HRP20240918T1 - Metoda proizvodnje neplodnih riba i vodenih životinja koje proizvode jaja te dostava spojeva u jaja i embrije - Google Patents
Metoda proizvodnje neplodnih riba i vodenih životinja koje proizvode jaja te dostava spojeva u jaja i embrije Download PDFInfo
- Publication number
- HRP20240918T1 HRP20240918T1 HRP20240918TT HRP20240918T HRP20240918T1 HR P20240918 T1 HRP20240918 T1 HR P20240918T1 HR P20240918T T HRP20240918T T HR P20240918TT HR P20240918 T HRP20240918 T HR P20240918T HR P20240918 T1 HRP20240918 T1 HR P20240918T1
- Authority
- HR
- Croatia
- Prior art keywords
- eggs
- immersion medium
- fish
- seq
- oligomer
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 14
- 235000013601 eggs Nutrition 0.000 title claims 13
- 241000251468 Actinopterygii Species 0.000 title claims 8
- 241001465754 Metazoa Species 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 210000002257 embryonic structure Anatomy 0.000 title 1
- 208000021267 infertility disease Diseases 0.000 title 1
- 230000000692 anti-sense effect Effects 0.000 claims 9
- 238000007654 immersion Methods 0.000 claims 9
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- NWZPZNRNVWLNDL-UHFFFAOYSA-N (4-nitrophenyl) 8-[1-[4,6-bis[bis[2-carbamoyloxy-8-[(2,2,2-trifluoroacetyl)amino]-2-[6-[(2,2,2-trifluoroacetyl)amino]hexyl]octyl]amino]-1H-triazin-2-yl]piperazin-2-yl]-8-oxooctanoate Chemical compound [N+](=O)([O-])C1=CC=C(C=C1)OC(=O)CCCCCCC(=O)C1N(CCNC1)N1NC(=CC(=N1)N(CC(CCCCCCNC(C(F)(F)F)=O)(CCCCCCNC(C(F)(F)F)=O)OC(=O)N)CC(OC(=O)N)(CCCCCCNC(C(F)(F)F)=O)CCCCCCNC(C(F)(F)F)=O)N(CC(CCCCCCNC(C(F)(F)F)=O)(CCCCCCNC(C(F)(F)F)=O)OC(=O)N)CC(OC(=O)N)(CCCCCCNC(C(F)(F)F)=O)CCCCCCNC(C(F)(F)F)=O NWZPZNRNVWLNDL-UHFFFAOYSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010039627 Aprotinin Proteins 0.000 claims 1
- 241000276616 Cichlidae Species 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 claims 1
- 241000143387 Moronidae Species 0.000 claims 1
- 241000277331 Salmonidae Species 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 229960004405 aprotinin Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 230000004720 fertilization Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims 1
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 claims 1
- 108010052968 leupeptin Proteins 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 210000004681 ovum Anatomy 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 230000001850 reproductive effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/40—Monitoring or fighting invasive species
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Marine Sciences & Fisheries (AREA)
- Farming Of Fish And Shellfish (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361904652P | 2013-11-15 | 2013-11-15 | |
| US201461968458P | 2014-03-21 | 2014-03-21 | |
| US201462050815P | 2014-09-16 | 2014-09-16 | |
| PCT/US2014/065698 WO2015073819A1 (en) | 2013-11-15 | 2014-11-14 | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
| EP14862081.8A EP3068216B1 (en) | 2013-11-15 | 2014-11-14 | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240918T1 true HRP20240918T1 (hr) | 2024-10-11 |
Family
ID=53058068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240918TT HRP20240918T1 (hr) | 2013-11-15 | 2014-11-14 | Metoda proizvodnje neplodnih riba i vodenih životinja koje proizvode jaja te dostava spojeva u jaja i embrije |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9999208B2 (https=) |
