HRP20140715T1 - Farmaceutski preparat koji sadrži lipazu bakterijskog porijekla - Google Patents
Farmaceutski preparat koji sadrži lipazu bakterijskog porijekla Download PDFInfo
- Publication number
- HRP20140715T1 HRP20140715T1 HRP20140715AT HRP20140715T HRP20140715T1 HR P20140715 T1 HRP20140715 T1 HR P20140715T1 HR P20140715A T HRP20140715A T HR P20140715AT HR P20140715 T HRP20140715 T HR P20140715T HR P20140715 T1 HRP20140715 T1 HR P20140715T1
- Authority
- HR
- Croatia
- Prior art keywords
- lipase
- pharmaceutical preparation
- treatment
- treatment according
- cystic fibrosis
- Prior art date
Links
- 102000004882 Lipase Human genes 0.000 title claims 7
- 108090001060 Lipase Proteins 0.000 title claims 7
- 239000004367 Lipase Substances 0.000 title claims 7
- 235000019421 lipase Nutrition 0.000 title claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 title claims 6
- 230000001580 bacterial effect Effects 0.000 title claims 3
- 201000003883 Cystic fibrosis Diseases 0.000 claims 3
- 208000016222 Pancreatic disease Diseases 0.000 claims 3
- 208000035467 Pancreatic insufficiency Diseases 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 230000001079 digestive effect Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 241001453380 Burkholderia Species 0.000 claims 1
- 241000134107 Burkholderia plantarii Species 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000006193 liquid solution Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
Claims (6)
1. Farmaceutski preparat koji sadrži bakterijsku lipazu u vodenoj otopini za liječenje probavnih poremećaja.
2. Farmaceutski preparat za liječenje prema zahtjevu 1, pri čemu je probavni poremećaj bolest pankreasa:
- mukoviscidoza
- pankreatitis.
3. Farmaceutski preparat za liječenje prema jednom od prethodnih zahtjeva 1 ili 2, okarakteriziran time da je vodena otopina pripremljena
a) direktnom proizvodnjom lipaze u obliku tekuće otopine
ili
b) tapanjem aktivnog sastojka lipaze u vodenom rastvaraču i poželjno inkubacijom na 4 °C, sobnoj temperaturi, ili 40 °C.
4. Farmaceutski preparat za liječenje prema jednom od prethodnih zahtjeva 1 do 3, pri čemu je bakterijska lipaza
- Burkholderia tipa,
- Pseudomonas tipa,
- Burkholderia plantarii tipa.
5. Tekućina i stabilan farmaceutski preparat za liječenje prema jednom od zahtjeva 1 do 4, za upotrebu primjenom lipaze u obliku stabilne otopine za liječenje insuficijencije pankreasa, kao što je mukoviscidoza, ili druga bolest pankreasa.
6. Lipaza je stabilna otopina u tekućem obliku koja sadrži stabilizatore, kao što su soli, organske kiseline, amino kiseline, deterdžente i šećer, za primjenu u liječenju insuficijencije pankreasa, kao što je mukoviscidoza, ili druga bolest pankreasa.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2009/000566 WO2010085975A1 (de) | 2009-01-29 | 2009-01-29 | Pharmazeutisches präparat enthaltend lipase bakteriellen ursprungs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140715T1 true HRP20140715T1 (hr) | 2014-09-26 |
Family
ID=41091375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140715AT HRP20140715T1 (hr) | 2009-01-29 | 2014-07-25 | Farmaceutski preparat koji sadrži lipazu bakterijskog porijekla |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20110293590A1 (hr) |
| EP (2) | EP2391382B1 (hr) |
| JP (1) | JP5970189B2 (hr) |
| CN (1) | CN102231988A (hr) |
| BR (1) | BRPI0922653B8 (hr) |
| CY (1) | CY1115519T1 (hr) |
| DK (1) | DK2391382T3 (hr) |
