HRP20221127T1 - Farmaceutske kompozicije koje sadrže posakonazol i postupak proizvodnje - Google Patents
Farmaceutske kompozicije koje sadrže posakonazol i postupak proizvodnje Download PDFInfo
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- HRP20221127T1 HRP20221127T1 HRP20221127TT HRP20221127T HRP20221127T1 HR P20221127 T1 HRP20221127 T1 HR P20221127T1 HR P20221127T T HRP20221127T T HR P20221127TT HR P20221127 T HRP20221127 T HR P20221127T HR P20221127 T1 HRP20221127 T1 HR P20221127T1
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- Prior art keywords
- granules
- liquid
- hpmcas
- excipient
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- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 title claims 7
- 229960001589 posaconazole Drugs 0.000 title claims 7
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000008187 granular material Substances 0.000 claims 43
- 239000007788 liquid Substances 0.000 claims 23
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 20
- 238000000034 method Methods 0.000 claims 20
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 19
- 239000000546 pharmaceutical excipient Substances 0.000 claims 19
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 12
- 238000001035 drying Methods 0.000 claims 11
- 238000002156 mixing Methods 0.000 claims 11
- 238000005507 spraying Methods 0.000 claims 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 8
- 238000000227 grinding Methods 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 238000007873 sieving Methods 0.000 claims 8
- 238000005550 wet granulation Methods 0.000 claims 7
- 239000011230 binding agent Substances 0.000 claims 5
- 239000000945 filler Substances 0.000 claims 5
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 4
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 3
- 239000007931 coated granule Substances 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 238000007906 compression Methods 0.000 claims 3
- 230000006835 compression Effects 0.000 claims 3
- 229960001681 croscarmellose sodium Drugs 0.000 claims 3
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 3
- 238000007908 dry granulation Methods 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 2
- 238000005056 compaction Methods 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 229960001375 lactose Drugs 0.000 claims 2
- 235000019359 magnesium stearate Nutrition 0.000 claims 2
- 229940057948 magnesium stearate Drugs 0.000 claims 2
- 229920002261 Corn starch Polymers 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 238000009505 enteric coating Methods 0.000 claims 1
- 239000002702 enteric coating Substances 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000009492 tablet coating Methods 0.000 claims 1
- 239000002700 tablet coating Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Claims (13)
1. Proces za izradu enterički obloženih granula koji obuhvaća
i. pripremu otopine otapanjem posakonazola u otapalu;
ii. pripremu tekućine za raspršivanje dodavanjem hidroksipropilmetilceluloza acetat sukcinata (HPMCAS) u otopinu dobivenu u (i);
iii. osiguravanje granula najmanje jednog ekscipijensa pomoću vlažne granulacije najmanje jednog sredstva za punjenje, najmanje jednog sredstva za vezivanje i otapala;
iv. raspršivanje tekućine dobivene u (ii) odozgo na granule iz (iii);
v. sušenje granula dobivenih u (iv) i po izboru prosijavanje.
2. Proces prema patentnom zahtjevu 1, pri čemu je sredstvo za punjenje kukuruzni škrob.
3. Proces prema patentnom zahtjevu 1, pri čemu je sredstvo za vezivanje hidroksipropilmetilceluloza.
4. Proces prema bilo kojem od patentnih zahtjeva 1 do 3, pri čemu su granule osigurane sa dodatnom enteričkom oblogom koja se nanosi na granule obložene tekućinom.
