HRP20171023T1 - Postupci i pripravci za dijagnozu i liječenje autoimune bolesti sekundarne u odnosu na multiplu sklerozu - Google Patents
Postupci i pripravci za dijagnozu i liječenje autoimune bolesti sekundarne u odnosu na multiplu sklerozu Download PDFInfo
- Publication number
- HRP20171023T1 HRP20171023T1 HRP20171023TT HRP20171023T HRP20171023T1 HR P20171023 T1 HRP20171023 T1 HR P20171023T1 HR P20171023T T HRP20171023T T HR P20171023TT HR P20171023 T HRP20171023 T HR P20171023T HR P20171023 T1 HRP20171023 T1 HR P20171023T1
- Authority
- HR
- Croatia
- Prior art keywords
- patient
- multiple sclerosis
- snp
- autoimmune disease
- therapeutic agent
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 29
- 201000006417 multiple sclerosis Diseases 0.000 title claims 29
- 208000023275 Autoimmune disease Diseases 0.000 title claims 20
- 238000011282 treatment Methods 0.000 title claims 8
- 238000003745 diagnosis Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 102100030704 Interleukin-21 Human genes 0.000 claims 28
- 108010074108 interleukin-21 Proteins 0.000 claims 28
- 239000003814 drug Substances 0.000 claims 14
- 229940124597 therapeutic agent Drugs 0.000 claims 12
- 210000004698 lymphocyte Anatomy 0.000 claims 10
- 238000002560 therapeutic procedure Methods 0.000 claims 8
- 102000013135 CD52 Antigen Human genes 0.000 claims 7
- 108010065524 CD52 Antigen Proteins 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 6
- 210000004369 blood Anatomy 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 3
- 229960000548 alemtuzumab Drugs 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- 238000002965 ELISA Methods 0.000 claims 2
- 208000028622 Immune thrombocytopenia Diseases 0.000 claims 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000007118 chronic progressive multiple sclerosis Diseases 0.000 claims 2
- 238000003205 genotyping method Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 206010055128 Autoimmune neutropenia Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
- 206010025327 Lymphopenia Diseases 0.000 claims 1
- 210000000068 Th17 cell Anatomy 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 208000010928 autoimmune thyroid disease Diseases 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 231100001023 lymphopenia Toxicity 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 206010063401 primary progressive multiple sclerosis Diseases 0.000 claims 1
- 201000008628 secondary progressive multiple sclerosis Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/285—Demyelinating diseases; Multipel sclerosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19565808P | 2008-10-08 | 2008-10-08 | |
| US19718708P | 2008-10-24 | 2008-10-24 | |
| US19863108P | 2008-11-07 | 2008-11-07 | |
| PCT/IB2009/007327 WO2010041149A2 (en) | 2008-10-08 | 2009-10-08 | Methods and compositions for diagnosis and treatment |
| EP09804308.6A EP2344677B1 (en) | 2008-10-08 | 2009-10-08 | Methods and compositions for diagnosis and treatment of autoimmune disease secondary to multiple sclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171023T1 true HRP20171023T1 (hr) | 2017-10-06 |
Family
ID=42061141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171023TT HRP20171023T1 (hr) | 2008-10-08 | 2017-07-04 | Postupci i pripravci za dijagnozu i liječenje autoimune bolesti sekundarne u odnosu na multiplu sklerozu |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20110229470A1 (es) |
| EP (2) | EP3241910B1 (es) |
| JP (2) | JP5856481B2 (es) |
| KR (2) | KR101825457B1 (es) |
| CN (1) | CN102245783B (es) |
| AU (1) | AU2009302117B2 (es) |
| BR (1) | BRPI0920546B1 (es) |
| CA (1) | CA2740077A1 (es) |
| CY (1) | CY1119513T1 (es) |
| DK (1) | DK2344677T3 (es) |
| ES (2) | ES2632213T3 (es) |
| HK (1) | HK1246364A1 (es) |
| HR (1) | HRP20171023T1 (es) |
| HU (1) | HUE035208T2 (es) |
| IL (1) | IL212069A (es) |
| LT (1) | LT2344677T (es) |
| MX (1) | MX336835B (es) |
| PL (2) | PL2344677T3 (es) |
| PT (2) | PT3241910T (es) |
| RU (1) | RU2563521C2 (es) |
| SI (1) | SI2344677T1 (es) |
| WO (1) | WO2010041149A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012256281B2 (en) | 2011-05-16 | 2017-06-15 | Genzyme Corporation | Induction of immune tolerance by using methotrexate |
| CN104114171A (zh) * | 2011-12-13 | 2014-10-22 | Io治疗公司 | 使用rxr激动剂的自身免疫紊乱的治疗 |
| WO2013176916A1 (en) * | 2012-05-25 | 2013-11-28 | Roman Galetto | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| CN102786595B (zh) * | 2012-08-03 | 2014-04-23 | 无锡傲锐东源生物科技有限公司 | 抗cd5蛋白单克隆抗体及其用途 |
| EP4166160A1 (en) | 2016-03-10 | 2023-04-19 | IO Therapeutics, Inc. | Treatment of autoimmune diseases with combinations of rxr agonists and thyroid hormones |
