HRP20151339T1 - Pripravak baziran na ubidekarenonu - Google Patents
Pripravak baziran na ubidekarenonu Download PDFInfo
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- HRP20151339T1 HRP20151339T1 HRP20151339TT HRP20151339T HRP20151339T1 HR P20151339 T1 HRP20151339 T1 HR P20151339T1 HR P20151339T T HRP20151339T T HR P20151339TT HR P20151339 T HRP20151339 T HR P20151339T HR P20151339 T1 HRP20151339 T1 HR P20151339T1
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- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims 17
- 235000017471 coenzyme Q10 Nutrition 0.000 title claims 17
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims 17
- 239000000203 mixture Substances 0.000 title claims 11
- 229960004747 ubidecarenone Drugs 0.000 title claims 3
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- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims 1
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- 229930195725 Mannitol Natural products 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 1
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- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- XZAGBDSOKNXTDT-UHFFFAOYSA-N Sucrose monopalmitate Chemical compound CCCCCCCCCCCCCCCC(O)=O.OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(CO)O1 XZAGBDSOKNXTDT-UHFFFAOYSA-N 0.000 claims 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 1
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- FOLJTMYCYXSPFQ-CJKAUBRRSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-(octadecanoyloxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl octadecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)O[C@@H]1O[C@@]1(COC(=O)CCCCCCCCCCCCCCCCC)[C@@H](O)[C@H](O)[C@@H](CO)O1 FOLJTMYCYXSPFQ-CJKAUBRRSA-N 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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Claims (25)
1. Ternarni pripravak baziran na ubidekarenonu, ili koenzimu Q10 ili CoQ10, naznačen time da se sastoji od tri komponente ili razreda komponenata: od CoQ10, od jednog ili više specifičnih hidrofilnih nosača odabranih iz razreda maltodekstrina i jednog ili više pomoćnih sredstava odabranih iz razreda sukroza-estera.
2. Pripravak prema zahtjevu 1, naznačen time da se u suhom stanju zajednički usitnjavaju CoQ10, jedan ili više specifičnih hidrofilnih nosača odabranih iz razreda maltodekstrina i jedno ili više pomoćnih sredstava odabranih iz razreda sukroza-estera.
3. Pripravak prema zahtjevu 1 ili 2, naznačen time da sadrži težinski postotak CoQ10 koji se nalazi između 5% i 30%.
4. Pripravak prema zahtjevu 1, 2 ili 3, naznačen time da sadrži težinski postotak CoQ10 koji se nalazi između 7.5% i 20%.
5. Pripravak prema bilo kojem prethodnom zahtjevu, naznačen time da sadrži težinski postotak CoQ10 koji se nalazi između 10% i 15%.
6. Pripravak prema bilo kojem prethodnom zahtjevu, naznačen time da sadrži težinski postotak jednog ili više pomoćnih sredstava odabranih iz razreda sukroza-estera koji se nalazi između 5% i 30%.
7. Pripravak prema bilo kojem prethodnom zahtjevu, naznačen time da sadrži težinski postotak jednog ili više pomoćnih sredstava odabranih iz razreda sukroza-estera koji se nalazi između 7.5% i 20%.
8. Pripravak prema bilo kojem prethodnom zahtjevu, naznačen time da sadrži težinski postotak jednog ili više pomoćnih sredstava odabranih iz razreda sukroza-estera koji se nalazi između 10% i 15%.
9. Pripravak prema bilo kojem prethodnom zahtjevu, naznačen time da je, s obzirom na težinski postotak CoQ10 i pomoćnog sredstva koje se zajednički usitnjava odabranog iz razreda sukroza-estera, predviđen težinski postotak hidrofilnog nosača iz razreda maltodekstrina tako da se dobije 100% težinski.
10. Pripravak prema bilo kojem prethodnom zahtjevu, naznačen time da su težinski postotci CoQ10 i sukroza-estera u pripravku prema predmetnom izumu jednaki.
