HRP20120634T1 - Antibiotik 107891, njegovi faktori, farmaceutski prihvatljive soli i sastavi, te njihova uporaba - Google Patents
Antibiotik 107891, njegovi faktori, farmaceutski prihvatljive soli i sastavi, te njihova uporaba Download PDFInfo
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- HRP20120634T1 HRP20120634T1 HRP20120634TT HRP20120634T HRP20120634T1 HR P20120634 T1 HRP20120634 T1 HR P20120634T1 HR P20120634T T HRP20120634T T HR P20120634TT HR P20120634 T HRP20120634 T HR P20120634T HR P20120634 T1 HRP20120634 T1 HR P20120634T1
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- Croatia
- Prior art keywords
- compound according
- group
- pharmaceutically acceptable
- antibiotic
- acceptable salts
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- 150000003839 salts Chemical class 0.000 title claims 5
- 230000003115 biocidal effect Effects 0.000 title claims 2
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 18
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 125000003118 aryl group Chemical group 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Spoj formule (SEQ ID br. 2) naznačen time, da se X odabire iz skupine koja se sastoji od H, F, Cl, Br i I; u čemu su Y1, Y2,Y3,Y4 i Y5 nezavisno odabrani iz skupine koja se sastoji od, S, S O-, S=O, O- S=O i O=S=O; i u čemu se R1, R2, R3, R4, R5, R6, R7 i R8, nezavisno odabiru iz skupine koja se sastoji od H, OH, alkila i arila, uz uvjet da je barem jedan od Y1, Y2,Y3,Y4 i Y5 različit od S. Patent sadrži još 17 patentnih zahtjeva.
Claims (18)
1. Spoj formule
[image]
(SEQ ID br. 2) naznačen time, da se X odabire iz skupine koja se sastoji od H, F, Cl, Br i I;
u čemu su Y1, Y2,Y3,Y4 i Y5 nezavisno odabrani iz skupine koja se sastoji od, S, SO-, S=O, O-S=O i O=S=O;
i u čemu se R1, R2, R3, R4, R5, R6, R7 i R8, nezavisno odabiru iz skupine koja se sastoji od H, OH, alkila i arila, uz uvjet da je barem jedan od Y1, Y2,Y3,Y4 i Y5 različit od S.
2. Spoj prema patentnom zahtjevu 1, naznačen time, da R4, R5, R6, R7 i R8 jesu H.
3. Spoj prema patentnom zahtjevu 2, naznačen time, da R1 jest H, R2 jest H i R3jest H.
4. Spoj prema patentnom zahtjevu 2, naznačen time, da R1 jest H, R2 jest H i R3jest OH.
5. Spoj prema patentnom zahtjevu 2, naznačen time, da R1 jest H, R2 jest OH i R3jest OH.
6. Spoj prema patentnom zahtjevu 2, naznačen time, da R1 jest OH, R2 jest OH i R3jest OH.
7. Spoj prema patentnom zahtjevu 2, naznačen time, da R1 jest OH, R2 jest H i R3jest H.
8. Spoj prema patentnom zahtjevu 2, naznačen time, da R1 jest OH, R2 jest H i R3jest OH.
9. Spoj prema patentnom zahtjevu 1, naznačen time, da se Y1 odabire iz skupine koja se sastoji od S-O-, S=O, O-S=O i O=S=O, a Y2,Y3,Y4 i Y5 jesu S.
10. Spoj prema patentnom zahtjevu 1, naznačen time, da se Y2 odabire iz skupine koja se sastoji od S-O-, S=O, O-S=O i O=S=O, a Y1,Y3,Y4 i Y5 jesu S.
11. Spoj prema patentnom zahtjevu 1, naznačen time, da se Y3 odabire iz skupine koja se sastoji od S-O-, S=O, O-S=O i O=S=O, a Y1,Y2,Y4 i Y5 jesu S.
12. Spoj prema patentnom zahtjevu 1, naznačen time, da se Y4 odabire iz skupine koja se sastoji od S-O-, S=O, O-S=O i O=S=O, a Y1,Y2,Y3 i Y5 jesu S.
