HRP20110086T1 - Dha esteri i njihova upotreba u tretmanu i prevenciji kardiovaskularnih bolesti - Google Patents
Dha esteri i njihova upotreba u tretmanu i prevenciji kardiovaskularnih bolesti Download PDFInfo
- Publication number
- HRP20110086T1 HRP20110086T1 HR20110086T HRP20110086T HRP20110086T1 HR P20110086 T1 HRP20110086 T1 HR P20110086T1 HR 20110086 T HR20110086 T HR 20110086T HR P20110086 T HRP20110086 T HR P20110086T HR P20110086 T1 HRP20110086 T1 HR P20110086T1
- Authority
- HR
- Croatia
- Prior art keywords
- docosahexaenoic acid
- treatment
- acid ester
- prevention
- pharmaceutical preparation
- Prior art date
Links
- 208000024172 Cardiovascular disease Diseases 0.000 title claims 6
- 230000002265 prevention Effects 0.000 title claims 5
- 150000002148 esters Chemical class 0.000 title claims 3
- -1 Docosahexaenoic acid ester Chemical class 0.000 claims abstract 14
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims abstract 12
- 229940090949 docosahexaenoic acid Drugs 0.000 claims abstract 10
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims abstract 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 5
- 229940101267 panthenol Drugs 0.000 claims abstract 4
- 235000020957 pantothenol Nutrition 0.000 claims abstract 4
- 239000011619 pantothenol Substances 0.000 claims abstract 4
- 229960002479 isosorbide Drugs 0.000 claims abstract 3
- 229960003827 isosorbide mononitrate Drugs 0.000 claims abstract 3
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 claims abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 4
- 230000033764 rhythmic process Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims 2
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000002600 fibrillogenic effect Effects 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000009862 primary prevention Effects 0.000 claims 2
- 230000009863 secondary prevention Effects 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 230000006794 tachycardia Effects 0.000 claims 2
- 208000003663 ventricular fibrillation Diseases 0.000 claims 2
- 206010047302 ventricular tachycardia Diseases 0.000 claims 2
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 208000014526 Conduction disease Diseases 0.000 claims 1
- TYLNXKAVUJJPMU-DNKOKRCQSA-N Docosahexaenoic acid ethyl ester Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(=O)OCC TYLNXKAVUJJPMU-DNKOKRCQSA-N 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 206010042434 Sudden death Diseases 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000005809 transesterification reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/02—Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0605649A FR2902659A1 (fr) | 2006-06-23 | 2006-06-23 | Ester de dha et son utilisation dans le traitement et la prevention des maladies cardiovasculaires |
| PCT/EP2007/056277 WO2007147899A2 (en) | 2006-06-23 | 2007-06-22 | Dha esters and use thereof in treatment and prevention of cardiovascular disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110086T1 true HRP20110086T1 (hr) | 2011-03-31 |
Family
ID=37686083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110086T HRP20110086T1 (hr) | 2006-06-23 | 2011-02-03 | Dha esteri i njihova upotreba u tretmanu i prevenciji kardiovaskularnih bolesti |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US8034377B2 (zh) |
| EP (1) | EP2034999B9 (zh) |
| JP (1) | JP5053372B2 (zh) |
| KR (1) | KR101380128B1 (zh) |
| CN (1) | CN101472590A (zh) |
| AR (1) | AR061622A1 (zh) |
| AT (1) | ATE489091T1 (zh) |
| AU (1) | AU2007262958B2 (zh) |
| BR (1) | BRPI0713725A2 (zh) |
| CA (1) | CA2655570C (zh) |
| CL (1) | CL2010001123A1 (zh) |
| CO (1) | CO6150156A2 (zh) |
| CR (1) | CR10507A (zh) |
| DE (1) | DE602007010776D1 (zh) |
| DK (1) | DK2034999T3 (zh) |
| EC (1) | ECSP099039A (zh) |
| ES (1) | ES2355611T3 (zh) |