11. Pripravak prema bilo kojem zahtjevu od 1 do 9, naznačen time da su težinski postotci CoQ10 i sukroza-estera u pripravku prema predmetnom izumu međusobno različiti.
12. Pripravak prema bilo kojem prethodnom zahtjevu, naznačen time da je odabrani sukroza-ester jedan ili više od saharoza monopalmitata, saharoza monostearata, saharoza dipalmitata, saharoza distearata, saharoza alhilata ili smjese dva ili više od navedenih.
13. Pripravak prema bilo kojem prethodnom zahtjevu naznačen time da je za uporabu u za terapijski farmaceutski tretman.
14. Pripravak prema bilo kojem prethodnom zahtjevu naznačen time da je za uporabu za dijetetski tretman ili za integralne dodatke prehrani.
15. Pripravak prema bilo kojem prethodnom zahtjevu naznačen time da je za uporabu za kozmetički tretman.
16. Pripravak prema bilo kojem prethodnom zahtjevu naznačen time da je za uporabu za terapijski veterinarski tretman, dijetetski tretman ili integralni dodatak prehrani.
17. Formulacija naznačena time da sadrži ternarni pripravak prema bilo kojem prethodnom zahtjevu sastavljen ili izmiješan s:
- jednim ili više vitamina iz skupine vitamina B, i
- jednim ili više minerala ili metala, kao što su magnezij, kalij, cink, selen, kalcij, fluor, fosfor, i
- jednom ili više drugih tvari koje su odabrane iz skupine koju čine: kreatin, karnitin, gama orizanol, lipoična kiselina, kolin, karnozin, fosfatidilserin, lutein, likopen, resveratrol, drugi antioksidansi, esencijalne masne kiseline omega-3 i/ili omega-6, biljne tvari, ekstrakti i/ili pripravci, kako što su ekstrakt borovnice, Ginsenga, Ginkgo bilobe, Rhodiola rosea, Boswellia serrata, kvasac, ksilitrol, eritritol, manitol, sorbitol, amino kiseline, razgranate ili modificirane amino kiseline.
18. Formulacija prema zahtjevu 17, naznačena time da sadrži ternarni pripravak prema bilo kojem zahtjevu od 1 do 16 i:
- vitamine iz skupine vitamina B, uključujući jedan ili više vitamina B1, B2, B3, B5, B6, B12,
- kreatin,
- Ginseng,
- magnezij i
- kalij.
19. Formulacija prema zahtjevu 17, naznačena time da sadrži ternarni pripravak prema bilo kojem zahtjevu od 1 do 16 i:
- kolin,
- L-arginin,
- vitamine iz skupine vitamina B, uključujući jedan ili više vitamina B1, B2, B3, B5, B6, B12,
- vitamin A,
- vitamin E,
- selen,
- cink,
- magnezij i
- Ginkgo biloba.
20. Formulacija prema zahtjevu 17, naznačena time da sadrži ternarni pripravak prema bilo kojem zahtjevu od 1 do 16 i:
- karnitin,
- karnozin,
- magnezij,
- cink i kalij,
- vitamine B1, B12, C i E.
21. Formulacija prema zahtjevu 17, naznačena time da sadrži ternarni pripravak prema bilo kojem zahtjevu od 1 do 16 i:
- lutein,
- ekstrakt borovnice,
- vitamine A i B12 i
- cink.
22. Formulacija prema zahtjevu 17, naznačena time da sadrži ternarni pripravak prema bilo kojem zahtjevu od 1 do 16 i:
- omega-3,
- vitamine A, B3, B5, C i D, H,
- kalcij,
- fluor,
- fosfor i magnezij i
- kslitol,
- sa ili bez Boswellia serrata.
23. Formulacija naznačena time da sadrži ternarni pripravak prema bilo kojem zahtjevu od 1 do 16 i vitamin A.
24. Postupak za pripremanje ternarnog pripravka baziranog na ubidekarenonu, ili koenzimu Q10 ili CoQ10 prema bilo kojem od zahtjeva 1 do 16, naznačen time da predviđa korak pripremanja navedenog ternarnog pripravka pomoću miješanja, uz korištenje samo tri komponente ili razreda komponenata: CoQ10, jednog ili više specifičnih hidrofilnih nosača koji su odabrani iz razreda maltodekstrina i jednog ili više pomoćnih sredstava odabranih iz razreda sukroza-estera.
