HRP921250B1 - Process for the preparation of new pharmacologically active catechol derivatives - Google Patents

Process for the preparation of new pharmacologically active catechol derivatives

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Publication number
HRP921250B1
HRP921250B1 HR921250A HRP921250A HRP921250B1 HR P921250 B1 HRP921250 B1 HR P921250B1 HR 921250 A HR921250 A HR 921250A HR P921250 A HRP921250 A HR P921250A HR P921250 B1 HRP921250 B1 HR P921250B1
Authority
HR
Croatia
Prior art keywords
preparation
pharmacologically active
catechol derivatives
new pharmacologically
active catechol
Prior art date
Application number
HR921250A
Other languages
English (en)
Inventor
Reijo Johannes Backstrom
Kalevi Evert Heinola
Erkki Juhani Honkanen
Seppo Kelavi Kaakkola
Pekka Juhani Kairisalo
Inge-Britt Yvonne Linden
Pekka Topias Mannisto
Erkki Aarne Olavi Nissinen
Pentti Pohto
Aino Kyllikki Pippuri
Jarmo Johan Pystynen
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from YU2189A external-priority patent/YU48020B/sh
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of HRP921250A2 publication Critical patent/HRP921250A2/xx
Publication of HRP921250B1 publication Critical patent/HRP921250B1/xx

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    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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HR921250A 1986-11-28 1992-11-12 Process for the preparation of new pharmacologically active catechol derivatives HRP921250B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI864875A FI864875A0 (fi) 1986-11-28 1986-11-28 Nya farmakologiskt aktiva foereningar, dessa innehaollande kompositioner samt foerfarande och mellanprodukter foer anvaendning vid framstaellning av dessa.
GB878712437A GB8712437D0 (en) 1986-11-28 1987-05-27 Pharmacologically active compounds
YU2189A YU48020B (sh) 1986-11-28 1989-01-06 Postupak za dobijanje novih farmakoloških aktivnih ketholnih derivata

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HRP921250A2 HRP921250A2 (en) 1998-06-30
HRP921250B1 true HRP921250B1 (en) 2000-06-30

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US (1) US5112861A (sv)
KR (1) KR960004771B1 (sv)
DD (1) DD281375A5 (sv)
FI (2) FI864875A0 (sv)
GB (1) GB8712437D0 (sv)
HR (1) HRP921250B1 (sv)
LT (1) LT3770B (sv)
MX (1) MX9524A (sv)
NO (1) NO1999010I1 (sv)
PL (1) PL154006B1 (sv)
SU (1) SU1729291A3 (sv)
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Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL91382A (en) * 1988-09-01 1995-06-29 Orion Yhtymae Oy Dicitons are converted into alkanyl or ethylmethylene, through their preparation and pharmaceutical preparations containing them
GB9113431D0 (en) * 1991-06-20 1991-08-07 Orion Yhytma Oy Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde
GB9626472D0 (en) 1996-12-20 1997-02-05 Aperia Anita C New use of comt inhibitors
US6506378B1 (en) 1998-12-16 2003-01-14 Arch Development Corporation Vesicular monoamine transporter gene therapy in Parkinson's disease
FI20000635A0 (sv) * 2000-03-17 2000-03-17 Orion Yhtymae Oyj Användning av COMT-inhibitorer som analgetika
US20060013875A1 (en) * 2002-05-29 2006-01-19 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
US7094427B2 (en) * 2002-05-29 2006-08-22 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
JP2008515956A (ja) * 2004-10-12 2008-05-15 ノボ ノルディスク アクティーゼルスカブ 11β−ヒドロキシステロイドデヒドロゲナーゼ1型活性スピロ化合物
CA2613631A1 (en) * 2005-06-23 2007-01-04 Spherics, Inc. Improved dosage forms for movement disorder treatment
US20090124598A1 (en) * 2005-11-01 2009-05-14 Henrik Sune Andersen Pharmaceutical use of substituted amides
WO2007051811A2 (en) * 2005-11-01 2007-05-10 Transtech Pharma Pharmaceutical use of substituted amides
WO2007107550A1 (en) * 2006-03-21 2007-09-27 High Point Pharmaceuticals, Llc Adamantane derivatives for the treatment of the metabolic syndrome
JP2009532418A (ja) 2006-04-07 2009-09-10 ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー 11β−ヒドロキシステロイドデヒドロゲナーゼ1型活性化合物
CA2655282A1 (en) * 2006-06-16 2007-12-21 High Point Pharmaceuticals, Llc Pharmaceutical use of substituted piperidine carboxamides
US20080131492A1 (en) * 2006-06-23 2008-06-05 Spherics, Inc. Dosage forms for movement disorder treatment
CA2657078A1 (en) * 2006-07-13 2008-01-17 High Point Pharmaceuticals, Llc 11beta-hydroxysteroid dehydrogenase type 1 active compounds
EP1878721A1 (en) * 2006-07-13 2008-01-16 Novo Nordisk A/S 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
AU2007338631A1 (en) * 2006-12-22 2008-07-03 Combinatorx, Incorporated Pharmaceutical compositions for treatment of parkinson's disease and related disorders
US8334305B2 (en) * 2007-02-23 2012-12-18 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
JP2010519240A (ja) * 2007-02-23 2010-06-03 ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー 11−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害剤としての、n−アダマンチルベンズアミド
US20110003852A1 (en) * 2007-02-23 2011-01-06 Soren Ebdrup N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
AU2008219326B2 (en) * 2007-02-23 2012-12-13 Vtv Therapeutics Llc N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
US8153798B2 (en) * 2007-03-09 2012-04-10 High Point Pharmaceuticals, Llc Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors
WO2008119017A1 (en) * 2007-03-28 2008-10-02 High Point Pharmaceuticals, Llc 11beta-hsd1 active compounds
CA2683852A1 (en) * 2007-04-11 2008-10-23 High Point Pharmaceuticals, Llc Novel compounds
JP2010526777A (ja) * 2007-04-24 2010-08-05 ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー 置換アミドの医薬用途
EP2543368A1 (en) 2007-12-11 2013-01-09 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
EP2362730A4 (en) * 2008-11-21 2012-08-29 High Point Pharmaceuticals Llc Adamantyl BENZAMIDE CONNECTIONS
EP3054929B1 (en) 2013-10-07 2020-08-05 Impax Laboratories, LLC Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
CN110225751A (zh) * 2016-08-24 2019-09-10 北京生命科学研究所 用于治疗损伤的与恩他卡朋相关的化合物
WO2018036498A1 (en) 2016-08-24 2018-03-01 National Institute Of Biological Sciences, Beijing Entacapone-related compounds to treat macular degeneration