| EP (1) | EP3068216B1 (https=) |
| JP (1) | JP6669650B2 (https=) |
| CN (1) | CN105764333B (https=) |
| AU (1) | AU2014348473B2 (https=) |
| CA (1) | CA2929496C (https=) |
| CL (1) | CL2016001113A1 (https=) |
| DK (1) | DK180609B1 (https=) |
| ES (1) | ES2981867T3 (https=) |
| FI (1) | FI3068216T3 (https=) |
| HR (1) | HRP20240918T1 (https=) |
| IL (1) | IL245293B (https=) |
| MX (1) | MX369329B (https=) |
| NZ (1) | NZ719421A (https=) |
| PL (1) | PL3068216T3 (https=) |
| PT (1) | PT3068216T (https=) |
| RU (1) | RU2723037C2 (https=) |
| WO (1) | WO2015073819A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3068216T3 (pl) | 2013-11-15 | 2024-10-14 | University Of Maryland At Baltimore County | Sposób wytwarzania bezpłodnych ryb i zwierząt wodnych wytwarzających jajeczka i dostarczania związków do jajeczek i zarodków |
| DK3169778T5 (da) * | 2014-07-14 | 2024-10-14 | Univ Washington State | Nanos-knockout, der eliminerer kimbaneceller |
| BR112017024662A2 (pt) * | 2015-05-19 | 2018-09-11 | Univ Maryland | métodos de entrega de agente em ovos e embriões de animais aquáticos produtores de ovos para triagem de fármacos, ensaio de toxicidade de agente e produção de peixe infértil |
| CN106614142B (zh) * | 2016-12-28 | 2019-12-03 | 浙江省海洋水产研究所 | 一种杂交不育黄姑鱼的生产方法 |
| CN109864017A (zh) * | 2017-12-05 | 2019-06-11 | 柳州市渔业技术推广站 | 山塘水库高产高效渔业养殖方法 |
| AU2018385901B2 (en) | 2017-12-15 | 2024-12-05 | Acd Pharmaceuticals As | Methods for the production of sterile fish and other egg-producing aquatic animals and compounds for use in the methods |
| CN108668984B (zh) * | 2018-04-15 | 2021-02-12 | 广西壮族自治区水产科学研究院 | 一种罗非鱼苗种高密度运输方法 |
| CN108739537B (zh) * | 2018-06-06 | 2021-02-09 | 江苏省淡水水产研究所 | 一种粉白体色斑点叉尾鮰家系制种方法 |
| BR112021020349A2 (pt) * | 2019-04-09 | 2021-12-14 | Mayo Found Medical Education & Res | Peixe estéril |
| CN112553205B (zh) * | 2020-12-29 | 2022-09-13 | 中国水产科学研究院淡水渔业研究中心 | 一种抑制黄颡鱼性腺发育的反义rna序列组合和方法及应用 |
| CN114982678B (zh) * | 2022-07-21 | 2024-02-23 | 新疆额河生态养殖科技有限公司 | 一种北极茴鱼人工繁殖操作方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780448A (en) * | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US7115794B2 (en) * | 2003-05-19 | 2006-10-03 | University Of Hawaii | Method for direct nucleic acid uptake |
| US7194978B2 (en) * | 2003-08-22 | 2007-03-27 | University Of Maryland Biotechnology Institute | Inducing sterility in fish by disrupting the development of the GnRH system |
| CN1294808C (zh) * | 2003-09-26 | 2007-01-17 | 中国科学院水生生物研究所 | 不育转基因鱼的制备方法 |
| CN1274822C (zh) * | 2004-02-19 | 2006-09-13 | 武汉康祥科技发展有限公司 | 活体化学诱导鱼类雌核发育方法 |
| NZ578390A (en) * | 2007-01-26 | 2012-01-12 | Synageva Biopharma Corp | Transgene expression in avians using oviduct specific promoters and SIN vectors |
| US7935816B2 (en) * | 2007-10-25 | 2011-05-03 | Gene Tools, Llc | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo |
| US8383880B2 (en) * | 2009-02-18 | 2013-02-26 | Academia Sinica | Infertility control of genetically modified fish |
| JP5843153B2 (ja) * | 2010-02-09 | 2016-01-13 | 国立大学法人北海道大学 | 生殖系列キメラを介して致死的魚類半数体に由来する生殖細胞から遺伝的に同一な配偶子を得る方法 |
| RU2422529C1 (ru) * | 2010-02-12 | 2011-06-27 | Учреждение Российской академии наук Институт цитологии и генетики Сибирского отделения РАН (ИЦиГ СО РАН) | ГЕННО-ИНЖЕНЕРНАЯ КОНСТРУКЦИЯ pGoatcasGCSF, ОБЕСПЕЧИВАЮЩАЯ ПРОДУКЦИЮ ГРАНУЛОЦИТ-КОЛОНИЕСТИМУЛИРУЮЩЕГО ФАКТОРА ЧЕЛОВЕКА В МОЛОКО ТРАНСГЕННЫХ ЖИВОТНЫХ |