25. Postupak prema zahtjevu 24, naznačen time da predviđa podvrgavanje suhom zajedničkom usitnjavanju, poželjno njihovom istovremenom zajedničkom usitnjavanju, CoQ10, jednog ili više specifičnih hidrofilnih nosača koji su odabrani iz razreda maltodekstrina i jednog ili više pomoćnih sredstava odabranih iz razreda sukroza-estera.
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Application Number | Priority Date | Filing Date | Title |
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IT000196A ITUD20110196A1 (it) | 2011-12-02 | 2011-12-02 | Composizione a base di ubidecarenone |
EP12813443.4A EP2713771B1 (en) | 2011-12-02 | 2012-12-03 | Composition based on ubidecarenone |
PCT/IB2012/002565 WO2013080028A1 (en) | 2011-12-02 | 2012-12-03 | Composition based on ubidecarenone |
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HRP20151339T1 true HRP20151339T1 (hr) | 2016-01-01 |
HRP20151339T8 HRP20151339T8 (en) | 2016-02-26 |
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HRP20151339TT HRP20151339T8 (en) | 2011-12-02 | 2015-12-08 | Composition based on ubidecarenone |
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US (1) | US9675564B2 (hr) |
EP (1) | EP2713771B1 (hr) |
JP (1) | JP5984956B2 (hr) |
KR (1) | KR101616853B1 (hr) |
CN (1) | CN104093322B (hr) |
BR (1) | BR112014013348A2 (hr) |
CA (1) | CA2857592C (hr) |
DK (1) | DK2713771T3 (hr) |
ES (1) | ES2550086T3 (hr) |
HR (1) | HRP20151339T8 (hr) |
HU (1) | HUE026130T2 (hr) |
IT (1) | ITUD20110196A1 (hr) |
PL (1) | PL2713771T3 (hr) |
PT (1) | PT2713771E (hr) |
SI (1) | SI2713771T1 (hr) |
WO (1) | WO2013080028A1 (hr) |
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WO2016074800A1 (en) * | 2014-11-14 | 2016-05-19 | Asoltech S.R.L. | Composition based on coq10 |
IT202000018970A1 (it) | 2020-08-03 | 2022-02-03 | Asoltech Srl | Composizione a base di mirra |
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SE512355C2 (sv) * | 1991-11-26 | 2000-03-06 | Luk Lamellen & Kupplungsbau | Friktionskoppling, särskilt för motorfordon, motorfordon med en dylik koppling samt kopplingsaggregat och drivenhet, speciellt för motorfordon |
US6056971A (en) | 1996-07-24 | 2000-05-02 | Biosytes Usa, Inc. | Method for enhancing dissolution properties of relatively insoluble dietary supplements and product incorporating same |
US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US7432097B2 (en) * | 1997-08-13 | 2008-10-07 | Verenium Corporation | Phytases, nucleic acids encoding them and methods of making and using them |
US6299896B1 (en) * | 2000-04-13 | 2001-10-09 | Cooper Concepts, Inc. | Multi-vitamin and mineral supplement |
US20050002992A1 (en) * | 2003-06-17 | 2005-01-06 | Mccleary Edward Larry | Foods, beverages, condiments, spices and salad dressings with specialized supplements |
US6300377B1 (en) | 2001-02-22 | 2001-10-09 | Raj K. Chopra | Coenzyme Q products exhibiting high dissolution qualities |
