HRP20151200T1 - Metoda za snižavanje intraokularnog tlaka kod ljudi - Google Patents
Metoda za snižavanje intraokularnog tlaka kod ljudi Download PDFInfo
- Publication number
- HRP20151200T1 HRP20151200T1 HRP20151200TT HRP20151200T HRP20151200T1 HR P20151200 T1 HRP20151200 T1 HR P20151200T1 HR P20151200T T HRP20151200T T HR P20151200TT HR P20151200 T HRP20151200 T HR P20151200T HR P20151200 T1 HRP20151200 T1 HR P20151200T1
- Authority
- HR
- Croatia
- Prior art keywords
- substance
- use according
- pharmaceutical composition
- glaucoma
- iop
- Prior art date
Links
- 230000004410 intraocular pressure Effects 0.000 title claims 2
- 239000000126 substance Substances 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 208000010412 Glaucoma Diseases 0.000 claims 4
- 206010030043 Ocular hypertension Diseases 0.000 claims 4
- 206010030348 Open-Angle Glaucoma Diseases 0.000 claims 4
- 201000006366 primary open angle glaucoma Diseases 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000004406 elevated intraocular pressure Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000004310 Ion Channels Human genes 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- LRMHVVPPGGOAJQ-UHFFFAOYSA-N methyl nitrate Chemical compound CO[N+]([O-])=O LRMHVVPPGGOAJQ-UHFFFAOYSA-N 0.000 claims 1
- 230000003547 miosis Effects 0.000 claims 1
- 239000003604 miotic agent Substances 0.000 claims 1
- 239000004090 neuroprotective agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 239000003590 rho kinase inhibitor Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17465509P | 2009-05-01 | 2009-05-01 | |
| US21999009P | 2009-06-24 | 2009-06-24 | |
| PCT/US2010/033112 WO2010127210A1 (en) | 2009-05-01 | 2010-04-30 | Method of reducing intraocular pressure in humans |
| EP10770402.5A EP2424546B1 (en) | 2009-05-01 | 2010-04-30 | Method of reducing intraocular pressure in humans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20151200T1 true HRP20151200T1 (hr) | 2016-01-15 |
Family
ID=43030847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151200TT HRP20151200T1 (hr) | 2009-05-01 | 2015-11-09 | Metoda za snižavanje intraokularnog tlaka kod ljudi |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8470800B2 (it) |
| EP (1) | EP2424546B1 (it) |
| JP (1) | JP5778663B2 (it) |
| KR (1) | KR101757940B1 (it) |
| CN (1) | CN102413832B (it) |
| AU (1) | AU2010242943B2 (it) |
| BR (1) | BRPI1009971A2 (it) |
| CA (1) | CA2762064A1 (it) |
| CL (1) | CL2011002675A1 (it) |
| DK (1) | DK2424546T3 (it) |
| EA (1) | EA024042B1 (it) |
| ES (1) | ES2554684T3 (it) |
| HK (1) | HK1167599A1 (it) |
| HR (1) | HRP20151200T1 (it) |
| HU (1) | HUE028068T2 (it) |
| IL (1) | IL216081A (it) |
| MX (1) | MX2011011229A (it) |
| MY (1) | MY159244A (it) |
| NZ (1) | NZ596428A (it) |
| PL (1) | PL2424546T3 (it) |
| PT (1) | PT2424546E (it) |
| RS (1) | RS54378B1 (it) |
| SG (1) | SG175346A1 (it) |
| SI (1) | SI2424546T1 (it) |
| SM (1) | SMT201500295B (it) |
| WO (1) | WO2010127210A1 (it) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008062567A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) * | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
