HRP20110643T1 - Mjesto vezanja visokog afiniteta za receptor faktora rasta hepatocita (hgfr) i postupci za identifikaciju njegovih antagonista - Google Patents
Mjesto vezanja visokog afiniteta za receptor faktora rasta hepatocita (hgfr) i postupci za identifikaciju njegovih antagonista Download PDFInfo
- Publication number
- HRP20110643T1 HRP20110643T1 HR20110643T HRP20110643T HRP20110643T1 HR P20110643 T1 HRP20110643 T1 HR P20110643T1 HR 20110643 T HR20110643 T HR 20110643T HR P20110643 T HRP20110643 T HR P20110643T HR P20110643 T1 HRP20110643 T1 HR P20110643T1
- Authority
- HR
- Croatia
- Prior art keywords
- growth factor
- factor receptor
- hepatocyte growth
- ipt
- cancer
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title claims 3
- 238000000034 method Methods 0.000 title claims 3
- 102000008022 Proto-Oncogene Proteins c-met Human genes 0.000 claims abstract 17
- 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 claims abstract 17
- 206010028980 Neoplasm Diseases 0.000 claims abstract 10
- 201000011510 cancer Diseases 0.000 claims abstract 10
- 239000013543 active substance Substances 0.000 claims abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 7
- 229920001184 polypeptide Polymers 0.000 claims abstract 6
- 230000008482 dysregulation Effects 0.000 claims abstract 3
- 108091033319 polynucleotide Proteins 0.000 claims abstract 3
- 239000002157 polynucleotide Substances 0.000 claims abstract 3
- 102000040430 polynucleotide Human genes 0.000 claims abstract 3
- 230000000694 effects Effects 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 3
- 230000003197 catalytic effect Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000005754 cellular signaling Effects 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08103958 | 2008-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110643T1 true HRP20110643T1 (hr) | 2011-10-31 |
Family
ID=40984839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110643T HRP20110643T1 (hr) | 2008-05-14 | 2011-09-07 | Mjesto vezanja visokog afiniteta za receptor faktora rasta hepatocita (hgfr) i postupci za identifikaciju njegovih antagonista |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US8404453B2 (ja) |
| EP (1) | EP2119448B1 (ja) |
| JP (1) | JP5623027B2 (ja) |
| KR (1) | KR101509263B1 (ja) |
| AT (1) | ATE513556T1 (ja) |
| BR (1) | BRPI0901502A2 (ja) |
| CA (1) | CA2665958C (ja) |
| CY (1) | CY1111853T1 (ja) |
| DK (1) | DK2119448T3 (ja) |
| EA (1) | EA017863B1 (ja) |
| ES (1) | ES2368603T3 (ja) |
| HR (1) | HRP20110643T1 (ja) |
| IL (1) | IL198545A0 (ja) |
| MX (1) | MX2009005049A (ja) |
| PL (1) | PL2119448T3 (ja) |
| PT (1) | PT2119448E (ja) |
| SG (1) | SG157312A1 (ja) |
| SI (1) | SI2119448T1 (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL198545A0 (en) | 2008-05-14 | 2011-07-31 | Metheresis Translational Res Sa | High affinity binding site of hgfr and methods for identification of antagonists thereof |
| RU2608644C2 (ru) | 2010-11-03 | 2017-01-23 | арДЖЕН-ИКС Н.В. | Антитела против белка рецептора с-мет |
| EP2773660A2 (en) | 2011-11-03 | 2014-09-10 | Argen-X B.V. | Chimeric human-camel antigens and their use |
| GB2504139B (en) | 2012-07-20 | 2014-12-31 | Argen X Bv | Antibodies to highly conserved targets produced by the immunisation of Camelidae species |
| EP2785741A1 (en) * | 2011-12-02 | 2014-10-08 | Cancer Research Technology Limited | Antibodies against hgf - receptor and uses |
| WO2016079194A1 (en) * | 2014-11-20 | 2016-05-26 | Stichting Katholieke Universiteit | A novel auto-active and intracellular mutant of met |
| IL265645B2 (en) * | 2016-09-29 | 2024-05-01 | Mitsubishi Tanabe Pharma Corp | Monoclonal CMET binding agents, their drug conjugates and uses thereof |
| CN113567685B (zh) * | 2021-09-26 | 2022-05-17 | 瑞博奥(广州)生物科技股份有限公司 | 基于核酸适配体探针的hgfr识别方法及检测hgfr的试剂盒 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2104914T3 (es) * | 1991-05-10 | 1997-10-16 | Pharmacia & Upjohn Spa | Formas truncadas del factor de crecimiento de hepatocitos (hgf). |
