HRP20201948T1 - Pripravci inhibitora dopa-dekarbokilaze - Google Patents
Pripravci inhibitora dopa-dekarbokilaze Download PDFInfo
- Publication number
- HRP20201948T1 HRP20201948T1 HRP20201948TT HRP20201948T HRP20201948T1 HR P20201948 T1 HRP20201948 T1 HR P20201948T1 HR P20201948T T HRP20201948T T HR P20201948TT HR P20201948 T HRP20201948 T HR P20201948T HR P20201948 T1 HRP20201948 T1 HR P20201948T1
- Authority
- HR
- Croatia
- Prior art keywords
- weight
- preparation
- accordance
- intended
- per hour
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952477P | 2014-03-13 | 2014-03-13 | |
| US201461990967P | 2014-05-09 | 2014-05-09 | |
| EP15731727.2A EP3116475B1 (en) | 2014-03-13 | 2015-03-12 | Dopa decarboxylase inhibitor compositions |
| PCT/IL2015/050258 WO2015136538A1 (en) | 2014-03-13 | 2015-03-12 | Dopa decarboxylase inhibitor compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201948T1 true HRP20201948T1 (hr) | 2021-01-22 |
Family
ID=53488380
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20231716TT HRP20231716T1 (hr) | 2014-03-13 | 2015-03-12 | Pripravci inhibitora dopa dekarboksilaze |
| HRP20201948TT HRP20201948T1 (hr) | 2014-03-13 | 2015-03-12 | Pripravci inhibitora dopa-dekarbokilaze |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20231716TT HRP20231716T1 (hr) | 2014-03-13 | 2015-03-12 | Pripravci inhibitora dopa dekarboksilaze |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US10022320B2 (OSRAM) |
| EP (3) | EP4299128A3 (OSRAM) |
| JP (2) | JP6591995B2 (OSRAM) |
| CN (1) | CN106413754B (OSRAM) |
| AU (1) | AU2015228369B2 (OSRAM) |
| BR (1) | BR112016021034A8 (OSRAM) |
| CA (1) | CA2942244C (OSRAM) |
| DK (2) | DK3116475T3 (OSRAM) |
| ES (2) | ES2967693T3 (OSRAM) |
| FI (1) | FI3777833T3 (OSRAM) |
| HR (2) | HRP20231716T1 (OSRAM) |
| HU (2) | HUE064818T2 (OSRAM) |
| IL (1) | IL247668B (OSRAM) |
| MX (1) | MX2016011837A (OSRAM) |
| PL (2) | PL3116475T3 (OSRAM) |
| PT (2) | PT3116475T (OSRAM) |
| RS (1) | RS65060B1 (OSRAM) |
| RU (1) | RU2684105C2 (OSRAM) |
| WO (1) | WO2015136538A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8193243B2 (en) | 2009-05-19 | 2012-06-05 | Neuroderm, Ltd. | Continuous administration of dopa decarboxylase inhibitors and compositions for same |
| JP5902705B2 (ja) | 2010-11-15 | 2016-04-13 | ニューロダーム リミテッドNeuroderm Ltd | L−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−o−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与 |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| EP4299128A3 (en) | 2014-03-13 | 2024-04-17 | Neuroderm Ltd. | Dopa decarboxylase inhibitor compositions |
| CA2997791A1 (en) | 2015-09-30 | 2017-04-06 | Duke University | Ascorbate formulations and methods of use as contrast agents |
| WO2018154447A1 (en) * | 2017-02-21 | 2018-08-30 | Neuroderm Ltd | Dopa decarboxylase inhibitor compositions |
| SG11202104499RA (en) | 2018-11-15 | 2021-05-28 | Abbvie Inc | Pharmaceutical formulations for subcutaneous administration |
| WO2020178810A1 (en) * | 2019-03-04 | 2020-09-10 | Neuroderm, Ltd. | Pharmaceutical compositions comprising levodopa amide derivatives and uses thereof |
