HRP20100216T1 - Kruti farmaceutski pripravak koji sadrži irbesartan - Google Patents
Kruti farmaceutski pripravak koji sadrži irbesartan Download PDFInfo
- Publication number
- HRP20100216T1 HRP20100216T1 HR20100216T HRP20100216T HRP20100216T1 HR P20100216 T1 HRP20100216 T1 HR P20100216T1 HR 20100216 T HR20100216 T HR 20100216T HR P20100216 T HRP20100216 T HR P20100216T HR P20100216 T1 HRP20100216 T1 HR P20100216T1
- Authority
- HR
- Croatia
- Prior art keywords
- mixture
- irbesartan hydrochloride
- formulation
- granulate
- irbesartan
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 4
- 239000007787 solid Substances 0.000 title claims abstract 4
- 239000002947 C09CA04 - Irbesartan Substances 0.000 title abstract 2
- 229960002198 irbesartan Drugs 0.000 title abstract 2
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 20
- ZUYFSRQJPNUOQU-UHFFFAOYSA-N 2-butyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one;hydrochloride Chemical compound Cl.O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C2=NNN=N2)C(CCCC)=NC21CCCC2 ZUYFSRQJPNUOQU-UHFFFAOYSA-N 0.000 claims abstract 12
- 229950010515 irbesartan hydrochloride Drugs 0.000 claims abstract 12
- 238000009472 formulation Methods 0.000 claims abstract 9
- 238000000034 method Methods 0.000 claims abstract 8
- 239000004480 active ingredient Substances 0.000 claims abstract 5
- 238000005469 granulation Methods 0.000 claims abstract 2
- 230000003179 granulation Effects 0.000 claims abstract 2
- 238000005550 wet granulation Methods 0.000 claims abstract 2
- 239000008187 granular material Substances 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 5
- 238000009736 wetting Methods 0.000 claims 4
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims 3
- 229960002003 hydrochlorothiazide Drugs 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 230000001476 alcoholic effect Effects 0.000 claims 2
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 229960003511 macrogol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06000329A EP1806130B1 (fr) | 2006-01-09 | 2006-01-09 | Préparations solides comprenant du irbesartan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100216T1 true HRP20100216T1 (hr) | 2010-05-31 |
Family
ID=35744710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100216T HRP20100216T1 (hr) | 2006-01-09 | 2010-04-16 | Kruti farmaceutski pripravak koji sadrži irbesartan |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20110045097A1 (fr) |
| EP (2) | EP1806130B1 (fr) |
| CN (1) | CN101370484B (fr) |
| AT (1) | ATE462414T1 (fr) |
| CA (1) | CA2636663A1 (fr) |
| DE (1) | DE602006013261D1 (fr) |
| EA (1) | EA016579B1 (fr) |
| ES (1) | ES2340701T3 (fr) |
| HR (1) | HRP20100216T1 (fr) |
| NO (1) | NO20083183L (fr) |
| PL (1) | PL1806130T3 (fr) |
| PT (1) | PT1806130E (fr) |
| SI (1) | SI1806130T1 (fr) |
| UA (1) | UA95274C2 (fr) |
| WO (1) | WO2007080074A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006006588A1 (de) * | 2006-02-13 | 2007-08-16 | Ratiopharm Gmbh | Schnell freisetzende Irbesartan-haltige pharmazeutische Zusammensetzung |
| WO2008125388A1 (fr) * | 2007-04-17 | 2008-10-23 | Ratiopharm Gmbh | Compositions pharmaceutiques contenant de l'irbesartan |
| EP2065035B1 (fr) | 2007-11-28 | 2010-07-21 | Laboratorios Lesvi, S.L. | Formules pharmaceutiques contenant de l'irbesartan |
| WO2011141783A2 (fr) | 2010-04-13 | 2011-11-17 | Micro Labs Limited | Composition pharmaceutique comprenant de l'irbésartan |
| CN101912390A (zh) * | 2010-08-08 | 2010-12-15 | 浙江华海药业股份有限公司 | 含厄贝沙坦的药用组合物 |
| CN103191076B (zh) * | 2013-04-27 | 2016-08-17 | 吕丕平 | 一种厄贝沙坦片剂的制备方法 |
| JP6445923B2 (ja) * | 2015-04-22 | 2018-12-26 | ダイト株式会社 | イルベサルタン含有錠剤の調製方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ237476A (en) | 1990-03-20 | 1994-01-26 | Sanofi Sa | N-substituted heterocyclic compounds and pharmaceutical compositions. |
