HRP20241559T1 - Ebselen za uporabu u liječenju menierove bolesti - Google Patents
Ebselen za uporabu u liječenju menierove bolesti Download PDFInfo
- Publication number
- HRP20241559T1 HRP20241559T1 HRP20241559TT HRP20241559T HRP20241559T1 HR P20241559 T1 HRP20241559 T1 HR P20241559T1 HR P20241559T T HRP20241559T T HR P20241559TT HR P20241559 T HRP20241559 T HR P20241559T HR P20241559 T1 HRP20241559 T1 HR P20241559T1
- Authority
- HR
- Croatia
- Prior art keywords
- composition
- use according
- administration
- ebselen
- image
- Prior art date
Links
- DYEFUKCXAQOFHX-UHFFFAOYSA-N Ebselen Chemical compound [se]1C2=CC=CC=C2C(=O)N1C1=CC=CC=C1 DYEFUKCXAQOFHX-UHFFFAOYSA-N 0.000 title claims 6
- 229950010033 ebselen Drugs 0.000 title claims 5
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000012360 testing method Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- -1 R2 is H Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 229920000858 Cyclodextrin Polymers 0.000 claims 2
- 239000001116 FEMA 4028 Substances 0.000 claims 2
- 102000006587 Glutathione peroxidase Human genes 0.000 claims 2
- 108700016172 Glutathione peroxidases Proteins 0.000 claims 2
- 208000009205 Tinnitus Diseases 0.000 claims 2
- 229960004853 betadex Drugs 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 231100000886 tinnitus Toxicity 0.000 claims 2
- 206010011878 Deafness Diseases 0.000 claims 1
- 208000027530 Meniere disease Diseases 0.000 claims 1
- 208000012886 Vertigo Diseases 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 238000012076 audiometry Methods 0.000 claims 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 231100000889 vertigo Toxicity 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662338443P | 2016-05-18 | 2016-05-18 | |
| EP17800188.9A EP3458045B1 (en) | 2016-05-18 | 2017-05-18 | Ebselen for use in the treatment of meniere's disease |
| PCT/US2017/033379 WO2017201318A1 (en) | 2016-05-18 | 2017-05-18 | Treatment of meniere's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20241559T1 true HRP20241559T1 (hr) | 2025-02-14 |
Family
ID=60326098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20241559TT HRP20241559T1 (hr) | 2016-05-18 | 2017-05-18 | Ebselen za uporabu u liječenju menierove bolesti |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US12427138B2 (https=) |
| EP (2) | EP4461360A3 (https=) |
| JP (1) | JP7100866B2 (https=) |
| KR (1) | KR102474830B1 (https=) |
| CN (1) | CN109475518A (https=) |
| AU (1) | AU2017267732B2 (https=) |
| CA (1) | CA3026007A1 (https=) |
| CY (1) | CY1127309T1 (https=) |
| DK (1) | DK3458045T3 (https=) |
| ES (1) | ES2990157T3 (https=) |
| FI (1) | FI3458045T3 (https=) |
| HR (1) | HRP20241559T1 (https=) |
| HU (1) | HUE069280T2 (https=) |
| LT (1) | LT3458045T (https=) |
| PL (1) | PL3458045T3 (https=) |
| PT (1) | PT3458045T (https=) |
| RS (1) | RS66167B1 (https=) |
| SI (1) | SI3458045T1 (https=) |
| SM (1) | SMT202400469T1 (https=) |
| WO (1) | WO2017201318A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115135321B (zh) | 2020-02-24 | 2023-12-05 | 上海科技大学 | N-取代吡啶基苯并异硒唑酮化合物的应用 |
| JP2025504263A (ja) * | 2021-12-23 | 2025-02-10 | ユニバーシティ オブ ロチェスター | 内耳への薬剤の送達のためのｃｓｆ輸送経路 |
| EP4536191A1 (en) | 2022-06-06 | 2025-04-16 | Sound Pharmaceuticals Incorporated | Ebselen containing oral dosage forms |
| US20250352482A1 (en) | 2022-06-06 | 2025-11-20 | Sound Pharmaceuticals Inc. | Amorphous dosage form containing ebselen |
| WO2026073143A1 (en) * | 2024-09-27 | 2026-04-02 | Sound Pharmaceuticals Inc. | Cochlear implant eluting ebselen for treating hearing loss |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3827093A1 (de) | 1988-08-10 | 1990-02-15 | Nattermann A & Cie | Verfahren zur herstellung von hochreinem ebselen |
| JPH02202818A (ja) | 1988-12-09 | 1990-08-10 | Allergan Inc | 白内障の治療における２―置換―チアゾリジン―４―カルボン酸類の用途 |