| CN111701024B (zh) * | 2020-05-26 | 2022-05-24 | 上海京新生物医药有限公司 | 一种左旋多巴制剂及其制备方法及其应用 |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| CN113396897B (zh) * | 2021-07-26 | 2022-06-07 | 苏州华测生物技术有限公司 | 一种稳定生物基质中卡比多巴/左旋多巴的方法 |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3769424A (en) | 1970-10-01 | 1973-10-30 | Merck & Co Inc | Composition and method of treating dopamine deficiency in brain tissue |
| AU6889274A (en) | 1973-05-17 | 1975-11-20 | Astra Laekemedel Ab | Treatment of neurological disorders |
| US3936495A (en) | 1973-11-27 | 1976-02-03 | Merck & Co., Inc. | Purification process |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4241082A (en) | 1977-09-02 | 1980-12-23 | Sankyo Company Limited | Agents for promoting reproductive ability of domestic animals |
| JPS5450700A (en) | 1977-09-28 | 1979-04-20 | Sankyo Co | Glazing agent of animal leather |
| JPS6021570B2 (ja) | 1978-07-04 | 1985-05-28 | 三共株式会社 | ド−パ類の高濃度製剤の製法 |
| JPS56115749A (en) | 1980-02-18 | 1981-09-11 | Sagami Chem Res Center | Dopa derivative |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4642316A (en) | 1985-05-20 | 1987-02-10 | Warner-Lambert Company | Parenteral phenytoin preparations |
| EP0252290B1 (en) | 1986-06-10 | 1992-06-03 | CHIESI FARMACEUTICI S.p.A. | Pharmaceutical compositions containing levodopa methyl ester, preparation and therapeutic applications thereof |
| US4832957A (en) | 1987-12-11 | 1989-05-23 | Merck & Co., Inc. | Controlled release combination of carbidopa/levodopa |
| US4684666A (en) | 1986-08-19 | 1987-08-04 | Haas Pharmaceuticals, Inc. | Stabilized liquid analgesic compositions |
| IT1226902B (it) | 1988-07-12 | 1991-02-21 | Mini Ricerca Scient Tecnolog | Processo per la sintesi del levodopa |
| US4963568A (en) | 1989-05-31 | 1990-10-16 | Abbott Laboratories | Dopamine agonists |
| WO1992007561A1 (en) | 1990-10-30 | 1992-05-14 | Ss Pharmaceutical Co., Ltd. | Antiphlogistic and analgesic gel preparation |
| US5877176A (en) | 1991-12-26 | 1999-03-02 | Cornell Research Foundation, Inc. | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| CA2143070C (en) | 1994-02-22 | 2001-12-18 | Pankaj Modi | Oral controlled release liquid suspension pharmaceutical formulation |
| WO1996037226A2 (en) | 1995-05-26 | 1996-11-28 | Pfizer Inc. | Combinations for the treatment of parkinsonism containing selective nmda antagonists |
| GB9523833D0 (en) | 1995-11-22 | 1996-01-24 | Boots Co Plc | Medical treatment |
| IL119417A (en) | 1996-10-13 | 2003-02-12 | Moshe Kushnir | Pharmaceutical composition for transdermal administration of levodopa for parkinson's disease |
| US6746688B1 (en) | 1996-10-13 | 2004-06-08 | Neuroderm Ltd. | Apparatus for the transdermal treatment of Parkinson's disease |
| US5861423A (en) | 1997-02-21 | 1999-01-19 | Caldwell; William Scott | Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds |
| US6245917B1 (en) | 1998-03-20 | 2001-06-12 | Warner-Lambert Company | Crystalline sodium phenytoin monohydrate |
| US7201923B1 (en) | 1998-03-23 | 2007-04-10 | General Mills, Inc. | Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles |
| PL204921B1 (pl) | 1998-05-15 | 2010-02-26 | Warner Lambert Co | Stabilizowana kompozycja farmaceutyczna zawierająca 4-amino-3-podstawioną pochodną kwasu butanowego i α-aminokwas oraz sposób jej wytwarzania |
