HRP20201468T1 - Postupak za proizvodnju polipeptida - Google Patents
Postupak za proizvodnju polipeptida Download PDFInfo
- Publication number
- HRP20201468T1 HRP20201468T1 HRP20201468TT HRP20201468T HRP20201468T1 HR P20201468 T1 HRP20201468 T1 HR P20201468T1 HR P20201468T T HRP20201468T T HR P20201468TT HR P20201468 T HRP20201468 T HR P20201468T HR P20201468 T1 HRP20201468 T1 HR P20201468T1
- Authority
- HR
- Croatia
- Prior art keywords
- cell
- nucleic acid
- polypeptide
- seq
- promoter
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 8
- 238000004519 manufacturing process Methods 0.000 title claims 5
- 210000004027 cell Anatomy 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- 108010025815 Kanamycin Kinase Proteins 0.000 claims 1
- 108010022394 Threonine synthase Proteins 0.000 claims 1
- 102000006646 aminoglycoside phosphotransferase Human genes 0.000 claims 1
- 102000004419 dihydrofolate reductase Human genes 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 108010002685 hygromycin-B kinase Proteins 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16141—Use of virus, viral particle or viral elements as a vector
- C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
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- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Claims (13)
1. Promotor, naznačen time, da ima nukleinsku kiselinu slijeda SEQ ID NO: 02.
2. Nukleinska kiselina, naznačena time, da se sastoji od nukleinske kiseline slijeda SEQ ID NO: 02 i ima snagu promotora od najmanje 80 % humanog CMV-glavnog neposrednog-ranog promotora slijeda SEQ ID NO: 01, kada je operativno povezan s nukleinskom kiselinom slijeda SEQ ID NO: 04.
3. Postupak za proizvodnju polipeptida, naznačen time, da uključuje sljedeće korake:
a) transfekcija eukariotske stanice s nukleinskom kiselinom koja sadrži ekspresijsku kazetu koja sadrži prvu nukleinsku kiselinu slijeda SEQ ID NO: 02, operativno povezanu s drugom nukleinskom kiselinom koja kodira polipeptid,
b) odabir stanice transfektirane u koraku a),
c) uzgoj odabrane stanice iz koraka b),
d) preuzimanje polipeptida iz stanice ili uzgojnog medija, čime se vrši proizvodnja polipeptida.
4. Postupak prema patentnom zahtjevu 3, naznačen time, da se kod proizvodnje radi o proizvodnji u velikim količinama.
5. Postupak u skladu s bilo kojim od patentnih zahtjeva 3 do 4, naznačen time, da je polipeptid laki lanac imunoglobulina ili teški lanac imunoglobulina ili inačica istog ili fragment istog ili fuzija istog.
6. Postupak u skladu s bilo kojim od patentnih zahtjeva 3 do 5, naznačen time, da nukleinska kiselina sadrži daljnju ekspresijsku kazetu koja kodira selekcijski marker.
7. Postupak u skladu s bilo kojim od patentnih zahtjeva 3 do 6, naznačen time, da navedena eukariotska stanica je stanica sisavca.
8. Postupak u skladu s patentnim zahtjevom 7, naznačen time, da je navedena stanica sisavca CHO stanica, BHK stanica, HEK stanica, Sp2/0 stanica ili Per.C6® stanica.
9. Postupak u skladu s patentnim zahtjevom 8, naznačen time, da je navedena stanica sisavca CHO stanica ili HEK stanica.
10. Postupak prema bilo kojem od zahtjeva 3 do 9, naznačen time, da je navedeni polipeptid imunoglobulin ili fragment imunoglobulina ili konjugat imunoglobulina.
11. Postupak u skladu s bilo kojim od patentnih zahtjeva 7 do 10, naznačen time, da je navedeni selekcijski marker dihidrofolatna reduktaza, aminoglikozidna fosfotransferaza ili higromicin-fosfotransferaza.
12. Upotreba promotora koji se sastoji od nukleotidnog slijeda SEQ ID NO: 02, naznačena time, da je za proizvodnju polipeptida.
