HRP20221459T1 - Miševi koji imaju modificirani lambda laki lanac imunoglobulina i njihove upotrebe - Google Patents

Miševi koji imaju modificirani lambda laki lanac imunoglobulina i njihove upotrebe Download PDF

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Publication number
HRP20221459T1
HRP20221459T1 HRP20221459TT HRP20221459T HRP20221459T1 HR P20221459 T1 HRP20221459 T1 HR P20221459T1 HR P20221459T T HRP20221459T T HR P20221459TT HR P20221459 T HRP20221459 T HR P20221459T HR P20221459 T1 HRP20221459 T1 HR P20221459T1
Authority
HR
Croatia
Prior art keywords
human
gene
gene segments
segments
genetically modified
Prior art date
Application number
HRP20221459TT
Other languages
English (en)
Croatian (hr)
Inventor
Andrew J. Murphy
Lynn Macdonald
Chunguang GUO
John Mcwhirter
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of HRP20221459T1 publication Critical patent/HRP20221459T1/hr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HRP20221459TT 2017-12-05 2018-12-04 Miševi koji imaju modificirani lambda laki lanac imunoglobulina i njihove upotrebe HRP20221459T1 (hr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762594944P 2017-12-05 2017-12-05
US201762594946P 2017-12-05 2017-12-05
US201762609241P 2017-12-21 2017-12-21
US201762609251P 2017-12-21 2017-12-21
EP18821945.5A EP3720279B1 (en) 2017-12-05 2018-12-04 Mice having an engineered immunoglobulin lambda light chain and uses thereof
PCT/US2018/063841 WO2019113065A1 (en) 2017-12-05 2018-12-04 Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof

Publications (1)

Publication Number Publication Date
HRP20221459T1 true HRP20221459T1 (hr) 2023-01-20

Family

ID=64734263

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20250920TT HRP20250920T1 (hr) 2017-12-05 2018-12-04 Miševi koji imaju modificirani lambda laki lanac imunoglobulina i njihove upotrebe
HRP20221459TT HRP20221459T1 (hr) 2017-12-05 2018-12-04 Miševi koji imaju modificirani lambda laki lanac imunoglobulina i njihove upotrebe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20250920TT HRP20250920T1 (hr) 2017-12-05 2018-12-04 Miševi koji imaju modificirani lambda laki lanac imunoglobulina i njihove upotrebe

Country Status (24)

Country Link
US (3) US11051498B2 (enExample)
EP (3) EP3720279B1 (enExample)
JP (2) JP7430636B2 (enExample)
KR (2) KR20250022220A (enExample)
CN (2) CN116058333A (enExample)
AU (2) AU2018381316B2 (enExample)
BR (1) BR112020011184A2 (enExample)
CA (1) CA3084049A1 (enExample)
DK (2) DK4140297T3 (enExample)
ES (2) ES2928995T3 (enExample)
FI (1) FI4140297T3 (enExample)
HR (2) HRP20250920T1 (enExample)
HU (2) HUE071852T2 (enExample)
IL (2) IL274797B2 (enExample)
LT (2) LT3720279T (enExample)
MX (2) MX2020005830A (enExample)
PL (2) PL4140297T3 (enExample)
PT (2) PT4140297T (enExample)
RS (2) RS63772B1 (enExample)
SG (1) SG11202003044SA (enExample)
SI (2) SI4140297T1 (enExample)
SM (2) SMT202500277T1 (enExample)
TW (2) TW202438676A (enExample)
WO (1) WO2019113065A1 (enExample)

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IL318197A (en) 2025-03-01
KR20200093570A (ko) 2020-08-05
BR112020011184A2 (pt) 2020-11-17
CN111432635A (zh) 2020-07-17
AU2018381316B2 (en) 2025-06-26
SMT202500277T1 (it) 2025-09-12
EP3720279B1 (en) 2022-09-21
US20210345591A1 (en) 2021-11-11
RU2020118699A (ru) 2022-01-10
HRP20250920T1 (hr) 2025-09-26
PL3720279T3 (pl) 2023-01-16
MX2020005830A (es) 2020-08-20
EP4140297A1 (en) 2023-03-01
PL4140297T3 (pl) 2025-08-25
IL274797B2 (en) 2025-06-01
JP2024036440A (ja) 2024-03-15
KR20250022220A (ko) 2025-02-14
HUE071852T2 (hu) 2025-09-28
DK4140297T3 (da) 2025-06-23
RS63772B1 (sr) 2022-12-30
MX2024004496A (es) 2024-05-08
RS67058B1 (sr) 2025-08-29
US20190223418A1 (en) 2019-07-25
HUE060608T2 (hu) 2023-03-28
TW201938019A (zh) 2019-10-01
EP3720279A1 (en) 2020-10-14
SMT202200448T1 (it) 2023-01-13
JP7430636B2 (ja) 2024-02-13
WO2019113065A1 (en) 2019-06-13
LT4140297T (lt) 2025-07-25
AU2018381316A1 (en) 2020-04-23
FI4140297T3 (fi) 2025-07-10
ES3035461T3 (en) 2025-09-03
SG11202003044SA (en) 2020-04-29
EP4596688A3 (en) 2025-11-12
PT3720279T (pt) 2022-10-06
US12356967B2 (en) 2025-07-15
CN116058333A (zh) 2023-05-05
US20210292439A1 (en) 2021-09-23
PT4140297T (pt) 2025-07-09
EP4596688A2 (en) 2025-08-06
TW202438676A (zh) 2024-10-01
IL274797B1 (en) 2025-02-01
SI3720279T1 (sl) 2022-11-30
IL274797A (en) 2020-07-30
CN111432635B (zh) 2022-10-21
DK3720279T3 (da) 2022-10-24
ES2928995T3 (es) 2022-11-24
LT3720279T (lt) 2022-10-25
SI4140297T1 (sl) 2025-08-29
JP7765514B2 (ja) 2025-11-06
TWI827567B (zh) 2024-01-01
CA3084049A1 (en) 2019-06-13
AU2025204547A1 (en) 2025-07-10
RU2020118699A3 (enExample) 2022-04-07
EP4140297B1 (en) 2025-05-21
US11051498B2 (en) 2021-07-06
KR102760506B1 (ko) 2025-02-04
JP2021505141A (ja) 2021-02-18

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