HRP20150788T1 - Sigma ligandi za sprjeäśavanje ili lijeäśenje boli izazvane kemoterapijom - Google Patents
Sigma ligandi za sprjeäśavanje ili lijeäśenje boli izazvane kemoterapijom Download PDFInfo
- Publication number
- HRP20150788T1 HRP20150788T1 HRP20150788TT HRP20150788T HRP20150788T1 HR P20150788 T1 HRP20150788 T1 HR P20150788T1 HR P20150788T T HRP20150788T T HR P20150788TT HR P20150788 T HRP20150788 T HR P20150788T HR P20150788 T1 HRP20150788 T1 HR P20150788T1
- Authority
- HR
- Croatia
- Prior art keywords
- substituted
- unsubstituted
- group
- nr8r9
- combination according
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382144A EP2292236A1 (en) | 2009-08-14 | 2009-08-14 | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
| EP10744560.3A EP2464356B1 (en) | 2009-08-14 | 2010-08-12 | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
| PCT/EP2010/061720 WO2011018487A1 (en) | 2009-08-14 | 2010-08-12 | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150788T1 true HRP20150788T1 (hr) | 2015-08-28 |
Family
ID=41531868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150788TT HRP20150788T1 (hr) | 2009-08-14 | 2010-08-12 | Sigma ligandi za sprjeäśavanje ili lijeäśenje boli izazvane kemoterapijom |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US20120141606A1 (https=) |
| EP (2) | EP2292236A1 (https=) |
| JP (1) | JP5922575B2 (https=) |
| KR (3) | KR101605151B1 (https=) |
| CN (1) | CN102497864B (https=) |
| AR (1) | AR077876A1 (https=) |
| AU (2) | AU2010283761B2 (https=) |
| BR (1) | BR112012003053A2 (https=) |
| CA (1) | CA2770441C (https=) |
| CO (1) | CO6511240A2 (https=) |
| CY (1) | CY1116697T1 (https=) |
| DK (1) | DK2464356T3 (https=) |
| EC (1) | ECSP12011658A (https=) |
| ES (1) | ES2543645T3 (https=) |
| HR (1) | HRP20150788T1 (https=) |
| HU (1) | HUE025642T2 (https=) |
| IL (1) | IL217911A0 (https=) |
| IN (1) | IN2012DN02149A (https=) |
| MA (1) | MA33569B1 (https=) |
| MX (1) | MX2012001877A (https=) |
| MY (1) | MY157334A (https=) |
| NZ (1) | NZ598213A (https=) |
| PH (1) | PH12012500286A1 (https=) |
| PL (1) | PL2464356T3 (https=) |
| PT (1) | PT2464356E (https=) |
| RU (1) | RU2543382C2 (https=) |
| SG (1) | SG178338A1 (https=) |
| SI (1) | SI2464356T1 (https=) |
| SM (1) | SMT201500189T1 (https=) |
| TN (1) | TN2012000048A1 (https=) |
| TW (1) | TWI529168B (https=) |
| UA (1) | UA108859C2 (https=) |
| WO (1) | WO2011018487A1 (https=) |
| ZA (1) | ZA201200843B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2388005A1 (en) * | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2426111A1 (en) * | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms |
| EP2524694A1 (en) * | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| EP2792352A1 (en) | 2013-04-16 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Alpha-2 adrenoreceptor and sigma receptor ligand combinations |
| SG11201601304XA (en) * | 2013-09-12 | 2016-03-30 | Esteve Labor Dr | Nsaid and sigma receptor ligand combinations |
| WO2015091505A1 (en) | 2013-12-17 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Gabapentinoids and sigma receptor ligands combinations |
| TW201607538A (zh) | 2013-12-17 | 2016-03-01 | 以斯提夫博士實驗室股份有限公司 | 血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物 |
| JP7094231B2 (ja) * | 2016-06-06 | 2022-07-01 | エスティーブ ファーマシューティカルズ エス エイ | がんにおけるシグマ受容体リガンドの使用 |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2024105225A1 (en) * | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU11248A1 (ru) | 1927-03-29 | 1929-09-30 | В.С. Григорьев | Способ очистки антрацена |
