JP2009291191A5 - - Google Patents
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- JP2009291191A5 JP2009291191A5 JP2009117725A JP2009117725A JP2009291191A5 JP 2009291191 A5 JP2009291191 A5 JP 2009291191A5 JP 2009117725 A JP2009117725 A JP 2009117725A JP 2009117725 A JP2009117725 A JP 2009117725A JP 2009291191 A5 JP2009291191 A5 JP 2009291191A5
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- JP
- Japan
- Prior art keywords
- growth factor
- factor receptor
- ipt
- hepatocyte growth
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Claims (11)
- 癌の治療に有用な薬理学的な活性を有する薬剤のスクリーニングおよび／または開発のための、肝細胞増殖因子受容体の細胞外ＩＰＴ−３およびＩＰＴ−４ドメインからなるポリペプチドをコードするポリヌクレオチドの使用。
- 癌の治療に有用な薬理学的な活性を有する薬剤のスクリーニングおよび／または開発のための、肝細胞増殖因子受容体の細胞外ＩＰＴ−３およびＩＰＴ−４ドメインからなるポリペプチドの使用。
- 前記薬理学的な活性を有する薬剤が、肝細胞増殖因子受容体の触媒活性、機能、安定性および／または発現を阻害する、請求項１または２記載の使用。
- 前記薬理学的な活性を有する薬剤が、肝細胞増殖因子受容体の触媒活性、機能、安定性および／または発現を下方調節する、請求項１または２記載の使用。
- 前記薬理学的な活性を有する薬剤が、肝細胞増殖因子受容体の阻害剤および／または拮抗剤である、請求項１〜４のいずれか１項記載の使用。
- 前記薬理学的な活性を有する薬剤が、小分子阻害剤、アプタマー、アンチセンスヌクレオチド、ＲＮＡを基にした阻害剤、ｓｉＲＮＡ、抗体、ペプチドおよびドミナントネガティブ因子から選択される、請求項１〜５のいずれか１項記載の使用。
- 癌が、肝細胞増殖因子受容体活性の調節不良を伴う癌である、請求項１〜６のいずれか１項記載の使用。
- 癌の治療に有用な肝細胞増殖因子受容体の拮抗剤／阻害剤として作用するテスト薬剤の能力を検出する方法であって、
（ａ）テスト薬剤を、ｉ）肝細胞増殖因子受容体の細胞外ＩＰＴ−３およびＩＰＴ−４ドメインからなるポリペプチドをコードするポリヌクレオチド、ｉｉ）肝細胞増殖因子受容体の細胞外ＩＰＴ−３およびＩＰＴ−４ドメインからなるポリペプチド、またはｉｉｉ）肝細胞増殖因子受容体の細胞外ＩＰＴ−３およびＩＰＴ−４ドメイン、膜貫通ヘリックスならびに全細胞質領域を発現する細胞と接触させ、
（ｂ）肝細胞増殖因子受容体の活性、機能、安定性および／または発現を測定し、次いで
（ｃ）肝細胞増殖因子受容体の活性、機能、安定性および／または発現を減少させる薬剤を選別する：
工程を含む方法。 - 前記工程（ｂ）の測定が、細胞シグナル伝達、細胞生存、および細胞増殖を測定することを含む、請求項８記載の方法。
- 癌を治療する医薬としての使用のための肝細胞増殖因子受容体の細胞外ＩＰＴ−３およびＩＰＴ−４ドメイン。
- 癌を治療するための医薬としての使用のための、肝細胞増殖因子受容体の細胞外ＩＰＴ−３およびＩＰＴ−４ドメインからなるポリペプチドをコードするヌクレオチド配列を含むベクター。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08103958 | 2008-05-14 | ||
| EP08103958.8 | 2008-05-14 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009291191A JP2009291191A (ja) | 2009-12-17 |
| JP2009291191A5 true JP2009291191A5 (ja) | 2012-06-28 |
| JP5623027B2 JP5623027B2 (ja) | 2014-11-12 |
Family
ID=40984839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009117725A Expired - Fee Related JP5623027B2 (ja) | 2008-05-14 | 2009-05-14 | Ｈｇｆｒの高親和結合部位およびその拮抗剤の同定方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US8404453B2 (ja) |
| EP (1) | EP2119448B1 (ja) |
| JP (1) | JP5623027B2 (ja) |
| KR (1) | KR101509263B1 (ja) |
| AT (1) | ATE513556T1 (ja) |
| BR (1) | BRPI0901502A2 (ja) |
| CA (1) | CA2665958C (ja) |
| CY (1) | CY1111853T1 (ja) |
| DK (1) | DK2119448T3 (ja) |
| EA (1) | EA017863B1 (ja) |
| ES (1) | ES2368603T3 (ja) |
| HR (1) | HRP20110643T1 (ja) |
| IL (1) | IL198545A0 (ja) |
| MX (1) | MX2009005049A (ja) |
| PL (1) | PL2119448T3 (ja) |
| PT (1) | PT2119448E (ja) |
| SG (1) | SG157312A1 (ja) |
| SI (1) | SI2119448T1 (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL198545A0 (en) | 2008-05-14 | 2011-07-31 | Metheresis Translational Res Sa | High affinity binding site of hgfr and methods for identification of antagonists thereof |
| EP2635602B1 (en) | 2010-11-03 | 2016-09-07 | Argen-X Nv | Anti c-met antibodies |
| GB2504139B (en) | 2012-07-20 | 2014-12-31 | Argen X Bv | Antibodies to highly conserved targets produced by the immunisation of Camelidae species |
| EP2773660A2 (en) | 2011-11-03 | 2014-09-10 | Argen-X B.V. | Chimeric human-camel antigens and their use |
| US20150147274A1 (en) * | 2011-12-02 | 2015-05-28 | Cancer Research Technology Limited | Antibodies against hgf - receptor and uses |
