HRP20120118T1 - Postupak proizvodnje [fenilsulfanilfenil] piperidina - Google Patents
Postupak proizvodnje [fenilsulfanilfenil] piperidina Download PDFInfo
- Publication number
- HRP20120118T1 HRP20120118T1 HR20120118T HRP20120118T HRP20120118T1 HR P20120118 T1 HRP20120118 T1 HR P20120118T1 HR 20120118 T HR20120118 T HR 20120118T HR P20120118 T HRP20120118 T HR P20120118T HR P20120118 T1 HRP20120118 T1 HR P20120118T1
- Authority
- HR
- Croatia
- Prior art keywords
- image
- compound
- alkyl
- formula
- process according
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 23
- 238000004519 manufacturing process Methods 0.000 title claims 4
- NUVVEDILYSTVDX-UHFFFAOYSA-N 1-(2-phenylsulfanylphenyl)piperidine Chemical class C1CCCCN1C1=CC=CC=C1SC1=CC=CC=C1 NUVVEDILYSTVDX-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 10
- 239000001257 hydrogen Substances 0.000 claims abstract 10
- SJZKULRDWHPHGG-UHFFFAOYSA-N 1-benzylpiperidin-4-one Chemical compound C1CC(=O)CCN1CC1=CC=CC=C1 SJZKULRDWHPHGG-UHFFFAOYSA-N 0.000 claims abstract 6
- 229910052736 halogen Inorganic materials 0.000 claims abstract 6
- 150000002367 halogens Chemical class 0.000 claims abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 6
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims abstract 6
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 14
- 239000002253 acid Substances 0.000 claims 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims 6
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 5
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 4
- -1 alkyl lithium Chemical compound 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229910052749 magnesium Inorganic materials 0.000 claims 4
- 239000011777 magnesium Substances 0.000 claims 4
- 229910052751 metal Inorganic materials 0.000 claims 4
- 239000002184 metal Substances 0.000 claims 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims 1
- LPLUHSYAFSMXGF-UHFFFAOYSA-N 1-benzyl-4-[2-(4-methylphenyl)sulfanylphenyl]piperidin-4-ol Chemical compound C1=CC(C)=CC=C1SC1=CC=CC=C1C1(O)CCN(CC=2C=CC=CC=2)CC1 LPLUHSYAFSMXGF-UHFFFAOYSA-N 0.000 claims 1
- OIRHKGBNGGSCGS-UHFFFAOYSA-N 1-bromo-2-iodobenzene Chemical compound BrC1=CC=CC=C1I OIRHKGBNGGSCGS-UHFFFAOYSA-N 0.000 claims 1
- WLHCBQAPPJAULW-UHFFFAOYSA-N 4-methylbenzenethiol Chemical compound CC1=CC=C(S)C=C1 WLHCBQAPPJAULW-UHFFFAOYSA-N 0.000 claims 1
- WCZWFNWHXKDCFB-UHFFFAOYSA-N ethyl 4-ethoxycarbonyloxy-4-[2-(4-methylphenyl)sulfanylphenyl]piperidine-1-carboxylate Chemical compound C=1C=CC=C(SC=2C=CC(C)=CC=2)C=1C1(OC(=O)OCC)CCN(C(=O)OCC)CC1 WCZWFNWHXKDCFB-UHFFFAOYSA-N 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3309308P | 2008-03-03 | 2008-03-03 | |
| DKPA200800314 | 2008-03-03 | ||
| PCT/EP2009/052440 WO2009109541A1 (en) | 2008-03-03 | 2009-03-02 | Process for the manufacture of [phenylsulfanylphenyl]piperidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120118T1 true HRP20120118T1 (hr) | 2012-03-31 |
Family
ID=40547924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120118T HRP20120118T1 (hr) | 2008-03-03 | 2012-02-03 | Postupak proizvodnje [fenilsulfanilfenil] piperidina |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8362255B2 (es) |
| EP (1) | EP2260024B1 (es) |
| JP (1) | JP5564439B2 (es) |
| KR (1) | KR20100122914A (es) |
| CN (1) | CN101959859B (es) |
| AR (1) | AR070737A1 (es) |
| AT (1) | ATE539055T1 (es) |
| AU (1) | AU2009221170B2 (es) |
| BR (1) | BRPI0908166A2 (es) |
| CA (1) | CA2715579A1 (es) |
| CL (1) | CL2009000490A1 (es) |
| CO (1) | CO6290758A2 (es) |
| CY (1) | CY1113887T1 (es) |
| DK (1) | DK2260024T3 (es) |
| EA (1) | EA017855B1 (es) |
| ES (1) | ES2377862T3 (es) |
| HK (1) | HK1153458A1 (es) |
| HR (1) | HRP20120118T1 (es) |
| IL (1) | IL207471A (es) |
| MX (1) | MX2010008729A (es) |
| NZ (1) | NZ587593A (es) |