| FR2301250A1 (fr) * | 1975-02-21 | 1976-09-17 | Bellon Labor Sa Roger | Nouveaux diaryl-1, 4o-aminoalcoxy-3 pyrazoles et leurs sels |
| MX2007002341A (es) * | 2004-08-27 | 2007-09-25 | Esteve Labor Dr | Inhibidores del receptor sigma. |
| EP1634872A1 (en) * | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
| CA2576144C (en) | 2004-08-27 | 2012-12-11 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
| MX2008011016A (es) * | 2006-03-01 | 2008-09-08 | Esteve Labor Dr | Inhibidores de receptor sigma. |
| CN101395157A (zh) * | 2006-03-01 | 2009-03-25 | 伊斯特芬博士实验室有限公司 | 作为西格玛受体抑制剂的吡唑衍生物 |
-
2009
- 2009-08-14 EP EP09382144A patent/EP2292236A1/en not_active Withdrawn
-
2010
- 2010-08-10 TW TW099126632A patent/TWI529168B/zh not_active IP Right Cessation
- 2010-08-12 DK DK10744560.3T patent/DK2464356T3/en active
- 2010-08-12 WO PCT/EP2010/061720 patent/WO2011018487A1/en not_active Ceased
- 2010-08-12 KR KR1020127006715A patent/KR101605151B1/ko not_active Expired - Fee Related
- 2010-08-12 HU HUE10744560A patent/HUE025642T2/en unknown
- 2010-08-12 PH PH1/2012/500286A patent/PH12012500286A1/en unknown
- 2010-08-12 MY MYPI2012000561A patent/MY157334A/en unknown
- 2010-08-12 KR KR1020177028558A patent/KR20170125951A/ko not_active Ceased
- 2010-08-12 PL PL10744560T patent/PL2464356T3/pl unknown
- 2010-08-12 ES ES10744560.3T patent/ES2543645T3/es active Active
- 2010-08-12 SG SG2012009098A patent/SG178338A1/en unknown
- 2010-08-12 PT PT107445603T patent/PT2464356E/pt unknown
- 2010-08-12 BR BR112012003053A patent/BR112012003053A2/pt not_active IP Right Cessation
- 2010-08-12 KR KR1020157034281A patent/KR20150140419A/ko not_active Ceased
- 2010-08-12 AU AU2010283761A patent/AU2010283761B2/en not_active Ceased
- 2010-08-12 US US13/389,733 patent/US20120141606A1/en not_active Abandoned
- 2010-08-12 NZ NZ598213A patent/NZ598213A/en not_active IP Right Cessation
- 2010-08-12 JP JP2012524233A patent/JP5922575B2/ja active Active
- 2010-08-12 HR HRP20150788TT patent/HRP20150788T1/hr unknown
- 2010-08-12 EP EP10744560.3A patent/EP2464356B1/en active Active
- 2010-08-12 IN IN2149DEN2012 patent/IN2012DN02149A/en unknown
- 2010-08-12 CA CA2770441A patent/CA2770441C/en not_active Expired - Fee Related
- 2010-08-12 CN CN201080036098.6A patent/CN102497864B/zh active Active
- 2010-08-12 MX MX2012001877A patent/MX2012001877A/es active IP Right Grant
- 2010-08-12 SI SI201030977T patent/SI2464356T1/sl unknown
- 2010-08-12 RU RU2012109554/04A patent/RU2543382C2/ru not_active IP Right Cessation
- 2010-08-13 AR ARP100102983A patent/AR077876A1/es unknown
- 2010-12-08 UA UAA201202969A patent/UA108859C2/ru unknown
-
2012
- 2012-01-31 TN TNP2012000048A patent/TN2012000048A1/en unknown
- 2012-02-02 IL IL217911A patent/IL217911A0/en unknown
- 2012-02-03 ZA ZA2012/00843A patent/ZA201200843B/en unknown
- 2012-02-09 EC ECSP12011658 patent/ECSP12011658A/es unknown
- 2012-03-08 MA MA34669A patent/MA33569B1/fr unknown
- 2012-03-14 CO CO12044528A patent/CO6511240A2/es not_active Application Discontinuation
-
2015
- 2015-07-15 CY CY20151100618T patent/CY1116697T1/el unknown
- 2015-08-05 SM SM201500189T patent/SMT201500189T1/xx unknown
-
2016
- 2016-03-17 US US15/073,460 patent/US20160199380A1/en not_active Abandoned
- 2016-04-07 US US15/093,589 patent/US20160220575A1/en not_active Abandoned
- 2016-09-14 AU AU2016228207A patent/AU2016228207B2/en not_active Ceased
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