HRP20110487T1 - Polimerni konjugati hmgb1 box-a i varijanti hmgb1 box-a - Google Patents
Polimerni konjugati hmgb1 box-a i varijanti hmgb1 box-a Download PDFInfo
- Publication number
- HRP20110487T1 HRP20110487T1 HR20110487T HRP20110487T HRP20110487T1 HR P20110487 T1 HRP20110487 T1 HR P20110487T1 HR 20110487 T HR20110487 T HR 20110487T HR P20110487 T HRP20110487 T HR P20110487T HR P20110487 T1 HRP20110487 T1 HR P20110487T1
- Authority
- HR
- Croatia
- Prior art keywords
- polymer conjugate
- hmgb1
- hmgb1 box
- diseases
- box
- Prior art date
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- 229920000642 polymer Polymers 0.000 title claims abstract 27
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 claims abstract 22
- 102000055207 HMGB1 Human genes 0.000 claims abstract 22
- 108700010013 HMGB1 Proteins 0.000 claims abstract 22
- 101150021904 HMGB1 gene Proteins 0.000 claims abstract 22
- 239000012634 fragment Substances 0.000 claims abstract 10
- 150000001413 amino acids Chemical group 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 235000001014 amino acid Nutrition 0.000 claims 7
- 229940024606 amino acid Drugs 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 241000256182 Anopheles gambiae Species 0.000 claims 4
- 101001025337 Homo sapiens High mobility group protein B1 Proteins 0.000 claims 4
- 102000053637 human HMGB1 Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
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- 102000002689 Toll-like receptor Human genes 0.000 claims 3
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
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- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
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- 230000021615 conjugation Effects 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
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- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
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- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
- Zoology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP06019362 | 2006-09-15 | ||
| US90477607P | 2007-03-05 | 2007-03-05 | |
| PCT/EP2007/008029 WO2008031612A1 (en) | 2006-09-15 | 2007-09-14 | Polymer conjugates of box-a of hmgb1 and box-a variants of hmgb1 |
Publications (1)
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| HRP20110487T1 true HRP20110487T1 (hr) | 2011-08-31 |
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| HR20110487T HRP20110487T1 (hr) | 2006-09-15 | 2011-07-01 | Polimerni konjugati hmgb1 box-a i varijanti hmgb1 box-a |
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|---|---|
| US (3) | US8546547B2 (ru) |
| EP (1) | EP2068935B8 (ru) |
| JP (3) | JP2010503630A (ru) |
| AU (1) | AU2007296843C1 (ru) |
| CA (1) | CA2663300C (ru) |
| HK (1) | HK1134779A1 (ru) |
| HR (1) | HRP20110487T1 (ru) |
| IL (1) | IL197441A (ru) |
| MX (1) | MX2009002820A (ru) |
| PL (1) | PL2068935T3 (ru) |
| WO (1) | WO2008031612A1 (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9919010B2 (en) | 2008-04-30 | 2018-03-20 | Genomix Co., Ltd. | Method for collecting functional cells in vivo with high efficiency |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| JP5467313B2 (ja) * | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
| CN101691580B (zh) * | 2009-09-28 | 2012-02-15 | 中国人民解放军第三军医大学 | 人HMGB1 A box和酸性尾端的新型融合蛋白及其应用 |
| CN102711777B (zh) | 2009-10-28 | 2015-04-15 | 吉诺米克斯股份有限公司 | 利用骨髓间充质干细胞和/或多能干细胞的血中动员的组织再生促进剂 |
| US20110123483A1 (en) * | 2009-11-23 | 2011-05-26 | Deutsches Krebsforschungszentrum | Hmgb1 for cancer treatment |
| US8981025B2 (en) | 2011-02-10 | 2015-03-17 | Corning Incorporated | Polymerizable catonic peptide monomers and polymers |
| PT3358011T (pt) | 2011-04-26 | 2020-04-23 | Univ Osaka | Péptido para induzir a regeneração de um tecido e a sua utilização |
| WO2014016417A1 (en) | 2012-07-26 | 2014-01-30 | Ospedale San Raffaele Srl | Hmgb1 variants and uses thereof |
| GB201508337D0 (en) | 2015-05-15 | 2015-06-24 | Hmgbiotech S R L | Novel peptides |
| US11274132B2 (en) | 2015-12-11 | 2022-03-15 | Ruprecht-Karls-Universität Heidelberg | Combined preparations of PKM2 modulators and HMGB1 |
| BR112019014921A2 (pt) | 2017-01-27 | 2020-03-31 | StemRIM Inc. | Agente terapêutico para miocardiopatia, infarto antigo do miocárdio e insuficiência cardíaca crônica |
