HRP20160735T1 - Derivati tetrahidro-kinazolinona kao inhibitori tank i parp - Google Patents
Derivati tetrahidro-kinazolinona kao inhibitori tank i parpInfo
- Publication number
- HRP20160735T1 HRP20160735T1 HRP20160735TT HRP20160735T HRP20160735T1 HR P20160735 T1 HRP20160735 T1 HR P20160735T1 HR P20160735T T HRP20160735T T HR P20160735TT HR P20160735 T HRP20160735 T HR P20160735T HR P20160735 T1 HRP20160735 T1 HR P20160735T1
- Authority
- HR
- Croatia
- Prior art keywords
- tetrahydro
- tank
- parp inhibitors
- quinazolinone derivatives
- quinazolinone
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12000841 | 2012-02-09 | ||
| EP13701703.4A EP2812323B1 (en) | 2012-02-09 | 2013-01-14 | Tetrahydro-quinazolinone derivatives as tank and parp inhibitors |
| PCT/EP2013/000078 WO2013117288A1 (en) | 2012-02-09 | 2013-01-14 | Tetrahydro-quinazolinone derivatives as tank and parp inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160735T1 true HRP20160735T1 (hr) | 2016-07-29 |
Family
ID=47628092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160735TT HRP20160735T1 (hr) | 2012-02-09 | 2016-06-24 | Derivati tetrahidro-kinazolinona kao inhibitori tank i parp |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9339503B2 (hr) |
| EP (1) | EP2812323B1 (hr) |
| JP (1) | JP6116592B2 (hr) |
| KR (1) | KR20140121477A (hr) |
| CN (1) | CN104093714B (hr) |
| AR (1) | AR089944A1 (hr) |
| AU (1) | AU2013218357B2 (hr) |
| BR (1) | BR112014019357A8 (hr) |
| CA (1) | CA2863991C (hr) |
| CL (1) | CL2014002097A1 (hr) |
| CO (1) | CO7020919A2 (hr) |
| DK (1) | DK2812323T3 (hr) |
| EA (1) | EA026611B1 (hr) |
| EC (1) | ECSP14017586A (hr) |
| ES (1) | ES2579980T3 (hr) |
| HK (1) | HK1202551A1 (hr) |
| HR (1) | HRP20160735T1 (hr) |
| HU (1) | HUE029717T2 (hr) |
| IL (1) | IL233984A (hr) |
| MX (1) | MX349736B (hr) |
| NZ (1) | NZ630170A (hr) |
| PE (1) | PE20141823A1 (hr) |
| PH (1) | PH12014501581B1 (hr) |
| PL (1) | PL2812323T3 (hr) |
| PT (1) | PT2812323T (hr) |
| RS (1) | RS55377B1 (hr) |
| SG (1) | SG11201404654SA (hr) |
| SI (1) | SI2812323T1 (hr) |
| TW (1) | TWI572593B (hr) |
| UA (1) | UA116627C2 (hr) |
| WO (1) | WO2013117288A1 (hr) |
| ZA (1) | ZA201406579B (hr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX346147B (es) | 2012-03-07 | 2017-03-09 | Inst Of Cancer Research: Royal Cancer Hospital (The) | Compuestos de 3-aril-5-substituido-isoquinolin-1-ona y su uso terapeutico. |
| US9505749B2 (en) | 2012-08-29 | 2016-11-29 | Amgen Inc. | Quinazolinone compounds and derivatives thereof |
| DK2938598T3 (en) | 2012-12-31 | 2017-02-13 | Cadila Healthcare Ltd | Substituted phthalazine-1 (2H) -one derivatives as selective inhibitors of poly (adp-ribose) polymerase-1 |
| CA2922469A1 (en) | 2013-09-11 | 2015-03-19 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| WO2015069512A1 (en) | 2013-11-07 | 2015-05-14 | Eli Lilly And Company | PYRIDO[2,3-d]PYRIMIDIN-4-ONE COMPOUNDS AS TANKYRASE INHIBITORS |
| US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
| KR101777475B1 (ko) * | 2015-12-08 | 2017-09-11 | 에스티팜 주식회사 | 신규한 디히드로피라노피리미디논 유도체 및 이들의 용도 |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| NZ749946A (en) * | 2016-06-30 | 2023-11-24 | Yakult Honsha Kk | Novel compound or pharmaceutically acceptable salt thereof |
| CN108727302A (zh) * | 2017-10-23 | 2018-11-02 | 科迈化工股份有限公司 | 一种环保型n-叔丁基-2-苯并噻唑次磺酰胺（ns）合成工艺 |
| US20210060016A1 (en) * | 2017-12-27 | 2021-03-04 | Japanese Foundation For Cancer Research | Anticancer agent |
| JP7288161B2 (ja) | 2017-12-27 | 2023-06-07 | 国立研究開発法人理化学研究所 | 新規ジヒドロキナゾリノン系化合物又はその薬理学的に許容される塩、及び細胞増殖阻害剤 |