13. Stanica, naznačena time, da sadrži promotor prema patentnom zahtjevu 1 ili nukleinsku kiselinu prema patentnom zahtjevu 2.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14168901 | 2014-05-19 | ||
| EP14191705 | 2014-11-04 | ||
| PCT/EP2015/060880 WO2015177084A1 (en) | 2014-05-19 | 2015-05-18 | Method for production of polypeptides |
| EP15723910.4A EP3146057B1 (en) | 2014-05-19 | 2015-05-18 | Method for production of polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201468T1 true HRP20201468T1 (hr) | 2020-12-11 |
Family
ID=53199978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201468TT HRP20201468T1 (hr) | 2014-05-19 | 2020-09-14 | Postupak za proizvodnju polipeptida |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10329595B2 (hr) |
| EP (1) | EP3146057B1 (hr) |
| JP (1) | JP6661549B2 (hr) |
| KR (1) | KR102337049B1 (hr) |
| CN (1) | CN106255757B (hr) |
| BR (1) | BR112016024103B1 (hr) |
| CA (1) | CA2943719A1 (hr) |
| ES (1) | ES2821940T3 (hr) |
| HK (1) | HK1232253A1 (hr) |
| HR (1) | HRP20201468T1 (hr) |
| MX (1) | MX2016014473A (hr) |
| PL (1) | PL3146057T3 (hr) |
| RU (1) | RU2699715C2 (hr) |
| SG (1) | SG11201609639VA (hr) |
| SI (1) | SI3146057T1 (hr) |
| WO (1) | WO2015177084A1 (hr) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4361734B2 (ja) * | 2001-02-23 | 2009-11-11 | ザ・スクリプス・リサーチ・インステイチユート | 血管形成の調節に有用なトリプトファニル−ｔＲＮＡシンテターゼ由来ポリペプチド |
| JP5171033B2 (ja) * | 2003-03-11 | 2013-03-27 | メルク セローノ ソシエテ アノニム | ｍＣＭＶＩＥ２プロモーターを含んで成る発現ベクター |
| US8153129B2 (en) * | 2006-12-15 | 2012-04-10 | Ribovax Biotechnologies S.A. | Antibodies against human cytimegalovirus (HCMV) |
| TW201120210A (en) * | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
| KR20130062262A (ko) * | 2010-04-14 | 2013-06-12 | 에프. 호프만-라 로슈 아게 | 장기간 생성 세포의 선별 방법 |
| SG191246A1 (en) * | 2010-12-24 | 2013-07-31 | Agency Science Tech & Res | Modified human cmv promoters that are resistant to gene silencing |
| WO2012099540A1 (en) * | 2011-01-17 | 2012-07-26 | Agency For Science, Technology And Research | Cmv promoter variants |
-
2015
- 2015-05-18 RU RU2016149411A patent/RU2699715C2/ru active
- 2015-05-18 BR BR112016024103-7A patent/BR112016024103B1/pt not_active IP Right Cessation
- 2015-05-18 JP JP2016568645A patent/JP6661549B2/ja active Active
- 2015-05-18 MX MX2016014473A patent/MX2016014473A/es active IP Right Grant
- 2015-05-18 KR KR1020167035518A patent/KR102337049B1/ko active IP Right Grant
- 2015-05-18 CA CA2943719A patent/CA2943719A1/en active Pending
- 2015-05-18 CN CN201580021834.3A patent/CN106255757B/zh active Active
- 2015-05-18 SG SG11201609639VA patent/SG11201609639VA/en unknown
- 2015-05-18 ES ES15723910T patent/ES2821940T3/es active Active
- 2015-05-18 SI SI201531373T patent/SI3146057T1/sl unknown
- 2015-05-18 PL PL15723910T patent/PL3146057T3/pl unknown
- 2015-05-18 EP EP15723910.4A patent/EP3146057B1/en active Active
- 2015-05-18 WO PCT/EP2015/060880 patent/WO2015177084A1/en active Application Filing
-
2016
- 2016-11-18 US US15/356,091 patent/US10329595B2/en active Active
-
2017
- 2017-06-13 HK HK17105828.8A patent/HK1232253A1/zh unknown
-
2019
- 2019-05-03 US US16/402,545 patent/US20190360014A1/en not_active Abandoned
-
2020
- 2020-09-14 HR HRP20201468TT patent/HRP20201468T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2016014473A (es) | 2017-01-23 |
| RU2699715C2 (ru) | 2019-09-09 |
| HK1232253A1 (zh) | 2018-01-05 |
| RU2016149411A3 (hr) | 2019-04-25 |
| PL3146057T3 (pl) | 2020-12-14 |
| SG11201609639VA (en) | 2016-12-29 |
| ES2821940T3 (es) | 2021-04-28 |
| CN106255757A (zh) | 2016-12-21 |
| JP2017515492A (ja) | 2017-06-15 |
| BR112016024103B1 (pt) | 2022-12-27 |
| RU2016149411A (ru) | 2018-06-20 |
| CN106255757B (zh) | 2020-08-11 |
| SI3146057T1 (sl) | 2020-11-30 |
| CA2943719A1 (en) | 2015-11-26 |
| US20170067087A1 (en) | 2017-03-09 |
| KR20170003699A (ko) | 2017-01-09 |
| EP3146057A1 (en) | 2017-03-29 |
| WO2015177084A1 (en) | 2015-11-26 |
| BR112016024103A2 (pt) | 2018-01-23 |
| KR102337049B1 (ko) | 2021-12-08 |
| US20190360014A1 (en) | 2019-11-28 |
| US10329595B2 (en) | 2019-06-25 |
| EP3146057B1 (en) | 2020-07-29 |
| JP6661549B2 (ja) | 2020-03-11 |
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