13. Spoj prema patentnom zahtjevu 1, naznačen time, da se Y5 odabire iz skupine koja se sastoji od S-O-, S=O, O-S=O i O=S=O, a Y1,Y2,Y3 i Y4 jesu S.
14. Farmaceutski sastav, naznačen time, da sadrži antibiotik odabran iz spojeva prema patentnom zahtjevu 1 ili njihovu farmaceutski prihvatljivu sol s kiselinom.
15. Farmaceutski sastav prema patentnom zahtjevu 14, naznačen time, da nadalje sadrži farmaceutski prihvatljiv nosilac.
16. Spojevi prema patentnom zahtjevu 1 ili njihove farmaceutski prihvatljive soli s kiselinom, naznačeni time, da su za uporabu kao lijek.
17. Uporaba spojeva prema patentnom zahtjevu 1 ili njihovih farmaceutski prihvatljivih soli s kiselinom, naznačena time, da jest za proizvodnju lijeka za liječenje ili prevenciju bakterijskih infekcija.
18. Uporaba spojeva prema patentnom zahtjevu 1 i njihovih netoksičnih soli s kiselinom, naznačena time, da jest za pospješivanje rasta životinja
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/045,628 US7351687B2 (en) | 2003-07-18 | 2005-01-26 | Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof |
| PCT/US2005/002733 WO2006080920A1 (en) | 2005-01-26 | 2005-01-27 | Antibiotic 107891, its factors a1 and a2, pharmaceutically acceptable salts and compositions, and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120634T1 true HRP20120634T1 (hr) | 2012-08-31 |
Family
ID=36740829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120634TT HRP20120634T1 (hr) | 2005-01-26 | 2012-08-02 | Antibiotik 107891, njegovi faktori, farmaceutski prihvatljive soli i sastavi, te njihova uporaba |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7351687B2 (hr) |
| EP (2) | EP1848731B1 (hr) |
| JP (1) | JP4191238B2 (hr) |
| KR (1) | KR100896826B1 (hr) |
| CN (1) | CN101189252B (hr) |
| AU (1) | AU2005326149C1 (hr) |
| BR (1) | BRPI0519942A2 (hr) |
| CA (1) | CA2593801A1 (hr) |
| CY (1) | CY1113030T1 (hr) |
| DK (1) | DK1848731T3 (hr) |
| EA (1) | EA016608B1 (hr) |
| ES (1) | ES2387557T3 (hr) |
| HR (1) | HRP20120634T1 (hr) |
| IL (1) | IL184377A0 (hr) |
| MA (1) | MA29237B1 (hr) |
| MX (1) | MX2007009059A (hr) |
| NO (1) | NO20073490L (hr) |
| NZ (1) | NZ556368A (hr) |
| PL (1) | PL1848731T3 (hr) |
| PT (1) | PT1848731E (hr) |
| RS (1) | RS52427B (hr) |
| SI (1) | SI1848731T1 (hr) |
| TN (1) | TNSN07286A1 (hr) |
| UA (1) | UA87548C2 (hr) |
| WO (1) | WO2006080920A1 (hr) |
| ZA (1) | ZA200705495B (hr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0600928D0 (en) | 2006-01-17 | 2006-02-22 | Novacta Biosystems Ltd | Improvements relating to lantibiotics |
| GB0714029D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | Lantibiotic-based compounds having antimicrobial activity |
| GB0714030D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
| NZ594011A (en) | 2009-01-14 | 2013-12-20 | Novacta Biosystems Ltd | Deoxyactagardine derivatives |
| JP5731407B2 (ja) | 2009-02-04 | 2015-06-10 | ノヴァクタ バイオシステムズ リミティッド | アクタガルジン誘導体 |
| GB201001688D0 (en) | 2010-02-02 | 2010-03-17 | Novacta Biosystems Ltd | Compounds |