| WO2012106026A2 (en) * | 2011-02-01 | 2012-08-09 | Purdue Research Foundation | Efficient sterilization of fish by disruption of germ cell development |
| GB201117538D0 (en) | 2011-10-11 | 2011-11-23 | Royal Veterinary College The | Methods |
| US9538734B2 (en) | 2013-03-12 | 2017-01-10 | The General Hospital Corporation | Germ cell ablation compounds and uses thereof |
| PL3068216T3 (pl) | 2013-11-15 | 2024-10-14 | University Of Maryland At Baltimore County | Sposób wytwarzania bezpłodnych ryb i zwierząt wodnych wytwarzających jajeczka i dostarczania związków do jajeczek i zarodków |
| BR112017024662A2 (pt) * | 2015-05-19 | 2018-09-11 | Univ Maryland | métodos de entrega de agente em ovos e embriões de animais aquáticos produtores de ovos para triagem de fármacos, ensaio de toxicidade de agente e produção de peixe infértil |
-
2014
- 2014-11-14 PL PL14862081.8T patent/PL3068216T3/pl unknown
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- 2014-11-14 CA CA2929496A patent/CA2929496C/en active Active
- 2014-11-14 JP JP2016530195A patent/JP6669650B2/ja active Active
- 2014-11-14 CN CN201480062691.6A patent/CN105764333B/zh active Active
- 2014-11-14 HR HRP20240918TT patent/HRP20240918T1/hr unknown
- 2014-11-14 WO PCT/US2014/065698 patent/WO2015073819A1/en not_active Ceased
- 2014-11-14 MX MX2016006315A patent/MX369329B/es active IP Right Grant
- 2014-11-14 AU AU2014348473A patent/AU2014348473B2/en active Active
- 2014-11-14 FI FIEP14862081.8T patent/FI3068216T3/fi active
- 2014-11-14 ES ES14862081T patent/ES2981867T3/es active Active
- 2014-11-14 RU RU2016123427A patent/RU2723037C2/ru active
- 2014-11-14 US US15/035,342 patent/US9999208B2/en active Active
- 2014-11-14 PT PT148620818T patent/PT3068216T/pt unknown
- 2014-11-14 NZ NZ719421A patent/NZ719421A/en unknown
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2016
- 2016-04-24 IL IL245293A patent/IL245293B/en active IP Right Grant
- 2016-05-10 CL CL2016001113A patent/CL2016001113A1/es unknown
- 2016-06-06 DK DKPA201670401A patent/DK180609B1/en active IP Right Grant
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2018
- 2018-06-18 US US16/011,631 patent/US10136621B2/en active Active
- 2018-10-22 US US16/166,387 patent/US20190104710A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CL2016001113A1 (es) | 2017-01-06 |
| CA2929496C (en) | 2022-08-23 |
| US20190104710A1 (en) | 2019-04-11 |
| ES2981867T3 (es) | 2024-10-10 |
| PL3068216T3 (pl) | 2024-10-14 |
| EP3068216A1 (en) | 2016-09-21 |
| WO2015073819A1 (en) | 2015-05-21 |
| US20160286768A1 (en) | 2016-10-06 |
| JP6669650B2 (ja) | 2020-03-18 |
| PT3068216T (pt) | 2024-07-12 |
| EP3068216B1 (en) | 2024-04-10 |
| EP3068216A4 (en) | 2017-10-11 |
| IL245293B (en) | 2020-04-30 |
| FI3068216T3 (fi) | 2024-07-10 |
| JP2017502651A (ja) | 2017-01-26 |
| MX2016006315A (es) | 2017-01-19 |
| IL245293A0 (en) | 2016-06-30 |
| RU2016123427A (ru) | 2017-12-20 |
| DK180609B1 (en) | 2021-10-14 |
| DK201670401A1 (en) | 2016-07-04 |
| US20180288984A1 (en) | 2018-10-11 |
| CA2929496A1 (en) | 2015-05-21 |
| BR112016011080A2 (pt) | 2017-12-05 |
| CN105764333A (zh) | 2016-07-13 |
| NZ719421A (en) | 2022-09-30 |
| US9999208B2 (en) | 2018-06-19 |
| AU2014348473A1 (en) | 2016-05-19 |
| CN105764333B (zh) | 2021-09-03 |
| RU2723037C2 (ru) | 2020-06-08 |
| MX369329B (es) | 2019-11-05 |
| US10136621B2 (en) | 2018-11-27 |
| AU2014348473B2 (en) | 2018-06-14 |
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