HRP20120106T1 - Farmaceutski pripravci entakapona koji su mikronizirani zajedno sa šećernim alkoholima - Google Patents
Farmaceutski pripravci entakapona koji su mikronizirani zajedno sa šećernim alkoholima Download PDFInfo
- Publication number
- HRP20120106T1 HRP20120106T1 HR20120106T HRP20120106T HRP20120106T1 HR P20120106 T1 HRP20120106 T1 HR P20120106T1 HR 20120106 T HR20120106 T HR 20120106T HR P20120106 T HRP20120106 T HR P20120106T HR P20120106 T1 HRP20120106 T1 HR P20120106T1
- Authority
- HR
- Croatia
- Prior art keywords
- capsule
- entacapone
- mill
- sugar alcohols
- following
- Prior art date
Links
- 150000005846 sugar alcohols Chemical class 0.000 title claims abstract 10
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical group CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 title claims abstract 9
- 229960003337 entacapone Drugs 0.000 title claims abstract 9
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 8
- 239000000203 mixture Substances 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 239000002775 capsule Substances 0.000 claims 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims 6
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- 239000008185 minitablet Substances 0.000 claims 4
- 239000008188 pellet Substances 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 239000007894 caplet Substances 0.000 claims 2
- -1 disk Substances 0.000 claims 2
- 239000002270 dispersing agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 239000000832 lactitol Substances 0.000 claims 2
- 235000010448 lactitol Nutrition 0.000 claims 2
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 2
- 229960003451 lactitol Drugs 0.000 claims 2
- 239000000845 maltitol Substances 0.000 claims 2
- 235000010449 maltitol Nutrition 0.000 claims 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 2
- 229940035436 maltitol Drugs 0.000 claims 2
- 229940043353 maltol Drugs 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- 229960001855 mannitol Drugs 0.000 claims 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 235000010356 sorbitol Nutrition 0.000 claims 2
- 229960002920 sorbitol Drugs 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 239000000811 xylitol Substances 0.000 claims 2
- 235000010447 xylitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 2
- 229960002675 xylitol Drugs 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000004576 sand Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Farmaceutski pripravak koji sadrži entakapon ili njegove soli u kombinaciji s jednim ili više šećernih alkohola, naznačen time, da je entakapon mikroniziran zajedno s jednim ili više šećernih alkohola. Patent sadrži još 11 patentnih zahtjeva.
Claims (12)
1. Farmaceutski pripravak koji sadrži entakapon ili njegove soli u kombinaciji s jednim ili više šećernih alkohola, naznačen time, da je entakapon mikroniziran zajedno s jednim ili više šećernih alkohola.
2. Farmaceutski pripravak iz patentnog zahtjeva 1, naznačen time, da se entakapon i šećerni alkohol nalaze u molarnom omjeru od oko 1:1 do 10:1.
3. Farmaceutski pripravak iz patentnog zahtjeva 1, naznačen time, da se pod šećernim alkoholima podrazumijeva jedan ili više sljedećih alkohola: manitol, maltitol, maltol, sorbitol, laktitol i ksilitol.
4. Farmaceutski pripravak iz patentnog zahtjeva 1, naznačen time, da je prosječna veličina čestice u smjesi istovremeno mikroniziranog entakapona i šećernog alkohola manja od oko 30 p.
5. Farmaceutski pripravak iz patentnog zahtjeva 1, naznačen time, da se predmetni pripravak nalazi u jednom ili više sljedećih oblika za doziranje: tableta, kapsula, prašak, disk, kapleta, zrnca, peleti, zrna u kapsuli, minitablete, minitablete u kapsuli, peleti u kapsuli i vrećica.
6. Farmaceutski pripravak iz patentnog zahtjeva 1, naznačen time, da taj pripravak dodatno sadrži jedan ili više farmaceutski prihvatljivih nosača.
7. Farmaceutski pripravak iz patentnog zahtjeva 6, naznačen time, da farmaceutski prihvatljivi nosači sadrže jednu ili više sljedećih tvari: vezivna sredstva, punila, lubrifikanti, raspršivači i sredstva za klizanje.
