HRP20121025T1 - Postupci za pripravu derivata ciklopropilamida - Google Patents
Postupci za pripravu derivata ciklopropilamida Download PDFInfo
- Publication number
- HRP20121025T1 HRP20121025T1 HRP20121025TT HRP20121025T HRP20121025T1 HR P20121025 T1 HRP20121025 T1 HR P20121025T1 HR P20121025T T HRP20121025T T HR P20121025TT HR P20121025 T HRP20121025 T HR P20121025T HR P20121025 T1 HRP20121025 T1 HR P20121025T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- compound
- iis
- image
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 5
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical class NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000003960 organic solvent Substances 0.000 claims 4
- 101100244064 Enterobacteria phage PRD1 XXII gene Proteins 0.000 claims 3
- 239000003638 chemical reducing agent Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (4)
1. Postupak za pripravu spoja formule (IIs)
[image]
ili njegovog hidrata, solvata ili farmaceutski prihvatljive soli, naznačen time da obuhvaća
[image]
reakciju spoja formule (XXs), u prvom organskom otapalu, kako bi se dobio odgovarajući spoj formule (XXIs ), gdje je L napuštajuća skupina i gdje spoj formule (XXIs) nije izoliran;
[image]
reakciju spoja formule (XXIs) sa spojem formule (XXIIs), u prisustvu organske i neorganske baze, u drugom organskom otapalu, kako bi se dobio odgovarajući spoj formule (XXIIIs), gdje spoj formule ( XXIIIs) nije izoliran;
[image]
i reakciju spoja formule (XXIIIs) sa spojem formule (XXIVs), u prisustvu redukcijskog sredstva, u trećem organskom otapalu, kako bi se dobio odgovarajući spoj formule (IIs), gdje su prvo, drugo i treće organsko otapalo isti i gdje je L klor.
2. Postupak prema zahtjevu 1, naznačen time da je spoj formule (XXIIs) prisutan u količini od oko jednog ekvivalenta.
3. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da je spoj formule (XXIVs) prisutan u količini većoj od oko jednog ekvivalenta, i gdje je redukcijski agens prisutan u količini od oko 1 do oko 2 ekvivalenta.
4. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da nadalje obuhvaća reakciju spoja formule (IIs) kako bi se dobila odgovarajuća farmaceutski prihvatljiva sol spoja formule (IIs).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73172505P | 2005-10-31 | 2005-10-31 | |
| PCT/US2006/041590 WO2007053386A2 (en) | 2005-10-31 | 2006-10-26 | Processes for the preparation of cyclopropyl-amide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20121025T1 true HRP20121025T1 (hr) | 2013-01-31 |
Family
ID=38001898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20121025TT HRP20121025T1 (hr) | 2005-10-31 | 2012-12-12 | Postupci za pripravu derivata ciklopropilamida |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1951699B1 (hr) |
| JP (1) | JP5185822B2 (hr) |
| KR (1) | KR20080067362A (hr) |
| CN (2) | CN102659718B (hr) |
| AR (2) | AR058171A1 (hr) |
| AU (1) | AU2006309124B2 (hr) |
| BR (1) | BRPI0618076A2 (hr) |
| CA (2) | CA2628187C (hr) |
| CR (1) | CR10036A (hr) |
| DK (1) | DK1951699T3 (hr) |
| EA (2) | EA201001872A1 (hr) |
| EC (1) | ECSP088417A (hr) |
| ES (1) | ES2395049T3 (hr) |
| HK (1) | HK1119676A1 (hr) |
| HR (1) | HRP20121025T1 (hr) |
| IL (2) | IL190965A (hr) |
| MX (1) | MX367916B (hr) |
| MY (2) | MY151028A (hr) |
| NO (1) | NO340950B1 (hr) |
| NZ (2) | NZ567359A (hr) |
| PL (1) | PL1951699T3 (hr) |
| PT (1) | PT1951699E (hr) |
| RS (1) | RS52569B (hr) |
| SG (1) | SG166803A1 (hr) |
| SI (1) | SI1951699T1 (hr) |
| TW (1) | TWI377201B (hr) |
| UA (1) | UA93892C2 (hr) |
| WO (1) | WO2007053386A2 (hr) |
| ZA (1) | ZA200804730B (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
| EA016687B8 (ru) | 2007-08-22 | 2012-07-30 | Астразенека Аб | Производные циклопропиламида |