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB902586A (en) * 1960-01-01 1962-08-01 Shell Res Ltd Herbicidal compositions and novel compounds for use therein
GB1188364A (en) * 1967-05-02 1970-04-15 May & Baker Ltd Quinoline Derivatives
BE759266A (fr) * 1969-11-24 1971-05-24 Hoffmann La Roche Procede pour la preparation de derives de l'indole
IE35838B1 (en) * 1970-12-07 1976-06-09 Reckitt & Colmann Prod Ltd Pharmaceutical compositions
US3886285A (en) * 1970-12-07 1975-05-27 Reckitt & Colmann Prod Ltd Pharmaceutical compositions containing substituted phenyl sulphoxides and sulphones and method of using same
CA1190223A (en) * 1977-11-01 1985-07-09 Anthony C. Richardson Substrates for enzymes
JPS5581832A (en) * 1978-12-13 1980-06-20 Sumitomo Chem Co Ltd Preparation of p-hydroxybenzaldehyde derivatives
FR2486523A1 (fr) * 1980-07-11 1982-01-15 Rhone Poulenc Ind Procede de preparation de polyphenols comportant eventuellement un groupement aldehyde
JPS5890534A (ja) * 1981-11-25 1983-05-30 Ono Pharmaceut Co Ltd 2−アミノフエノ−ル誘導体、その製造方法およびその誘導体を有効成分として含有する治療剤
SU1424729A3 (ru) * 1983-05-13 1988-09-15 Яманоути Фармасьютикал Ко,Лтд (Фирма) Способ получени производных катехина
FR2557097B1 (fr) * 1983-12-22 1986-06-13 Rhone Poulenc Spec Chim Procede de preparation de bromobenzaldehydes hydroxy et/ou alkoxy substitues
FR2557098B1 (fr) * 1983-12-22 1986-06-13 Rhone Poulenc Spec Chim Procede de preparation de bromobenzaldehydes hydroxy et/ou alkoxy substitues
EP0155335A1 (de) * 1984-03-21 1985-09-25 LUDWIG HEUMANN & CO GMBH Verfahren zur Herstellung von 3,5-Dimethoxy-4-alkoxybenzaldehyden
DK175069B1 (da) * 1986-03-11 2004-05-24 Hoffmann La Roche Pyrocatecholderivater
CH676845A5 (sv) * 1986-11-07 1991-03-15 Oreal
WO2001081240A2 (en) 2000-04-24 2001-11-01 Shell Internationale Research Maatschappij B.V. In-situ heating of coal formation to produce fluid

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DD281375A5 (de) 1990-08-08
KR960004771B1 (en) 1996-04-13
FI875229A (sv) 1988-05-29
FI93350B (sv) 1994-12-15
PL154006B1 (en) 1991-06-28
SU1729291A3 (ru) 1992-04-23
MX9524A (es) 1993-12-01
FI93350C (sv) 1995-03-27
NO1999010I1 (no) 1999-06-10
KR880006170A (ko) 1988-07-21
GB8712437D0 (en) 1987-07-01
HRP921250A2 (en) 1998-06-30
ZA878953B (en) 1988-05-24
US5112861A (en) 1992-05-12
FI875229A0 (sv) 1987-11-27
FI864875A0 (fi) 1986-11-28
LT3770B (en) 1996-03-25
LTIP915A (en) 1995-03-27

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