HRP20120228T1 - Kladribinski režim za liječenje multiple skleroze - Google Patents

Kladribinski režim za liječenje multiple skleroze Download PDF

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Publication number
HRP20120228T1
HRP20120228T1 HR20120228T HRP20120228T HRP20120228T1 HR P20120228 T1 HRP20120228 T1 HR P20120228T1 HR 20120228 T HR20120228 T HR 20120228T HR P20120228 T HRP20120228 T HR P20120228T HR P20120228 T1 HRP20120228 T1 HR P20120228T1
Authority
HR
Croatia
Prior art keywords
cladribine
period
months
pharmaceutical formulation
administered
Prior art date
Application number
HR20120228T
Other languages
English (en)
Croatian (hr)
Inventor
De Luca Giampiero
Ythier Arnaud
Munafo Alain
Lopez-Bresnahan Maria
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36227798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20120228(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of HRP20120228T1 publication Critical patent/HRP20120228T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HR20120228T 2004-12-22 2005-12-20 Kladribinski režim za liječenje multiple skleroze HRP20120228T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63866904P 2004-12-22 2004-12-22
EP04106909 2004-12-22
PCT/EP2005/056954 WO2006067141A1 (en) 2004-12-22 2005-12-20 Cladribine regimen for treating multiple sclerosis

Publications (1)

Publication Number Publication Date
HRP20120228T1 true HRP20120228T1 (hr) 2012-04-30

Family

ID=36227798

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20120228T HRP20120228T1 (hr) 2004-12-22 2005-12-20 Kladribinski režim za liječenje multiple skleroze

Country Status (25)

Country Link
US (2) US7713947B2 (https=)
EP (7) EP3332789B1 (https=)
JP (7) JP5795456B2 (https=)
KR (1) KR20070091662A (https=)
AR (1) AR052830A1 (https=)
AU (2) AU2005318190B2 (https=)
BR (1) BRPI0517132B8 (https=)
CA (2) CA3087419C (https=)
CY (3) CY1112614T1 (https=)
DK (3) DK3332789T3 (https=)
EA (1) EA015799B1 (https=)
ES (2) ES3007339T3 (https=)
FI (1) FI4070800T3 (https=)
FR (1) FR18C1008I2 (https=)
HR (1) HRP20120228T1 (https=)
HU (3) HUE059133T2 (https=)
IL (2) IL183930A0 (https=)
LT (3) LT3332789T (https=)
LU (1) LUC00064I2 (https=)
MX (1) MX2007007610A (https=)
NO (1) NO20073813L (https=)
PL (4) PL3332789T3 (https=)
SG (1) SG160391A1 (https=)
SI (3) SI4070800T1 (https=)
WO (1) WO2006067141A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3332789B1 (en) 2004-12-22 2022-04-06 Merck Serono SA Cladribine regimen for treating multiple sclerosis
AU2007253254B2 (en) * 2006-05-24 2013-01-17 Merck Serono Sa Cladribine regimen for treating multiple sclerosis
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
WO2011117267A1 (en) 2010-03-24 2011-09-29 Merck Serono Sa Cladribine treatment of multiple sclerosis in patient groups defined by genotype
EP2428201A1 (en) 2010-09-08 2012-03-14 Merck Serono S.A. Oral administration of nucleoside monophosphates
WO2012097867A1 (en) 2011-01-18 2012-07-26 Synthon Bv Cladribine particles and pharmaceutical compositions comprising them
GB201401465D0 (en) * 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
EP3713582A1 (en) * 2017-11-24 2020-09-30 Merck Patent GmbH Cladribine regimen for use intreating progressive forms of multiple sclerosis
CA3194812A1 (en) 2020-09-10 2022-03-17 Merck Patent Gmbh Novel treatment regimen for the treatment of autoimmune disorders
GB2601786A (en) 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1269659A (en) 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
US4964848A (en) * 1988-06-27 1990-10-23 Bloom Philip M Treatment of multiple sclerosis with lymphocytapheresis and chemo-immunosuppression
US5208327A (en) 1991-12-18 1993-05-04 Ortho Pharmaceutical Corporation Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
US5641757A (en) 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
ES2182920T3 (es) 1994-12-22 2003-03-16 Ortho Pharma Corp Formulaciones solubles de 2-cloro02'-deoxiadenosina.
US6194395B1 (en) 1999-02-25 2001-02-27 Orthro-Mcneil Pharmaceutical, Inc. Cyclodextrin cladribine formulations
WO2000064918A1 (en) 1999-04-28 2000-11-02 Sterrenbeld Biotechnologie North America, Inc. METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE
DE10237146A1 (de) * 2002-08-13 2004-03-04 Medac Gesellschaft für klinische Spezialpräparate mbH Verwendung von Treosulfan und Derivaten davon zur Behandlung der Multiplen Sklerose
ES2405825T3 (es) 2002-09-25 2013-06-03 Brigham Young University Método para la preparación de compuestos 2-halo-2'-desoxiadenosina a partir de 2'-desoxiguanosina
GB2394658A (en) * 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
AU2004216485B2 (en) * 2003-02-25 2009-06-11 Merck Serono Sa Combined use of ribavirin and interferon beta in demyelinating diseases
HRP20050924A2 (en) 2003-03-28 2006-08-31 Ivax Corporation Cladribine formulations for improved oral and transmucosal delivery
ES2409884T3 (es) * 2003-03-28 2013-06-28 Ares Trading S.A. Formulaciones orales de cladribina
EP3332789B1 (en) 2004-12-22 2022-04-06 Merck Serono SA Cladribine regimen for treating multiple sclerosis
AU2007253254B2 (en) * 2006-05-24 2013-01-17 Merck Serono Sa Cladribine regimen for treating multiple sclerosis