| MA51777A (fr) | 2018-08-16 | 2021-04-21 | Hoffmann La Roche | Composés cycliques condensés |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| TR199801530T2 (xx) | 1996-02-13 | 1998-11-23 | Zeneca Limited | VEGF �nhibit�rleri olarak kinazolin t�revleri. |
| JP4464466B2 (ja) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | ４―アニリノキナゾリン誘導体 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| WO2001092224A1 (en) | 2000-05-31 | 2001-12-06 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| BR0112225A (pt) | 2000-07-07 | 2003-05-06 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto, e, processo papa preparar um composto |
| IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
| AUPR201600A0 (en) * | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| AUPR975601A0 (en) | 2001-12-24 | 2002-01-31 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivatives |
| AUPS019702A0 (en) * | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
| DE602005026391D1 (de) * | 2004-06-30 | 2011-03-31 | Janssen Pharmaceutica Nv | Chinazolinonderivate als parp-hemmer |
| JP5102196B2 (ja) * | 2005-03-11 | 2012-12-19 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | テトラヒドロキナゾリノンおよびジヒドロキナゾリノン |
| US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| WO2011078143A1 (ja) | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | ピリミジン誘導体およびそれらを含有する医薬組成物 |
| WO2011111880A1 (ko) * | 2010-03-08 | 2011-09-15 | 주식회사 메디젠텍 | 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물 |
-
2013
- 2013-01-14 KR KR1020147024967A patent/KR20140121477A/ko not_active Application Discontinuation
- 2013-01-14 AU AU2013218357A patent/AU2013218357B2/en active Active
- 2013-01-14 CN CN201380008647.2A patent/CN104093714B/zh active Active
- 2013-01-14 CA CA2863991A patent/CA2863991C/en active Active
- 2013-01-14 BR BR112014019357A patent/BR112014019357A8/pt not_active Application Discontinuation
- 2013-01-14 HU HUE13701703A patent/HUE029717T2/en unknown
- 2013-01-14 WO PCT/EP2013/000078 patent/WO2013117288A1/en active Application Filing
- 2013-01-14 PT PT137017034T patent/PT2812323T/pt unknown
- 2013-01-14 PL PL13701703.4T patent/PL2812323T3/pl unknown
- 2013-01-14 US US14/378,009 patent/US9339503B2/en active Active
- 2013-01-14 MX MX2014009491A patent/MX349736B/es active IP Right Grant
- 2013-01-14 EA EA201400879A patent/EA026611B1/ru not_active IP Right Cessation
- 2013-01-14 EP EP13701703.4A patent/EP2812323B1/en active Active
- 2013-01-14 SG SG11201404654SA patent/SG11201404654SA/en unknown
- 2013-01-14 RS RS20160507A patent/RS55377B1/sr unknown
- 2013-01-14 JP JP2014555963A patent/JP6116592B2/ja active Active
- 2013-01-14 UA UAA201409705A patent/UA116627C2/uk unknown
- 2013-01-14 SI SI201330228A patent/SI2812323T1/sl unknown
- 2013-01-14 NZ NZ630170A patent/NZ630170A/en not_active IP Right Cessation
- 2013-01-14 DK DK13701703.4T patent/DK2812323T3/en active
- 2013-01-14 PE PE2014001242A patent/PE20141823A1/es not_active Application Discontinuation
- 2013-01-14 ES ES13701703.4T patent/ES2579980T3/es active Active
- 2013-02-08 TW TW102105039A patent/TWI572593B/zh not_active IP Right Cessation
- 2013-02-08 AR ARP130100401A patent/AR089944A1/es unknown
-
2014
- 2014-07-09 PH PH12014501581A patent/PH12014501581B1/en unknown
- 2014-07-30 CO CO14165918A patent/CO7020919A2/es unknown
- 2014-08-06 IL IL233984A patent/IL233984A/en active IP Right Grant
- 2014-08-07 CL CL2014002097A patent/CL2014002097A1/es unknown
- 2014-09-05 EC ECIEPI201417586A patent/ECSP14017586A/es unknown
- 2014-09-08 ZA ZA2014/06579A patent/ZA201406579B/en unknown
-
2015
- 2015-04-01 HK HK15103292.2A patent/HK1202551A1/zh not_active IP Right Cessation
-
2016
- 2016-06-24 HR HRP20160735TT patent/HRP20160735T1/hr unknown
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