| BR112012009841A2 (pt) * | 2009-10-26 | 2016-11-29 | Inotek Pharmaceuticals Corp | formulação oftálmica e processo para a sua preparação |
| SI2523669T1 (sl) | 2010-01-11 | 2017-05-31 | Inotek Pharmaceuticals Corporation | Kombinacija, komplet in metoda za zmanjšanje intraokularnega tlaka |
| RS55616B1 (sr) * | 2010-03-19 | 2017-06-30 | Inotek Pharmaceuticals Corp | Kombinovane kompozicije adenozinskih a1 agonista i ne-selektivnih beta-adrenergičnih receptor blokera za snižavanje intraokularnog pritiska |
| ME02593B (me) * | 2010-03-19 | 2017-06-20 | Inotek Pharmaceuticals Corp | Kombinovane kompozicije adenozinskih a1 agonista i inhibitora ugljene anhidraze za snižavanje intraokularnog pritiska |
| WO2011119969A1 (en) | 2010-03-26 | 2011-09-29 | Inotek Pharmaceuticals Corporation | Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof |
| DE102010030688A1 (de) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dicyanopyridine und ihre Verwendung |
| US20120058983A1 (en) | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
| DK2807178T3 (en) | 2012-01-26 | 2017-09-04 | Inotek Pharmaceuticals Corp | Anhydrous polymorphs of (2R, 3S, 4R, 5R) -5- (6- (cyclopentylamino) -9H-purin-9-yl) -3,4-dihydroxytetrahydrofuran-2-yl) methyl nitrate and processes for their preparation |
| SG11201506882YA (en) | 2013-03-15 | 2015-09-29 | Inotek Pharmaceuticals Corp | Ophthalmic formulations |
| CA2967446A1 (en) * | 2014-12-03 | 2016-06-09 | Inotek Pharmaceuticals Corporation | Methods of preventing, reducing or treating macular degeneration |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA011826B1 (ru) * | 2004-05-26 | 2009-06-30 | Инотек Фармасьютикалз Корпорейшн | Пуриновые производные в качестве агонистов аденозиновых арецепторов и способы их применения |
| CN101010085B (zh) | 2004-05-26 | 2012-12-26 | 伊诺泰克制药公司 | 嘌呤衍生物作为腺苷a1受体激动剂及其用法 |
| JP5203214B2 (ja) * | 2005-11-30 | 2013-06-05 | イノテック ファーマシューティカルズ コーポレイション | プリン化合物およびその使用方法 |
| BR112012009841A2 (pt) * | 2009-10-26 | 2016-11-29 | Inotek Pharmaceuticals Corp | formulação oftálmica e processo para a sua preparação |
| SI2523669T1 (sl) * | 2010-01-11 | 2017-05-31 | Inotek Pharmaceuticals Corporation | Kombinacija, komplet in metoda za zmanjšanje intraokularnega tlaka |
| RS55616B1 (sr) * | 2010-03-19 | 2017-06-30 | Inotek Pharmaceuticals Corp | Kombinovane kompozicije adenozinskih a1 agonista i ne-selektivnih beta-adrenergičnih receptor blokera za snižavanje intraokularnog pritiska |
| ME02593B (me) * | 2010-03-19 | 2017-06-20 | Inotek Pharmaceuticals Corp | Kombinovane kompozicije adenozinskih a1 agonista i inhibitora ugljene anhidraze za snižavanje intraokularnog pritiska |
-
2010
- 2010-04-30 SG SG2011078151A patent/SG175346A1/en unknown
- 2010-04-30 RS RS20150782A patent/RS54378B1/en unknown
- 2010-04-30 US US12/771,289 patent/US8470800B2/en not_active Expired - Fee Related
- 2010-04-30 MX MX2011011229A patent/MX2011011229A/es unknown
- 2010-04-30 AU AU2010242943A patent/AU2010242943B2/en not_active Ceased
- 2010-04-30 EP EP10770402.5A patent/EP2424546B1/en active Active
- 2010-04-30 BR BRPI1009971A patent/BRPI1009971A2/pt not_active IP Right Cessation
- 2010-04-30 WO PCT/US2010/033112 patent/WO2010127210A1/en active Application Filing
- 2010-04-30 CA CA2762064A patent/CA2762064A1/en not_active Abandoned