Also Published As

Publication number Publication date
LT3332789T (lt) 2022-07-25
CA3087419C (en) 2023-03-07
LTPA2018503I1 (lt) 2018-03-12
ES2921858T3 (es) 2022-09-01
EP2275110B1 (en) 2013-07-10
EA015799B1 (ru) 2011-12-30
EP4070800A1 (en) 2022-10-12
EP2805723B1 (en) 2018-01-17
EP2263678A2 (en) 2010-12-22
LTC2805723I2 (lt) 2022-04-25
BRPI0517132A (pt) 2008-09-30
FR18C1008I1 (https=) 2018-03-30
IL212421A (en) 2014-01-30
CA3087419A1 (en) 2006-06-29
EP3332789B1 (en) 2022-04-06
SG160391A1 (en) 2010-04-29
BRPI0517132B1 (pt) 2020-02-18
WO2006067141A1 (en) 2006-06-29
LT4070800T (lt) 2025-01-10
PL3332789T3 (pl) 2022-08-22
JP2015180685A (ja) 2015-10-15
JP6290962B2 (ja) 2018-03-07
JP6092945B2 (ja) 2017-03-08
DK3332789T3 (da) 2022-07-11
DK4070800T3 (da) 2025-01-02
JP2020193206A (ja) 2020-12-03
KR20070091662A (ko) 2007-09-11
SI4070800T1 (sl) 2025-03-31
AR052830A1 (es) 2007-04-04
HUE070333T2 (hu) 2025-05-28
AU2011200768B2 (en) 2012-09-13
IL212421A0 (en) 2011-06-30
SI2805723T1 (en) 2018-02-28
JP5908863B2 (ja) 2016-04-26
US20090081163A1 (en) 2009-03-26
FI4070800T3 (fi) 2025-01-14
PL1827461T3 (pl) 2012-07-31
SI3332789T1 (sl) 2022-08-31
MX2007007610A (es) 2007-08-03
EA200701221A1 (ru) 2008-02-28
ES3007339T3 (en) 2025-03-19
US8377903B2 (en) 2013-02-19
EP3332789A1 (en) 2018-06-13
EP2263678B1 (en) 2014-06-11
CY1112614T1 (el) 2016-02-10
AU2011200768A1 (en) 2011-03-17
JP2013216664A (ja) 2013-10-24
AU2005318190B2 (en) 2010-11-25
EP2805723A1 (en) 2014-11-26
PL2805723T3 (pl) 2018-04-30
EP4523753A2 (en) 2025-03-19
CA2588966A1 (en) 2006-06-29
FR18C1008I2 (fr) 2019-03-01
JP5795456B2 (ja) 2015-10-14
HUS1800009I1 (hu) 2018-05-02
IL183930A0 (en) 2007-10-31
EP4523753A3 (en) 2025-05-28
HUE059133T2 (hu) 2022-10-28
EP2275110A3 (en) 2011-04-27
CY2018006I2 (el) 2018-06-27
JP2008524313A (ja) 2008-07-10
CY2018006I1 (el) 2018-06-27
PL4070800T3 (pl) 2025-03-10
CA2588966C (en) 2020-07-21
JP2017101061A (ja) 2017-06-08
EP1827461A1 (en) 2007-09-05
CY1119790T1 (el) 2018-06-27
AU2005318190A1 (en) 2006-06-29
LUC00064I2 (https=) 2018-03-28
EP2263678A3 (en) 2011-04-27
DK2805723T3 (da) 2018-01-29
US20100203017A1 (en) 2010-08-12
JP2018165271A (ja) 2018-10-25
LUC00064I1 (https=) 2018-02-14
JP6430554B2 (ja) 2018-11-28
JP2016138128A (ja) 2016-08-04
US7713947B2 (en) 2010-05-11
BRPI0517132B8 (pt) 2021-05-25
NO20073813L (no) 2007-09-21
EP4070800B1 (en) 2024-10-16
EP2275110A2 (en) 2011-01-19
EP1827461B1 (en) 2012-02-29

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