| FR (1) | FR2902659A1 (zh) |
| GE (1) | GEP20125464B (zh) |
| HN (1) | HN2008001771A (zh) |
| HR (1) | HRP20110086T1 (zh) |
| IL (1) | IL195562A (zh) |
| MA (1) | MA30584B1 (zh) |
| MX (1) | MX2009000103A (zh) |
| MY (1) | MY145985A (zh) |
| NO (1) | NO20090334L (zh) |
| NZ (1) | NZ573454A (zh) |
| PL (1) | PL2034999T3 (zh) |
| PT (1) | PT2034999E (zh) |
| RS (1) | RS51629B (zh) |
| RU (1) | RU2451672C2 (zh) |
| SA (1) | SA07280345B1 (zh) |
| SI (1) | SI2034999T1 (zh) |
| TN (1) | TNSN08527A1 (zh) |
| TW (1) | TWI389888B (zh) |
| UA (1) | UA96156C2 (zh) |
| WO (1) | WO2007147899A2 (zh) |
| ZA (1) | ZA200900334B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2334536B1 (es) * | 2008-04-11 | 2011-01-24 | Universidad Complutense De Madrid | Procedimiento para la obtencion selectiva de 12-hidroxi-9-cis-octadecenoato de (1,4:3,6-dianhidro-d-glucitol) utilizando lipasas inmovilizadas como catalizador. |
| FR2949063B1 (fr) * | 2009-08-11 | 2011-09-30 | Pf Medicament | Composition pharmaceutique comprenant un ester de dha destinee a etre administree par voie parenterale |
| KR102167261B1 (ko) * | 2010-06-18 | 2020-10-20 | 엑스바이오테크, 인크. | 관절염 치료 |
| FR2963790B1 (fr) * | 2010-08-11 | 2012-09-28 | Pf Medicament | Docosahexaeneoate de panthenyle et son utilisation dans le traitement et la prevention des maladies cardiovasculaires |
| EP2608808B1 (en) | 2010-08-23 | 2017-01-18 | XBiotech, Inc | Treatment for neoplastic diseases |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| CN102757444B (zh) * | 2011-04-29 | 2016-02-10 | 南京信诺泰医药有限公司 | 具有一氧化氮供体性质的苯并呋喃类化合物 |
| FR2998479B1 (fr) * | 2012-11-27 | 2017-04-28 | Pf Medicament | Utilisation d'un ester de dha pour le traitement prophylactique et/ou curatif de la drepanocytose |
| WO2016024283A1 (en) * | 2014-08-12 | 2016-02-18 | Praj Industries Limited | Process for the preparation of triglycerides of epa and dha |
| US10441087B2 (en) | 2015-02-24 | 2019-10-15 | Sleep Number Corporation | Mattress with adjustable firmness |
| EP3582813A4 (en) | 2017-02-16 | 2020-12-30 | XBiotech, Inc | TREATMENT OF SUPPURATIVE HIDRADENITIS |
| US11116731B2 (en) * | 2017-02-20 | 2021-09-14 | Brd. of Sup. of LSU and A &M College | Hydrogen sulfide and/or nitrite in the treatment and prevention of atrial fibrillation |
| CN110950881A (zh) * | 2018-09-27 | 2020-04-03 | 中国科学院上海药物研究所 | 一类三环类似物、其制备方法和用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL133049C (zh) | 1966-02-24 | |||
| JPS5967263A (ja) | 1982-10-07 | 1984-04-16 | Terumo Corp | ペンタエン高級脂肪酸ピリジルアルコ−ルエステルおよびその製法 |
| JPS5967264A (ja) | 1982-10-08 | 1984-04-16 | Terumo Corp | 血小板凝集抑制剤 |
| WO1984001899A1 (en) | 1982-11-16 | 1984-05-24 | Georges Motschan | New utilization of a unique vitamin or a combination of various vitamins |
| JPS6034947A (ja) * | 1983-08-05 | 1985-02-22 | Terumo Corp | ドコサヘキサエン酸誘導体およびそれを用いた血小板凝集阻止剤 |
| GB9300125D0 (en) * | 1993-01-06 | 1993-03-03 | Scotia Holdings Plc | Compositions containing esters of unsaturated fatty acids |
| US5760081A (en) | 1994-05-10 | 1998-06-02 | The General Hospital Corporation | Omega 3 fatty acids in the prevention of ventricular fibrillation |
| NZ306510A (en) | 1995-05-01 | 1999-05-28 | Scotia Holdings Plc | Niacin derivatives which include a fatty acid or fatty acid alcohol residue and their use in medicaments and skin care compositions |
| IL118092A0 (en) | 1995-05-03 | 1996-09-12 | Smithkline Beecham Plc | Antibacterial compounds their preparation and pharmaceutical compositions containing them |
| US5919815A (en) | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| AUPQ480399A0 (en) | 1999-12-22 | 2000-02-03 | Commonwealth Scientific And Industrial Research Organisation | Unsaturated fatty acids and their uses in therapy |
| DK1157692T3 (da) | 2000-05-22 | 2006-02-06 | Pro Aparts Investimentos E Con | Sammensætning af fedtsyrer indeholdende mindst 80 vægt-% EPA og DHA, derivater deraf og farmaceutisk anvendelse deraf |
