HUE047669T2 - Eljárás fexofenadin és az eljárásban használt köztitermékek elõállítására - Google Patents

Eljárás fexofenadin és az eljárásban használt köztitermékek elõállítására

Info

Publication number
HUE047669T2
HUE047669T2 HUE16784529A HUE16784529A HUE047669T2 HU E047669 T2 HUE047669 T2 HU E047669T2 HU E16784529 A HUE16784529 A HU E16784529A HU E16784529 A HUE16784529 A HU E16784529A HU E047669 T2 HUE047669 T2 HU E047669T2
Authority
HU
Hungary
Prior art keywords
fexofenadine
preparation
intermediates used
intermediates
Prior art date
Application number
HUE16784529A
Other languages
English (en)
Inventor
Hermut Wehlan
Kai Rossen
Guenter Billen
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of HUE047669T2 publication Critical patent/HUE047669T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
HUE16784529A 2015-10-22 2016-10-21 Eljárás fexofenadin és az eljárásban használt köztitermékek elõállítására HUE047669T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15191020 2015-10-22

Publications (1)

Publication Number Publication Date
HUE047669T2 true HUE047669T2 (hu) 2020-05-28

Family

ID=54360053

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16784529A HUE047669T2 (hu) 2015-10-22 2016-10-21 Eljárás fexofenadin és az eljárásban használt köztitermékek elõállítására

Country Status (12)

Country Link
US (1) US10696633B2 (hu)
EP (1) EP3365327B1 (hu)
CN (1) CN109071438B (hu)
CA (1) CA3002425C (hu)
DK (1) DK3365327T3 (hu)
ES (1) ES2770341T3 (hu)
HR (1) HRP20200106T1 (hu)
HU (1) HUE047669T2 (hu)
PL (1) PL3365327T3 (hu)
PT (1) PT3365327T (hu)
RS (1) RS59874B1 (hu)
WO (1) WO2017068129A1 (hu)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2804422A (en) 1954-12-29 1957-08-27 Wm S Merrell Co Tranquilizing composition comprising alpha phenyl, alpha-(4-piperidyl)-benzyl alcohol and method of using same
US4254129A (en) 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
HU226559B1 (en) * 1993-06-24 2009-03-30 Amr Technology Process for the production of piperidine derivatives
CN1275916C (zh) * 1993-06-25 2006-09-20 阿温蒂斯公司 用于制备抗组胺哌啶衍生物的新中间体
GB0018691D0 (en) * 2000-07-28 2000-09-20 Rolabo Sl Process
US6743941B2 (en) 2001-06-15 2004-06-01 Aventis Pharma Deutschland Gmbh Process for the production of piperidine derivatives
EP1401815A1 (en) 2001-06-25 2004-03-31 Aurobindo Pharma Limited Process for the preparation of a highly pure pharmaceutical intermediate, 4-(cyclopropylcarbonyl)-alpha,alpha-dimethylphenyl acetic acid
US7498345B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
WO2007135693A2 (en) 2006-05-18 2007-11-29 Ind-Swift Laboratories Limited Intermediates useful for the preparation of antihistaminic piperidine derivative
PL3247699T3 (pl) * 2015-01-22 2019-11-29 Sanofi Aventis Deutschland Sposób wytwarzania 2-[4-(cyklopropanokarbonylo)fenylo]-2-metylo-propanonitrylu

Also Published As

Publication number Publication date
US20180297951A1 (en) 2018-10-18
CN109071438B (zh) 2023-02-21
WO2017068129A1 (en) 2017-04-27
EP3365327A1 (en) 2018-08-29
CN109071438A (zh) 2018-12-21
CA3002425A1 (en) 2017-04-27
DK3365327T3 (da) 2020-02-24
ES2770341T3 (es) 2020-07-01
HRP20200106T1 (hr) 2020-04-03
EP3365327B1 (en) 2019-11-20
PL3365327T3 (pl) 2020-05-18
PT3365327T (pt) 2020-02-06
RS59874B1 (sr) 2020-03-31
CA3002425C (en) 2023-10-17
US10696633B2 (en) 2020-06-30

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