| CN107002133B (zh) * | 2014-11-20 | 2022-07-05 | 天主教大学基金会 | Met的新型自活化且细胞内的突变体 |
| WO2018062402A1 (en) | 2016-09-29 | 2018-04-05 | Mitsubishi Tanabe Pharma Corporation | Cmet monoclonal binding agents, drug conjugates thereof and uses thereof |
| CN113567685B (zh) * | 2021-09-26 | 2022-05-17 | 瑞博奥(广州)生物科技股份有限公司 | 基于核酸适配体探针的hgfr识别方法及检测hgfr的试剂盒 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0520158A1 (en) * | 1991-05-10 | 1992-12-30 | PHARMACIA S.p.A. | Truncated forms of the hepatocyte growth factor (HGF) receptor |
| US5686292A (en) * | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| AU2760602A (en) | 2001-03-23 | 2002-09-26 | Agouron Pharmaceuticals, Inc. | Catalytic domains of the human hepatocyte growth factor receptor tyrosine kinase, and materials and methods for identification of inhibitors thereof |
| AU2004298483A1 (en) | 2003-12-11 | 2005-06-30 | Genentech, Inc. | Methods and compositions for inhibiting c-met dimerization and activation |
| WO2005108424A1 (en) | 2004-05-06 | 2005-11-17 | Genentech, Inc. | Crystal structure of the complex of hepatocyte growth factor bata chain with met receptor and methods of use |
| US20060008844A1 (en) * | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| ES2561155T3 (es) * | 2005-07-28 | 2016-02-24 | Anges Mg, Inc. | Promotor de la linfangiogénesis |
| AU2006296171A1 (en) | 2005-09-30 | 2007-04-05 | Compugen Ltd. | Hepatocyte growth factor receptor splice variants and methods of using same |
| KR101429297B1 (ko) * | 2006-02-06 | 2014-08-12 | 메테레시스 트랜스레이셔날 리서치 에스.에이. | 종양 치료를 위한 항-Ｍｅｔ 단클론 항체, 이의 단편과벡터 및 상응하는 산물 |
| IL198545A0 (en) | 2008-05-14 | 2011-07-31 | Metheresis Translational Res Sa | High affinity binding site of hgfr and methods for identification of antagonists thereof |
-
2009
- 2009-05-04 IL IL198545A patent/IL198545A0/en not_active IP Right Cessation
- 2009-05-07 EP EP09159644A patent/EP2119448B1/en active Active
- 2009-05-07 SI SI200930068T patent/SI2119448T1/sl unknown
- 2009-05-07 AT AT09159644T patent/ATE513556T1/de active
- 2009-05-07 PT PT09159644T patent/PT2119448E/pt unknown
- 2009-05-07 PL PL09159644T patent/PL2119448T3/pl unknown
- 2009-05-07 DK DK09159644.5T patent/DK2119448T3/da active
- 2009-05-07 ES ES09159644T patent/ES2368603T3/es active Active
- 2009-05-11 KR KR1020090040560A patent/KR101509263B1/ko not_active IP Right Cessation
- 2009-05-12 BR BRPI0901502-7A patent/BRPI0901502A2/pt not_active IP Right Cessation
- 2009-05-12 MX MX2009005049A patent/MX2009005049A/es active IP Right Grant
- 2009-05-12 CA CA2665958A patent/CA2665958C/en not_active Expired - Fee Related
- 2009-05-13 EA EA200900537A patent/EA017863B1/ru not_active IP Right Cessation
- 2009-05-13 US US12/465,307 patent/US8404453B2/en not_active Expired - Fee Related
- 2009-05-14 JP JP2009117725A patent/JP5623027B2/ja not_active Expired - Fee Related
- 2009-05-14 SG SG200903318-4A patent/SG157312A1/en unknown
-
2011
- 2011-08-31 US US13/137,641 patent/US20120115219A1/en not_active Abandoned
- 2011-08-31 US US13/137,640 patent/US9121854B2/en not_active Expired - Fee Related
- 2011-09-07 HR HR20110643T patent/HRP20110643T1/hr unknown
- 2011-09-22 CY CY20111100917T patent/CY1111853T1/el unknown
-
2013
- 2013-02-21 US US13/773,497 patent/US9310377B2/en not_active Expired - Fee Related
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