HRP20120815T1 - Postupak proizvodnje filmom obloženih tableta koje sadrže drospirenon kao aktivni sastojak - Google Patents
Postupak proizvodnje filmom obloženih tableta koje sadrže drospirenon kao aktivni sastojak Download PDFInfo
- Publication number
- HRP20120815T1 HRP20120815T1 HRP20120815AT HRP20120815T HRP20120815T1 HR P20120815 T1 HRP20120815 T1 HR P20120815T1 HR P20120815A T HRP20120815A T HR P20120815AT HR P20120815 T HRP20120815 T HR P20120815T HR P20120815 T1 HRP20120815 T1 HR P20120815T1
- Authority
- HR
- Croatia
- Prior art keywords
- film
- forming polymer
- tablets containing
- drospirenone
- coated tablets
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 title claims 3
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 title claims 3
- 229960004845 drospirenone Drugs 0.000 title claims 3
- 239000007941 film coated tablet Substances 0.000 title claims 2
- 239000013543 active substance Substances 0.000 title 1
- 229920000642 polymer Polymers 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
- -1 polytetrafluoroethylene Polymers 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- HFCUBKYHMMPGBY-UHFFFAOYSA-N 2-methoxyethyl prop-2-enoate Chemical compound COCCOC(=O)C=C HFCUBKYHMMPGBY-UHFFFAOYSA-N 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 239000005033 polyvinylidene chloride Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (3)
1. Postupak proizvodnje filmom obloženih tableta koje sadrže drospirenon kao aktivni sastojak, naznačen time, da obuhvaća otapanje drospirenona u etanolu, zatim kontinuirano ili periodično kapanje dobivene otopine na površinu fluidne podloge u fluidiziranoj opremi bez tlaka pulverizacije, prilikom čega se kontrolira temperatura dobivenog proizvoda odstranjujući molekule otopine iz vlažnog materijala pomoću vrućeg zračnog strujanja, te se dobivene jezgre oblažu filmom s organskom i/ili vodenom otopinom ili se raspršuje polimer koji tvori film.
2. Postupak prema zahtjevu 1, naznačen time, da je polimer koji tvori film odabran iz skupine koju čine akrilna kiselina, metakrilna kiselina, metoksietilakrilat, celulozni acetat, etilen oksid i polietilen oksid, kopolimer etilen vinil acetata, metil celuloza, polivinil acetat, polivinil alkohol, polivinil pirolidon, politetrafluoretilen i poliviniliden klorid.
3. Postupak prema zahtjevu 2, naznačen time, da polimer koji tvori film je kopolimer E amino alkil metakrilata.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0700826A HUP0700826A3 (en) | 2007-12-20 | 2007-12-20 | Coated tablet containing drospirenone and process for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120815T1 true HRP20120815T1 (hr) | 2012-11-30 |
Family
ID=89987951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120815AT HRP20120815T1 (hr) | 2007-12-20 | 2012-10-11 | Postupak proizvodnje filmom obloženih tableta koje sadrže drospirenon kao aktivni sastojak |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20110002993A1 (hr) |
| EP (2) | EP2072041B1 (hr) |
| JP (1) | JP5679819B2 (hr) |
| CN (1) | CN101896166B (hr) |
| AU (1) | AU2008339588B2 (hr) |
| BR (1) | BRPI0820450A2 (hr) |
| CA (1) | CA2708875A1 (hr) |
| CY (1) | CY1113416T1 (hr) |
| DK (1) | DK2072041T3 (hr) |
| EA (1) | EA017869B1 (hr) |
| ES (1) | ES2391953T3 (hr) |
| HK (1) | HK1147054A1 (hr) |
| HR (1) | HRP20120815T1 (hr) |
| HU (1) | HUP0700826A3 (hr) |
| IL (1) | IL205818A (hr) |
| MY (1) | MY148138A (hr) |
| NZ (1) | NZ585554A (hr) |
| PL (1) | PL2072041T3 (hr) |
| PT (1) | PT2072041E (hr) |
| SI (1) | SI2072041T1 (hr) |
| UA (1) | UA103182C2 (hr) |
| WO (1) | WO2009081216A1 (hr) |
| ZA (1) | ZA201003913B (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160048305A1 (en) * | 2014-08-14 | 2016-02-18 | Microsoft Corporation | Group-Based User Interface Rearrangement |
| RU2753049C2 (ru) * | 2016-08-04 | 2021-08-11 | БиПиЭсАй ХОЛДИНГЗ, ЭлЭлСи | Легкие для глотания покрытия и покрытые ими субстраты |
| EP3747364A4 (en) * | 2018-01-29 | 2021-11-10 | PHC Holdings Corporation | PROTECTIVE FILM MATERIAL FOR BIOCAPTER PROBE |