| AU2008294708B2 (en) | 2007-09-06 | 2012-03-15 | Glaxo Group Limited | Piperazine derivative having affinity for the histamine H3 receptor |
| TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| KR20130004296A (ko) | 2010-02-18 | 2013-01-09 | 아스트라제네카 아베 | 시클로프로필 아미드 유도체의 제조 방법 및 그와 관련된 중간체 |
| FR2962729B1 (fr) | 2010-07-13 | 2012-09-21 | Arkema France | Molecules porteuses de groupes associatifs |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK5202000A3 (en) * | 2000-04-07 | 2001-12-03 | Slovakofarma As | Method for the preparation of (e)-n-(6,6-dimethyl-2-hepten-4- inyl)-n-methyl-1-naphthalenemethylamine (terbinaphin) |
| DE50108012D1 (de) * | 2000-07-05 | 2005-12-15 | Basf Ag | Verfahren zur herstellung von trioximderivaten |
| US20040010746A1 (en) | 2002-07-10 | 2004-01-15 | Lucas L. Victor | Forward error correction system for wireless communications |
| DK1558595T3 (da) * | 2002-10-23 | 2010-03-29 | Janssen Pharmaceutica Nv | Piperazinyl- og diazapanylbenzamider og -benzthioamider |
| US7276610B2 (en) * | 2003-08-27 | 2007-10-02 | Janssen Pharaceutica, Nv | Aryl piperidine amides |
| US7687499B2 (en) * | 2005-09-16 | 2010-03-30 | Janssen Pharmaceutica Nv | Cyclopropyl amines as modulators of the histamine H3 receptor |
-
2006
- 2006-10-26 RS RS20120537A patent/RS52569B/sr unknown
- 2006-10-26 MX MX2011007097A patent/MX367916B/es unknown
- 2006-10-26 NZ NZ567359A patent/NZ567359A/en not_active IP Right Cessation
- 2006-10-26 SG SG201007997-8A patent/SG166803A1/en unknown
- 2006-10-26 WO PCT/US2006/041590 patent/WO2007053386A2/en active Application Filing
- 2006-10-26 EP EP06826616A patent/EP1951699B1/en active Active
- 2006-10-26 MY MYPI20081400 patent/MY151028A/en unknown
- 2006-10-26 SI SI200631478T patent/SI1951699T1/sl unknown
- 2006-10-26 BR BRPI0618076-0A patent/BRPI0618076A2/pt not_active Application Discontinuation
- 2006-10-26 EA EA201001872A patent/EA201001872A1/ru unknown
- 2006-10-26 NZ NZ592864A patent/NZ592864A/xx not_active IP Right Cessation
- 2006-10-26 MY MYPI2011000184A patent/MY174411A/en unknown
- 2006-10-26 PT PT68266162T patent/PT1951699E/pt unknown
- 2006-10-26 EA EA200801240A patent/EA014935B1/ru unknown
- 2006-10-26 CN CN201210156081.5A patent/CN102659718B/zh not_active Expired - Fee Related
- 2006-10-26 UA UAA200807477A patent/UA93892C2/ru unknown
- 2006-10-26 DK DK06826616.2T patent/DK1951699T3/da active
- 2006-10-26 JP JP2008538922A patent/JP5185822B2/ja not_active Expired - Fee Related
- 2006-10-26 ES ES06826616T patent/ES2395049T3/es active Active
- 2006-10-26 CN CN2006800405726A patent/CN101300242B/zh not_active Expired - Fee Related
- 2006-10-26 PL PL06826616T patent/PL1951699T3/pl unknown
- 2006-10-26 CA CA2628187A patent/CA2628187C/en active Active
- 2006-10-26 AU AU2006309124A patent/AU2006309124B2/en not_active Ceased
- 2006-10-26 KR KR1020087012921A patent/KR20080067362A/ko not_active Application Discontinuation
- 2006-10-26 CA CA2869539A patent/CA2869539C/en active Active
- 2006-10-30 TW TW095139962A patent/TWI377201B/zh not_active IP Right Cessation
- 2006-10-31 AR ARP060104772A patent/AR058171A1/es not_active Application Discontinuation
-
2008
- 2008-04-17 IL IL190965A patent/IL190965A/en active IP Right Grant
- 2008-04-30 EC EC2008008417A patent/ECSP088417A/es unknown
- 2008-05-30 ZA ZA200804730A patent/ZA200804730B/xx unknown
- 2008-05-30 CR CR10036A patent/CR10036A/es unknown
- 2008-05-30 NO NO20082458A patent/NO340950B1/no not_active IP Right Cessation
- 2008-10-17 HK HK08111538.8A patent/HK1119676A1/xx not_active IP Right Cessation
-
2011
- 2011-06-12 IL IL213474A patent/IL213474A/en active IP Right Grant
-
2012
- 2012-12-12 HR HRP20121025TT patent/HRP20121025T1/hr unknown
-
2019
- 2019-04-17 AR ARP190101031A patent/AR114493A2/es unknown
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