CO6290758A2 - Proceso para la elaboracion de [fenilsulfanilfenil]piperidinas - Google Patents
Proceso para la elaboracion de [fenilsulfanilfenil]piperidinasInfo
- Publication number
- CO6290758A2 CO6290758A2 CO10108740A CO10108740A CO6290758A2 CO 6290758 A2 CO6290758 A2 CO 6290758A2 CO 10108740 A CO10108740 A CO 10108740A CO 10108740 A CO10108740 A CO 10108740A CO 6290758 A2 CO6290758 A2 CO 6290758A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- formula
- compound
- preparation
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Los inventores de la presente han descubierto sorpresivamente que el uso de un bencilo opcionalmente sustituido como grupo protector de N-piperidina permite un proceso para obtener el piperidin-4-ol protegido que se realiza a temperaturas más altas, que da lugar a rendimientos generales más altos y que permite un aislamiento y una purificación más fácil y conveniente de los productos intermedios por cristalización. Por lo tanto, en una modalidad, la invención se relaciona con un proceso en el cual un compuesto de fórmula IIen donde R' y R" representan independientemente uno, dos o tres hidrógenos, halógenos, alquilo-C1-6 o alquileno-C2-6, y L representa un grupo, que sale, se hace reaccionar con una N-bencil-4-piperidona opcionalmente sustituida,opcionalmente en presencia de un agente de metalación seleccionado de alquil litio, alquil magnesio o magnesio;en donde R''' representa hidrógeno u -O-alquilo-C1-6 para obtener un compuesto de fórmula IIIEn una modalidad, la invención se refiere a un proceso para la elaboración de un compuesto de acuerdo con la fórmula I
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200800314 | 2008-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6290758A2 true CO6290758A2 (es) | 2011-06-20 |
Family
ID=40547924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10108740A CO6290758A2 (es) | 2008-03-03 | 2010-09-02 | Proceso para la elaboracion de [fenilsulfanilfenil]piperidinas |
Country Status (29)
Country | Link |
---|---|
US (1) | US8362255B2 (es) |
EP (1) | EP2260024B1 (es) |
JP (1) | JP5564439B2 (es) |
KR (1) | KR20100122914A (es) |
CN (1) | CN101959859B (es) |
AR (1) | AR070737A1 (es) |
AT (1) | ATE539055T1 (es) |
AU (1) | AU2009221170B2 (es) |
BR (1) | BRPI0908166A2 (es) |
CA (1) | CA2715579A1 (es) |
CL (1) | CL2009000490A1 (es) |
CO (1) | CO6290758A2 (es) |
CY (1) | CY1113887T1 (es) |
DK (1) | DK2260024T3 (es) |
EA (1) | EA017855B1 (es) |
ES (1) | ES2377862T3 (es) |
HK (1) | HK1153458A1 (es) |
HR (1) | HRP20120118T1 (es) |
IL (1) | IL207471A (es) |
MX (1) | MX2010008729A (es) |
NZ (1) | NZ587593A (es) |
PL (1) | PL2260024T3 (es) |
PT (1) | PT2260024E (es) |
RS (1) | RS52128B (es) |
SI (1) | SI2260024T1 (es) |
TW (1) | TW200940505A (es) |
UA (1) | UA98698C2 (es) |
WO (1) | WO2009109541A1 (es) |
ZA (1) | ZA201006135B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2044020T3 (pl) * | 2006-06-16 | 2011-09-30 | H Lundbeck As | Krystaliczne postaci 4-[2-(4-metylofenylosulfanylo)-fenylo]piperydyny z równoczesnym hamowaniem wychwytu zwrotnego serotoniny i norepinefryny do leczenia bólu neuropatycznego |
JP2012163850A (ja) * | 2011-02-08 | 2012-08-30 | Nippon Sheet Glass Co Ltd | 正立等倍レンズアレイプレート、光走査ユニット、画像読取装置および画像書込装置 |
