HRP20140241T1 - Postupak za pripremu sevelamera - Google Patents
Postupak za pripremu sevelamera Download PDFInfo
- Publication number
- HRP20140241T1 HRP20140241T1 HRP20140241AT HRP20140241T HRP20140241T1 HR P20140241 T1 HRP20140241 T1 HR P20140241T1 HR P20140241A T HRP20140241A T HR P20140241AT HR P20140241 T HRP20140241 T HR P20140241T HR P20140241 T1 HRP20140241 T1 HR P20140241T1
- Authority
- HR
- Croatia
- Prior art keywords
- sevelamer
- polyallylamine
- converted
- bicarbonate
- salt
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 11
- 229960003693 sevelamer Drugs 0.000 title claims 5
- ZNSIZMQNQCNRBW-UHFFFAOYSA-N sevelamer Chemical compound NCC=C.ClCC1CO1 ZNSIZMQNQCNRBW-UHFFFAOYSA-N 0.000 title claims 5
- 238000002360 preparation method Methods 0.000 title claims 2
- 229920000083 poly(allylamine) Polymers 0.000 claims 5
- PADGNZFOVSZIKZ-UHFFFAOYSA-N 2-(chloromethyl)oxirane;hydrogen carbonate;prop-2-enylazanium Chemical compound NCC=C.OC(O)=O.ClCC1CO1 PADGNZFOVSZIKZ-UHFFFAOYSA-N 0.000 claims 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229960005441 sevelamer carbonate Drugs 0.000 claims 3
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical group NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 238000009938 salting Methods 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F26/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/18—Introducing halogen atoms or halogen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/44—Preparation of metal salts or ammonium salts
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2339/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Derivatives of such polymers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Saccharide Compounds (AREA)
Claims (10)
1. Postupak za pripremu sevelamera, naznačen time, da obuhvaća sljedeće stupnjeve:
(a) djelomično prevođenje u sol vodene otopine polialilamina koja ima koncentraciju između 10% i 14,5 tež.%;
(b) dodavanje epiklorohidrina;
(c) održavanje reakcijske smjese uz miješanje;
(d) izoliranje tako dobivenog sevelamera;
i također, naznačen time, da se stupnjevi od (a) do (c) izvode u odsutnosti bilo kojeg organskog otapala.
2. Postupak prema patentnom zahtjevu 1, naznačen time, da se polialilamin prevodi u sol do stupnja prevođenja u sol od 25-40%.
3. Postupak prema patentnom zahtjevu 1 ili 2, naznačen time, da molni odnos "alilaminska jedinica"/"epiklorohidrin" jest 8-11/1.
4. Postupak prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time, da se u stupnju (c) održava uz miješanje pri 65 do 85 °C.
5. Postupak prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da navedena vodena otopina polialilamina ima koncentraciju između 12,5 i 14,5%.
6. Postupak prema patentnom zahtjevu 5, naznačen time, da navedena vodena otopina polialilamina ima koncentraciju između 13 i 14%.
7. Postupak prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da se polialilamin djelomično prevodi u sol sa solnom kiselinom.
8. Postupak prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da se na taj način dobiven sevelamer pretvara u sevelamer karbonat/bikarbonat.
9. Postupak prema patentnom zahtjevu 8, naznačen time, da se na taj način dobiveni sevelamer pretvara u sevelamer karbonat/bikarbonat reakcijom s plinovitim CO2.