| ITMI20010129A1 (it) | 2001-01-25 | 2002-07-25 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco |
| US7704542B2 (en) * | 2001-09-12 | 2010-04-27 | Xanodyne Pharmaceuticals, Inc. | Vitamin/mineral compositions with DHA |
| US8729124B2 (en) | 2002-03-05 | 2014-05-20 | Pronova Biopharma Norge As | Use of EPA and DHA in secondary prevention |
| ITMI20022511A1 (it) * | 2002-11-26 | 2004-05-27 | Victorix Assets Ltd | Uso di composizioni farmaceutiche contenenti esteri etilici di acidi poliinsaturi omega-3 nella orevenzione della fibrillazione atriale. |
| EP1466597A1 (en) * | 2003-04-07 | 2004-10-13 | Clinigenetics | Use of dha esters to control or prevent cardiovascular diseases |
| WO2004091603A1 (fr) * | 2003-04-07 | 2004-10-28 | Clinigenetics | Utilisation d’un ester de dha pour le traitement des malades cardiovasculaires |
| BRPI0409585A (pt) | 2003-04-17 | 2006-04-18 | Boehringer Ingelheim Int | suplemento multivitamìnico e mineral para mulheres grávidas |
-
2006
- 2006-06-23 FR FR0605649A patent/FR2902659A1/fr active Pending
-
2007
- 2007-06-22 KR KR1020097001053A patent/KR101380128B1/ko not_active IP Right Cessation
- 2007-06-22 US US12/305,162 patent/US8034377B2/en not_active Expired - Fee Related
- 2007-06-22 ES ES07765584T patent/ES2355611T3/es active Active
- 2007-06-22 RU RU2008152248/04A patent/RU2451672C2/ru not_active IP Right Cessation
- 2007-06-22 WO PCT/EP2007/056277 patent/WO2007147899A2/en active Application Filing
- 2007-06-22 EP EP07765584A patent/EP2034999B9/en active Active
- 2007-06-22 PL PL07765584T patent/PL2034999T3/pl unknown
- 2007-06-22 GE GEAP200711074A patent/GEP20125464B/en unknown
- 2007-06-22 PT PT07765584T patent/PT2034999E/pt unknown
- 2007-06-22 DE DE602007010776T patent/DE602007010776D1/de active Active
- 2007-06-22 SI SI200730469T patent/SI2034999T1/sl unknown
- 2007-06-22 BR BRPI0713725-7A patent/BRPI0713725A2/pt not_active IP Right Cessation
- 2007-06-22 AT AT07765584T patent/ATE489091T1/de active
- 2007-06-22 MY MYPI20084785A patent/MY145985A/en unknown
- 2007-06-22 CA CA2655570A patent/CA2655570C/en not_active Expired - Fee Related
- 2007-06-22 JP JP2009517144A patent/JP5053372B2/ja not_active Expired - Fee Related
- 2007-06-22 NZ NZ573454A patent/NZ573454A/en not_active IP Right Cessation
- 2007-06-22 TW TW096122472A patent/TWI389888B/zh not_active IP Right Cessation
- 2007-06-22 DK DK07765584.3T patent/DK2034999T3/da active
- 2007-06-22 MX MX2009000103A patent/MX2009000103A/es active IP Right Grant
- 2007-06-22 RS RS20110091A patent/RS51629B/en unknown
- 2007-06-22 AR ARP070102779A patent/AR061622A1/es not_active Application Discontinuation
- 2007-06-22 CN CNA2007800228209A patent/CN101472590A/zh active Pending
- 2007-06-22 UA UAA200900468A patent/UA96156C2/ru unknown
- 2007-06-22 AU AU2007262958A patent/AU2007262958B2/en not_active Ceased
- 2007-06-23 SA SA07280345A patent/SA07280345B1/ar unknown
-
2008
- 2008-11-27 HN HN2008001771A patent/HN2008001771A/es unknown
- 2008-11-27 IL IL195562A patent/IL195562A/en active IP Right Grant
- 2008-12-12 CR CR10507A patent/CR10507A/es unknown
- 2008-12-19 TN TNP2008000527A patent/TNSN08527A1/en unknown
-
2009
- 2009-01-07 EC EC2009009039A patent/ECSP099039A/es unknown
- 2009-01-09 MA MA31561A patent/MA30584B1/fr unknown
- 2009-01-15 ZA ZA2009/00334A patent/ZA200900334B/en unknown
- 2009-01-21 NO NO20090334A patent/NO20090334L/no not_active Application Discontinuation
- 2009-01-22 CO CO09005510A patent/CO6150156A2/es unknown
-
2010
- 2010-10-13 CL CL2010001123A patent/CL2010001123A1/es unknown
-
2011
- 2011-02-03 HR HR20110086T patent/HRP20110086T1/hr unknown
- 2011-06-13 US US13/159,022 patent/US8227479B2/en not_active Expired - Fee Related
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