BR112014028954A2 (pt) | 2012-05-21 | 2017-07-18 | Novartis Ag | amidas de n-piridinila substituídas no anel como inibidores da quinase |
CN104710345B (zh) * | 2013-12-17 | 2017-09-05 | 江苏恩华药业股份有限公司 | 用于制备4‑(2‑(4‑甲基苯基硫基))苯基哌啶的化合物、其制备方法及应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2324087A (en) * | 1997-04-10 | 1998-10-14 | Merck & Co Inc | Preparation of (S)-3-Carbethoxy-3-benzylpiperidine |
EP1244623A1 (en) | 1999-12-20 | 2002-10-02 | Eli Lilly And Company | A process for preparing 4-substituted piperidines |
UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
UA81300C2 (en) * | 2003-04-04 | 2007-12-25 | Lundbeck & Co As H | Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture |
US7732463B2 (en) * | 2003-04-04 | 2010-06-08 | H. Lundbeck A/S | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors |
PL2044020T3 (pl) * | 2006-06-16 | 2011-09-30 | H Lundbeck As | Krystaliczne postaci 4-[2-(4-metylofenylosulfanylo)-fenylo]piperydyny z równoczesnym hamowaniem wychwytu zwrotnego serotoniny i norepinefryny do leczenia bólu neuropatycznego |
-
2009
- 2009-02-03 UA UAA201011031A patent/UA98698C2/ru unknown
- 2009-02-19 TW TW098105235A patent/TW200940505A/zh unknown
- 2009-03-02 CL CL2009000490A patent/CL2009000490A1/es unknown
- 2009-03-02 RS RS20120063A patent/RS52128B/en unknown
- 2009-03-02 AT AT09717792T patent/ATE539055T1/de active
- 2009-03-02 EP EP09717792A patent/EP2260024B1/en active Active
- 2009-03-02 AU AU2009221170A patent/AU2009221170B2/en not_active Ceased
- 2009-03-02 ES ES09717792T patent/ES2377862T3/es active Active
- 2009-03-02 KR KR1020107019480A patent/KR20100122914A/ko not_active Application Discontinuation
- 2009-03-02 DK DK09717792.7T patent/DK2260024T3/da active
- 2009-03-02 MX MX2010008729A patent/MX2010008729A/es active IP Right Grant
- 2009-03-02 US US12/920,357 patent/US8362255B2/en not_active Expired - Fee Related
- 2009-03-02 BR BRPI0908166-6A patent/BRPI0908166A2/pt not_active IP Right Cessation
- 2009-03-02 SI SI200930184T patent/SI2260024T1/sl unknown
- 2009-03-02 EA EA201071025A patent/EA017855B1/ru not_active IP Right Cessation
- 2009-03-02 CA CA2715579A patent/CA2715579A1/en not_active Abandoned
- 2009-03-02 WO PCT/EP2009/052440 patent/WO2009109541A1/en active Application Filing
- 2009-03-02 JP JP2010549114A patent/JP5564439B2/ja not_active Expired - Fee Related
- 2009-03-02 NZ NZ587593A patent/NZ587593A/en not_active IP Right Cessation
- 2009-03-02 AR ARP090100734A patent/AR070737A1/es unknown
- 2009-03-02 CN CN200980108235XA patent/CN101959859B/zh not_active Expired - Fee Related
- 2009-03-02 PT PT09717792T patent/PT2260024E/pt unknown
- 2009-03-02 PL PL09717792T patent/PL2260024T3/pl unknown
-
2010
- 2010-08-08 IL IL207471A patent/IL207471A/en not_active IP Right Cessation
- 2010-08-27 ZA ZA2010/06135A patent/ZA201006135B/en unknown
- 2010-09-02 CO CO10108740A patent/CO6290758A2/es active IP Right Grant
-
2011
- 2011-07-18 HK HK11107430.0A patent/HK1153458A1/xx not_active IP Right Cessation
-
2012
- 2012-02-03 HR HR20120118T patent/HRP20120118T1/hr unknown
- 2012-02-13 CY CY20121100145T patent/CY1113887T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Application granted |