| WO2019176339A1 (ja) * | 2018-03-13 | 2019-09-19 | Ｐｈｃホールディングス株式会社 | バイオセンサプローブ用保護膜材料 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2652761C2 (de) | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| DE3022337A1 (de) | 1980-06-11 | 1982-01-07 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen |
| EP2044941A1 (en) * | 1999-08-31 | 2009-04-08 | Bayer Schering Pharma AG | Multiple-phase formulation of drospirenone and estradiol as a contraceptive |
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| EP1216713A1 (en) * | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Compositions of estrogen-cyclodextrin complexes |
| JP2004315713A (ja) * | 2003-04-18 | 2004-11-11 | Shin Etsu Chem Co Ltd | 非イオン性セルロースエーテルの製造方法及びこれにより得られる非イオン性セルロースエーテル造粒物 |
| EP1625849A1 (en) * | 2004-08-09 | 2006-02-15 | Liconsa, Liberacion Controlada de Sustancias Activas, S.A. | Pharmaceutical composition comprising drospirenone and ethynylestradiol |
| US8475838B2 (en) * | 2005-06-03 | 2013-07-02 | Sandoz Ag | Rapidly-dissolving pharmaceutical composition for inhibiting ovulation |
| EP1767194A1 (de) * | 2005-06-09 | 2007-03-28 | Helm AG | Verfahren zur Herstellung von Adsorbaten des Drospirenons |
-
2007
- 2007-12-20 HU HU0700826A patent/HUP0700826A3/hu unknown
-
2008
- 2008-09-02 CA CA2708875A patent/CA2708875A1/en not_active Abandoned
- 2008-09-02 MY MYPI2010002356A patent/MY148138A/en unknown
- 2008-09-02 EA EA201001032A patent/EA017869B1/ru unknown
- 2008-09-02 NZ NZ585554A patent/NZ585554A/en unknown
- 2008-09-02 CN CN2008801205209A patent/CN101896166B/zh active Active
- 2008-09-02 BR BRPI0820450-0A patent/BRPI0820450A2/pt not_active Application Discontinuation
- 2008-09-02 AU AU2008339588A patent/AU2008339588B2/en active Active
- 2008-09-02 JP JP2010538923A patent/JP5679819B2/ja active Active
- 2008-09-02 WO PCT/HU2008/000100 patent/WO2009081216A1/en active Application Filing
- 2008-09-02 US US12/809,441 patent/US20110002993A1/en not_active Abandoned
- 2008-09-02 UA UAA201009145A patent/UA103182C2/ru unknown
- 2008-10-06 ES ES08462008T patent/ES2391953T3/es active Active
- 2008-10-06 SI SI200830763T patent/SI2072041T1/sl unknown
- 2008-10-06 PT PT08462008T patent/PT2072041E/pt unknown
- 2008-10-06 EP EP08462008A patent/EP2072041B1/en not_active Revoked
- 2008-10-06 PL PL08462008T patent/PL2072041T3/pl unknown
- 2008-10-06 EP EP12151732A patent/EP2446880A1/en not_active Withdrawn
- 2008-10-06 DK DK08462008.7T patent/DK2072041T3/da active
-
2010
- 2010-05-17 IL IL205818A patent/IL205818A/en active IP Right Grant
- 2010-06-01 ZA ZA2010/03913A patent/ZA201003913B/en unknown
-
2011
- 2011-02-01 HK HK11101080.6A patent/HK1147054A1/xx unknown
-
2012
- 2012-10-05 CY CY20121100930T patent/CY1113416T1/el unknown
- 2012-10-11 HR HRP20120815AT patent/HRP20120815T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011507825A (ja) | 2011-03-10 |
| CN101896166A (zh) | 2010-11-24 |
| PL2072041T3 (pl) | 2012-12-31 |
| NZ585554A (en) | 2012-06-29 |
| JP5679819B2 (ja) | 2015-03-04 |
| HUP0700826A3 (en) | 2010-03-29 |
| SI2072041T1 (sl) | 2012-11-30 |
| AU2008339588A1 (en) | 2009-07-02 |
| CA2708875A1 (en) | 2009-07-02 |
| UA103182C2 (ru) | 2013-09-25 |
| ZA201003913B (en) | 2011-03-30 |
| IL205818A0 (en) | 2010-11-30 |
| EP2446880A1 (en) | 2012-05-02 |
| IL205818A (en) | 2016-05-31 |
| DK2072041T3 (da) | 2012-11-05 |
| MY148138A (en) | 2013-02-28 |
| WO2009081216A1 (en) | 2009-07-02 |
| US20110002993A1 (en) | 2011-01-06 |
| CY1113416T1 (el) | 2016-06-22 |
| HU0700826D0 (en) | 2008-02-28 |
| HK1147054A1 (en) | 2011-07-29 |
| EP2072041B1 (en) | 2012-08-01 |
| EP2072041A1 (en) | 2009-06-24 |
| ES2391953T3 (es) | 2012-12-03 |
| PT2072041E (pt) | 2012-10-31 |
| CN101896166B (zh) | 2013-05-01 |
| EA017869B1 (ru) | 2013-03-29 |
| AU2008339588B2 (en) | 2014-06-26 |
| HUP0700826A2 (en) | 2009-07-28 |
| EA201001032A1 (ru) | 2010-12-30 |
| BRPI0820450A2 (pt) | 2015-06-16 |
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