HRP940366B1 - Bifuncional derivatives of urokinase wiht improved fibrinolytic activiy and thrombin inhibiting activity - Google Patents
Bifuncional derivatives of urokinase wiht improved fibrinolytic activiy and thrombin inhibiting activityInfo
- Publication number
- HRP940366B1 HRP940366B1 HRP940366A HRP940366B1 HR P940366 B1 HRP940366 B1 HR P940366B1 HR P940366 A HRP940366 A HR P940366A HR P940366 B1 HRP940366 B1 HR P940366B1
- Authority
- HR
- Croatia
- Prior art keywords
- bifuncional
- activiy
- wiht
- urokinase
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4323754A DE4323754C1 (de) | 1993-07-15 | 1993-07-15 | Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP940366A2 HRP940366A2 (en) | 1997-04-30 |
HRP940366B1 true HRP940366B1 (en) | 2001-02-28 |
Family
ID=6492909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP4323754.1 HRP940366B1 (en) | 1993-07-15 | 1994-06-23 | Bifuncional derivatives of urokinase wiht improved fibrinolytic activiy and thrombin inhibiting activity |
Country Status (27)
Country | Link |
---|---|
US (2) | US5681721A (zh) |
EP (1) | EP0669394B1 (zh) |
JP (1) | JPH07143878A (zh) |
KR (1) | KR960014346A (zh) |
CN (1) | CN1057124C (zh) |
AT (1) | ATE189261T1 (zh) |
AU (1) | AU679512B2 (zh) |
CA (1) | CA2127897A1 (zh) |
CZ (1) | CZ288536B6 (zh) |
DE (2) | DE4323754C1 (zh) |
DK (1) | DK0669394T3 (zh) |
ES (1) | ES2145075T3 (zh) |
FI (1) | FI943354A (zh) |
GR (1) | GR3032488T3 (zh) |
HK (1) | HK1010109A1 (zh) |
HR (1) | HRP940366B1 (zh) |
HU (1) | HU217101B (zh) |
IL (1) | IL109107A0 (zh) |
NO (1) | NO941561L (zh) |
NZ (1) | NZ260991A (zh) |
PL (1) | PL176971B1 (zh) |
PT (1) | PT669394E (zh) |
RU (1) | RU2143490C1 (zh) |
SI (1) | SI0669394T1 (zh) |
SK (1) | SK281586B6 (zh) |
UA (1) | UA27132C2 (zh) |
ZA (1) | ZA944202B (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4440892A1 (de) * | 1994-11-17 | 1996-05-23 | Gruenenthal Gmbh | Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften |
DE4442665A1 (de) * | 1994-11-30 | 1996-06-05 | Gruenenthal Gmbh | Chimäre Proteine mit fibrinolytischen und thrombinhemmenden Eigenschaften |
CN1057125C (zh) * | 1996-04-26 | 2000-10-04 | 南京大学 | 五种尿激酶变体基因及在大肠杆菌中的表达 |
CN1111739C (zh) * | 1997-02-04 | 2003-06-18 | 许文俊 | 凝血、纤溶功能动态测定试剂 |
WO1999037149A1 (en) * | 1998-01-27 | 1999-07-29 | Brigham & Women's Hospital | Methods of treating cytotoxic damage |
US7498310B1 (en) | 1998-08-13 | 2009-03-03 | Beiersdorf Ag | Cosmetic or dermatological preparations comprising oligopeptides for lightening the skin of age marks and/or for preventing tanning of the skin, in particular tanning of the skin caused by UV radiation |
WO2001097752A2 (en) * | 2000-06-20 | 2001-12-27 | The Trustees Of The University Of Pennsylvania | Compositions comprising urokinase for modulating muscle contractility and angiogenisis |
US7361493B1 (en) | 2004-05-26 | 2008-04-22 | The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs | Production of urokinase in a three-dimensional cell culture |
DE602005023429D1 (de) | 2004-10-19 | 2010-10-21 | Lonza Ag | Verfahren zur festphasen-peptidsynthese |
CN104193807B (zh) * | 2014-09-28 | 2016-06-15 | 广州贝奥吉因生物科技有限公司 | 凝血酶抑制多肽及其制备方法、应用 |
CN105385617A (zh) * | 2015-09-23 | 2016-03-09 | 河北省科学院生物研究所 | 一株产纤溶酶的海洋放线菌株、用途以及由其制备的纤溶酶及纤溶酶的应用 |
JP2020501561A (ja) | 2016-12-16 | 2020-01-23 | ザ・ユニバーシティ・オブ・シドニー | 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3445517C2 (de) * | 1984-12-13 | 1993-11-18 | Ciba Geigy | Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins |
US4751180A (en) * | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US5002887A (en) * | 1986-01-31 | 1991-03-26 | Genetics Institute, Inc. | Truncated thrombolytic proteins |
