HRP20231044T1 - Novi polipeptidi i njihova upotreba u medicini - Google Patents
Novi polipeptidi i njihova upotreba u medicini Download PDFInfo
- Publication number
- HRP20231044T1 HRP20231044T1 HRP20231044TT HRP20231044T HRP20231044T1 HR P20231044 T1 HRP20231044 T1 HR P20231044T1 HR P20231044T T HRP20231044T T HR P20231044TT HR P20231044 T HRP20231044 T HR P20231044T HR P20231044 T1 HRP20231044 T1 HR P20231044T1
- Authority
- HR
- Croatia
- Prior art keywords
- polypeptide
- streptococcus
- group
- resistant
- streptococci
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title claims 38
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 38
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 38
- 244000005700 microbiome Species 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 6
- 241000191967 Staphylococcus aureus Species 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 6
- 241000588724 Escherichia coli Species 0.000 claims 5
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 5
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 239000007943 implant Substances 0.000 claims 5
- 230000000813 microbial effect Effects 0.000 claims 5
- 241000194032 Enterococcus faecalis Species 0.000 claims 4
- 241000606768 Haemophilus influenzae Species 0.000 claims 4
- 241000194008 Streptococcus anginosus Species 0.000 claims 4
- 241000194042 Streptococcus dysgalactiae Species 0.000 claims 4
- 229940032049 enterococcus faecalis Drugs 0.000 claims 4
- 229940047650 haemophilus influenzae Drugs 0.000 claims 4
- 229940115920 streptococcus dysgalactiae Drugs 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 102000002734 Collagen Type VI Human genes 0.000 claims 3
- 108010043741 Collagen Type VI Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 229940088710 antibiotic agent Drugs 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 241000186045 Actinomyces naeslundii Species 0.000 claims 2
- 241000194033 Enterococcus Species 0.000 claims 2
- 241000605986 Fusobacterium nucleatum Species 0.000 claims 2
- 241000588655 Moraxella catarrhalis Species 0.000 claims 2
- 241001135221 Prevotella intermedia Species 0.000 claims 2
- 241000193985 Streptococcus agalactiae Species 0.000 claims 2
- 241000194049 Streptococcus equinus Species 0.000 claims 2
- 241001134658 Streptococcus mitis Species 0.000 claims 2
- 241000194019 Streptococcus mutans Species 0.000 claims 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 2
- 241000193996 Streptococcus pyogenes Species 0.000 claims 2
- 241000194023 Streptococcus sanguinis Species 0.000 claims 2
- 241001505901 Streptococcus sp. 'group A' Species 0.000 claims 2
- 241000194021 Streptococcus suis Species 0.000 claims 2
- 241001312524 Streptococcus viridans Species 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241001430197 Mollicutes Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 230000009435 amidation Effects 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- 230000001986 anti-endotoxic effect Effects 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- -1 carrier Substances 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 238000009109 curative therapy Methods 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 230000006320 pegylation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
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- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Claims (17)
1. Polipeptid koji obuhvaća ili se sastoji od aminokiselinske sekvence izabrane iz grupe koju čine:
(a) bilo koja od SEQ ID NO: 1, 2, 3 i 5 iz α3 lanca kolagena tipa VI; i
(b) aminokiselinska sekvenca s najmanje 80% sličnosti sa sekvencom prema bilo kojoj od SEQ ID NO: 1, 2, 3 i 5;
pri čemu je polipeptid dužine između 20 i 200 aminokiselina; i
pri čemu je polipeptid sposoban usmrtiti ili oslabiti rast mikroorganizama.
2. Polipeptid prema patentnom zahtjevu 1, gdje:
(i) su mikroorganizmi odabrani iz grupe koju čine bakterije, mikoplazme, kvasci, glјive i virusi; i/ili
(ii) polipeptid ima sposobnost vezati se za membranu mikroorganizma; i/ili
(iii) polipeptid ima sposobnost izazvati narušavanje membrane mikroorganizama; i/ili
(iv) polipeptid ima sposobnost potaknuti zatvaranje rane; i/ili
(v) polipeptid ima sposobnost ispoljiti antimikrobni efekt koji je veći ili jednak onom kod LL-37.