| US6274168B1 (en) | 1999-02-23 | 2001-08-14 | Mylan Pharmaceuticals Inc. | Phenytoin sodium pharmaceutical compositions |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| WO2000054773A1 (en) | 1999-03-12 | 2000-09-21 | Nitromed, Inc. | Dopamine agonists in combination with nitric oxide donors, compositions and methods of use |
| FI109453B (fi) | 1999-06-30 | 2002-08-15 | Orion Yhtymae Oyj | Farmaseuttinen koostumus |
| US7479498B2 (en) | 1999-08-23 | 2009-01-20 | Phoenix Biosciences, Inc. | Treatments for viral infections |
| US6348965B1 (en) | 1999-09-24 | 2002-02-19 | Henry Palladino | Solid state fluorescence and absorption spectroscopy |
| SE0001151D0 (sv) | 2000-03-31 | 2000-03-31 | Amarin Dev Ab | Method for producing a controlled-release composition |
| US20020028799A1 (en) | 2000-07-06 | 2002-03-07 | Naylor Alasdair Mark | Treatment of male sexual dysfunction |
| GB0017387D0 (en) | 2000-07-14 | 2000-08-30 | Pfizer Ltd | Novel enzyme |
| US20020099013A1 (en) | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
| US20030119714A1 (en) | 2000-12-15 | 2003-06-26 | Naylor Alasdair Mark | Treatment of male sexual dysfunction |
| WO2002068415A1 (en) | 2000-12-21 | 2002-09-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| IL159812A0 (en) | 2001-07-12 | 2004-06-20 | Teva Pharma | Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in immediate release layer with levodopa ethyl ester in a controlled release core |
| AU2002335077B2 (en) | 2001-10-19 | 2006-09-07 | Idexx Laboratories, Inc. | Injectable compositions for the controlled delivery of pharmacologically active compound |
| AU2002357137A1 (en) | 2001-12-10 | 2003-06-23 | Bristol-Myers Squibb Company | (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase |
| ES2189682B1 (es) | 2001-12-11 | 2004-04-01 | Laboratorios Del Dr. Esteve, S.A. | Preparacion bebible que comprende ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamacion y/o dolor, en un colectivo de animales, de forma simultanea. |
| US20060159751A1 (en) | 2002-04-11 | 2006-07-20 | Mona Gogia | Controlled release pharmaceutical compositions of carbidopa and levodopa |
| US7985422B2 (en) | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
| US7223776B2 (en) | 2002-10-10 | 2007-05-29 | Morphochem Ag | Compounds with anti-bacterial activity |
| WO2004069146A2 (en) | 2003-02-07 | 2004-08-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | L-dopa amide derivatives and uses thereof |
| AU2004280158B2 (en) | 2003-07-18 | 2011-02-17 | Baxter International, Inc. | Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation |
| US8173840B2 (en) | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
| US7589233B2 (en) | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
| GB0319935D0 (en) | 2003-08-26 | 2003-09-24 | Cipla Ltd | Polymorphs |
| ES2360759T3 (es) * | 2003-08-29 | 2011-06-08 | Centocor Ortho Biotech Inc. | Composiciones farmacéuticas y procedimiento de utilización de la levodopa y de la carbidopa. |
| JP5160786B2 (ja) * | 2003-08-29 | 2013-03-13 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 医薬組成物及びレボドパ及びカルビドパの使用方法 |