| GB201013513D0 (en) | 2010-08-11 | 2010-09-22 | Novacta Biosystems Ltd | Formulations |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59198982A (ja) | 1983-04-28 | 1984-11-10 | Meiji Seika Kaisha Ltd | 新抗生物質ｓｆ−２２４０物質およびその製造法 |
| EP0592835A3 (en) | 1992-09-23 | 1995-03-15 | Bristol Myers Squibb Co | Antibiotics of type BU-4803T. |
| US6551591B1 (en) | 2001-09-07 | 2003-04-22 | Essential Therapeutics, Inc. | Antibiotics from microbispora |
| US6551581B1 (en) | 2001-12-27 | 2003-04-22 | Avon Products, Inc. | Methods for improving the aesthetic appearance of skin and hair |
| JP4163737B2 (ja) | 2003-07-18 | 2008-10-08 | ヴァイキュロン ファーマシューティカルズ， インコーポレイテッド | 抗生物質１０７８９１、そのａ１因子とａ２因子、その薬剤学的に許容される塩、組成物、およびその使用 |
| AU2005324536B2 (en) * | 2005-01-12 | 2009-03-05 | Sentinella Pharmaceuticals, Inc. | Antibiotic 107891, its Factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof |
| PT1855705E (pt) * | 2005-01-12 | 2012-10-16 | Sentinella Pharmaceuticals Inc Sentinella | Antibiótico 107891, seus factores, seus sais aceitáveis sob o ponto de vista farmacêutico e suas composições, e sua utilização |
| WO2006075988A1 (en) | 2005-01-12 | 2006-07-20 | Vicuron Pharmaceuticals Inc. | Antibiotic 107891, its factors a1 and a2, pharmaceutically acceptable salts and compositions, and use thereof |
-
2005
- 2005-01-26 US US11/045,628 patent/US7351687B2/en not_active Expired - Lifetime
- 2005-01-27 PL PL05712250T patent/PL1848731T3/pl unknown
- 2005-01-27 CA CA002593801A patent/CA2593801A1/en not_active Abandoned
- 2005-01-27 CN CN2005800472656A patent/CN101189252B/zh not_active Expired - Fee Related
- 2005-01-27 EP EP05712250A patent/EP1848731B1/en active Active
- 2005-01-27 EP EP11001502A patent/EP2402366A1/en not_active Withdrawn
- 2005-01-27 NZ NZ556368A patent/NZ556368A/en not_active IP Right Cessation
- 2005-01-27 MX MX2007009059A patent/MX2007009059A/es active IP Right Grant
- 2005-01-27 JP JP2007553072A patent/JP4191238B2/ja not_active Expired - Fee Related
- 2005-01-27 SI SI200531553T patent/SI1848731T1/sl unknown
- 2005-01-27 RS RS20120359A patent/RS52427B/en unknown
- 2005-01-27 ES ES05712250T patent/ES2387557T3/es active Active
- 2005-01-27 WO PCT/US2005/002733 patent/WO2006080920A1/en active Application Filing
- 2005-01-27 KR KR1020077017177A patent/KR100896826B1/ko not_active IP Right Cessation
- 2005-01-27 BR BRPI0519942-5A patent/BRPI0519942A2/pt not_active IP Right Cessation
- 2005-01-27 DK DK05712250.9T patent/DK1848731T3/da active
- 2005-01-27 PT PT05712250T patent/PT1848731E/pt unknown
- 2005-01-27 AU AU2005326149A patent/AU2005326149C1/en not_active Ceased
- 2005-01-27 EA EA200701384A patent/EA016608B1/ru not_active IP Right Cessation
- 2005-01-27 UA UAA200708557A patent/UA87548C2/ru unknown
-
2007
- 2007-07-03 IL IL184377A patent/IL184377A0/en unknown
- 2007-07-05 ZA ZA200705495A patent/ZA200705495B/xx unknown
- 2007-07-05 NO NO20073490A patent/NO20073490L/no not_active Application Discontinuation
- 2007-07-24 TN TNP2007000286A patent/TNSN07286A1/fr unknown
- 2007-07-26 MA MA30106A patent/MA29237B1/fr unknown
-
2012
- 2012-08-02 HR HRP20120634TT patent/HRP20120634T1/hr unknown
- 2012-08-13 CY CY20121100727T patent/CY1113030T1/el unknown
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