3. Polipeptid prema patentnom zahtjevu 1 ili 2, pri čemu:
(i) mikroorganizmi su gram-pozitivne ili gram-negativne bakterije, po potrebi gdje se mikroorganizmi biraju iz grupe koju čine: Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, streptokok grupe A (npr. Streptococcus pyogenes), streptokok grupe B (npr. Streptococcus agalactiae), streptokok grupe C (npr. Streptococcus dysgalactiae), streptokok grupe D (npr. Enterococcus faecalis), streptokok grupe F (npr. Streptococcus anginosus), streptokok grupe G (npr. Streptococcus dysgalactiae equisimilis), alfa-hemolitički streptokok (npr. Streptococcus viridans, Streptococcus pneumoniae), Streptococcus bovis, Streptococcus mitis, Streptococcus anginosus, Streptococcus sanguinis, Streptococcus suis, Streptococcus mutans, Moraxella catarrhalis, „non-typeable“ Haemophilus influenzae (NTHi), Haemophilus influenzae b (Hib), Actinomyces naeslundii, Fusobacterium nucleatum, Prevotella intermedia, Klebsiella pneumoniae, Enterococcus cloacae, Enterococcus faecalis, Staphylococcus epidermidis, višestruko rezistentan Pseudomonas aeruginosa (MRPA), višestruko rezistentan Staphylococcus aureus (MRSA), višestruko rezistentna Escherichia coli (MREC), višestruko rezistentan Staphylococcus epidermidis (MRSE) i višestruko rezistentna Klebsiella pneumoniae (MRKP); i/ili
(ii) mikroorganizmi su bakterije koje su rezistentne na jedan ili više konvencionalnih antibiotika, po potrebi
mikroorganizam se bira iz grupe koju čine: rezistentan na više lijekova Staphylococcus aureus (MRSA), rezistentan na više lijekova Pseudomonas aeruginosa (MRPA), višestruko rezistentna Escherichia coli (MREC), višestruko rezistentan Staphylococcus epidermidis (MRSE) i višestruko rezistentna Klebsiella pneumoniae (MRKP).
4. Polipeptid prema bilo kojem od prethodnih patentnih zahtjeva, gdje: (i) polipeptid je suštinski netoksičan za ćelije sisavaca; i/ili
(ii) polipeptid je sposoban ispoljavati anti-endotoksični efekt; i/ili
(iii) polipeptid je izveden iz domene tipa A von Wilebrandovovog faktora; i/ili
(iv) polipeptid je izveden iz α3 lanca kolagena tipa VI; i/ili
(v) polipeptid je izveden iz N2, N3 ili C1 domena α3 lanca kolagena tipa VI; i/ili
(vi) polipeptid ima neto pozitivni naboj, po potrebi se naboj polipeptida kreće između +2 i +9; i/ili
(vii) polipeptid ima najmanje 30% hidrofobnih ostataka.
5. Polipeptid prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu:
(i) polipeptid je dužine između 20 i 150 aminokiselina, na primjer između 20 i 100, 20 i 50, 20 i 40 ili 25 i 35 aminokiselina u dužini; i/ili
(ii) polipeptid sadrži jednu ili više aminokiselina koje su modificirane ili izvedene; jedna ili više aminokiselina su po potrebi modificirane ili izvedene PEGilacijom, amidacijom, esterifikacijom, acilacijom, acetilacijom i/ili alkilacijom; i/ili
(iii) polipeptid je rekombinantni polipeptid.
6. Polipeptid prema bilo kojem od prethodnih patentnih zahtjeva, gdje polipeptid obuhvaća ili se sastoji od aminokiselinske sekvence s najmanje 90% identičnosti prema bilo kojoj od SEQ ID NO: 1, 2, 3 ili 5.
7. Molekula nukleinske kiseline koji kodira polipeptid prema bilo kojem od prethodnih patentnih zahtjeva, ili vektor koji obuhvaća molekulu nukleinske kiseline, gdje je po potrebi vektor ekspresijski vektor.
8. Stanica domaćin koja obuhvaća molekulu nukleinske kiseline ili vektor prema patentnom zahtjevu 7.
9. Postupak za dobivanje polipeptida prema bilo kojem od patentnih zahtjeva od 1 do 6 koji obuhvaća:
(i) uzgoj populacije stanica domaćina u kulturi prema patentnom zahtjevu 8 pod uvjetima u kojima je spomenuti polipeptid eksprimiran, i izoliranje polipeptida iz njih; ili
(ii) sinteza polipeptida u tekućoj ili čvrstoj fazi.
10. Farmaceutski sastav koja sadrži polipeptid prema bilo kojem od patentnih zahtjeva od 1 do 6 zajedno s farmaceutski prihvatlјivim ekscipijensom, razrjeđivačem, nosačem, puferom ili pomoćnim sredstvom, gdje je po potrebi farmaceutski sastav pogodan za primjenu odabranim putem i to načinom odabranim iz grupe koja se sastoji od oralne primjene, parenteralne primjene i lokalne primjene.