| ES (1) | ES2488407T3 (hr) |
| HR (1) | HRP20140715T1 (hr) |
| PL (1) | PL2391382T3 (hr) |
| PT (1) | PT2391382E (hr) |
| SI (1) | SI2391382T1 (hr) |
| WO (1) | WO2010085975A1 (hr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2165717A1 (de) | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
| PL2295039T5 (pl) | 2009-08-28 | 2023-02-27 | Nordmark Pharma Gmbh | Sposób wytwarzania granulek zawierających pankreatynę, w szczególności mikrogranulek zawierających pankreatynę, oraz wytworzone tym sposobem granulki zawierające pankreatynę |
| PL2489349T3 (pl) | 2011-02-17 | 2014-09-30 | Nordmark Arzneimittel Gmbh & Co Kg | Granulki pankreatynowe, zwłaszcza mikrogranulki pankreatynowe, oraz sposób ich produkcji |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| WO2013146529A1 (ja) * | 2012-03-28 | 2013-10-03 | 不二製油株式会社 | ランダムエステル交換油脂の製造方法 |
| DE102015114857A1 (de) | 2015-09-04 | 2017-03-09 | Nordmark Arzneimittel Gmbh & Co. Kg | Getränk, enthaltend eine pharmazeutische Zusammensetzung |
| DE102017104482A1 (de) | 2017-03-03 | 2018-09-06 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutische Zusammensetzung umfassend Pankreatin und einen lipasehaltigen Überzug |
| DE102017104501A1 (de) | 2017-03-03 | 2018-09-06 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutische Zusammensetzung umfassend einen Träger und einen Überzug enthaltend wenigstens eine Lipase |
| DE102017104480A1 (de) | 2017-03-03 | 2018-09-06 | Nordmark Arzneimittel Gmbh & Co. Kg | Wässrige Lösung von Burlulipase umfassend Kalziumionen |
| DE102017104472A1 (de) * | 2017-03-03 | 2018-09-06 | Nordmark Arzneimittel Gmbh & Co. Kg | Schmelztablette enthaltend Burlulipase und daraus hergestellte pharmazeutische Zusammensetzung |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2189948A (en) | 1938-10-31 | 1940-02-13 | Griffith Laboratories | Sterilization of pancreatin |
| DE2923279B1 (de) | 1979-06-08 | 1980-11-20 | Kali Chemie Pharma Gmbh | Verfahren zur Herstellung von Pankreatin-Pellets |
| US5063160A (en) * | 1989-03-16 | 1991-11-05 | Olin Corporation | Identification, characterization, and method of production of a novel microbial lipase |
| JP3025528B2 (ja) | 1989-11-24 | 2000-03-27 | ビオヘミー・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | パンクレアチン製剤 |
| DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| DE59209604D1 (de) | 1991-07-01 | 1999-02-11 | Basf Ag | Verwendung von lipasen zur herstellung von arzneimitteln |
| DE4227385A1 (de) | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | Pankreatinmikropellets |
| JPH08143469A (ja) * | 1994-11-14 | 1996-06-04 | Amano Pharmaceut Co Ltd | 膵外分泌機能不全症治療剤 |
| DE19724845A1 (de) | 1996-08-28 | 1998-03-05 | Solvay Pharm Gmbh | Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen |
| US6270723B1 (en) | 1998-06-15 | 2001-08-07 | Bbi Bioseq, Inc. | Rapid cryobaric sterilization and vaccine preparation |
| US20010046493A1 (en) * | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
| ATE272945T1 (de) * | 2000-04-06 | 2004-08-15 | Hannah Res Inst | Protein-stabilisierte emulsionen |
| AT502588B1 (de) * | 2002-11-26 | 2010-05-15 | Brenner Franz | Papaya-mus |
| EP1486415A1 (en) | 2003-06-12 | 2004-12-15 | SSP Technology A/S | Wind turbine blade and method of manufacturing a blade root |
| US6908789B1 (en) | 2003-12-15 | 2005-06-21 | Intel Corporation | Method of making a microelectronic assembly |
| PT1729797E (pt) * | 2004-03-22 | 2008-12-17 | Solvay Pharm Gmbh | Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos |
| JP4908420B2 (ja) * | 2004-10-14 | 2012-04-04 | アルタス ファーマシューティカルズ インコーポレイテッド | 膵機能不全を治療するための、リパーゼ、プロテアーゼおよびアミラーゼを含有する組成物 |
| DE102004056340B4 (de) | 2004-11-22 | 2010-11-18 | Repower Systems Ag | Vorrichtung und Verfahren zur Montage und/oder Demontage eines Bauteils einer Windkraftanlage |
| DE102005014868A1 (de) | 2005-03-30 | 2006-10-05 | Repower Systems Ag | Offshore-Windenergieanlage mit rutschfesten Füßen |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| DE102006021982C5 (de) | 2006-05-10 | 2010-10-07 | Repower Systems Ag | Gestaffelt abschaltbarer Windpark |
| US8246950B2 (en) * | 2007-02-20 | 2012-08-21 | Aptalis Pharma Limited | Stable digestive enzyme compositions |
| DE102007014863A1 (de) | 2007-03-26 | 2008-10-02 | Repower Systems Ag | Verfahren zum Betreiben einer Windenergieanlage |
| WO2008127567A1 (en) * | 2007-04-13 | 2008-10-23 | Beth Israel Deaconess Medical Center, Inc. | Novel nutritional food products for improved digestion and intestinal absorption |
| DE102008012664A1 (de) | 2008-01-30 | 2009-08-06 | Repower Systems Ag | Windenergieanlage und ein Turm oder Turmsegment und eine Türzarge dafür |
| EP2165717A1 (de) | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
| PL2295039T5 (pl) | 2009-08-28 | 2023-02-27 | Nordmark Pharma Gmbh | Sposób wytwarzania granulek zawierających pankreatynę, w szczególności mikrogranulek zawierających pankreatynę, oraz wytworzone tym sposobem granulki zawierające pankreatynę |
| PL2489349T3 (pl) | 2011-02-17 | 2014-09-30 | Nordmark Arzneimittel Gmbh & Co Kg | Granulki pankreatynowe, zwłaszcza mikrogranulki pankreatynowe, oraz sposób ich produkcji |
-
2009
- 2009-01-29 SI SI200930988T patent/SI2391382T1/sl unknown
- 2009-01-29 EP EP09776346.0A patent/EP2391382B1/de active Active
- 2009-01-29 DK DK09776346.0T patent/DK2391382T3/da active
- 2009-01-29 CN CN2009801474407A patent/CN102231988A/zh active Pending
- 2009-01-29 PL PL09776346T patent/PL2391382T3/pl unknown
- 2009-01-29 PT PT97763460T patent/PT2391382E/pt unknown
- 2009-01-29 BR BRPI0922653A patent/BRPI0922653B8/pt active IP Right Grant
- 2009-01-29 WO PCT/EP2009/000566 patent/WO2010085975A1/de active Application Filing
- 2009-01-29 ES ES09776346.0T patent/ES2488407T3/es active Active
- 2009-01-29 US US13/146,653 patent/US20110293590A1/en not_active Abandoned
- 2009-01-29 JP JP2011546599A patent/JP5970189B2/ja active Active
- 2009-01-29 EP EP14170910.5A patent/EP2786761A1/de not_active Withdrawn
-
2014
- 2014-07-25 HR HRP20140715AT patent/HRP20140715T1/hr unknown
- 2014-09-02 CY CY20141100699T patent/CY1115519T1/el unknown
-
2016
- 2016-06-15 US US15/182,779 patent/US10596235B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2786761A1 (de) | 2014-10-08 |
| PT2391382E (pt) | 2014-08-22 |
| BRPI0922653B8 (pt) | 2021-05-25 |
| PL2391382T3 (pl) | 2014-11-28 |
| US20160287679A1 (en) | 2016-10-06 |
| BRPI0922653A2 (pt) | 2016-01-05 |
| BRPI0922653B1 (pt) | 2021-04-13 |
| WO2010085975A1 (de) | 2010-08-05 |
| EP2391382A1 (de) | 2011-12-07 |
| DK2391382T3 (da) | 2014-08-25 |
| SI2391382T1 (sl) | 2014-10-30 |
| JP2012516289A (ja) | 2012-07-19 |
| US20110293590A1 (en) | 2011-12-01 |
| CY1115519T1 (el) | 2017-01-04 |
| CN102231988A (zh) | 2011-11-02 |
| JP5970189B2 (ja) | 2016-08-17 |
| ES2488407T3 (es) | 2014-08-27 |
| US10596235B2 (en) | 2020-03-24 |
| EP2391382B1 (de) | 2014-06-04 |
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