HRP20100627T1 - Postupak dobivanja reakcije za izmjenu litija - Google Patents
Postupak dobivanja reakcije za izmjenu litija Download PDFInfo
- Publication number
- HRP20100627T1 HRP20100627T1 HR20100627T HRP20100627T HRP20100627T1 HR P20100627 T1 HRP20100627 T1 HR P20100627T1 HR 20100627 T HR20100627 T HR 20100627T HR P20100627 T HRP20100627 T HR P20100627T HR P20100627 T1 HRP20100627 T1 HR P20100627T1
- Authority
- HR
- Croatia
- Prior art keywords
- reactant
- reaction
- lithium
- group
- liquids
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 17
- 238000006243 chemical reaction Methods 0.000 title claims abstract 13
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical group [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 title claims abstract 10
- 229910052744 lithium Inorganic materials 0.000 title claims abstract 10
- 238000002347 injection Methods 0.000 claims abstract 5
- 239000007924 injection Substances 0.000 claims abstract 5
- 239000012530 fluid Substances 0.000 claims abstract 2
- 239000000376 reactant Substances 0.000 claims 10
- 239000007788 liquid Substances 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 238000001816 cooling Methods 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000005265 dialkylamine group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005266 diarylamine group Chemical group 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical class [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/02—Lithium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07002522A EP1956023A1 (en) | 2007-02-06 | 2007-02-06 | Method for lithium exchange reactions |
| PCT/EP2008/000808 WO2008095646A1 (en) | 2007-02-06 | 2008-02-01 | Method for lithium exchange reactions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100627T1 true HRP20100627T1 (hr) | 2010-12-31 |
Family
ID=38179681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100627T HRP20100627T1 (hr) | 2007-02-06 | 2010-11-19 | Postupak dobivanja reakcije za izmjenu litija |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8198487B2 (ru) |
| EP (2) | EP1956023A1 (ru) |
| JP (1) | JP5394258B2 (ru) |
| CN (1) | CN101605800B (ru) |
| AT (1) | ATE478877T1 (ru) |
| BR (1) | BRPI0807155A2 (ru) |
| CA (1) | CA2674560A1 (ru) |
| DE (1) | DE602008002321D1 (ru) |
| EA (1) | EA015237B1 (ru) |
| ES (1) | ES2351376T3 (ru) |
| HK (1) | HK1138008A1 (ru) |
| HR (1) | HRP20100627T1 (ru) |
| IL (1) | IL199749A (ru) |
| MX (1) | MX2009008352A (ru) |
| PL (1) | PL2109616T3 (ru) |
| PT (1) | PT2109616E (ru) |
| SI (1) | SI2109616T1 (ru) |
| WO (1) | WO2008095646A1 (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101801371B (zh) | 2007-09-10 | 2012-11-28 | 詹森药业有限公司 | 可用作sglt抑制剂的化合物的制备方法 |
| US9056850B2 (en) | 2008-10-17 | 2015-06-16 | Janssen Pharmaceutica N.V. | Process for the preparation of compounds useful as inhibitors of SGLT |
| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| SI2451797T1 (sl) | 2009-07-10 | 2013-07-31 | Janssen Pharmaceutica, N.V. | Postopek kristalizacije 1-(beta-d-glukopiranosil)-4-metil-3-(5-(4-fluorofenil)-2-tienilmetil) benzena |
| BR112012008939B1 (pt) * | 2009-10-14 | 2021-06-22 | Janssen Pharmaceutica Nv | Processo para a preparação de compostos úteis como inibidores de sglt2 |
| EA022365B1 (ru) | 2010-05-11 | 2015-12-30 | Янссен Фармацевтика Нв | Фармацевтические композиции, содержащие производные 1-(бета-d-глюкопиранозил)-2-тиенилметилбензола как ингибиторы нзпг |
| CA2832938C (en) | 2011-04-13 | 2019-09-03 | Janssen Pharmaceutica Nv | Process for the preparation of compounds useful as inhibitors of sglt2 |
| US9035044B2 (en) | 2011-05-09 | 2015-05-19 | Janssen Pharmaceutica Nv | L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