11. Farmaceutski sastav prema patentnom zahtjevu 10, gdje je sastav u obliku polimernog gela, gdje po potrebi polimer sadrži kolagen.
12. Medicinski uređaj, implantat, proizvod za njegu rana ili materijal za upotrebu u istom, koji je obložen, impregniran, pomiješan ili na drugi način povezan s farmaceutskim sastavom prema patentnom zahtjevu 10 ili 11, gdje je po potrebi:
(i) uređaj, implantat, proizvod za njegu rana ili materijal za upotrebu u by-pass kirurgiji, ekstrakorporalnoj cirkulaciji, njezi rana i/ili dijalizi; i/ili
(ii) farmaceutski sastav je obložen, obojen, poprskan ili na drugi način nanesen na šav, protezu, implantat, zavoj za ranu, kateter, leću, kožni graft, zamjenu za kožu, fibrinsko ljepilo ili zavoj; i/ili
(iii) medicinski uređaj, implantat, proizvod za njegu rana ili materijal za upotrebu sadrži ili se sastoji od polimera, metala, metalnog oksida i/ili keramike.
13. Komplet koji sadrži farmaceutski sastav prema patentnom zahtjevu 10 ili 11 ili medicinski uređaj, implantat, proizvod za njegu rana ili materijal za upotrebu u istom, prema patentnom zahtjevu 12.
14. Polipeptid kao što je definirano u bilo kojem od patentnih zahtjeva od 1 do 6, ili molekula nukleinske kiseline kao što je definirano u patentnom zahtjevu 7, ili farmaceutski sastav kao što je definirano u patentnom zahtjevu 10 ili 11 za upotrebu u medicini.
15. Polipeptid prema bilo kojem od patentnih zahtjeva od 1 do 6, ili molekulu nukleinske kiseline kao što je definiran u patentnom zahtjevu 7, ili farmaceutski sastav prema patentnom zahtjevu 10 ili 11 za upotrebu u kurativnom i/ili profilaktičkom tretmanu mikrobnih infekcija, gdje po potrebi:
(i) mikrobna infekcija je sistemska infekcija; i/ili
(ii) mikrobna infekcija je rezistentna na jedan ili više konvencionalnih antibiotika; i/ili
(iii) mikrobnu infekciju izaziva mikroorganizam izabran iz grupe koju čine: Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, streptokok grupe A (npr. Streptococcus pyogenes), streptokok grupe B (npr. Streptococcus agalactiae), streptokok grupe C (npr. Streptococcus dysgalactiae), streptokok grupe D (npr. Entero-coccus faecalis), streptokok grupe F (npr. Streptococcus anginosus), streptokok grupe G (npr. Streptococcus dysgalactiae equisimilis), alfa-hemolitički streptokok (npr. Streptococcus viridans, Streptococcus pneumoniae), Streptococcus bovis, Streptococcus mitis, Streptococcus anginosus, Streptococcus sanguinis, Streptococcus suis, Streptococcus mutans, Moraxella catarrhalis, „non-typeable“ Haemophilus influenzae (NTHi), Haemophilus influenzae b (Hib), Actinomyces naeslundii, Fusobacterium nucleatum, Prevotella intermedia, Klebsiella pneumoniae, Enterococcus cloacae, Enterococcus faecalis, Staphylococcus epidermidis, višestruko rezistentan Pseudomonas aeruginosa (MRPA) i višestruko rezistentan Staphylococcus aureus (MRSA), višestruko rezistentna Escherichia coli (MREC), višestruko rezistentan Staphylococcus epidermidis (MRSE) i višestruko rezistentna Klebsiella pneumoniae (MRKP); i/ili
(iv) mikrobnu infekciju izaziva mikroorganizam izabran iz grupe koju čine: rezistentan na više lijekova Staphylococcus aureus (MRSA) i višestruko rezistentan Pseudomonas aeruginosa (MRPA); i/ili
(v) polipeptid, molekula nukleinske kiseline ili farmaceutski sastav je za upotrebu u kombinaciji s jednim ili više dodatnih antimikrobnih agenasa, pri čemu se po potrebi jedno ili više dodatnih antimikrobnih agenasa bira iz grupe koju čine: antimikrobni polipeptidi i antibiotici.
16. Polipeptid kao što je definiran u bilo kojem od patentnih zahtjeva od 1 do 6, ili molekula nukleinske kiseline kao što je definirana u patentnom zahtjevu 7, ili farmaceutski sastav prema patentnom zahtjevu 10 ili 11 za upotrebu u njezi rana.