5. Proces prema patentnom zahtjevu 4, pri čemu enterički obložene granule se dalje podvrgavaju suhoj granulaciji.
6. Proces prema patentnom zahtjevu 5, pri čemu se suha granulacija dobiva sabijanjem valjkom.
7. Proces prema patentnom zahtjevu 6, pri čemu proces obuhvaća korake;
i. dobivanja otopine otapanjem posakonazola u otapalu;
ii. dobivanja tekućine dodavanjem HPMCAS-a u otopinu dobivenu u (i);
iii. granuliranja najmanje jednog ekscipijensa da se dobiju granule ekscipijensa primjenom procesa vlažne granulacije;
iv. raspršivanja odozgo tekućine dobivene u (ii) na granule dobivene u (iii);
v. sušenja granula dobivenih u (iv);
vi. sabijanja granula sa ili bez najmanje jednog farmaceutskog ekscipijensa primjenom valjka kompaktora;
vii. mljevenja kompakta dobivenih u (vi) primjenom prikladne opreme za mljevenje da bi se dobile granule;
viii. dodavanja najmanje jednog farmaceutski prihvatljivog ekscipijensa granulama dobivenim u (vii), i zatim miješanja i;
ix. komprimiranja tableta.
8. Proces prema patentnom zahtjevu 6, pri čemu proces obuhvaća korake;
i. dobivanja otopine otapanjem posakonazola u diklorometanu;
ii. dodavanja prvog dijela HPMCAS-a u otopinu dobivenu u (i) da se dobije prva tekućina;
iii. granuliranja najmanje jednog ekscipijensa da se dobiju granule ekscipijensa primjenom procesa vlažne granulacije;
iv. raspršivanja odozgo prve tekućine dobivene u (ii) na granule ekscipijensa dobivene u (iii);
v. sušenja granula dobivenih u (iv) i po izboru prosijavanja;
vi. miješanja drugog dijela HPMCAS-a sa smjesom etanola i vode da se dobije druga tekućina;
vii. raspršivanja druge tekućine dobivene u (vi) na granule dobivene u (v);
viii. sušenja granula dobivenih u (vii);
ix. sabijanja granula dobivenih u (viii) primjenom valjka kompaktora;
x. mljevenja dobivenih kompakta i zatim miješanja dobivenih granula sa najmanje jednim farmaceutskim ekscipijensom odabranim od sredstva za punjenje, sredstva za raspadanje, glidanta, lubrikanta, sredstva za vezivanje ili njihove smjese;
xi. komprimiranja tableta i po izboru oblaganje tableta; pri čemu maseni odnos prvog dijela HPMCAS-a prema drugom dijelu HPMCAS-a je 3:1.
9. Proces prema patentnom zahtjevu 6, pri čemu proces obuhvaća korake;
i. dobivanja otopine otapanjem posaknazola u diklorometanu;
ii. dodavanja prvog dijela HPMCAS-a u otopinu dobivenu u (i) da se dobije prva tekućina;
iii. granuliranja najmanje jednog ekscipijensa da se dobiju granule ekscipijensa primjenom procesa vlažne granulacije;
iv. raspršivanja odozgo prve tekućine dobivene u (ii) na granule dobivene u (iii);
v. sušenja granula dobivenih u (iv) i prosijavanja;
vi. miješanja drugog dijela HPMCAS-a sa smešom etanola i vode da se dobije druga tekućina;
vii. raspršivanja druge tekućine dobivene u (vi) odozgo na granule dobivene u (v);
viii. sušenja granula dobivenih u (vii);
ix. sabijanja granula dobivenih u (viii) primjenom valjka kompaktora;
x. mljevenje dobivenih kompakta i zatim miješanje granula sa laktozom, mikrokristalnom celulozom, kroskarmelozom natrij, koloidnim silicij dioksidom, hidroksipropilcelulozom i magnezij stearatom;
xi. komprimiranja tableta i po izboru oblaganja tableta; pri čemu maseni odnos prvog dijela HPMCAS-a prema drugom dijelu HPMCAS-a je 3:1.
