HRP20211803T1 - Genska terapija - Google Patents
Genska terapija Download PDFInfo
- Publication number
- HRP20211803T1 HRP20211803T1 HRP20211803TT HRP20211803T HRP20211803T1 HR P20211803 T1 HRP20211803 T1 HR P20211803T1 HR P20211803T T HRP20211803T T HR P20211803TT HR P20211803 T HRP20211803 T HR P20211803T HR P20211803 T1 HRP20211803 T1 HR P20211803T1
- Authority
- HR
- Croatia
- Prior art keywords
- cells
- vector
- csh
- viral vector
- population
- Prior art date
Links
- 238000001415 gene therapy Methods 0.000 title claims 3
- 210000004027 cell Anatomy 0.000 claims 24
- 108010019251 cyclosporin H Proteins 0.000 claims 14
- 239000013603 viral vector Substances 0.000 claims 14
- PMATZTZNYRCHOR-JLPRAAIDSA-N (3r,6s,9s,12r,15s,18s,21s,24s,30s,33s)-30-ethyl-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-JLPRAAIDSA-N 0.000 claims 13
- 239000013598 vector Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 229960002986 dinoprostone Drugs 0.000 claims 4
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 4
- 230000001419 dependent effect Effects 0.000 claims 3
- 230000012202 endocytosis Effects 0.000 claims 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 238000010361 transduction Methods 0.000 claims 3
- 230000026683 transduction Effects 0.000 claims 3
- -1 dimethyl prostaglandin E2 Chemical compound 0.000 claims 2
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6045—RNA rev transcr viruses
- C12N2810/6054—Retroviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
- C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1706394.2A GB201706394D0 (en) | 2017-04-21 | 2017-04-21 | Gene Therapy |
| PCT/EP2018/060237 WO2018193118A1 (en) | 2017-04-21 | 2018-04-20 | Gene therapy |
| EP18719544.1A EP3612237B1 (en) | 2017-04-21 | 2018-04-20 | Gene therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211803T1 true HRP20211803T1 (hr) | 2022-03-04 |
Family
ID=58795636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211803TT HRP20211803T1 (hr) | 2017-04-21 | 2018-04-20 | Genska terapija |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11964027B2 (https=) |
| EP (2) | EP3612237B1 (https=) |
| JP (2) | JP7443063B2 (https=) |
| CN (1) | CN110769860B (https=) |
| AU (1) | AU2018253958B2 (https=) |
| CA (1) | CA3060128A1 (https=) |
| DK (1) | DK3612237T3 (https=) |
| ES (1) | ES2900560T3 (https=) |
| GB (1) | GB201706394D0 (https=) |
| HR (1) | HRP20211803T1 (https=) |
| HU (1) | HUE056570T2 (https=) |
| IL (1) | IL270032B2 (https=) |
| LT (1) | LT3612237T (https=) |
| PL (1) | PL3612237T3 (https=) |
| PT (1) | PT3612237T (https=) |
| RS (1) | RS62619B1 (https=) |
| SI (1) | SI3612237T1 (https=) |
| WO (1) | WO2018193118A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2769270T3 (es) * | 2011-09-30 | 2020-06-25 | Bluebird Bio Inc | Compuestos para transducción viral mejorada |
| US20250230511A1 (en) * | 2021-10-29 | 2025-07-17 | Sana Biotechnology, Inc. | Methods and reagents for amplifying viral vector nucleic acid products |
| GB202208550D0 (en) * | 2022-06-10 | 2022-07-27 | Ospedale San Raffaele Srl | Cyclosporin h and uses thereof |
| GB202209098D0 (en) * | 2022-06-21 | 2022-08-10 | Ucl Business Ltd | Cyclosporine analogues |
| US20260048148A1 (en) | 2022-08-11 | 2026-02-19 | Fondazione Telethon Ets (50%) | Gene therapy |
| EP4602153A1 (en) | 2022-10-11 | 2025-08-20 | Fondazione Telethon ETS | 3d cell culture methods |
| IT202300011790A1 (it) | 2023-06-08 | 2024-12-08 | Fond Telethon Ets | Protocolli di manipolazione genica in cellule immunitarie |
| IT202300022191A1 (it) | 2023-10-24 | 2025-04-24 | Fond Telethon Ets | Mezzi e metodi per la modifica genetica di uba1 |