8. Postupak za pripravu farmaceutskog pripravka entakapona, naznačen time, da taj postupak uključuje zajedničku mikronizaciju entakapona ili njegove soli s jednim ili više šećernih alkohola, miješanje s drugim farmaceutski prihvatljivim ekscipijensima i oblikovanje smjese u farmaceutski oblik za doziranje.
9. Postupak iz patentnog zahtjeva 8, naznačen time, da šećerni alkoholi obuhvaćaju jedan ili više sljedećih alkohola: manitol, maltitol, maltol, sorbitol, laktitol i ksilitol.
10. Postupak iz patentnog zahtjeva 8, naznačen time, da farmaceutski prihvatljivi ekscipijensa obuhvaćaju jednu ili više od sljedećih tvari: vezivna sredstva, punila, lubrifikanti, raspršivači i sredstva za klizanje.
11. Postupak iz patentnog zahtjeva 8, naznačen time, da se postupak zajedničke mikronizacije obavlja jednom od sljedećih naprava: nano mlin, mlin s kuglama, atritorski mlin, vibratorni mlin, pješčani mlin, mlin s perlama, mlazni mlin i ultrazvučni dezintergrator.
12. Postupak iz patentnog zahtjeva 8, naznačen time, da farmaceutski oblik za doziranje uključuje jedno ili više od sljedećeg: tableta, kapsula, prašak, disk, kapleta, zrnca, peleti, zrna u kapsuli, minitablete, minitablete u kapsuli, peleti u kapsuli i vrećica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN264MU2008 | 2008-02-06 | ||
| PCT/IB2009/050490 WO2009098663A1 (en) | 2008-02-06 | 2009-02-06 | Pharmaceutical compositions of entacapone co-micronized with sugar alcohols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120106T1 true HRP20120106T1 (hr) | 2012-02-29 |
Family
ID=40626966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120106T HRP20120106T1 (hr) | 2008-02-06 | 2012-02-01 | Farmaceutski pripravci entakapona koji su mikronizirani zajedno sa šećernim alkoholima |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8728517B2 (hr) |
| EP (1) | EP2293791B1 (hr) |
| JP (1) | JP5651478B2 (hr) |
| KR (1) | KR101532810B1 (hr) |
| CN (1) | CN101939002B (hr) |
| AT (1) | ATE534382T1 (hr) |
| AU (1) | AU2009211030B2 (hr) |
| BR (1) | BRPI0907727A2 (hr) |
| CA (1) | CA2714113C (hr) |
| CY (1) | CY1116484T1 (hr) |
| DK (1) | DK2293791T3 (hr) |
| ES (1) | ES2377597T3 (hr) |
| HR (1) | HRP20120106T1 (hr) |
| MX (1) | MX2010008707A (hr) |
| NZ (1) | NZ587169A (hr) |
| PL (1) | PL2293791T3 (hr) |
| PT (1) | PT2293791E (hr) |
| RU (1) | RU2010136934A (hr) |
| SI (1) | SI2293791T1 (hr) |
| WO (1) | WO2009098663A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010023828A1 (de) * | 2010-06-15 | 2011-12-15 | IIP - Institut für industrielle Pharmazie, Forschungs- und Entwicklungsgesellschaft mbH | Pharmazeutisches Präparat, welches Entacapon, Levodopa und Carbidopa enthält |
| CN106880607A (zh) * | 2015-12-15 | 2017-06-23 | 北大方正集团有限公司 | 一种含有瑞戈非尼的口腔崩解片及其制备方法 |
| CN115715767B (zh) * | 2022-11-02 | 2023-06-09 | 石家庄四药有限公司 | 一种恩他卡朋片剂的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2642486B2 (ja) * | 1989-08-04 | 1997-08-20 | 田辺製薬株式会社 | 難溶性薬物の超微粒子化法 |