| US5686292A (en) * | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| AU2760602A (en) | 2001-03-23 | 2002-09-26 | Agouron Pharmaceuticals, Inc. | Catalytic domains of the human hepatocyte growth factor receptor tyrosine kinase, and materials and methods for identification of inhibitors thereof |
| AU2004298483A1 (en) | 2003-12-11 | 2005-06-30 | Genentech, Inc. | Methods and compositions for inhibiting c-met dimerization and activation |
| WO2005108424A1 (en) | 2004-05-06 | 2005-11-17 | Genentech, Inc. | Crystal structure of the complex of hepatocyte growth factor bata chain with met receptor and methods of use |
| US20060008844A1 (en) * | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| WO2007013603A1 (ja) * | 2005-07-28 | 2007-02-01 | Anges Mg, Inc. | リンパ管新生促進剤 |
| US7758862B2 (en) | 2005-09-30 | 2010-07-20 | Compugen Ltd. | Hepatocyte growth factor receptor splice variants and methods of using same |
| KR101429297B1 (ko) * | 2006-02-06 | 2014-08-12 | 메테레시스 트랜스레이셔날 리서치 에스.에이. | 종양 치료를 위한 항-Ｍｅｔ 단클론 항체, 이의 단편과벡터 및 상응하는 산물 |
| IL198545A0 (en) | 2008-05-14 | 2011-07-31 | Metheresis Translational Res Sa | High affinity binding site of hgfr and methods for identification of antagonists thereof |
-
2009
- 2009-05-04 IL IL198545A patent/IL198545A0/en not_active IP Right Cessation
- 2009-05-07 PL PL09159644T patent/PL2119448T3/pl unknown
- 2009-05-07 ES ES09159644T patent/ES2368603T3/es active Active
- 2009-05-07 SI SI200930068T patent/SI2119448T1/sl unknown
- 2009-05-07 AT AT09159644T patent/ATE513556T1/de active
- 2009-05-07 DK DK09159644.5T patent/DK2119448T3/da active
- 2009-05-07 PT PT09159644T patent/PT2119448E/pt unknown
- 2009-05-07 EP EP09159644A patent/EP2119448B1/en active Active
- 2009-05-11 KR KR1020090040560A patent/KR101509263B1/ko not_active IP Right Cessation
- 2009-05-12 CA CA2665958A patent/CA2665958C/en not_active Expired - Fee Related
- 2009-05-12 BR BRPI0901502-7A patent/BRPI0901502A2/pt not_active IP Right Cessation
- 2009-05-12 MX MX2009005049A patent/MX2009005049A/es active IP Right Grant
- 2009-05-13 US US12/465,307 patent/US8404453B2/en not_active Expired - Fee Related
- 2009-05-13 EA EA200900537A patent/EA017863B1/ru not_active IP Right Cessation
- 2009-05-14 JP JP2009117725A patent/JP5623027B2/ja not_active Expired - Fee Related
- 2009-05-14 SG SG200903318-4A patent/SG157312A1/en unknown
-
2011
- 2011-08-31 US US13/137,641 patent/US20120115219A1/en not_active Abandoned
- 2011-08-31 US US13/137,640 patent/US9121854B2/en not_active Expired - Fee Related
- 2011-09-07 HR HR20110643T patent/HRP20110643T1/hr unknown
- 2011-09-22 CY CY20111100917T patent/CY1111853T1/el unknown
-
2013
- 2013-02-21 US US13/773,497 patent/US9310377B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20120115219A1 (en) | 2012-05-10 |
| US9121854B2 (en) | 2015-09-01 |
| KR20090118846A (ko) | 2009-11-18 |
| SI2119448T1 (sl) | 2012-02-29 |
| EP2119448A1 (en) | 2009-11-18 |
| JP5623027B2 (ja) | 2014-11-12 |
| AU2009201893A1 (en) | 2009-12-03 |
| IL198545A0 (en) | 2011-07-31 |
| EA200900537A1 (ru) | 2009-12-30 |
| EP2119448B1 (en) | 2011-06-22 |
| SG157312A1 (en) | 2009-12-29 |
| CA2665958A1 (en) | 2009-11-14 |
| EA017863B1 (ru) | 2013-03-29 |
| KR101509263B1 (ko) | 2015-04-06 |
| US8404453B2 (en) | 2013-03-26 |
| US9310377B2 (en) | 2016-04-12 |
| ES2368603T3 (es) | 2011-11-18 |
| BRPI0901502A2 (pt) | 2010-01-26 |
| US20090298079A1 (en) | 2009-12-03 |
| PT2119448E (pt) | 2011-09-27 |
| MX2009005049A (es) | 2009-12-18 |
| US20120108789A1 (en) | 2012-05-03 |
| US20130183690A1 (en) | 2013-07-18 |
| PL2119448T3 (pl) | 2011-11-30 |
| CA2665958C (en) | 2014-01-07 |
| JP2009291191A (ja) | 2009-12-17 |
| CY1111853T1 (el) | 2015-11-04 |
| ATE513556T1 (de) | 2011-07-15 |
| DK2119448T3 (da) | 2011-09-26 |
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