HRP20140721T1 - Spojevi porfirina za uništavanje, inhibiranje ili sprjeäśavanje rasta mikrobnih biofilmova - Google Patents

Spojevi porfirina za uništavanje, inhibiranje ili sprjeäśavanje rasta mikrobnih biofilmova Download PDF

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HRP20140721T1
HRP20140721T1 HRP20140721AT HRP20140721T HRP20140721T1 HR P20140721 T1 HRP20140721 T1 HR P20140721T1 HR P20140721A T HRP20140721A T HR P20140721AT HR P20140721 T HRP20140721 T HR P20140721T HR P20140721 T1 HRP20140721 T1 HR P20140721T1
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phenyl
porphyrin
compound according
group
use according
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HRP20140721AT
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William Guy Love
William Rhys-Williams
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Destiny Pharma Limited
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Claims (16)

1. Spoj prema dolje navedenoj formuli I ili II za uporabu u liječenju ili sprječavanju stanja ili poremećaja koji je povezan sa prisutnošću ili rastom mikrobnog biofilma na ili u tijelu živog sisavca [image] [image] naznačen time da: X1, X2, X3 i X4 neovisno predstavlja atom vodika, lipofilni dio, fenilnu skupinu, nižu alkil, alkaril ili aralkil skupinu, ili kationsku skupinu sa slijedećom formulom; -L-R1-N+(R2)(R3)R4 pri čemu: L je vezujući dio ili nije prisutan; R1 predstavlja niži alkilen, niži alkenilen ili niži alkinilen, koji je proizvoljno supstituiran sa jednim ili više supstituenata odabranih iz skupine koju čine niži alkil, niži alkilen (proizvoljno isprekidan sa kisikom), fluoro, OR5, C(O)R6, C(O)OR7, C(O)NR8R9, NR10R11 i N+R12R13R14; i R2, R3 i R4 neovisno predstavljaju H, aril, niži alkil, niži alkenil ili niži alkinil, od kojih su zadnja tri proizvoljno supstituirani sa jednim ili više supstituenata odabranih iz skupine koju čine niži alkil, niži alkilen (proizvoljno isprekidan sa kisikom), aril, OR5, C(O)R6, C(O)OR7, C(O)NR8R9, NR10R11 i N+R12R13R14 Z je -CH ili N; i Y1, Y2, Y3 i Y4 nisu prisutni ili neovisno predstavljaju aril, niži alkil, niži alkenil ili niži alkinil, od kojih su zadnja tri proizvoljno supstituirani sa jednim ili više supstituenata odabranih iz skupine koju čine niži alkil, niži alkilen (proizvoljno isprekidan sa kisikom), aril, OR5, C(O)R6, C(O)OR7, C(O)NR8R9, NR10R11, N+R12R13R14, ili, uzeti zajedno sa pirol prstenom na koji se spajaju, tvore cikličku skupinu; R5, R6, R7, R8, R9, R10, R11, R12, R13 i R14 neovisno predstavljaju H ili niži alkil; i M je metalni element ili metaloidni element pod uvjetom da barem jedan od X1, X2, X3 i X4 je kationska skupina kako je gore definirano i barem jedan od X1, X2, X3 i X4 je atom vodika.
2. Spoj prema zahtjevu 1 za uporabu prema zahtjevu 1 naznačen time da R1 je nesupstituirana niža alkilen, niža alkenilen ili niža alkenilen skupina.
3. Spoj prema zahtjevu 1 ili 2 za uporabu prema zahtjevu 1 naznačen time da R2, R3 i/ili R4 su nesupstituirane niže alkil skupine.
4. Spoj prema bilo kojem od prethodnih zahtjeva za uporabu prema zahtjevu 1 naznačen time da X1, X2, X3 i/ili X4 su [image] pri čemu svaki R je neovisno –R1-N+(R2)(R3)R4, kako je definirano u zahtjevu 1 i 'n' i 'm' su cijeli brojevi između 0 i 3 i pri čemu je suma 'n' i 'm' cijeli broj između 1 i 3.