| US11298403B2 (en) | 2017-12-01 | 2022-04-12 | StemRIM Inc. | Therapeutic agent for inflammatory bowel disease |
| JP2022504139A (ja) * | 2018-10-05 | 2022-01-13 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | バイオフィルムの除去のためのｈｍｇｂ１タンパク質誘導体 |
| CN113423466A (zh) * | 2018-10-25 | 2021-09-21 | 国立大学法人大阪大学 | 软骨病症的治疗剂 |
| US11684653B2 (en) * | 2019-03-06 | 2023-06-27 | The Cleveland Clinic Foundation | Compositions and method for reducing virulence of microorganisms |
| CN114829368B (zh) | 2019-12-18 | 2024-06-04 | 豪夫迈·罗氏有限公司 | 通过使用连续标记方案的合成进行测序的方法 |
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| JP2524586B2 (ja) * | 1985-06-26 | 1996-08-14 | シタス コーポレイション | ポリマ−接合を利用する医薬組成物用蛋白質の可溶化 |
| EP1656952B1 (en) * | 1998-10-16 | 2013-12-18 | Biogen Idec MA Inc. | Polyalkylene glycol conjugates of interferon beta-1A and uses thereof |
| GEP20063916B (en) | 2001-02-01 | 2006-09-11 | Biogen Idec Inc | Polymer conjugates of neublastin and methods of using same |
| ITMI20010562A1 (it) | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| US20030060410A1 (en) * | 2001-05-15 | 2003-03-27 | North Shore Long Island Jewish Research Institute | Use of HMG fragments as anti-inflammatory agents |
| CA2506328A1 (en) * | 2002-11-20 | 2004-06-03 | Critical Therapeutics, Inc. | Use of hmgb fragments as anti-inflammatory agents |
| MXPA05006688A (es) | 2002-12-19 | 2006-02-22 | Nektar Therapeutics Al Corp | Conjugados de polimero con una variante de cianovirina. |
| EP2261244A3 (en) | 2003-04-15 | 2011-02-23 | Glaxosmithkline LLC | Human il-18 substitution mutants and their conjugates |
| EP1814576A2 (en) * | 2004-07-20 | 2007-08-08 | Critical Therapeutics, Inc. | Combination therapies of hmgb and complement inhibitors against inflammation |
| MX2007002557A (es) * | 2004-09-03 | 2007-10-10 | Creabilis Therapeutics Spa | Uso de polipeptidos obtenidos a traves de mutaciones sistematicas de aminoacidos unicos de bloque-a humano y no humano de hmgb1 para prevenir y/o antagonizar las patologias inducidas por hmgb1. |
| BRPI0519430A2 (pt) | 2004-12-22 | 2009-02-10 | Ambrx Inc | hormânio do crescimento humano modificado |
| SI1919979T2 (sl) | 2005-08-25 | 2017-07-31 | Creabilis Therapeutics S.P.A. | Polimerni konjugati K-252A in njihovi derivati |
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- 2007-09-14 PL PL07818168T patent/PL2068935T3/pl unknown
- 2007-09-14 JP JP2009527748A patent/JP2010503630A/ja active Pending
- 2007-09-14 MX MX2009002820A patent/MX2009002820A/es active IP Right Grant
- 2007-09-14 CA CA2663300A patent/CA2663300C/en not_active Expired - Fee Related
- 2007-09-14 EP EP07818168A patent/EP2068935B8/en not_active Revoked
- 2007-09-14 US US12/441,478 patent/US8546547B2/en not_active Expired - Fee Related
- 2007-09-14 AU AU2007296843A patent/AU2007296843C1/en not_active Ceased
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2009
- 2009-03-05 IL IL197441A patent/IL197441A/en active IP Right Grant
- 2009-12-18 HK HK09111955.1A patent/HK1134779A1/en not_active IP Right Cessation
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2011
- 2011-07-01 HR HR20110487T patent/HRP20110487T1/hr unknown
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2012
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2015
- 2015-07-13 JP JP2015139496A patent/JP2015193646A/ja active Pending
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2017
- 2017-04-28 US US15/581,358 patent/US20170304398A1/en not_active Abandoned
- 2017-06-08 JP JP2017113232A patent/JP2017200930A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1134779A1 (en) | 2010-05-14 |
| AU2007296843B2 (en) | 2012-02-23 |
| JP2017200930A (ja) | 2017-11-09 |
| CA2663300C (en) | 2014-10-07 |
| JP2010503630A (ja) | 2010-02-04 |
| IL197441A (en) | 2013-07-31 |
| IL197441A0 (en) | 2009-12-24 |
| EP2068935B8 (en) | 2011-09-14 |
| US20090324677A1 (en) | 2009-12-31 |
| AU2007296843A1 (en) | 2008-03-20 |
| EP2068935B1 (en) | 2011-04-13 |
| PL2068935T3 (pl) | 2011-11-30 |
| US8546547B2 (en) | 2013-10-01 |
| US9707298B2 (en) | 2017-07-18 |
| JP2015193646A (ja) | 2015-11-05 |
| US20170304398A1 (en) | 2017-10-26 |
| CA2663300A1 (en) | 2008-03-20 |
| MX2009002820A (es) | 2009-06-04 |
| EP2068935A1 (en) | 2009-06-17 |
| AU2007296843C1 (en) | 2012-08-16 |
| WO2008031612A1 (en) | 2008-03-20 |
| US20140065094A1 (en) | 2014-03-06 |
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