HRP20191146T1 - Postupak za proizvodnju 2-[4-(ciklopropankarbonil)fenil]-2-metil-propan nitrila - Google Patents
Postupak za proizvodnju 2-[4-(ciklopropankarbonil)fenil]-2-metil-propan nitrila Download PDFInfo
- Publication number
- HRP20191146T1 HRP20191146T1 HRP20191146TT HRP20191146T HRP20191146T1 HR P20191146 T1 HRP20191146 T1 HR P20191146T1 HR P20191146T T HRP20191146T T HR P20191146TT HR P20191146 T HRP20191146 T HR P20191146T HR P20191146 T1 HRP20191146 T1 HR P20191146T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- alkyl
- phenyl
- added
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 18
- OEGDIOHJCJQYBA-UHFFFAOYSA-N 2-[4-(cyclopropanecarbonyl)phenyl]-2-methylpropanenitrile Chemical compound C1=CC(C(C)(C#N)C)=CC=C1C(=O)C1CC1 OEGDIOHJCJQYBA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 11
- -1 -CH2-phenyl Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 229920001451 polypropylene glycol Polymers 0.000 claims 2
- WRIKHQLVHPKCJU-UHFFFAOYSA-N sodium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([Na])[Si](C)(C)C WRIKHQLVHPKCJU-UHFFFAOYSA-N 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- FYJKEHKQUPSJDH-UHFFFAOYSA-N [dimethyl-(trimethylsilylamino)silyl]methane;potassium Chemical group [K].C[Si](C)(C)N[Si](C)(C)C FYJKEHKQUPSJDH-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000003055 glycidyl group Chemical group C(C1CO1)* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- LRDFRRGEGBBSRN-UHFFFAOYSA-N isobutyronitrile Chemical compound CC(C)C#N LRDFRRGEGBBSRN-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 claims 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15152101 | 2015-01-22 | ||
EP16701157.6A EP3247699B1 (en) | 2015-01-22 | 2016-01-21 | Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile |
PCT/EP2016/051223 WO2016116555A1 (en) | 2015-01-22 | 2016-01-21 | Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20191146T1 true HRP20191146T1 (hr) | 2019-10-04 |
Family
ID=52394944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20191146TT HRP20191146T1 (hr) | 2015-01-22 | 2019-06-24 | Postupak za proizvodnju 2-[4-(ciklopropankarbonil)fenil]-2-metil-propan nitrila |
Country Status (12)
Country | Link |
---|---|
US (1) | US10336698B2 (da) |
EP (1) | EP3247699B1 (da) |
CN (1) | CN107428678B (da) |
CA (1) | CA2974449C (da) |
DK (1) | DK3247699T3 (da) |
ES (1) | ES2738630T3 (da) |
HR (1) | HRP20191146T1 (da) |
HU (1) | HUE044642T2 (da) |
PL (1) | PL3247699T3 (da) |
PT (1) | PT3247699T (da) |
RS (1) | RS58961B1 (da) |
WO (1) | WO2016116555A1 (da) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE047669T2 (hu) * | 2015-10-22 | 2020-05-28 | Sanofi Aventis Deutschland | Eljárás fexofenadin és az eljárásban használt köztitermékek elõállítására |
WO2019232294A1 (en) * | 2018-06-01 | 2019-12-05 | Cornell University | Metal-chelating compositions and their use in methods of removing or inhibiting barium scale |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4254129A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
JPS60130561A (ja) | 1983-12-16 | 1985-07-12 | Torii Yakuhin Kk | アミジン誘導体およびそれを含む強心剤 |
DE3839170A1 (de) | 1988-11-19 | 1990-05-31 | Bayer Ag | Cyclopropyl-substituierte azolylmethylcarbinole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
CA2166059C (en) | 1993-06-25 | 2005-08-16 | Richard Carl Krauss | Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives |
US5420322A (en) | 1994-08-31 | 1995-05-30 | Mine Safety Appliances Company | Preparation of alkali-metal hexamethydisilazanes |
US6303782B1 (en) * | 1999-04-20 | 2001-10-16 | Pfizer Inc | Process for preparing benzylnitriles |
GB0018691D0 (en) | 2000-07-28 | 2000-09-20 | Rolabo Sl | Process |
US20050222154A1 (en) | 2004-04-05 | 2005-10-06 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
ATE414693T1 (de) | 2004-05-18 | 2008-12-15 | Hoffmann La Roche | Neuartige cis-imidazoline |
MX2007013450A (es) | 2005-04-29 | 2008-01-21 | Wyeth Corp | Procedimniento de preparacion de oxindoles y tio-oxindoles 3,3-disustituidos. |
DE102005045132A1 (de) | 2005-09-22 | 2007-03-29 | Archimica Gmbh | Verfahren zur Herstellung von 2-Arylcarbonylverbindungen, 2-Arylestern und 2-Arylnitrilen sowie ihrer heteroaromatischen Analoga |
GB0705656D0 (en) | 2007-03-23 | 2007-05-02 | Addex Pharmaceuticals Sa | Novel compounds E1 |
WO2009001127A1 (en) | 2007-06-26 | 2008-12-31 | Astrazeneca Ab | Cyanocyclopropylcarboxamides as cathepsin inhibitors |
JP5409968B2 (ja) | 2010-08-05 | 2014-02-05 | ゾエティス・エルエルシー | 駆虫剤としてのイソオキサゾリン誘導体 |
EP2744804B1 (en) | 2011-08-17 | 2017-05-17 | F. Hoffmann-La Roche AG | Inhibitors of bruton's tyrosine kinase |
CA2891634A1 (en) | 2012-11-30 | 2014-06-05 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
-
2016
- 2016-01-21 RS RS20190866A patent/RS58961B1/sr unknown
- 2016-01-21 HU HUE16701157 patent/HUE044642T2/hu unknown
- 2016-01-21 US US15/544,493 patent/US10336698B2/en active Active
- 2016-01-21 WO PCT/EP2016/051223 patent/WO2016116555A1/en active Application Filing
- 2016-01-21 CA CA2974449A patent/CA2974449C/en active Active
- 2016-01-21 PT PT16701157T patent/PT3247699T/pt unknown
- 2016-01-21 CN CN201680016895.5A patent/CN107428678B/zh active Active
- 2016-01-21 PL PL16701157T patent/PL3247699T3/pl unknown
- 2016-01-21 DK DK16701157.6T patent/DK3247699T3/da active
- 2016-01-21 ES ES16701157T patent/ES2738630T3/es active Active
- 2016-01-21 EP EP16701157.6A patent/EP3247699B1/en active Active
-
2019
- 2019-06-24 HR HRP20191146TT patent/HRP20191146T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
DK3247699T3 (da) | 2019-08-12 |
US10336698B2 (en) | 2019-07-02 |
CN107428678B (zh) | 2021-01-01 |
ES2738630T3 (es) | 2020-01-24 |
CA2974449C (en) | 2023-08-29 |
HUE044642T2 (hu) | 2019-11-28 |
PT3247699T (pt) | 2019-08-06 |
EP3247699B1 (en) | 2019-05-15 |
EP3247699A1 (en) | 2017-11-29 |
US20170369440A1 (en) | 2017-12-28 |
PL3247699T3 (pl) | 2019-11-29 |
WO2016116555A1 (en) | 2016-07-28 |
CN107428678A (zh) | 2017-12-01 |
RS58961B1 (sr) | 2019-08-30 |
CA2974449A1 (en) | 2016-07-28 |
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