5. Spoj prema bilo kojem od prethodnih zahtjeva za uporabu prema zahtjevu 1 naznačen time da X1 i X2 su vodik i X3 i X4 su kationske skupine, ili X2 i X3 su vodik i X4 i X1 su kationske skupine.
6. Spoj prema zahtjevu 1 za uporabu prema zahtjevu 1 naznačen time daje spoj odabran iz skupine koja sadrži 5,15-bis-(4-{3-[(3-Dimetilamino-propil)-dimetil-amonio]-propil-oksi}-fenil)-porfirin, 5,15-bis-[4-(3-Trietilamonio-propiloksi)-fenil]-porfirin, 5,15-bis-[3-(3-Trimetilamonio-propiloksi)-fenil]-porfirin, 5,15-bis-[4-(3-Trimetilamonio-propiloksi)-fenil]-porfirin, 5-[3,5-bis-(3-Trimetilamonio-propiloksi)-fenil]-15-undecil-porfirin, 5-{4-[3-Dimetil-(3-dimetilaminopropil)-amonio-propil-oksi]-fenil}-15-(4-dodeciloksi-fenil)-porfirin, 3-[({3-[(3-{4-[15-(4-Dodeciloksi-fenil)-porfirin-5-il]-fenoksi}-propil)-dimetil-amonio]-propil}-dimetil-amonio)-propil]-trimetil-amonijum, 5,15-bis-[3-(3-Trimetilamonio-propiloksi)-fenil]-10-undecil-porfirin, 5-{4-[3-Dimetil-(3-trimetilamonio-propil)-amonio-propiloksi]-fenil}-15-(4-dodeciloksi-fenil)-porfirin, 5-[4-(3-Dimetildecil-amoniopropiloksi)-fenil]-15-{4-[3-di-metil-(3-dimetilaminopropil)-amoniopropiloksi]-fenil}-porfirin, te njihove soli.
7. Spoj prema zahtjevu 6 za uporabu prema zahtjevu 1 naznačen time da spoj je 5,15-bis-[4-(3-Trimetilamonio-propiloksi)-fenil]-porfirin ("XF-73") ili 5,15-bis-[3-(3-Trimetilamonio-propiloksi)-fenil]-porfirin ("XF-70"), ili njegova dikloridna sol.
8. Spoj prema zahtjevu 6 ili 7 za uporabu prema zahtjevu 1 naznačen time da spoj sadrži središnji metalni ion.
9. Spoj prema bilo kojem od prethodnih zahtjeva za uporabu prema zahtjevu 1 naznačen time da mikrobni biofilm sadrži ili se sastoji od bakterija.
10. Spoj prema bilo kojem od prethodnih zahtjeva za uporabu prema zahtjevu 1 naznačen time da je za biofilm u usnoj šupljini, mokraćnim putevima, sinusima, uhu, srcu, prostati, kostima, plućima, bubrezima ili koži.
11. Spoj prema bilo kojem od prethodnih zahtjeva za uporabu prema zahtjevu 1 naznačen time da je biofilm vezan na inertnom nosaču unutar tijela.
12. Spoj kako je definirano u bilo kojem zahtjevu od 1 do 11 za uporabu prema zahtjevu 1 naznačen time da je za uporabu za uništavanje, inhibiranje ili sprječavanje rasta bakterija u spororastućoj ili statičnoj fazi.
13. Implantibilni medicinski uređaj naznačen time da je impregniran, prevučen ili na drugi način obrađen sa spojem kako je opisano u bilo kojem zahtjevu od 1 do 12.
14. Implantibilni medicinski uređaj prema zahtjevu 13 naznačen time da je odabran iz skupine koja sadrži intravaskularne uređaje, katetere, šantove, cijevi za intubiranje i traheotomiju, oftalmičke uređaje, proteze za udove, umjetne srčane zaliske i implantate za grudi.
15. In vitro postupak za uništavanje, inhibiranje ili sprječavanje rasta mikrobnog biofilma naznačen time da se sastoji od dovođenja u kontakt biofilma sa spojem prema bilo kojem zahtjevu od 1 do 12.
16. Postupak prema zahtjevu 15 naznačen time da je biofilm dostupan u domaćoj, komercijalnoj ili industrijskoj okolini.
HRP20140721AT 2008-10-24 2014-07-28 Spojevi porfirina za uništavanje, inhibiranje ili sprjeäśavanje rasta mikrobnih biofilmova HRP20140721T1 (hr)

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