| US20050053669A1 (en) | 2003-09-05 | 2005-03-10 | Boehringer Ingelheim International Gmbh | Administration form for the oral application of poorly soluble acidic and amphorteric drugs |
| US20050163841A1 (en) | 2003-10-31 | 2005-07-28 | Wong Patrick S. | Compositions and dosage forms for enhanced absorption of 3-amino-n-butyl-phosphinic acid |
| WO2005099678A1 (en) | 2004-04-06 | 2005-10-27 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions and method of using levodopa and carbidopa |
| SE0401842D0 (sv) | 2004-07-12 | 2004-07-12 | Dizlin Medical Design Ab | Infusion and injection solution of levodopa |
| WO2006029411A2 (en) | 2004-09-09 | 2006-03-16 | Yeda Research And Development Co. Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof |
| US20060241183A1 (en) | 2004-09-28 | 2006-10-26 | Farouk Karoum | Compositions and methods of using D-DOPA to treat Parkinson's disease |
| EP1809283A2 (en) | 2004-10-01 | 2007-07-25 | The Research Foundation Of State University Of New York | Morphine and morphine precursors |
| US20080187590A1 (en) | 2005-06-08 | 2008-08-07 | Kari Vahervuo | Oral Dosage Form |
| DE102006021872B4 (de) | 2006-05-11 | 2008-04-17 | Sanofi-Aventis | 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2063865A1 (en) | 2006-05-31 | 2009-06-03 | Solvay Pharmaceuticals GmbH | Long term 24 hour intestinal administration of levodopa/carbidopa |
| AR062659A1 (es) | 2006-09-08 | 2008-11-26 | Drug Tech Corp | Composicion de liberacion sostenida de levodopa y metodo para su uso |
| CA2606658A1 (en) | 2006-10-13 | 2008-04-13 | Mike Tyers | Compositions and methods for treating neurological disorders or damage |
| US8563013B2 (en) | 2007-04-06 | 2013-10-22 | Janssen Biotech, Inc. | Systems and methods for delivering a fluid drug |
| CL2008003507A1 (es) | 2007-11-26 | 2009-11-27 | Neuroderm Ltd | Composicion farmaceutica que comprende nicotina y un inhibidor de la desensibilizacion del receptor de acetilcolina nicotinico (nachr) opipramol; kit farmaceutico; dispositivo medico; y uso para tratar una enfermedad o trastorno del sistema nervioso central o periferico. |
| KR101444979B1 (ko) * | 2008-02-06 | 2014-10-07 | 욱크하르트 리미티드 | 생체 이용율이 개선된 엔타카폰, 레보도파 및 카르비도파의 약학 조성물 |
| CN101669925B (zh) | 2008-09-10 | 2011-08-10 | 天津药物研究院 | 干粉吸入剂、其制备方法和用途 |
| WO2010055133A1 (en) | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| US8193243B2 (en) * | 2009-05-19 | 2012-06-05 | Neuroderm, Ltd. | Continuous administration of dopa decarboxylase inhibitors and compositions for same |
| US20130253056A1 (en) | 2009-05-19 | 2013-09-26 | Neuroderm, Ltd. | Continuous Administration of Levodopa and/or Dopa Decarboxylase Inhibitors and Compositions for Same |
| CN101987081B (zh) | 2010-07-16 | 2012-08-08 | 钟术光 | 一种控释制剂 |
| KR101187064B1 (ko) | 2010-07-18 | 2012-09-28 | 주식회사 바이오폴리메드 | 양이온성 지질, 이의 제조 방법 및 이를 포함하는 세포내 이행성을 갖는 전달체 |
| US10150792B2 (en) | 2010-11-08 | 2018-12-11 | Synthonics, Inc. | Bismuth-containing compounds, coordination polymers, methods for modulating pharmacokinetic properties of biologically active agents, and methods for treating patients |
| JP5902705B2 (ja) | 2010-11-15 | 2016-04-13 | ニューロダーム リミテッドNeuroderm Ltd | L−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−o−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与 |