| CA3030165A1 (en) * | 2016-07-19 | 2018-01-25 | Arete Discoveries, Inc. | Biomarkers for detection and treatment of mast cell activity-associated disorders |
| CN109963570A (zh) | 2017-01-21 | 2019-07-02 | 宁波知明生物科技有限公司 | 芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用 |
| CA3076373A1 (en) | 2017-09-20 | 2019-03-28 | Io Therapeutics, Inc. | Treatment of disease with esters of selective rxr agonists |
| US11672092B2 (en) * | 2019-11-06 | 2023-06-06 | Steiner Enterprises | Modular electrical distribution system for vehicles |
| EP4001919A1 (en) * | 2020-11-13 | 2022-05-25 | Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal | Predictive biomarkers of autoimmunity in patients treated with alemtuzumab |
| WO2022241259A1 (en) * | 2021-05-13 | 2022-11-17 | Genzyme Corporation | Novel predictive biomarkers for secondary autoimmunity after lymphocyte depleting therapy |
| WO2023108015A1 (en) | 2021-12-07 | 2023-06-15 | Io Therapeutics, Inc. | Use of an rxr agonist in treating drug resistant her2+ cancers |
| CA3242046A1 (en) | 2021-12-07 | 2023-06-15 | Io Therapeutics, Inc. | Use of an rxr agonist and taxanes in treating her2+ cancers |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6351720B1 (en) | 1997-10-24 | 2002-02-26 | Mitsubishi Heavy Industries, Ltd. | Trolley camera position detecting apparatus |
| US6045501A (en) * | 1998-08-28 | 2000-04-04 | Celgene Corporation | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug |
| US6315720B1 (en) * | 2000-10-23 | 2001-11-13 | Celgene Corporation | Methods for delivering a drug to a patient while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug |
| EA009956B1 (ru) | 2001-09-04 | 2008-04-28 | Йеда Рисерч Энд Дивелопмент Ко. Лтд. | Внутриклеточный полипептид (cari) и способы его применения |
| US6929932B2 (en) | 2001-11-05 | 2005-08-16 | Zymogenetics, Inc. | IL-21 antagonists |
| AU2002360525A1 (en) | 2001-12-06 | 2003-06-23 | University Of Florida | Targeting leukemia cells |
| PT1531850E (pt) | 2002-06-07 | 2012-05-07 | Zymogenetics Inc | Utilização de il-21 e anticorpo monoclonal para tratar cancros sólidos |
| KR20060015482A (ko) * | 2003-03-21 | 2006-02-17 | 와이어쓰 | 인터루킨-21/인터루킨-21 수용체의 작용제를 이용한면역장애의 치료 |
| WO2005030196A2 (en) * | 2003-09-25 | 2005-04-07 | Zymogenetics, Inc. | Methods of treating autoimmune diseases using il-21 |
| EP1773394A2 (en) | 2004-08-05 | 2007-04-18 | Wyeth a Corporation of the State of Delaware | Antagonizing interleukin-21 receptor activity |
| EP2567973B1 (en) * | 2005-11-28 | 2014-05-14 | Zymogenetics, Inc. | IL-21 antagonists |
-
2009
- 2009-10-08 PL PL09804308T patent/PL2344677T3/pl unknown
- 2009-10-08 KR KR1020167033277A patent/KR101825457B1/ko active IP Right Grant
- 2009-10-08 EP EP17159235.5A patent/EP3241910B1/en active Active
- 2009-10-08 JP JP2011530591A patent/JP5856481B2/ja active Active
- 2009-10-08 US US13/123,188 patent/US20110229470A1/en not_active Abandoned
- 2009-10-08 PT PT171592355T patent/PT3241910T/pt unknown
- 2009-10-08 LT LTEP09804308.6T patent/LT2344677T/lt unknown
- 2009-10-08 PT PT98043086T patent/PT2344677T/pt unknown
- 2009-10-08 SI SI200931691T patent/SI2344677T1/sl unknown
- 2009-10-08 CN CN200980149287.1A patent/CN102245783B/zh active Active
- 2009-10-08 EP EP09804308.6A patent/EP2344677B1/en active Active
- 2009-10-08 ES ES09804308.6T patent/ES2632213T3/es active Active
- 2009-10-08 ES ES17159235T patent/ES2784830T3/es active Active
- 2009-10-08 RU RU2011118477/10A patent/RU2563521C2/ru active
- 2009-10-08 AU AU2009302117A patent/AU2009302117B2/en active Active
- 2009-10-08 HU HUE09804308A patent/HUE035208T2/hu unknown
- 2009-10-08 WO PCT/IB2009/007327 patent/WO2010041149A2/en active Application Filing
- 2009-10-08 PL PL17159235T patent/PL3241910T3/pl unknown
- 2009-10-08 KR KR1020117010362A patent/KR101682730B1/ko active Application Filing
- 2009-10-08 CA CA2740077A patent/CA2740077A1/en not_active Withdrawn
- 2009-10-08 DK DK09804308.6T patent/DK2344677T3/en active
- 2009-10-08 MX MX2011003730A patent/MX336835B/es active IP Right Grant
- 2009-10-08 BR BRPI0920546-2A patent/BRPI0920546B1/pt active IP Right Grant
-
2011
- 2011-03-31 IL IL212069A patent/IL212069A/en active IP Right Grant
-
2014
- 2014-06-17 JP JP2014124055A patent/JP2014195462A/ja active Pending
-
2016
- 2016-02-02 US US15/013,808 patent/US10598670B2/en active Active
-
2017
- 2017-07-04 HR HRP20171023TT patent/HRP20171023T1/hr unknown
- 2017-07-04 CY CY20171100709T patent/CY1119513T1/el unknown
-
2018
- 2018-05-04 HK HK18105788.5A patent/HK1246364A1/zh unknown
-
2020
- 2020-02-25 US US16/801,009 patent/US11243211B2/en active Active
-
2022
- 2022-01-12 US US17/574,282 patent/US20220349899A1/en active Pending
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