- 2010-04-30 DK DK10770402.5T patent/DK2424546T3/en active
- 2010-04-30 ES ES10770402.5T patent/ES2554684T3/es active Active
- 2010-04-30 PT PT107704025T patent/PT2424546E/pt unknown
- 2010-04-30 MY MYPI2011004858A patent/MY159244A/en unknown
- 2010-04-30 SI SI201031070T patent/SI2424546T1/sl unknown
- 2010-04-30 JP JP2012508764A patent/JP5778663B2/ja not_active Expired - Fee Related
- 2010-04-30 CN CN201080018539.XA patent/CN102413832B/zh not_active Expired - Fee Related
- 2010-04-30 PL PL10770402T patent/PL2424546T3/pl unknown
- 2010-04-30 KR KR1020117025057A patent/KR101757940B1/ko active IP Right Grant
- 2010-04-30 HU HUE10770402A patent/HUE028068T2/en unknown
- 2010-04-30 EA EA201171339A patent/EA024042B1/ru not_active IP Right Cessation
- 2010-04-30 NZ NZ596428A patent/NZ596428A/en not_active IP Right Cessation
-
2011
- 2011-10-27 CL CL2011002675A patent/CL2011002675A1/es unknown
- 2011-11-01 IL IL216081A patent/IL216081A/en not_active IP Right Cessation
-
2012
- 2012-08-23 HK HK12108295.1A patent/HK1167599A1/xx not_active IP Right Cessation
-
2013
- 2013-04-03 US US13/855,919 patent/US20130217643A1/en not_active Abandoned
-
2015
- 2015-11-09 HR HRP20151200TT patent/HRP20151200T1/hr unknown
- 2015-11-30 SM SM201500295T patent/SMT201500295B/it unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20151200T1 (hr) | Metoda za snižavanje intraokularnog tlaka kod ljudi | |
| Sturdivant et al. | Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma | |
| Lu et al. | Focus: drug development: novel pharmacologic candidates for treatment of primary open-angle glaucoma | |
| HRP20170007T1 (hr) | Kombinacija, komplet i metoda za smanjivanje intraokularnog tlaka | |
| AU2011282681B2 (en) | Preservative free bimatoprost and timolol solutions | |
| JP2011513229A (ja) | 補助剤としての眼科用ｎｓａｉｄ | |
| AU2011282683B2 (en) | Preservative free brimonidine and timolol solutions | |
| HRP20170009T1 (hr) | Kombinacija sastava agonista adenozina a1 i neselektivnih blokatora beta adrenergičkih receptora za smanjivanje intraokularnog tlaka | |
| Aptel et al. | Intraocular pressure-lowering combination therapies with prostaglandin analogues | |
| AU2021203665A1 (en) | Fixed dose combination of brimonidine and timolol | |
| CA3026053A1 (en) | Treatment of dry eye disease with parasympathetic and anti-sympathetic agents | |
| JP2023168397A (ja) | 眼科組成物 | |
| CA3073718A1 (en) | Ocular pharmaceutical compositions | |
| JP7174175B2 (ja) | 近視の治療、近視の予防および／または近視の進行抑制のための医薬 | |
| Lindén | Therapeutic potential of prostaglandin analogues in glaucoma | |
| ES2900524T3 (es) | Métodos para el uso de la 5'-adenosina difosfato de ribosa (ADPR) | |
| JP2012250951A (ja) | アデノシン誘導体とプロスタグランジン類とβ受容体遮断薬の組合せ剤 | |
| CA3081593A1 (en) | Pharmaceutical compositions for controlling and/or reducing the progression of myopia | |
| WO2016169698A1 (en) | Parthenolide and its derivatives for use in the treatment of axonal damage | |
| CN102458413A (zh) | 治疗黄斑变性的方法和组合物 | |
| JPWO2006098292A1 (ja) | 眼疾患治療剤 | |
| WO2019124523A1 (ja) | ＦＰ作動薬とβ遮断薬を含有する緑内障治療剤 | |
| JP2012250949A (ja) | アデノシン誘導体と炭酸脱水酵素阻害剤とβ受容体遮断薬の組合せ剤 | |
| JP2012250953A (ja) | アデノシン誘導体とα２受容体作動薬の組合せ剤 | |
| JP2012250947A (ja) | アデノシン誘導体とβ受容体遮断薬の組合せ剤 |