HRP20210240T1 - Vezujući proteini slični protutijelu s dvostrukom varijabilnom regijom koji imaju unakrsno orjentiranu vezujuću regiju - Google Patents
Vezujući proteini slični protutijelu s dvostrukom varijabilnom regijom koji imaju unakrsno orjentiranu vezujuću regiju Download PDFInfo
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- HRP20210240T1 HRP20210240T1 HRP20210240TT HRP20210240T HRP20210240T1 HR P20210240 T1 HRP20210240 T1 HR P20210240T1 HR P20210240T T HRP20210240T T HR P20210240TT HR P20210240 T HRP20210240 T HR P20210240T HR P20210240 T1 HRP20210240 T1 HR P20210240T1
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Classifications
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- A61P37/00—Drugs for immunological or allergic disorders
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- C07K—PEPTIDES
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/241—Tumor Necrosis Factors
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- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
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- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/46—Hybrid immunoglobulins
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161468276P | 2011-03-28 | 2011-03-28 | |
| FR1160311 | 2011-11-14 | ||
| EP16205057.9A EP3199547B1 (en) | 2011-03-28 | 2012-03-28 | Dual variable region antibody-like binding proteins having cross-over binding region orientation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20210240T1 true HRP20210240T1 (hr) | 2021-04-02 |
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ID=65657124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20210240TT HRP20210240T1 (hr) | 2011-03-28 | 2021-02-11 | Vezujući proteini slični protutijelu s dvostrukom varijabilnom regijom koji imaju unakrsno orjentiranu vezujuću regiju |
Country Status (11)
| Country | Link |
|---|---|
| KR (1) | KR102240802B1 (he) |
| CL (1) | CL2013002763A1 (he) |
| ES (1) | ES2859906T3 (he) |
| HR (1) | HRP20210240T1 (he) |
| HU (1) | HUE053139T2 (he) |
| IL (3) | IL249369B (he) |
| LT (1) | LT3199547T (he) |
| MX (2) | MX366923B (he) |
| PH (1) | PH12018501305A1 (he) |
| PT (1) | PT3199547T (he) |
| RU (1) | RU2019122155A (he) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5989830A (en) * | 1995-10-16 | 1999-11-23 | Unilever Patent Holdings Bv | Bifunctional or bivalent antibody fragment analogue |
| JP5718637B2 (ja) * | 2007-06-21 | 2015-05-13 | マクロジェニクス，インコーポレーテッド | 共有結合型ダイアボディおよびその使用 |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
-
2012
- 2012-03-28 HU HUE16205057A patent/HUE053139T2/hu unknown
- 2012-03-28 KR KR1020197012135A patent/KR102240802B1/ko active IP Right Grant
- 2012-03-28 ES ES16205057T patent/ES2859906T3/es active Active
- 2012-03-28 MX MX2016000274A patent/MX366923B/es unknown
- 2012-03-28 RU RU2019122155A patent/RU2019122155A/ru unknown
- 2012-03-28 PT PT162050579T patent/PT3199547T/pt unknown
- 2012-03-28 LT LTEP16205057.9T patent/LT3199547T/lt unknown
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2013
- 2013-09-26 CL CL2013002763A patent/CL2013002763A1/es unknown
- 2013-09-27 MX MX2019009016A patent/MX2019009016A/es unknown
-
2016
- 2016-12-04 IL IL24936916A patent/IL249369B/he active IP Right Grant
-
2018
- 2018-06-19 PH PH12018501305A patent/PH12018501305A1/en unknown
-
2020
- 2020-05-24 IL IL274876A patent/IL274876A/he unknown
- 2020-05-24 IL IL274870A patent/IL274870B2/he unknown
-
2021
- 2021-02-11 HR HRP20210240TT patent/HRP20210240T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT3199547T (pt) | 2021-02-02 |
| ES2859906T3 (es) | 2021-10-04 |
| IL274870B1 (he) | 2023-01-01 |
| KR20190049902A (ko) | 2019-05-09 |
| MX2019009016A (es) | 2019-09-10 |
| LT3199547T (lt) | 2021-02-25 |
| IL274870A (he) | 2020-07-30 |
| RU2019122155A (ru) | 2020-03-16 |
| IL274870B2 (he) | 2023-05-01 |
| IL274876A (he) | 2020-07-30 |
| IL249369A0 (he) | 2017-02-28 |
| PH12018501305A1 (en) | 2020-01-27 |
| HUE053139T2 (hu) | 2021-06-28 |
| IL249369B (he) | 2019-11-28 |
| MX366923B (es) | 2019-07-31 |
| KR102240802B1 (ko) | 2021-04-16 |
| CL2013002763A1 (es) | 2014-03-07 |
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