| PL (1) | PL2260024T3 (es) |
| PT (1) | PT2260024E (es) |
| RS (1) | RS52128B (es) |
| SI (1) | SI2260024T1 (es) |
| TW (1) | TW200940505A (es) |
| UA (1) | UA98698C2 (es) |
| WO (1) | WO2009109541A1 (es) |
| ZA (1) | ZA201006135B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA016054B1 (ru) * | 2006-06-16 | 2012-01-30 | Х. Лундбекк А/С | Кристаллические формы 4-[2-(4-метилфенилсульфанил)фенил] пиперидина с объединенным ингибированием повторного поглощения серотонина и норадреналина для лечения невропатической боли |
| JP2012163850A (ja) * | 2011-02-08 | 2012-08-30 | Nippon Sheet Glass Co Ltd | 正立等倍レンズアレイプレート、光走査ユニット、画像読取装置および画像書込装置 |
| US9173883B2 (en) | 2012-05-21 | 2015-11-03 | Novartis Ag | Ring-substituted N-pyridinyl amides as kinase inhibitors |
| CN104710345B (zh) * | 2013-12-17 | 2017-09-05 | 江苏恩华药业股份有限公司 | 用于制备4‑（2‑（4‑甲基苯基硫基））苯基哌啶的化合物、其制备方法及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2324087A (en) * | 1997-04-10 | 1998-10-14 | Merck & Co Inc | Preparation of (S)-3-Carbethoxy-3-benzylpiperidine |
| AU1805701A (en) | 1999-12-20 | 2001-07-03 | Eli Lilly And Company | A process for preparing trans-2,4-disubstituted piperidines |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| AU2004226838B8 (en) * | 2003-04-04 | 2009-06-11 | H. Lundbeck A/S | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors |
| UA81300C2 (en) * | 2003-04-04 | 2007-12-25 | Lundbeck & Co As H | Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture |
| EA016054B1 (ru) * | 2006-06-16 | 2012-01-30 | Х. Лундбекк А/С | Кристаллические формы 4-[2-(4-метилфенилсульфанил)фенил] пиперидина с объединенным ингибированием повторного поглощения серотонина и норадреналина для лечения невропатической боли |
-
2009
- 2009-02-03 UA UAA201011031A patent/UA98698C2/ru unknown
- 2009-02-19 TW TW098105235A patent/TW200940505A/zh unknown
- 2009-03-02 NZ NZ587593A patent/NZ587593A/en not_active IP Right Cessation
- 2009-03-02 ES ES09717792T patent/ES2377862T3/es active Active
- 2009-03-02 PT PT09717792T patent/PT2260024E/pt unknown
- 2009-03-02 AT AT09717792T patent/ATE539055T1/de active
- 2009-03-02 JP JP2010549114A patent/JP5564439B2/ja not_active Expired - Fee Related
- 2009-03-02 SI SI200930184T patent/SI2260024T1/sl unknown
- 2009-03-02 BR BRPI0908166-6A patent/BRPI0908166A2/pt not_active IP Right Cessation
- 2009-03-02 EA EA201071025A patent/EA017855B1/ru not_active IP Right Cessation
- 2009-03-02 AR ARP090100734A patent/AR070737A1/es unknown
- 2009-03-02 WO PCT/EP2009/052440 patent/WO2009109541A1/en active Application Filing
- 2009-03-02 KR KR1020107019480A patent/KR20100122914A/ko not_active Application Discontinuation
- 2009-03-02 RS RS20120063A patent/RS52128B/en unknown
- 2009-03-02 DK DK09717792.7T patent/DK2260024T3/da active
- 2009-03-02 US US12/920,357 patent/US8362255B2/en not_active Expired - Fee Related
- 2009-03-02 PL PL09717792T patent/PL2260024T3/pl unknown
- 2009-03-02 MX MX2010008729A patent/MX2010008729A/es active IP Right Grant
- 2009-03-02 CL CL2009000490A patent/CL2009000490A1/es unknown
- 2009-03-02 CA CA2715579A patent/CA2715579A1/en not_active Abandoned
- 2009-03-02 CN CN200980108235XA patent/CN101959859B/zh not_active Expired - Fee Related
- 2009-03-02 AU AU2009221170A patent/AU2009221170B2/en not_active Ceased
- 2009-03-02 EP EP09717792A patent/EP2260024B1/en active Active
-
2010
- 2010-08-08 IL IL207471A patent/IL207471A/en not_active IP Right Cessation
- 2010-08-27 ZA ZA2010/06135A patent/ZA201006135B/en unknown
- 2010-09-02 CO CO10108740A patent/CO6290758A2/es active IP Right Grant
-
2011
- 2011-07-18 HK HK11107430.0A patent/HK1153458A1/xx not_active IP Right Cessation
-
2012
- 2012-02-03 HR HR20120118T patent/HRP20120118T1/hr unknown
- 2012-02-13 CY CY20121100145T patent/CY1113887T1/el unknown
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