HRP20200829T1 - Farmaceutski pripravak u obliku oralne suspenzije koja uključuje flavonoidnu frakciju i ksantansku gumu - Google Patents
Farmaceutski pripravak u obliku oralne suspenzije koja uključuje flavonoidnu frakciju i ksantansku gumu Download PDFInfo
- Publication number
- HRP20200829T1 HRP20200829T1 HRP20200829TT HRP20200829T HRP20200829T1 HR P20200829 T1 HRP20200829 T1 HR P20200829T1 HR P20200829T T HRP20200829T T HR P20200829TT HR P20200829 T HRP20200829 T HR P20200829T HR P20200829 T1 HRP20200829 T1 HR P20200829T1
- Authority
- HR
- Croatia
- Prior art keywords
- xanthan gum
- pharmaceutical preparation
- preparation according
- oral suspension
- flavonoid fraction
- Prior art date
Links
- 229920001285 xanthan gum Polymers 0.000 title claims 4
- 229940082509 xanthan gum Drugs 0.000 title claims 4
- 235000010493 xanthan gum Nutrition 0.000 title claims 4
- 239000000230 xanthan gum Substances 0.000 title claims 4
- 229930003935 flavonoid Natural products 0.000 title claims 3
- 150000002215 flavonoids Chemical class 0.000 title claims 3
- 235000017173 flavonoids Nutrition 0.000 title claims 3
- 229940100692 oral suspension Drugs 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 6
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 claims 2
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims 1
- GZSOSUNBTXMUFQ-NJGQXECBSA-N 5,7,3'-Trihydroxy-4'-methoxyflavone 7-O-rutinoside Natural products O(C[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](Oc2cc(O)c3C(=O)C=C(c4cc(O)c(OC)cc4)Oc3c2)O1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 GZSOSUNBTXMUFQ-NJGQXECBSA-N 0.000 claims 1
- YFVGIJBUXMQFOF-PJOVQGMDSA-N 5-hydroxy-2-(4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one Chemical compound C1=CC(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)O1 YFVGIJBUXMQFOF-PJOVQGMDSA-N 0.000 claims 1
- QAGGICSUEVNSGH-UHFFFAOYSA-N Diosmetin Natural products C1=C(O)C(OC)=CC=C1C1=CC(=O)C2=CC=C(O)C=C2O1 QAGGICSUEVNSGH-UHFFFAOYSA-N 0.000 claims 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 claims 1
- FKIYLTVJPDLUDL-SLNHTJRHSA-N Isorhoifolin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C=C3C(C(C=C(O3)C=3C=CC(O)=CC=3)=O)=C(O)C=2)O1 FKIYLTVJPDLUDL-SLNHTJRHSA-N 0.000 claims 1
- YFVGIJBUXMQFOF-SAXLCNSLSA-N Linarin Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@H](Oc2cc(O)c3C(=O)C=C(c4ccc(OC)cc4)Oc3c2)O1)[C@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 YFVGIJBUXMQFOF-SAXLCNSLSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 235000019568 aromas Nutrition 0.000 claims 1
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 claims 1
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 claims 1
- MBNGWHIJMBWFHU-UHFFFAOYSA-N diosmetin Chemical compound C1=C(O)C(OC)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 MBNGWHIJMBWFHU-UHFFFAOYSA-N 0.000 claims 1
- 229960001876 diosmetin Drugs 0.000 claims 1
- 235000015428 diosmetin Nutrition 0.000 claims 1
- GZSOSUNBTXMUFQ-YFAPSIMESA-N diosmin Chemical compound C1=C(O)C(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)O1 GZSOSUNBTXMUFQ-YFAPSIMESA-N 0.000 claims 1
- 229960004352 diosmin Drugs 0.000 claims 1
- IGBKNLGEMMEWKD-UHFFFAOYSA-N diosmin Natural products COc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 IGBKNLGEMMEWKD-UHFFFAOYSA-N 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 claims 1
- 229940025878 hesperidin Drugs 0.000 claims 1
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 201000002282 venous insufficiency Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Claims (6)
1. Farmaceutski pripravak u obliku pitke oralne suspenzije u vrećici, naznačen time, da kao aktivnu tvar sadrži mikroniziranu pročišćenu flavonoidnu frakciju koja sadrži od 87% do 93% diosmina, od 2,5% do 5,0% hesperidina, od 0,9% do 2,8% izorhoifolina, od 0,9 % do 2,8% linarina i manje od 1% diosmetina, čija je veličina čestica strogo manja od 5 µm, i ksantansku gumu kao pomoćnu tvar.
2. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time, da je količina flavonoidne frakcije između 7% m/m i 20% m/m.
3. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time, što je koncentracija ksantanske gume 0,5% m/v.
4. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time, da je količina ksantanske gume između 0,30% m/m i 0,60% m/m.
5. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time, da sadrži jedan ili više farmaceutski prihvatljivih pomoćnih tvari odabranih između zaslađivača, aroma, konzervansa ili korektora pH.
6. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačen time, da je namijenjen uporabi u liječenju venske insuficijencije.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1203579A FR2999934B1 (fr) | 2012-12-21 | 2012-12-21 | Composition pharmaceutique sous la forme d'une suspension orale comprenant une fraction flavonoique et de la gomme xanthane |
| EP13198744.8A EP2745839B1 (fr) | 2012-12-21 | 2013-12-20 | Composition pharmaceutique sous la forme d'une suspension orale comprenant une fraction flavonoïque et de la gomme xanthane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200829T1 true HRP20200829T1 (hr) | 2020-08-07 |
Family
ID=47754590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200829TT HRP20200829T1 (hr) | 2012-12-21 | 2020-05-21 | Farmaceutski pripravak u obliku oralne suspenzije koja uključuje flavonoidnu frakciju i ksantansku gumu |
Country Status (41)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101725461B1 (ko) * | 2015-12-29 | 2017-04-10 | 연세대학교 산학협력단 | 디오스민을 유효성분으로 포함하는 탈모 예방 또는 치료용, 또는 발모 또는 육모 촉진용 조성물 |
| RU2704976C2 (ru) * | 2017-05-10 | 2019-11-01 | Общество с ограниченной ответственностью "Трейдсервис" | Флеботропная комбинированная фармацевтическая композиция |
| FR3083980B1 (fr) * | 2018-07-20 | 2021-04-16 | Servier Lab | Composition pharmaceutique sous la forme d'un comprime a croquer de diosmine ou d'une fraction flavonoique |
| WO2021123341A1 (en) | 2019-12-20 | 2021-06-24 | Krka, D.D., Novo Mesto | Composition comprising diosmin |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR6967M (hr) * | 1968-01-22 | 1969-05-19 | ||
| FR2661610B1 (fr) * | 1990-05-02 | 1994-09-30 | Rhone Poulenc Sante | Nouvelle forme lyophilisee de la diosmine et sa preparation. |
| JPH0724560B2 (ja) | 1990-06-01 | 1995-03-22 | 株式会社ヤクルト本社 | 植物体エキス含有飲料 |
| FR2668705A1 (fr) * | 1990-11-06 | 1992-05-07 | Bouchara Sa | Nouvelles preparations dermiques a action phlebotonique et leur procede de preparation. |
| FR2726469B1 (fr) * | 1994-11-08 | 1996-12-13 | Adir | Composition pharmaceutique pour l'administration orale de flavonoides |
| FR2748025B1 (fr) * | 1996-04-25 | 1998-10-30 | Adir | Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant |
| JP4202439B2 (ja) * | 1996-10-01 | 2008-12-24 | 江崎グリコ株式会社 | フラボノイド可溶化法、その糖転移法及び高濃度フラボノイド溶液 |
| AU730391B2 (en) * | 1996-10-10 | 2001-03-08 | Mcneil-Ppc, Inc. | Liquid antacid compositions |
| FR2781156B1 (fr) * | 1998-07-20 | 2001-06-29 | Lafon Labor | Composition pharmaceutique destinee notamment a la prevention et au traitement des radiomucites et des chimiomucites |
| US20040161435A1 (en) * | 2003-02-14 | 2004-08-19 | Gupta Shyam K. | Skin Firming Anti-Aging Cosmetic Mask Compositions |
| US20040219124A1 (en) * | 2003-05-01 | 2004-11-04 | Gupta Shyam K. | Cosmetic and Pharmaceutical Masks Based on Ion-Pair Delivery System |
| US20080069779A1 (en) * | 2003-08-04 | 2008-03-20 | Foamix Ltd. | Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof |
| US20070166255A1 (en) * | 2004-11-22 | 2007-07-19 | Gupta Shyam K | Treatment of Topical Discomforts Including Acne, Sunburn, Diaper Rash, Wound, Wrinkles and Dandruff/Hair Loss by Natural Lignans via Fatty Acid Desaturase Inhibition |
| ITMI20050517A1 (it) * | 2005-03-30 | 2006-09-30 | Therapicon Srl | Composizione farmaceutica di una tipica frazione microcristallina di flavonoidi |
| CN100444847C (zh) * | 2006-01-11 | 2008-12-24 | 刘展欣 | 一种微粒化地奥司明和橙皮甙组合物栓剂 |
| DE102006020382A1 (de) * | 2006-04-28 | 2007-10-31 | Henkel Kgaa | Schnell trocknende kosmetische Emulsionen zur Roll-on-Applikation |
| KR20080030835A (ko) * | 2006-10-02 | 2008-04-07 | 쎄라피콘 에스.알.엘. | 약학 조성물 |
| KR20090094090A (ko) * | 2006-12-28 | 2009-09-03 | 리머릭 바이오파르마 인코오포레이티드 | 치료를 위한 방법 및 조성물 |
| US8999395B2 (en) * | 2007-02-09 | 2015-04-07 | Ceva Sante Animale | Pharmaceutical compositions for oral administration in the form of stabilised aqueous suspensions |