10. Proces prema patentnom zahtjevu 5, pri čemu se suha granulacija dobiva pomoću metode briketiranja.
11. Proces prema patentnom zahtjevu 10; pri čemu proces obuhvaća korake;
i. dobivanja otopine otapanjem posakonazola u otapalu;
ii. dobivanja tekućine dodavanjem HPMCAS-a otopini dobivenoj u (i);
iii. granuliranja najmanje jednog ekscipijensa da se dobiju granule ekscipijensa primjenom procesa vlažne granulacije;
iv. raspršivanja tekućine dobivene u (ii) odozgo na granule dobivene u (iii);
v. sušenja granula dobivenih u (iv) i po izboru prosijavanja;
vi. komprimiranje granula u obliku briketa sa ili bez najmanje jednog farmaceutskog ekscipijensa;
vii. mljevenja briketa iz (vi) primjenom prikladne opreme za mljevenje da se dobiju granule,
viii. dodavanja najmanje jednog farmaceutski prihvatljivog ekscipijensa granulama dobivenim u (vii), i zatim miješanja i;
ix. komprimiranja tableta.
12. Proces prema patentnom zahtjevu 10; pri čemu proces obuhvaća korake;
i. dobivanja otopine otapanjem posakonazola u diklorometanu;
ii. dodavanja prvog dijela HPMCAS-a otopini dobivenoj u (i) da se dobije prva tekućina;
iii. granuliranja najmanje jednog ekscipijensa da se dobiju granule primjenom procesa vlažne granulacije;
iv. raspršivanja prve tekućine dobivene u (ii) odozgo na granule dobivene u (iii);
v. sušenja granula dobivenih u (iv) i prosijavanja;
vi. miješanje drugog dijela HPMCAS-a sa smjesom etanola i vode da se dobije druga tekućina;
vii. raspršivanje druge tekućine dobivene u (vi) na granule dobivene u (v);
viii. sušenje granula dobivenih u (vii) i prosijavanje,
ix. miješanja granula sa najmanje jednim ekscipijensom odabranim od sredstva za punjenje, sredstva za raspadanje, glidanta, lubrikanta, sredstva za vezivanje ili njihovih smjesa i komprimiranje smjese u brikete;
x. mljevenja dobivenih briketa i zatim miješanja granula dobivenih sa najmanje jednim farmaceutskim ekscipijensom odabranim od sredstva za punjenje, sredstva za raspadanje, glidanta, lubrikanta, sredstva za vezivanje ili njihovih smjesa;
xi. komprimiranja tableta i po izboru oblaganja tableta; pri čemu maseni odnos prvog dijela HPMCAS-a prema drugom dijelu HPMCAS-a je 3:1.
13. Proces prema patentnom zahtjevu 10; pri čemu proces obuhvaća korake;
i. dobivanja otopine otapanjem posakonazola u diklorometanu;
ii. dodavanja prvog dijela HPMCAS-a u otopinu dobivenu u (i) da se dobije prva tekućina;
iii. granuliranja najmanje jednog ekscipijensa da se dobiju granule primjenom procesa vlažne granulacije;
iv. raspršivanja prve tekućine dobivene u (ii) odozgo na granule dobivene u (iii);
v. sušenja granula dobivenih u (iv) i prosijavanja;
vi. miješanja drugog dijela HPMCAS-a sa smjesom etanola i vode da se dobije druga tekućina;
vii. raspršivanja druge tekućine dobivene u (vi) odozgo na granule dobivene u (v);
viii. sušenja granula dobivenih u (vii) i prosijavanja;
ix. komprimiranja briketa sa laktozom, mikokristalnom celulozom, kroskarmelozom natrij, koloidnim silicij dioksidom, hidroksipropilcelulozom i magnezij stearatom,
x. mljevenja dobivenih briketa i zatim miješanja granula dobivenih sa kroskarmelozom natrij;
xi. komprimiranja tableta i po izboru oblaganja tableta; pri čemu maseni odnos prvog dijela HPMCAS-a prema drugom dijelu HPMCAS-a je 3:1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2016/20462A TR201620462A2 (tr) | 2016-12-31 | 2016-12-31 | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
| EP17020595.9A EP3342399B1 (en) | 2016-12-31 | 2017-12-31 | Pharmaceutical compositions comprising posaconazole and manufacturing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20221127T1 true HRP20221127T1 (hr) | 2022-12-09 |