US5188829A (en) * | 1987-08-19 | 1993-02-23 | Sagami Chemical Research Center | Rapidly acting prourokinase |
DE3804600A1 (de) * | 1988-02-13 | 1989-08-24 | Basf Ag | Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz |
GB8822147D0 (en) * | 1988-09-21 | 1988-10-26 | Ciba Geigy Ag | Pharmaceutically active combination |
US5256770A (en) * | 1990-04-09 | 1993-10-26 | Schering Ag | Oxidation resistant thrombomodulin analogs |
WO1991001142A1 (en) * | 1989-07-20 | 1991-02-07 | Biogen, Inc. | Combinations and methods for treating or preventing thrombotic diseases |
GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
US5328898A (en) * | 1990-06-22 | 1994-07-12 | Duke University | Factor XIIIA fibrin binding fragments |
US5242810A (en) * | 1990-12-07 | 1993-09-07 | Biogen, Inc. | Bifunctional inhibitors of thrombin and platelet activation |
US5688768A (en) * | 1991-02-19 | 1997-11-18 | Cor Therapeutics, Inc. | Recombinant thrombin receptor and related pharmaceuticals |
AU1873092A (en) * | 1991-04-09 | 1992-11-17 | Brigham And Women's Hospital | Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques |
US5376367A (en) * | 1991-11-22 | 1994-12-27 | Immunex Corporation | Fusion proteins comprising MGF and IL-3 |
US5571708A (en) * | 1993-04-19 | 1996-11-05 | Bristol-Myers Squibb Company | Thrombin-activatable plasminogen activator |
-
1993
- 1993-07-15 DE DE4323754A patent/DE4323754C1/de not_active Expired - Fee Related
- 1993-07-20 US US08/093,741 patent/US5681721A/en not_active Expired - Fee Related
-
1994
- 1994-03-24 IL IL10910794A patent/IL109107A0/xx unknown
- 1994-04-28 NO NO941561A patent/NO941561L/no not_active Application Discontinuation
- 1994-06-03 AU AU64525/94A patent/AU679512B2/en not_active Ceased
- 1994-06-09 AT AT94108872T patent/ATE189261T1/de not_active IP Right Cessation
- 1994-06-09 EP EP94108872A patent/EP0669394B1/de not_active Expired - Lifetime
- 1994-06-09 PT PT94108872T patent/PT669394E/pt unknown
- 1994-06-09 ES ES94108872T patent/ES2145075T3/es not_active Expired - Lifetime
- 1994-06-09 DK DK94108872T patent/DK0669394T3/da active
- 1994-06-09 SI SI9430300T patent/SI0669394T1/xx unknown
- 1994-06-09 DE DE59409104T patent/DE59409104D1/de not_active Expired - Fee Related
- 1994-06-14 ZA ZA944202A patent/ZA944202B/xx unknown
- 1994-06-23 HR HRP4323754.1 patent/HRP940366B1/xx not_active IP Right Cessation
- 1994-07-08 UA UA94075621A patent/UA27132C2/uk unknown
- 1994-07-11 HU HU9402063A patent/HU217101B/hu not_active IP Right Cessation
- 1994-07-12 CN CN94108262A patent/CN1057124C/zh not_active Expired - Fee Related
- 1994-07-12 RU RU94026095A patent/RU2143490C1/ru active
- 1994-07-13 CA CA002127897A patent/CA2127897A1/en not_active Abandoned
- 1994-07-13 NZ NZ260991A patent/NZ260991A/xx unknown
- 1994-07-13 KR KR1019940016792A patent/KR960014346A/ko not_active Application Discontinuation
- 1994-07-14 CZ CZ19941706A patent/CZ288536B6/cs not_active IP Right Cessation
- 1994-07-14 JP JP6162445A patent/JPH07143878A/ja active Pending
- 1994-07-14 SK SK845-94A patent/SK281586B6/sk unknown
- 1994-07-14 FI FI943354A patent/FI943354A/fi unknown
- 1994-07-14 PL PL94304290A patent/PL176971B1/pl unknown
-
1996
- 1996-09-27 US US08/720,012 patent/US5747291A/en not_active Expired - Fee Related
-
1998
- 1998-09-25 HK HK98110957A patent/HK1010109A1/xx not_active IP Right Cessation
-
2000
- 2000-01-27 GR GR20000400181T patent/GR3032488T3/el not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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A1OB | Publication of a patent application | ||
AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
B1PR | Patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20010623 Year of fee payment: 8 |
|
PBON | Lapse due to non-payment of renewal fee |
Effective date: 20020624 |