| TR201808178T4 (tr) | 2010-11-15 | 2018-07-23 | Neuroderm Ltd | Aktif ajanların transdermal dağıtımı için bileşimler. |
| CA2823642A1 (en) | 2010-12-10 | 2012-06-14 | Synagile Corporation | Subcutaneously infusible levodopa prodrug compositions and methods of infusion |
| WO2013061161A2 (en) | 2011-10-28 | 2013-05-02 | Green Bcn Consulting Services Sl | New combination therapies for treating neurological disorders |
| TR201204839A2 (tr) * | 2012-04-25 | 2012-12-21 | Ali̇ Rai̇f İlaç Sanayi̇ A.Ş. | Uzatılmış salım sağlayan levodopa karbıdopa entakapon içeren tablet formülasyonu. |
| WO2013184646A2 (en) | 2012-06-05 | 2013-12-12 | Synagile Corporation | Dosing regimens for subcutaneously infusible acidic compositions |
| MX2014014902A (es) | 2012-06-05 | 2015-03-04 | Neuroderm Ltd | Composiciones que comprenden apomorfina y acidos organicos y usos de las mismas. |
| WO2014141261A1 (en) | 2013-03-13 | 2014-09-18 | Neuroderm Ltd | Method for treatment of parkinson's disease |
| EP4299128A3 (en) | 2014-03-13 | 2024-04-17 | Neuroderm Ltd. | Dopa decarboxylase inhibitor compositions |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| MX381069B (es) | 2014-10-21 | 2025-03-12 | Abbvie Inc | Profármacos de carbidopa y l-dopa y métodos de uso. |
| EP3380076A2 (en) | 2015-11-24 | 2018-10-03 | Neuroderm, Ltd. | Pharmaceutical compositions comprising levodopa amide and uses thereof |
| WO2018154447A1 (en) | 2017-02-21 | 2018-08-30 | Neuroderm Ltd | Dopa decarboxylase inhibitor compositions |
| WO2019038639A1 (en) | 2017-08-21 | 2019-02-28 | Neuroderm Ltd | FREE LEOPODOPA CRYSTALLINE AMIDE BASE AND METHODS OF MAKING AND USING SAME |
| AR112472A1 (es) | 2017-08-21 | 2019-10-30 | Neuroderm Ltd | Forma de sales cristalinas de amida de levodopa y métodos para elaborarlas y usarlas |
| AR112473A1 (es) | 2017-08-21 | 2019-10-30 | Neuroderm Ltd | Proceso para preparar amida de levodopa purificada |
-
2015
- 2015-03-12 EP EP23204007.1A patent/EP4299128A3/en not_active Withdrawn
- 2015-03-12 PT PT157317272T patent/PT3116475T/pt unknown
- 2015-03-12 DK DK15731727.2T patent/DK3116475T3/da active
- 2015-03-12 FI FIEP20198371.5T patent/FI3777833T3/fi active
- 2015-03-12 JP JP2016556969A patent/JP6591995B2/ja active Active
- 2015-03-12 US US14/645,848 patent/US10022320B2/en active Active
- 2015-03-12 CN CN201580024073.7A patent/CN106413754B/zh active Active
- 2015-03-12 ES ES20198371T patent/ES2967693T3/es active Active
- 2015-03-12 RU RU2016135952A patent/RU2684105C2/ru active
- 2015-03-12 CA CA2942244A patent/CA2942244C/en active Active
- 2015-03-12 HR HRP20231716TT patent/HRP20231716T1/hr unknown
- 2015-03-12 MX MX2016011837A patent/MX2016011837A/es active IP Right Grant
- 2015-03-12 EP EP15731727.2A patent/EP3116475B1/en active Active
- 2015-03-12 HR HRP20201948TT patent/HRP20201948T1/hr unknown
- 2015-03-12 PT PT201983715T patent/PT3777833T/pt unknown
- 2015-03-12 HU HUE20198371A patent/HUE064818T2/hu unknown
- 2015-03-12 DK DK20198371.5T patent/DK3777833T3/da active
- 2015-03-12 HU HUE15731727A patent/HUE052642T2/hu unknown
- 2015-03-12 PL PL15731727T patent/PL3116475T3/pl unknown
- 2015-03-12 AU AU2015228369A patent/AU2015228369B2/en active Active