Family
ID=60888079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20221127TT HRP20221127T1 (hr) | 2016-12-31 | 2017-12-31 | Farmaceutske kompozicije koje sadrže posakonazol i postupak proizvodnje |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3342399B1 (hr) |
| ES (1) | ES2927852T3 (hr) |
| HR (1) | HRP20221127T1 (hr) |
| TR (2) | TR201620462A2 (hr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201722493A2 (tr) * | 2017-12-28 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon |
| WO2020159562A1 (en) | 2019-01-29 | 2020-08-06 | Slayback Pharma Llc | Pharmaceutical compositions of posaconazole |
| WO2022034232A1 (en) | 2020-08-13 | 2022-02-17 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Gastro-resistant high-strength formulation containing posaconazole |
| CN112641756B (zh) * | 2020-12-29 | 2022-08-19 | 卓和药业集团股份有限公司 | 一种泊沙康唑肠溶微丸及其制备方法 |
| EP4091604B1 (en) | 2021-11-25 | 2024-04-03 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Granules containing posaconazole |
| EP4181883A1 (en) | 2021-11-25 | 2023-05-24 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Granules containing posaconazole |
| CN117545470A (zh) * | 2023-09-18 | 2024-02-09 | 北京德立福瑞医药科技有限公司 | 泊沙康唑固体分散体及其制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK283035B6 (sk) | 1993-12-21 | 2003-02-04 | Schering Corporation | Tetrahydrofuránová zlúčenina, spôsob jej prípravy, jej farmaceuticky prijateľný ester, soľ a farmaceutický prostriedok |
| AU719109B2 (en) | 1996-05-24 | 2000-05-04 | Merck Sharp & Dohme Corp. | Antifungal composition with enhanced bioavailability |
| EP0954288B1 (en) | 1996-06-28 | 2004-08-11 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
| CN1125067C (zh) | 1997-10-07 | 2003-10-22 | 先灵公司 | 结晶抗真菌多晶型物 |
| JP5124267B2 (ja) * | 2005-02-25 | 2013-01-23 | 武田薬品工業株式会社 | 顆粒の製造方法 |
| JP2009538927A (ja) | 2006-05-30 | 2009-11-12 | エラン ファーマ インターナショナル，リミティド | ナノ粒子状のポサコナゾール製剤 |
| EP2285351A2 (en) | 2008-04-15 | 2011-02-23 | Schering Corporation | Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and hpmcas |
| EP2130540A1 (en) | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| CA2874797A1 (en) | 2012-06-14 | 2013-12-19 | Sandoz Ag | Pharmaceutical composition comprising crystalline posaconazole |
| ITMI20132114A1 (it) | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| US20150231081A1 (en) | 2014-02-20 | 2015-08-20 | Cadila Healthcare Limited | Delayed release posaconazole tablets |
| US11058682B2 (en) * | 2015-08-08 | 2021-07-13 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Gastro-resistant formulation containing posaconazole |
| EP3210599A1 (en) * | 2016-02-26 | 2017-08-30 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor |
| WO2017032908A1 (en) * | 2016-07-08 | 2017-03-02 | Synthon B.V. | Pharmaceutical composition comprising amorphous posaconazole |
-
2016
- 2016-12-31 TR TR2016/20462A patent/TR201620462A2/tr unknown
-
2017
- 2017-12-31 ES ES17020595T patent/ES2927852T3/es active Active
- 2017-12-31 HR HRP20221127TT patent/HRP20221127T1/hr unknown
- 2017-12-31 EP EP17020595.9A patent/EP3342399B1/en active Active
-
2018
- 2018-12-30 TR TR2018/21116A patent/TR201821116A2/tr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3342399B1 (en) | 2022-08-31 |
| EP3342399A1 (en) | 2018-07-04 |
| TR201620462A2 (tr) | 2018-07-23 |
| ES2927852T3 (es) | 2022-11-11 |
| TR201821116A2 (tr) | 2019-07-22 |
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