HRP20160676T1 - Derivati biciklo[3.1.0]heksan-2,6-dikarboksilne kiseline kao agonisti receptora mglu2 - Google Patents
Derivati biciklo[3.1.0]heksan-2,6-dikarboksilne kiseline kao agonisti receptora mglu2Info
- Publication number
- HRP20160676T1 HRP20160676T1 HRP20160676TT HRP20160676T HRP20160676T1 HR P20160676 T1 HRP20160676 T1 HR P20160676T1 HR P20160676T T HRP20160676T T HR P20160676TT HR P20160676 T HRP20160676 T HR P20160676T HR P20160676 T1 HRP20160676 T1 HR P20160676T1
- Authority
- HR
- Croatia
- Prior art keywords
- hexan
- bicycles
- derivative
- dicarboxylic acids
- receptor agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11382208 | 2011-06-17 | ||
| US201161522791P | 2011-08-12 | 2011-08-12 | |
| EP12729769.5A EP2721012B1 (en) | 2011-06-17 | 2012-06-07 | Bicyclo(3.1.0)hexane-2,6-dicarboxylic acid derivatives as mglu2 receptor agonist |
| PCT/US2012/041229 WO2012173850A1 (en) | 2011-06-17 | 2012-06-07 | Bicyclo (3.1.0) hexane- 2, 6 -dicarboxylic acid derivatives as mglu2 receptor agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160676T1 true HRP20160676T1 (hr) | 2016-07-15 |
Family
ID=47357416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160676TT HRP20160676T1 (hr) | 2011-06-17 | 2012-06-07 | Derivati biciklo[3.1.0]heksan-2,6-dikarboksilne kiseline kao agonisti receptora mglu2 |
Country Status (20)
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993006127A1 (en) | 1991-09-17 | 1993-04-01 | Warner-Lambert Company | Novel amino acid prodrug renin inhibitors |
| US5576323A (en) | 1993-12-03 | 1996-11-19 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5849525A (en) | 1994-03-09 | 1998-12-15 | Brigham And Women's Hospital, Inc. | Compositions corresponding to a proton-coupled peptide transporter and methods of making and using same |
| KR19990067598A (ko) | 1995-11-16 | 1999-08-25 | 피터 지. 스트링거 | 여기성 아미노산 유도체 |
| US5688826A (en) | 1995-11-16 | 1997-11-18 | Eli Lilly And Company | Excitatory amino acid derivatives |
| GB9605429D0 (en) | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
| US5952294A (en) | 1996-07-31 | 1999-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peptidyl prodrugs and methods of making and using the same |
| ZA983930B (en) | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| DK1052246T3 (da) | 1998-01-28 | 2003-06-16 | Taisho Pharmaceutical Co Ltd | Fluorholdige aminosyrederivater |
| DE69918136T2 (de) | 1998-08-31 | 2005-07-07 | Taisho Pharmaceutical Co., Ltd. | 6-Fluorobicyclo[3.1.0]Hexan-Derivate |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| AU6785401A (en) | 2000-06-28 | 2002-01-08 | Taisho Pharmaceutical Co Ltd | Novel dicarboxylic acid derivatives |
| US7038077B2 (en) | 2001-01-11 | 2006-05-02 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| CN1267407C (zh) | 2001-01-11 | 2006-08-02 | 伊莱利利公司 | 兴奋性氨基酸前体药物 |
| WO2002068380A1 (en) * | 2001-02-22 | 2002-09-06 | Eli Lilly And Company | Synthetic excitatory amino acids |
| WO2002100399A1 (en) | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| NZ533699A (en) | 2001-12-27 | 2006-05-26 | Taisho Pharmaceutical Co Ltd | 6-fluorobicyclo[3.1.0]hexane derivatives |
| WO2003084610A1 (en) | 2002-04-03 | 2003-10-16 | Eli Lilly And Company | Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist |
| US20050192273A1 (en) | 2002-04-03 | 2005-09-01 | Johnson Bryan G. | Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist |
| CN100482680C (zh) * | 2002-06-11 | 2009-04-29 | 伊莱利利公司 | 兴奋性氨基酸前药 |
| JP4342437B2 (ja) * | 2002-06-11 | 2009-10-14 | イーライ リリー アンド カンパニー | 興奮性アミノ酸のプロドラッグ |
| CN100582087C (zh) * | 2003-06-26 | 2010-01-20 | 大正制药株式会社 | 2-氨基-双环[3.1.0]己烷-2,6-二甲酸酯衍生物 |
| US7381746B2 (en) * | 2003-06-26 | 2008-06-03 | Taisho Pharmaceutical Co., Ltd. | 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative |
| SI2513085T1 (sl) * | 2009-11-18 | 2017-02-28 | Suven Life Sciences Limited | Biciklične spojine kot alfa4beta2 nikotinski acetilholinski receptor ligandi |
| AR079343A1 (es) * | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
-
2012
- 2012-06-07 ES ES12729769.5T patent/ES2587204T3/es active Active
- 2012-06-07 WO PCT/US2012/041229 patent/WO2012173850A1/en not_active Ceased
- 2012-06-07 EP EP12729769.5A patent/EP2721012B1/en active Active
- 2012-06-07 BR BR112013031928-3A patent/BR112013031928B1/pt active IP Right Grant
- 2012-06-07 EA EA201391700A patent/EA023553B1/ru not_active IP Right Cessation
- 2012-06-07 JP JP2014515878A patent/JP5945592B2/ja active Active
- 2012-06-07 KR KR1020137033028A patent/KR101598679B1/ko active Active
- 2012-06-07 CA CA2836485A patent/CA2836485C/en active Active
- 2012-06-07 US US14/123,768 patent/US9296710B2/en active Active
- 2012-06-07 RS RS20160491A patent/RS54888B1/sr unknown
- 2012-06-07 HU HUE12729769A patent/HUE030171T2/en unknown
- 2012-06-07 MX MX2013014802A patent/MX2013014802A/es active IP Right Grant
- 2012-06-07 HR HRP20160676TT patent/HRP20160676T1/hr unknown
- 2012-06-07 CN CN201280029080.2A patent/CN103596933B/zh active Active
- 2012-06-07 AU AU2012271024A patent/AU2012271024B2/en active Active
- 2012-06-07 DK DK12729769.5T patent/DK2721012T3/en active
- 2012-06-07 PL PL12729769T patent/PL2721012T3/pl unknown
- 2012-06-07 PT PT127297695T patent/PT2721012T/pt unknown
- 2012-06-07 SI SI201230569A patent/SI2721012T1/sl unknown
-
2016
- 2016-06-24 CY CY20161100570T patent/CY1117682T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5945592B2 (ja) | 2016-07-05 |
| CA2836485C (en) | 2016-12-13 |
| PL2721012T3 (pl) | 2017-05-31 |
| PT2721012T (pt) | 2016-07-27 |
| HUE030171T2 (en) | 2017-05-29 |
| EA201391700A1 (ru) | 2014-04-30 |
| ES2587204T3 (es) | 2016-10-21 |
| CA2836485A1 (en) | 2012-12-20 |
| EP2721012A1 (en) | 2014-04-23 |
| CY1117682T1 (el) | 2017-05-17 |
| EA023553B1 (ru) | 2016-06-30 |
| US20140113944A1 (en) | 2014-04-24 |
| KR101598679B1 (ko) | 2016-02-29 |
| CN103596933B (zh) | 2016-03-23 |
| SI2721012T1 (sl) | 2016-08-31 |
| RS54888B1 (sr) | 2016-10-31 |
| JP2014517035A (ja) | 2014-07-17 |
| WO2012173850A1 (en) | 2012-12-20 |
| DK2721012T3 (en) | 2016-08-15 |
| KR20140009568A (ko) | 2014-01-22 |
| EP2721012B1 (en) | 2016-05-25 |
| BR112013031928B1 (pt) | 2022-05-24 |
| BR112013031928A2 (pt) | 2016-12-13 |
| CN103596933A (zh) | 2014-02-19 |
| AU2012271024B2 (en) | 2015-07-09 |
| US9296710B2 (en) | 2016-03-29 |
| AU2012271024A1 (en) | 2013-11-21 |
| MX2013014802A (es) | 2014-01-24 |
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