17. Postupak za in vitro ubijanje mikroorganizama koji obuhvaća dovođenje u kontakt mikroorganizama s polipeptidom kao što je opisano u bilo kojem od patentnih zahtjeva od 1 do 6, ili s molekulom nukleinske kiseline kao što je definirano u patentnom zahtjevu 7, ili s farmaceutskim sastavom kao što je definirano u patentnom zahtjevu 10 ili 11.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1601136.3A GB201601136D0 (en) | 2016-01-21 | 2016-01-21 | Novel polypeptides and medical uses thereof |
| PCT/EP2017/051246 WO2017125585A2 (en) | 2016-01-21 | 2017-01-20 | Novel polypeptides and medical uses thereof |
| EP17726194.8A EP3405222B1 (en) | 2016-01-21 | 2017-01-20 | Novel polypeptides and medical uses thereof |
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| HRP20231044T1 true HRP20231044T1 (hr) | 2023-12-22 |
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| TW202039535A (zh) * | 2018-12-18 | 2020-11-01 | 德商英麥提克生物技術股份有限公司 | B*08限制肽和肽組合物抗癌免疫治療和相關方法 |
| CN113993885A (zh) | 2019-04-12 | 2022-01-28 | 格尔托公司 | 重组弹性蛋白及其生产 |
| GB201909298D0 (en) | 2019-06-28 | 2019-08-14 | Colzyx Ab | Novel compositions and uses thereof |
| GB2610313B (en) | 2020-01-24 | 2024-07-03 | Geltor Inc | Animal-free dietary collagen |
| GB202016456D0 (en) | 2020-10-16 | 2020-12-02 | Colzyx Ab | Novel bioactive peptide combinations and uses thereof |
| SK289101B6 (sk) * | 2020-12-17 | 2023-08-09 | Ústav molekulárnej biológie Slovenskej akadémie vied, verejná výskumná inštitúcia | Antimikrobiálny proteín, antimikrobiálny rekombinantný proteín s lytickými vlastnosťami, expresný vektor, spôsob ich prípravy a použitie |
| CN113521247A (zh) * | 2021-07-15 | 2021-10-22 | 北京华芢生物技术有限公司 | 一种聚离子复合物纳米材料多肽载体及其制备方法 |
| CN113633818A (zh) * | 2021-07-20 | 2021-11-12 | 南方医科大学 | 一种多肽抗生素抗菌人工敷料的研制 |
| WO2024118297A1 (en) * | 2022-11-28 | 2024-06-06 | Edwards Lifesciences Corporation | Bioprosthetic tissue and prosthetic antimicrobial treatment |
| CN115960211B (zh) * | 2022-12-23 | 2023-11-21 | 江苏创健医疗科技股份有限公司 | 一种重组人源ⅵ型胶原蛋白及其制备方法和应用 |
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| US6008058A (en) | 1993-06-18 | 1999-12-28 | University Of Louisville | Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
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| US9155799B2 (en) * | 2012-11-19 | 2015-10-13 | Mimedx Group, Inc. | Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent |
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| CN105924522A (zh) * | 2016-04-22 | 2016-09-07 | 四川耀康生物科技有限公司 | 一种vi型胶原蛋白抗体、制备方法及其应用 |
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| CN113717271A (zh) | 2021-11-30 |
| CN109069693B (zh) | 2021-09-07 |
| CN109069693A (zh) | 2018-12-21 |
| WO2017125585A2 (en) | 2017-07-27 |
| GB201601136D0 (en) | 2016-03-09 |
| US20210403535A1 (en) | 2021-12-30 |
| ES2952858T3 (es) | 2023-11-06 |
| EP3405222A2 (en) | 2018-11-28 |
| EP4253406A2 (en) | 2023-10-04 |
| EP3405222B1 (en) | 2023-06-14 |
| EP3405222C0 (en) | 2023-06-14 |
| RS64556B1 (sr) | 2023-10-31 |
| US11136374B2 (en) | 2021-10-05 |
| PL3405222T3 (pl) | 2023-11-20 |
| US20190023767A1 (en) | 2019-01-24 |
| EP4253406A3 (en) | 2023-12-27 |
| US11814422B2 (en) | 2023-11-14 |
| WO2017125585A3 (en) | 2017-08-31 |
| US20240043500A1 (en) | 2024-02-08 |
| US20200392207A1 (en) | 2020-12-17 |
| WO2017125585A9 (en) | 2017-10-19 |
| US10793618B2 (en) | 2020-10-06 |
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