| ES2497716T3 (es) * | 2002-01-04 | 2014-09-23 | Sound Pharmaceuticals Incorporated | Composiciones para utilizar en métodos destinados a tratar la pérdida auditiva |
| US20070105782A1 (en) * | 2005-10-07 | 2007-05-10 | Board Of Trustees Of Southern Illinois University | Protectant Combinations for Reducing Toxicities |
| AU2007277193B2 (en) * | 2006-07-25 | 2013-06-13 | Hough Ear Institute | Methods for treating acute acoustic trauma |
| CA2723621A1 (en) | 2008-05-15 | 2009-11-19 | Edison Pharmaceuticals, Inc | Treatment of hearing and balance impairments using compounds having erythropoietin activity |
| JP6013736B2 (ja) | 2008-12-22 | 2016-10-25 | オトノミ—，インク． | 耳の障害の処置のための耳感覚細胞モジュレータ組成物の制御放出及びその方法 |
| ES2893825T3 (es) | 2011-02-04 | 2022-02-10 | Hough Ear Inst | Métodos de tratamiento de lesiones cerebrales |
| EP2736890A4 (en) | 2011-07-28 | 2015-07-15 | Promentis Pharm Inc | Cysteine PRODRUGS |
| CN102526734A (zh) * | 2012-01-12 | 2012-07-04 | 王玉丰 | 治疗年龄相关性听力损失的药物组合物及其应用 |
| US20150374779A1 (en) | 2014-06-26 | 2015-12-31 | Auris Medical Ag | Pharmacologic treatments of meniére's disease |
| KR20230107890A (ko) * | 2014-09-15 | 2023-07-18 | 사운드 파마슈티칼스 인코퍼레이티드 | 정신병적 장애를 치료하기 위한 방법 및 조성물 |
| JP7033789B2 (ja) * | 2016-06-29 | 2022-03-11 | オトノミー，インク． | トリグリセリド耳用製剤とその使用 |
| US10750005B2 (en) | 2018-09-27 | 2020-08-18 | International Business Machines Corporation | Selective email narration system |
-
2017
- 2017-05-18 HR HRP20241559TT patent/HRP20241559T1/hr unknown
- 2017-05-18 PT PT178001889T patent/PT3458045T/pt unknown
- 2017-05-18 US US16/300,935 patent/US12427138B2/en active Active
- 2017-05-18 EP EP24190158.6A patent/EP4461360A3/en active Pending
- 2017-05-18 HU HUE17800188A patent/HUE069280T2/hu unknown
- 2017-05-18 SM SM20240469T patent/SMT202400469T1/it unknown
- 2017-05-18 AU AU2017267732A patent/AU2017267732B2/en active Active
- 2017-05-18 PL PL17800188.9T patent/PL3458045T3/pl unknown
- 2017-05-18 DK DK17800188.9T patent/DK3458045T3/da active
- 2017-05-18 SI SI201731567T patent/SI3458045T1/sl unknown
- 2017-05-18 JP JP2018560665A patent/JP7100866B2/ja active Active
- 2017-05-18 ES ES17800188T patent/ES2990157T3/es active Active
- 2017-05-18 EP EP17800188.9A patent/EP3458045B1/en active Active
- 2017-05-18 CN CN201780044883.8A patent/CN109475518A/zh active Pending
- 2017-05-18 WO PCT/US2017/033379 patent/WO2017201318A1/en not_active Ceased
- 2017-05-18 LT LTEPPCT/US2017/033379T patent/LT3458045T/lt unknown
- 2017-05-18 FI FIEP17800188.9T patent/FI3458045T3/fi active
- 2017-05-18 KR KR1020187036629A patent/KR102474830B1/ko active Active
- 2017-05-18 CA CA3026007A patent/CA3026007A1/en active Pending
- 2017-05-18 RS RS20241265A patent/RS66167B1/sr unknown
-
2024
- 2024-11-15 CY CY20241100811T patent/CY1127309T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2990157T3 (es) | 2024-11-29 |
| EP4461360A3 (en) | 2025-01-22 |
| LT3458045T (lt) | 2024-12-10 |
| AU2017267732B2 (en) | 2023-04-13 |
| CY1127309T1 (el) | 2026-02-25 |
| JP2019516727A (ja) | 2019-06-20 |
| HUE069280T2 (hu) | 2025-02-28 |
| RS66167B1 (sr) | 2024-12-31 |
| KR102474830B1 (ko) | 2022-12-06 |
| US20200261417A1 (en) | 2020-08-20 |
| EP3458045A4 (en) | 2020-09-16 |
| EP3458045A1 (en) | 2019-03-27 |
| US12427138B2 (en) | 2025-09-30 |
| CA3026007A1 (en) | 2017-11-23 |
| SI3458045T1 (sl) | 2025-03-31 |
| KR20190043499A (ko) | 2019-04-26 |
| EP4461360A2 (en) | 2024-11-13 |
| AU2017267732A1 (en) | 2018-12-20 |
| PT3458045T (pt) | 2024-10-28 |
| FI3458045T3 (fi) | 2024-10-24 |
| SMT202400469T1 (it) | 2025-01-14 |
| JP7100866B2 (ja) | 2022-07-14 |
| EP3458045B1 (en) | 2024-08-21 |
| WO2017201318A1 (en) | 2017-11-23 |
| CN109475518A (zh) | 2019-03-15 |
| DK3458045T3 (da) | 2024-11-04 |
| PL3458045T3 (pl) | 2025-01-07 |
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