | Publication of a patent application | ||
AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
B1PR | Patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20110202 Year of fee payment: 20 |
|
PB20 | Patent expired after termination of 20 years |
Effective date: 20120331 |