10. Postupak prema patentnom zahtjevu 9, naznačen time, da se pretvorba u sevelamer karbonat/bikarbonat s plinovitim CO2 izvodi u krutoj fazi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2009A000816A IT1394299B1 (it) | 2009-05-12 | 2009-05-12 | Procedimento per la preparazione di sevelamer |
| PCT/IB2010/001071 WO2010131092A1 (en) | 2009-05-12 | 2010-05-10 | Process for the preparation of sevelamer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140241T1 true HRP20140241T1 (hr) | 2014-04-11 |
Family
ID=41257151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140241AT HRP20140241T1 (hr) | 2009-05-12 | 2014-03-14 | Postupak za pripremu sevelamera |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20120101234A1 (hr) |
| EP (1) | EP2430078B1 (hr) |
| JP (1) | JP5658744B2 (hr) |
| CY (1) | CY1114915T1 (hr) |
| DK (1) | DK2430078T3 (hr) |
| EA (1) | EA021074B1 (hr) |
| ES (1) | ES2453114T3 (hr) |
| HR (1) | HRP20140241T1 (hr) |
| IT (1) | IT1394299B1 (hr) |
| PL (1) | PL2430078T3 (hr) |
| PT (1) | PT2430078E (hr) |
| SI (1) | SI2430078T1 (hr) |
| WO (1) | WO2010131092A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101853260B1 (ko) * | 2016-11-29 | 2018-06-14 | 주식회사 퍼슨 | 세벨라머 카보네이트의 제조방법 |
| US10479865B2 (en) * | 2017-11-01 | 2019-11-19 | Strides Shasun Limited | Process for the preparation of sevelamer carbonate |
| CN115260355A (zh) * | 2022-05-16 | 2022-11-01 | 江苏中天药业有限公司 | 一种阴离子交换树脂、其制备方法、该树脂与药物的复合物和其掩味制剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3541511A1 (de) * | 1985-11-19 | 1987-05-21 | Grace W R Ab | Promoter fuer die papierleimung, verfahren zu dessen herstellung und dessen verwendung |
| US6423754B1 (en) * | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| DE60035414T2 (de) * | 1999-04-16 | 2008-03-13 | Abbott Laboratories, Abbott Park | Verfahren zur herstellung von vernetzten polyallyaminderivaten |
| US6362266B1 (en) * | 1999-09-03 | 2002-03-26 | The Dow Chemical Company | Process for reducing cohesiveness of polyallylamine polymer gels during drying |
| US6180754B1 (en) * | 1999-09-03 | 2001-01-30 | The Dow Chemical Company | Process for producing cross-linked polyallylamine polymer |
| US6600011B2 (en) * | 2001-10-09 | 2003-07-29 | Genzyme Corporation | Process for purification and drying of polymer hydrogels |
| WO2004037274A1 (en) * | 2002-10-22 | 2004-05-06 | Genzyme Corporation | Amine polymers for promoting bone formation |
| US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| JP2005138540A (ja) * | 2003-11-10 | 2005-06-02 | Konica Minolta Photo Imaging Inc | インクジェット記録材料 |
| JP2009542653A (ja) * | 2006-07-05 | 2009-12-03 | ジェンザイム コーポレーション | リン酸塩過剰血症のための鉄（ｉｉ）含有治療剤 |
| CA2661987C (en) * | 2006-09-01 | 2012-11-06 | Usv Limited | Process for the preparation of sevelamer hydrochloride and formulation thereof |
-
2009
- 2009-05-12 IT ITMI2009A000816A patent/IT1394299B1/it active
-
2010
- 2010-05-10 SI SI201030544T patent/SI2430078T1/sl unknown
- 2010-05-10 DK DK10727834.3T patent/DK2430078T3/en active
- 2010-05-10 EA EA201101613A patent/EA021074B1/ru not_active IP Right Cessation
- 2010-05-10 WO PCT/IB2010/001071 patent/WO2010131092A1/en active Application Filing
- 2010-05-10 PL PL10727834T patent/PL2430078T3/pl unknown
- 2010-05-10 ES ES10727834.3T patent/ES2453114T3/es active Active