| US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| US5541209A (en) * | 1994-08-22 | 1996-07-30 | Bristol-Myers Squibb Company | Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative |
| FR2725987B1 (fr) | 1994-10-19 | 1997-01-10 | Sanofi Sa | Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive |
| TW442301B (en) * | 1995-06-07 | 2001-06-23 | Sanofi Synthelabo | Pharmaceutical compositions containing irbesartan |
| FR2780403B3 (fr) * | 1998-06-24 | 2000-07-21 | Sanofi Sa | Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant |
| CA2311734C (fr) * | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Forme pharmaceutique orale a dissolution ultra-rapide |
| TWI324074B (en) * | 2001-10-09 | 2010-05-01 | Bristol Myers Squibb Co | Flashmelt oral dosage formulation |
| US20050176793A1 (en) | 2001-12-10 | 2005-08-11 | Reddy Reguri B. | Amorphous form of 2-n-butyl-3-((2-(1h-tetrazol-5-yl)([1,1'-biphenyl)-4-yl)methyl)-1, 3-diazaspiro(4,4')non-1-en-4-one |
| CN1668612A (zh) | 2002-07-16 | 2005-09-14 | 特瓦制药工业有限公司 | 厄贝沙坦的新合成方法 |
| TR200301553A1 (tr) * | 2003-09-18 | 2005-10-21 | Nobel �La� Sanay�� Ve T�Caret A.�. | İrbesartan etken maddesi içeren yeni oral farmasötik formülasyonlar |
| CA2568640C (fr) * | 2004-06-04 | 2011-08-09 | Teva Pharmaceutical Industries Ltd. | Composition pharmaceutique contenant de l'irbesartan |
| WO2006013545A1 (fr) * | 2004-07-28 | 2006-02-09 | Ranbaxy Laboratories Limited | Compositions pharmaceutiques d'irbesartan |
| SI21849A (sl) * | 2004-07-29 | 2006-02-28 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Priprava hidrokloridnih soli tetrazolskega derivata |
| GB2419592A (en) * | 2004-10-26 | 2006-05-03 | Cipla Ltd | Process for the preparation of irbesartan hydrochloride |
| US20060160871A1 (en) * | 2004-12-07 | 2006-07-20 | Nektar Therapeutics | Stable non-crystalline formulation comprising losartan |
| WO2006067601A1 (fr) * | 2004-12-23 | 2006-06-29 | Ranbaxy Laboratories Limited | Compositions pharmaceutiques orales a base d'irbesartan et d'hydrochlorothiazide et procedes de preparation desdites compositions |
-
2006
- 2006-01-09 EP EP06000329A patent/EP1806130B1/fr active Active
- 2006-01-09 AT AT06000329T patent/ATE462414T1/de not_active IP Right Cessation
- 2006-01-09 PT PT06000329T patent/PT1806130E/pt unknown
- 2006-01-09 DE DE602006013261T patent/DE602006013261D1/de active Active
- 2006-01-09 PL PL06000329T patent/PL1806130T3/pl unknown
- 2006-01-09 SI SI200630660T patent/SI1806130T1/sl unknown
- 2006-01-09 ES ES06000329T patent/ES2340701T3/es active Active
-
2007
- 2007-01-05 CN CN2007800021754A patent/CN101370484B/zh not_active Expired - Fee Related
- 2007-01-05 UA UAA200810224A patent/UA95274C2/ru unknown
- 2007-01-05 CA CA002636663A patent/CA2636663A1/fr not_active Abandoned
- 2007-01-05 EA EA200801634A patent/EA016579B1/ru not_active IP Right Cessation
- 2007-01-05 US US12/160,206 patent/US20110045097A1/en not_active Abandoned
- 2007-01-05 WO PCT/EP2007/000074 patent/WO2007080074A1/fr active Application Filing
- 2007-01-05 EP EP07700188.1A patent/EP1981485B1/fr active Active
-
2008
- 2008-07-17 NO NO20083183A patent/NO20083183L/no not_active Application Discontinuation
-
2010
- 2010-04-16 HR HR20100216T patent/HRP20100216T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007080074A1 (fr) | 2007-07-19 |
| PL1806130T3 (pl) | 2010-08-31 |
| EP1806130A1 (fr) | 2007-07-11 |
| EP1981485A1 (fr) | 2008-10-22 |
| CN101370484A (zh) | 2009-02-18 |
| SI1806130T1 (sl) | 2010-06-30 |
| ATE462414T1 (de) | 2010-04-15 |
| EP1806130B1 (fr) | 2010-03-31 |
| EA200801634A1 (ru) | 2008-10-30 |
| UA95274C2 (ru) | 2011-07-25 |
| ES2340701T3 (es) | 2010-06-08 |
| EP1981485B1 (fr) | 2014-10-08 |
| EA016579B1 (ru) | 2012-06-29 |
| CA2636663A1 (fr) | 2007-07-19 |
| CN101370484B (zh) | 2011-06-01 |
| PT1806130E (pt) | 2010-05-11 |
| DE602006013261D1 (de) | 2010-05-12 |
| US20110045097A1 (en) | 2011-02-24 |
| NO20083183L (no) | 2008-09-26 |
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