ITMI20021074A1 (it) * | 2002-05-20 | 2003-11-20 | Actimex S R L | Composizione ternaria comprendente una sostanza attiva e processo di comacinazione per la sua preparazione |
US7438903B2 (en) | 2003-06-06 | 2008-10-21 | Nbty, Inc. | Methods and compositions that enhance bioavailability of coenzyme-Q10 |
JP4601934B2 (ja) * | 2003-10-06 | 2010-12-22 | ナガセ医薬品株式会社 | ユビデカレノン錠 |
JP2005139122A (ja) * | 2003-11-07 | 2005-06-02 | Toyo Shinyaku:Kk | 補酵素q10含有乳化物 |
US7803366B2 (en) | 2004-05-07 | 2010-09-28 | Nbty, Inc. | Methods and compositions that enhance bioavailability of coenzyme-Q10 |
JP4842824B2 (ja) | 2004-08-24 | 2011-12-21 | 日清ファルマ株式会社 | コエンザイムq10含有組成物 |
EP1802287A2 (en) * | 2004-09-27 | 2007-07-04 | Sigmoid Biotechnologies Limited | Minicapsule formulations |
ITPD20050224A1 (it) * | 2005-07-19 | 2007-01-20 | Actimex Srl | Composizioni contenenti micronutrienti aventi in particolare attivita' antiossidante e loro impiego |
CN1969833A (zh) * | 2005-11-25 | 2007-05-30 | 浙江医药股份有限公司新昌制药厂 | 含辅酶q10的干粉组合物及其制备方法 |
KR100956583B1 (ko) * | 2006-01-26 | 2010-05-11 | 주식회사 대웅제약 | 유비데카레논의 고체분산체와 그 제조방법 및 이를포함하는 약제학적 조성물 |
US7476405B2 (en) | 2006-02-23 | 2009-01-13 | Iomedix Sleep International Srl | Compositions and methods for the induction and maintenance of quality sleep |
MX2008011639A (es) * | 2006-03-13 | 2008-09-23 | Hershey Co | Composiciones de infusion de cacao y bebidas funcionales de cacao elaboradas a partir de las mismas. |
JPWO2007125915A1 (ja) | 2006-04-24 | 2009-09-10 | 株式会社カネカ | 補酵素q含有固形物 |
US20070286902A1 (en) * | 2006-06-07 | 2007-12-13 | Abrika Pharmaceuticals | Dosage forms comprising a short acting sedative-hypnotic or salt thereof |
EP2172196B1 (en) * | 2007-06-22 | 2020-03-25 | Kaneka Corporation | Composition containing coenzyme q10 |
CN101966171B (zh) * | 2010-09-30 | 2012-10-24 | 杭州华东医药集团康润制药有限公司 | 水溶性还原型辅酶q10组合物及其制备方法 |
CN101940564A (zh) | 2010-09-30 | 2011-01-12 | 杭州华东医药集团康润制药有限公司 | 水溶性辅酶q10组合物及其制备方法 |
IT1403248B1 (it) * | 2010-11-12 | 2013-10-17 | Scharper Therapeutics Srl | Composizione per il trattamento di disfunzioni degli apparati fonatorio ed olfattorio |
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BR112014013348A2 (pt) | 2017-06-13 |
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PT2713771E (pt) | 2016-01-06 |
JP2015505826A (ja) | 2015-02-26 |
CA2857592A1 (en) | 2013-06-06 |
PL2713771T3 (pl) | 2016-01-29 |
WO2013080028A1 (en) | 2013-06-06 |
ES2550086T3 (es) | 2015-11-04 |
CN104093322A (zh) | 2014-10-08 |
US9675564B2 (en) | 2017-06-13 |
KR101616853B1 (ko) | 2016-04-29 |
ITUD20110196A1 (it) | 2013-06-03 |
EP2713771A1 (en) | 2014-04-09 |
HRP20151339T8 (en) | 2016-02-26 |
DK2713771T3 (en) | 2015-12-14 |
HUE026130T2 (en) | 2016-05-30 |
EP2713771B1 (en) | 2015-09-16 |
US20140322189A1 (en) | 2014-10-30 |
KR20150000470A (ko) | 2015-01-02 |
CA2857592C (en) | 2018-06-05 |
SI2713771T1 (sl) | 2016-01-29 |
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