- 2010-05-10 JP JP2012510378A patent/JP5658744B2/ja not_active Expired - Fee Related
- 2010-05-10 US US13/319,821 patent/US20120101234A1/en not_active Abandoned
- 2010-05-10 PT PT107278343T patent/PT2430078E/pt unknown
- 2010-05-10 EP EP10727834.3A patent/EP2430078B1/en active Active
-
2014
- 2014-02-06 US US14/173,898 patent/US9303105B2/en not_active Expired - Fee Related
- 2014-02-27 CY CY20141100161T patent/CY1114915T1/el unknown
- 2014-03-14 HR HRP20140241AT patent/HRP20140241T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2430078B1 (en) | 2014-01-01 |
| US9303105B2 (en) | 2016-04-05 |
| EP2430078A1 (en) | 2012-03-21 |
| SI2430078T1 (sl) | 2014-04-30 |
| JP2012526887A (ja) | 2012-11-01 |
| DK2430078T3 (en) | 2014-03-24 |
| CY1114915T1 (el) | 2016-12-14 |
| EA201101613A1 (ru) | 2012-04-30 |
| IT1394299B1 (it) | 2012-06-06 |
| PT2430078E (pt) | 2014-02-11 |
| ES2453114T3 (es) | 2014-04-04 |
| ITMI20090816A1 (it) | 2010-11-13 |
| US20140213736A1 (en) | 2014-07-31 |
| PL2430078T3 (pl) | 2014-06-30 |
| US20120101234A1 (en) | 2012-04-26 |
| JP5658744B2 (ja) | 2015-01-28 |
| WO2010131092A1 (en) | 2010-11-18 |
| EA021074B1 (ru) | 2015-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201200153A1 (ru) | Сухая композиция для смешивания с водой (варианты), раствор для очищения кишечника на ее основе, водный раствор, набор, способ очищения толстой кишки | |
| IN2012DN00306A (hr) | ||
| HRP20140241T1 (hr) | Postupak za pripremu sevelamera | |
| WO2007125533A3 (en) | Orally administrable films and preparation thereof | |
| WO2007025293A3 (en) | Use of acid derivatives of fluoropolymers for fouling-resistant surfaces | |
| WO2009149381A3 (en) | Chemical framework compositions and methods of use | |
| NO20062465L (no) | Method and for cleaning of gases and uses thereof | |
| SV2009003192A (es) | Procedimiento de preparacion de halogenuros de n-alquil-naltrexona | |
| BR112012013954B8 (pt) | derivado de ácido hialurônico, método de preparação do derivado de ácido hialurônico | |
| WO2010111436A3 (en) | Antiviral compounds and uses thereof | |
| WO2012075091A3 (en) | Synthetic acid and associated methods | |
| WO2013082856A8 (zh) | 湿法石灰石烟气脱硫浆液稳定剂及其使用方法 | |
| MY157838A (en) | Metalworking fluid | |
| MY156294A (en) | Absorption agent for removing acidic gases from a fluid flow | |
| WO2009117498A3 (en) | Methods of making cyclododecatriene and methods of making laurolactone | |
| WO2010035965A3 (ko) | 이산화티타늄 졸 제조장치 및 제조방법 및 이를 이용한 페이스트 조성물 | |
| WO2008077035A3 (en) | Processes for the preparation of levetiracetam | |
| NO20063779L (no) | Kalk- og polymer-inneholdende herdbar blanding. | |
| WO2009029529A3 (en) | Method and apparatus for producing ammonium carbonate from urea | |
| ATE524428T1 (de) | Verfahren zur herstellung von pharmazeutischen zwischenprodukten | |
| WO2012017313A3 (en) | Method for producing composition for external use containing physiologically acceptable salt of tranexamate | |
| WO2010116321A3 (en) | Biopolymer-containing calcium phosphate foam, process for obtaining thereof and use for bone regeneration | |
| BRPI0509923A (pt) | processo para formação de cálcio de atorvastatina amorfa | |
| ATE501239T1 (de) | Reinigungsprodukt in fester form für glasoberflächen eines fahrzeugs | |
| JP2012526887A5 (hr) |