| US20170071970A1 (en) | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
| US11407769B2 (en) | 2017-11-14 | 2022-08-09 | Albemarle Germany Gmbh | Organolithium process under continuous flow conditions |
| DE102019008481A1 (de) | 2018-12-21 | 2020-06-25 | Merck Patent Gmbh | Kontinuierliches Verfahren zur Funktionalisierung von fluorierten Benzolverbindungen im Strömungsrohr |
| CN110510637B (zh) * | 2019-08-22 | 2021-02-23 | 山东师范大学 | 一种锂循环合成氨的系统及工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19858856A1 (de) * | 1998-12-19 | 2000-06-21 | Merck Patent Gmbh | Verfahren zur Herstellung von Arylmetallverbindungen und deren Umsetzung mit Elektrophilen |
| DE10028754A1 (de) * | 2000-06-09 | 2001-12-13 | Clariant Gmbh | Verfahren zur Herstellung von alkoholischen Lösungen von Alkalialkoholaten |
| DE10333174A1 (de) * | 2003-07-22 | 2005-02-17 | Cpc Cellular Process Chemistry Systems Gmbh | Verfahren zur Durchführung einer In-Situ-Quench Reaktion |
| JP4639042B2 (ja) * | 2003-09-29 | 2011-02-23 | 富士フイルムファインケミカルズ株式会社 | ハロゲン−リチウム交換反応を用いる有機化合物の製造法 |
| JP4794873B2 (ja) * | 2005-03-03 | 2011-10-19 | 富士フイルムファインケミカルズ株式会社 | ハロゲン−リチウム交換反応を用いる有機化合物の製造法 |
| AT501927B1 (de) * | 2005-05-23 | 2007-06-15 | Dsm Fine Chem Austria Gmbh | Verbessertes verfahren zur durchführung von ritterreaktionen, elektrophilen additionen an alkenen oder friedel-crafts-alkylierungen |
| JPWO2008035633A1 (ja) * | 2006-09-19 | 2010-01-28 | 萬有製薬株式会社 | 反応装置及び反応方法 |
-
2007
- 2007-02-06 EP EP07002522A patent/EP1956023A1/en not_active Withdrawn
-
2008
- 2008-02-01 AT AT08707494T patent/ATE478877T1/de active
- 2008-02-01 JP JP2009548607A patent/JP5394258B2/ja active Active
- 2008-02-01 MX MX2009008352A patent/MX2009008352A/es active IP Right Grant
- 2008-02-01 EA EA200901037A patent/EA015237B1/ru not_active IP Right Cessation
- 2008-02-01 ES ES08707494T patent/ES2351376T3/es active Active
- 2008-02-01 WO PCT/EP2008/000808 patent/WO2008095646A1/en active Application Filing
- 2008-02-01 CN CN200880004269XA patent/CN101605800B/zh active Active
- 2008-02-01 PT PT08707494T patent/PT2109616E/pt unknown
- 2008-02-01 US US12/524,910 patent/US8198487B2/en active Active
- 2008-02-01 SI SI200830092T patent/SI2109616T1/sl unknown
- 2008-02-01 PL PL08707494T patent/PL2109616T3/pl unknown
- 2008-02-01 BR BRPI0807155-1A2A patent/BRPI0807155A2/pt not_active IP Right Cessation
- 2008-02-01 DE DE602008002321T patent/DE602008002321D1/de active Active
- 2008-02-01 EP EP08707494A patent/EP2109616B1/en active Active
- 2008-02-01 CA CA002674560A patent/CA2674560A1/en not_active Abandoned
-
2009
- 2009-07-07 IL IL199749A patent/IL199749A/en not_active IP Right Cessation
-
2010
- 2010-04-23 HK HK10104030.2A patent/HK1138008A1/xx not_active IP Right Cessation
- 2010-11-19 HR HR20100627T patent/HRP20100627T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1956023A1 (en) | 2008-08-13 |
| PT2109616E (pt) | 2010-11-29 |
| WO2008095646A1 (en) | 2008-08-14 |
| SI2109616T1 (sl) | 2010-12-31 |
| DE602008002321D1 (de) | 2010-10-07 |
| PL2109616T3 (pl) | 2011-05-31 |
| ES2351376T3 (es) | 2011-02-03 |
| CN101605800A (zh) | 2009-12-16 |
| EA200901037A1 (ru) | 2010-02-26 |
| EP2109616B1 (en) | 2010-08-25 |
| IL199749A0 (en) | 2010-04-15 |
| JP5394258B2 (ja) | 2014-01-22 |
| MX2009008352A (es) | 2009-10-30 |
| IL199749A (en) | 2013-02-28 |
| EP2109616A1 (en) | 2009-10-21 |
| CA2674560A1 (en) | 2008-08-14 |
| HK1138008A1 (en) | 2010-08-13 |
| BRPI0807155A2 (pt) | 2014-04-22 |
| EA015237B1 (ru) | 2011-06-30 |
| US8198487B2 (en) | 2012-06-12 |
| CN101605800B (zh) | 2013-01-09 |
| JP2010518035A (ja) | 2010-05-27 |
| US20100113839A1 (en) | 2010-05-06 |
| ATE478877T1 (de) | 2010-09-15 |
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