| JP2011508768A (ja) * | 2008-01-03 | 2011-03-17 | ウォックハート リサーチ センター | パラセタモール及びイブプロフェンを含む医薬用経口懸濁剤 |
| EP2353596A1 (en) * | 2010-02-02 | 2011-08-10 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Combination composition, comprising as active ingredients L-carnitine or propionyl L-carnitine, for the prevention or treatment of chronic venous insufficiency |
| US20120070475A1 (en) * | 2010-03-11 | 2012-03-22 | Pepsico, Inc | Zero Calorie Polyphenol Aqueous Dispersions |
| US20110223256A1 (en) * | 2010-03-11 | 2011-09-15 | Stokely-Van Camp, Inc. | Method For Stabilizing Flavonoid Aqueous Dispersion |
-
2012
- 2012-12-21 FR FR1203579A patent/FR2999934B1/fr active Active
-
2013
- 2013-12-02 PH PH12013000362A patent/PH12013000362A1/en unknown
- 2013-12-03 SG SG2013089255A patent/SG2013089255A/en unknown
- 2013-12-05 PE PE2013002757A patent/PE20141302A1/es not_active Application Discontinuation
- 2013-12-05 TN TNP2013000505A patent/TN2013000505A1/fr unknown
- 2013-12-06 CH CH02023/13A patent/CH707354B1/fr unknown
- 2013-12-09 SV SV2013004600A patent/SV2013004600A/es unknown
- 2013-12-09 MX MX2013014519A patent/MX355719B/es active IP Right Grant
- 2013-12-09 JO JOP/2013/0355A patent/JO3688B1/ar active
- 2013-12-12 UY UY0001035190A patent/UY35190A/es not_active Application Discontinuation
- 2013-12-12 CR CR20130652A patent/CR20130652A/es unknown
- 2013-12-13 CL CL2013003588A patent/CL2013003588A1/es unknown
- 2013-12-13 CO CO13291852A patent/CO6970124A1/es unknown
- 2013-12-17 RO ROA201301007A patent/RO130611A2/ro unknown
- 2013-12-17 MY MYPI2013702456A patent/MY160753A/en unknown
- 2013-12-17 AP AP2013007323A patent/AP2013007323A0/xx unknown
- 2013-12-17 BR BR102013032405-1A patent/BR102013032405A2/pt not_active Application Discontinuation
- 2013-12-18 CU CUP2013000166A patent/CU24209B1/es active IP Right Grant
- 2013-12-18 MA MA36588A patent/MA35600B1/fr unknown
- 2013-12-18 UA UAA201314859A patent/UA119025C2/uk unknown
- 2013-12-19 GT GT201300316A patent/GT201300316A/es unknown
- 2013-12-20 EA EA201301300A patent/EA030949B1/ru unknown
- 2013-12-20 DK DK19213282.7T patent/DK3669879T3/da active
- 2013-12-20 CN CN201310711339.8A patent/CN103877108A/zh active Pending
- 2013-12-20 PT PT192132827T patent/PT3669879T/pt unknown
- 2013-12-20 PL PL13198744T patent/PL2745839T3/pl unknown
- 2013-12-20 EP EP19213282.7A patent/EP3669879B1/fr active Active
- 2013-12-20 ES ES13198744T patent/ES2781755T3/es active Active
- 2013-12-20 HU HUE13198744A patent/HUE048969T2/hu unknown
- 2013-12-20 NI NI201300144A patent/NI201300144A/es unknown
- 2013-12-20 DK DK13198744.8T patent/DK2745839T3/da active
- 2013-12-20 RS RS20240401A patent/RS65369B1/sr unknown
- 2013-12-20 RS RS20200422A patent/RS60172B1/sr unknown
- 2013-12-20 LT LTEP19213282.7T patent/LT3669879T/lt unknown
- 2013-12-20 CN CN201810253066.XA patent/CN108392468A/zh active Pending
- 2013-12-20 PT PT131987448T patent/PT2745839T/pt unknown
- 2013-12-20 AR ARP130104961A patent/AR094224A1/es not_active Application Discontinuation
- 2013-12-20 KR KR1020130160482A patent/KR101595107B1/ko active IP Right Grant
- 2013-12-20 ME MEP-2020-73A patent/ME03771B/me unknown
- 2013-12-20 RU RU2013156775/15A patent/RU2582954C2/ru active
- 2013-12-20 SI SI201331727T patent/SI2745839T1/sl unknown
- 2013-12-20 LT LTEP13198744.8T patent/LT2745839T/lt unknown
- 2013-12-20 WO PCT/FR2013/053231 patent/WO2014096740A1/fr active Application Filing
- 2013-12-20 EP EP13198744.8A patent/EP2745839B1/fr active Active
-
2014
- 2014-12-15 HK HK14112567.2A patent/HK1198934A1/xx unknown
- 2014-12-23 HK HK14112848.3A patent/HK1199216A1/xx unknown
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2020
- 2020-05-21 HR HRP20200829TT patent/HRP20200829T1/hr unknown
- 2020-06-04 CY CY20201100502T patent/CY1123021T1/el unknown
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