| EP4640830A1 (en) | 2024-04-23 | 2025-10-29 | Fondazione Telethon ETS | Means and methods for safe and efficient gene editing in cells |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723315A (en) | 1996-08-23 | 1998-03-03 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| WO1998005635A1 (en) | 1996-08-07 | 1998-02-12 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| PT904392E (pt) | 1996-10-17 | 2001-06-29 | Oxford Biomedica Ltd | Vectores retrovirais |
| ATE528406T1 (de) | 1999-04-29 | 2011-10-15 | Gbp Ip Llc | Verfahren und mittel zur herstellung von sicheren,rekombinanten lentivirusvektoren mit hohem titer |
| ATE527347T1 (de) | 2001-08-02 | 2011-10-15 | Inst Clayton De La Rech | Verfahren und zusammensetzungen im zusammenhang mit verbesserten lentivirusvektor- produktionssystemen |
| EP1549347A1 (en) * | 2002-10-09 | 2005-07-06 | Lorantis Limited | Modulation of immune function |
| WO2004098531A2 (en) * | 2003-05-05 | 2004-11-18 | Virxsys Corporation | Increased transduction using abc transporter substrates and/or inhibitors |
| WO2012058673A2 (en) * | 2010-10-31 | 2012-05-03 | Tocagen Inc. | Enhanced cancer treatment and monitoring using recombinant vectors |
| EP2943203A4 (en) | 2013-01-11 | 2016-08-24 | Scripps Research Inst | METHOD AND COMPOSITIONS FOR INCREASING THE TRANSDUCTION EFFICIENCY OF RETROVIRAL VECTORS |
| EP3060670B1 (en) | 2013-10-24 | 2019-07-10 | Ospedale San Raffaele S.r.l. | Method |
| GB201407322D0 (en) * | 2014-04-25 | 2014-06-11 | Ospedale San Raffaele | Gene therapy |
| CA2986310A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
-
2017
- 2017-04-21 GB GBGB1706394.2A patent/GB201706394D0/en not_active Ceased
-
2018
- 2018-04-20 RS RS20211471A patent/RS62619B1/sr unknown
- 2018-04-20 HR HRP20211803TT patent/HRP20211803T1/hr unknown
- 2018-04-20 EP EP18719544.1A patent/EP3612237B1/en active Active
- 2018-04-20 SI SI201830485T patent/SI3612237T1/sl unknown
- 2018-04-20 PL PL18719544T patent/PL3612237T3/pl unknown
- 2018-04-20 JP JP2019556865A patent/JP7443063B2/ja active Active
- 2018-04-20 ES ES18719544T patent/ES2900560T3/es active Active
- 2018-04-20 CN CN201880038804.7A patent/CN110769860B/zh active Active
- 2018-04-20 DK DK18719544.1T patent/DK3612237T3/da active
- 2018-04-20 IL IL270032A patent/IL270032B2/en unknown
- 2018-04-20 PT PT187195441T patent/PT3612237T/pt unknown
- 2018-04-20 LT LTEPPCT/EP2018/060237T patent/LT3612237T/lt unknown
- 2018-04-20 HU HUE18719544A patent/HUE056570T2/hu unknown
- 2018-04-20 AU AU2018253958A patent/AU2018253958B2/en active Active
- 2018-04-20 EP EP21194123.2A patent/EP3973996A1/en active Pending
- 2018-04-20 WO PCT/EP2018/060237 patent/WO2018193118A1/en not_active Ceased
- 2018-04-20 CA CA3060128A patent/CA3060128A1/en active Pending
- 2018-04-20 US US16/606,633 patent/US11964027B2/en active Active
-
2023
- 2023-12-26 JP JP2023219262A patent/JP2024045128A/ja active Pending
-
2024
- 2024-03-06 US US18/597,488 patent/US12485187B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110769860A (zh) | 2020-02-07 |
| US20210121579A1 (en) | 2021-04-29 |
| EP3612237A1 (en) | 2020-02-26 |
| WO2018193118A1 (en) | 2018-10-25 |
| JP7443063B2 (ja) | 2024-03-05 |
| IL270032A (https=) | 2019-12-31 |
| DK3612237T3 (da) | 2021-12-06 |
| LT3612237T (lt) | 2022-01-25 |
| PT3612237T (pt) | 2021-12-02 |
| EP3612237B1 (en) | 2021-09-01 |
| SI3612237T1 (sl) | 2022-02-28 |
| RS62619B1 (sr) | 2021-12-31 |
| CA3060128A1 (en) | 2018-10-25 |
| ES2900560T3 (es) | 2022-03-17 |
| GB201706394D0 (en) | 2017-06-07 |
| CN110769860B (zh) | 2024-03-08 |
| IL270032B1 (en) | 2024-11-01 |
| US11964027B2 (en) | 2024-04-23 |
| IL270032B2 (en) | 2025-03-01 |
| PL3612237T3 (pl) | 2022-02-14 |
| AU2018253958A1 (en) | 2019-11-21 |
| US12485187B2 (en) | 2025-12-02 |
| AU2018253958B2 (en) | 2024-03-07 |
| HUE056570T2 (hu) | 2022-02-28 |
| JP2024045128A (ja) | 2024-04-02 |
| EP3973996A1 (en) | 2022-03-30 |
| US20240350661A1 (en) | 2024-10-24 |
| JP2020517253A (ja) | 2020-06-18 |
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