- 2015-03-12 ES ES15731727T patent/ES2836325T3/es active Active
- 2015-03-12 RS RS20240006A patent/RS65060B1/sr unknown
- 2015-03-12 BR BR112016021034A patent/BR112016021034A8/pt not_active Application Discontinuation
- 2015-03-12 EP EP20198371.5A patent/EP3777833B1/en active Active
- 2015-03-12 PL PL20198371.5T patent/PL3777833T3/pl unknown
- 2015-03-12 WO PCT/IL2015/050258 patent/WO2015136538A1/en not_active Ceased
-
2016
- 2016-09-06 IL IL247668A patent/IL247668B/en active IP Right Grant
-
2018
- 2018-06-14 US US16/008,228 patent/US10624839B2/en active Active
-
2019
- 2019-09-19 JP JP2019170864A patent/JP6770158B2/ja active Active
-
2020
- 2020-03-16 US US16/819,740 patent/US20210038505A1/en not_active Abandoned
-
2022
- 2022-09-01 US US17/901,078 patent/US20230240980A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20201948T1 (hr) | Pripravci inhibitora dopa-dekarbokilaze | |
| HRP20180514T1 (hr) | Kontinuirana primjena l-dopa, inhibitora dopa dekarboksilaze, inhibitora katekol-o-metiltransferaze i sastava za isto | |
| JP2017507973A5 (OSRAM) | ||
| ECSP13012966A (es) | Derivados de acido 3-fenilpropionoco ramificados y su uso | |
| MX2022013590A (es) | Metodos y composiciones para el tratamiento de trastorno por deficit de atencion. | |
| CO6771409A2 (es) | Acidos 1-bencilcicloalquilcarboxilicos sustituidos y su uso | |
| MX389052B (es) | Formulaciones de insulina de accion prolongada. | |
| MX2020005942A (es) | Delgada pelicula oral con alta carga de agente activo. | |
| MX2020010300A (es) | Sales monoacidas de 6-aminoisoquinolinas y usos de las mismas. | |
| PE20171178A1 (es) | Composicion de rehidratacion oral y los metodos de la misma | |
| UA117480C2 (uk) | Лікування цукрового діабету за допомогою складу інсуліну тривалої дії | |
| PH12014500240A1 (en) | Formulations of deoxycholic acid and salts thereof | |
| HRP20240166T1 (hr) | Postupak liječenja prader-willijevog sindroma | |
| GT201400027A (es) | Acuosa suspensión concentrada que comprende un ácido sal de dodecilguanidina | |
| ZA201906327B (en) | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication | |
| BR112019005456A2 (pt) | composição farmacêutica e método para tratamento de esteatose hepática não alcoólica | |
| EA201890018A1 (ru) | Композиция для придания формы волосам | |
| BR112015000275A2 (pt) | utilização de um extrato de mirta como agente anti-biopelícula face p. acnes | |
| RS53408B2 (sr) | Farmaceutska kompozicija ibuprofena za injekciju | |
| BR112015014836A2 (pt) | método para tratamento alvo de uma ou mais condições do fígado, e, uso oral de uma quantidade terapeuticamente eficaz de pelo menos um análogo de diamidina ou um sal farmaceuticamente aceitável da mesma | |
| MX387263B (es) | Composición farmacéutica de liberación prolongada que comprende cisteamina o sal de la misma. | |
| BR112018069201A2 (pt) | composição enzimática e método para a preparação de uma composição enzimática em forma líquida | |
| ME02839B (me) | Derivati indolouree supstituirani glukopiranozilom i njihova upotreba kao inhibitora sglt | |
| AR092220A1 (es) | Preparacion nutritiva que contiene potasio y proceso para su produccion | |
| AR089323A1 (es) | Composicion para el tratamiento de telas |