| US6599530B2 (en) * | 1998-09-14 | 2003-07-29 | Orion Corporation | Oral compacted composition comprising catechol derivatives |
| FI109453B (fi) * | 1999-06-30 | 2002-08-15 | Orion Yhtymae Oyj | Farmaseuttinen koostumus |
| CA2611114C (en) * | 2005-06-08 | 2014-09-23 | Orion Corporation | An entacapone-containing oral dosage form |
| GB2429645A (en) * | 2006-03-10 | 2007-03-07 | Sekhsaria Chemicals Ltd | Solid pharmaceutical composition comprising a COMT inhibitor, a starch and a wetting agent |
-
2009
- 2009-02-06 CA CA2714113A patent/CA2714113C/en not_active Expired - Fee Related
- 2009-02-06 SI SI200930145T patent/SI2293791T1/sl unknown
- 2009-02-06 WO PCT/IB2009/050490 patent/WO2009098663A1/en active Application Filing
- 2009-02-06 NZ NZ587169A patent/NZ587169A/en not_active IP Right Cessation
- 2009-02-06 BR BRPI0907727A patent/BRPI0907727A2/pt not_active IP Right Cessation
- 2009-02-06 ES ES09708991T patent/ES2377597T3/es active Active
- 2009-02-06 AT AT09708991T patent/ATE534382T1/de active
- 2009-02-06 DK DK09708991.6T patent/DK2293791T3/da active
- 2009-02-06 JP JP2010545597A patent/JP5651478B2/ja not_active Expired - Fee Related
- 2009-02-06 CN CN2009801045469A patent/CN101939002B/zh not_active Expired - Fee Related
- 2009-02-06 PL PL09708991T patent/PL2293791T3/pl unknown
- 2009-02-06 KR KR1020107019493A patent/KR101532810B1/ko not_active IP Right Cessation
- 2009-02-06 RU RU2010136934/15A patent/RU2010136934A/ru not_active Application Discontinuation
- 2009-02-06 EP EP09708991A patent/EP2293791B1/en active Active
- 2009-02-06 US US12/865,783 patent/US8728517B2/en not_active Expired - Fee Related
- 2009-02-06 AU AU2009211030A patent/AU2009211030B2/en not_active Ceased
- 2009-02-06 MX MX2010008707A patent/MX2010008707A/es active IP Right Grant
- 2009-02-06 PT PT09708991T patent/PT2293791E/pt unknown
-
2012
- 2012-01-17 CY CY20121100050T patent/CY1116484T1/el unknown
- 2012-02-01 HR HR20120106T patent/HRP20120106T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ587169A (en) | 2011-03-31 |
| AU2009211030B2 (en) | 2013-12-05 |
| ES2377597T3 (es) | 2012-03-29 |
| JP5651478B2 (ja) | 2015-01-14 |
| AU2009211030A1 (en) | 2009-08-13 |
| EP2293791B1 (en) | 2011-11-23 |
| DK2293791T3 (da) | 2012-02-13 |
| JP2011526241A (ja) | 2011-10-06 |
| CY1116484T1 (el) | 2017-03-15 |
| CA2714113C (en) | 2015-11-24 |
| EP2293791A1 (en) | 2011-03-16 |
| BRPI0907727A2 (pt) | 2017-06-13 |
| ATE534382T1 (de) | 2011-12-15 |
| CN101939002B (zh) | 2012-12-26 |
| SI2293791T1 (sl) | 2012-03-30 |
| CN101939002A (zh) | 2011-01-05 |
| US20110052681A1 (en) | 2011-03-03 |
| PL2293791T3 (pl) | 2012-04-30 |
| PT2293791E (pt) | 2012-01-11 |
| MX2010008707A (es) | 2011-03-25 |
| CA2714113A1 (en) | 2009-08-13 |
| US8728517B2 (en) | 2014-05-20 |
| KR20100117096A (ko) | 2010-11-02 |
| WO2009098663A1 (en) | 2009-08-13 |
| KR101532810B1 (ko) | 2015-06-30 |
| RU2010136934A (ru) | 2012-03-20 |
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