HRP20060286T3 - Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof - Google Patents

Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof

Info

Publication number
HRP20060286T3
HRP20060286T3 HR20060286T HRP20060286T HRP20060286T3 HR P20060286 T3 HRP20060286 T3 HR P20060286T3 HR 20060286 T HR20060286 T HR 20060286T HR P20060286 T HRP20060286 T HR P20060286T HR P20060286 T3 HRP20060286 T3 HR P20060286T3
Authority
HR
Croatia
Prior art keywords
ring
thioxy
haloalkylsulfinyl
haloalkylsulfonyl
haloalkylthio
Prior art date
Application number
HR20060286T
Other languages
English (en)
Croatian (hr)
Inventor
Semple Graeme
Schrader Thomas
J. Skinner Philip
L. Colletti Steven
E. Imbriglio Jason
Liang Rui
Raghavan Subharekha
Schmidt Darby
R. Tata James
Gharbaoui Tawfik
Jung Jae-Kyu
Original Assignee
Arena Pharmaceuticals Inc
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharmaceuticals Inc, Merck & Co. Inc. filed Critical Arena Pharmaceuticals Inc
Publication of HRP20060286T3 publication Critical patent/HRP20060286T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20060286T 2003-10-31 2004-10-29 Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof HRP20060286T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51623803P 2003-10-31 2003-10-31
PCT/US2004/035927 WO2005044816A1 (en) 2003-10-31 2004-10-29 Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof

Publications (1)

Publication Number Publication Date
HRP20060286T3 true HRP20060286T3 (en) 2007-03-31

Family

ID=34572875

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20060286T HRP20060286T3 (en) 2003-10-31 2004-10-29 Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof

Country Status (37)

Country Link
US (2) US8637555B2 (enExample)
EP (2) EP1599469B1 (enExample)
JP (2) JP4533898B2 (enExample)
KR (1) KR100850591B1 (enExample)
CN (1) CN1867562B (enExample)
AR (1) AR046611A1 (enExample)
AT (1) ATE328880T1 (enExample)
AU (1) AU2004287861B2 (enExample)
BR (1) BRPI0415631A (enExample)
CA (1) CA2539985C (enExample)
CO (1) CO5690551A2 (enExample)
CR (1) CR8270A (enExample)
CY (1) CY1105479T1 (enExample)
DE (1) DE602004001134T2 (enExample)
DK (1) DK1599469T3 (enExample)
EA (1) EA011484B1 (enExample)
EC (1) ECSP066529A (enExample)
ES (1) ES2267077T3 (enExample)
GE (1) GEP20094801B (enExample)
HR (1) HRP20060286T3 (enExample)
IL (1) IL174042A0 (enExample)
IS (1) IS2372B (enExample)
MA (1) MA28171A1 (enExample)
MX (1) MXPA06004556A (enExample)
MY (1) MY140410A (enExample)
NO (1) NO20062509L (enExample)
NZ (1) NZ546285A (enExample)
PE (1) PE20050483A1 (enExample)
PL (1) PL1599469T3 (enExample)
PT (1) PT1599469E (enExample)
RS (1) RS20060290A (enExample)
SI (1) SI1599469T1 (enExample)
TN (1) TNSN06150A1 (enExample)
TW (1) TWI258478B (enExample)
UA (1) UA86783C2 (enExample)
WO (1) WO2005044816A1 (enExample)
ZA (2) ZA200603419B (enExample)

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AU2004293415A1 (en) 2003-11-21 2005-06-09 Arena Pharmaceuticals, Inc. 4-oxo-4,5-dihydro-furan-2-carboxylic and acid derivatives and methods of treatment of metabolic-related disorders thereof
WO2006026273A2 (en) * 2004-08-25 2006-03-09 Merck & Co., Inc. Method of treating atherosclerosis, dyslipidemias and related conditions
JP2008519080A (ja) * 2004-11-05 2008-06-05 アリーナ ファーマシューティカルズ， インコーポレイテッド ナイアシン受容体部分的アゴニストを含む、潮紅および脂質関連障害を処置するための組成物
PE20060949A1 (es) 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
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SI1901731T1 (sl) 2005-06-28 2011-07-29 Merck Sharp & Dohme Niacin receptorski antagonisti, sestavki vsebujoäśi take spojine in postopki zdravljenja
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US9975910B2 (en) 2013-07-23 2018-05-22 Eisai R&D Management Co., Ltd. Hetero-fused cyclic compound
CN103755637A (zh) * 2013-12-26 2014-04-30 平湖优康药物研发有限公司 一种医药中间体1,4,5,6-四氢-3-环戊并吡唑甲腈的合成工艺
CA3096145A1 (en) * 2019-10-11 2021-04-11 Royal Bank Of Canada System and method of machine learning using embedding networks

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US8168799B2 (en) 2005-04-28 2012-05-01 Merck Sharpe & Dohme Ltd. Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles

Also Published As

Publication number Publication date
EP1683794A1 (en) 2006-07-26
ZA200606203B (en) 2007-04-25
EP1599469A1 (en) 2005-11-30
US20070072924A1 (en) 2007-03-29
ATE328880T1 (de) 2006-06-15
TWI258478B (en) 2006-07-21
EP1599469B1 (en) 2006-06-07
NZ546285A (en) 2010-04-30
TW200530221A (en) 2005-09-16
WO2005044816A1 (en) 2005-05-19
MXPA06004556A (es) 2006-07-06
MY140410A (en) 2009-12-31
AU2004287861B2 (en) 2008-08-14
HK1076468A1 (en) 2006-01-20
EA011484B1 (ru) 2009-04-28
DE602004001134T2 (de) 2007-04-19
JP2010163448A (ja) 2010-07-29
AU2004287861A1 (en) 2005-05-19
ZA200603419B (en) 2006-10-25
UA86783C2 (ru) 2009-05-25
PL1599469T3 (pl) 2006-10-31
RS20060290A (sr) 2008-11-28
PE20050483A1 (es) 2005-08-25
BRPI0415631A (pt) 2006-12-12
KR20060073974A (ko) 2006-06-29
ES2267077T3 (es) 2007-03-01
CY1105479T1 (el) 2010-07-28
CN1867562A (zh) 2006-11-22
CN1867562B (zh) 2011-07-13
DE602004001134D1 (de) 2006-07-20
IL174042A0 (en) 2006-08-01
IS2372B (is) 2008-06-15
DK1599469T3 (da) 2006-10-09
KR100850591B1 (ko) 2008-08-05
GEP20094801B (en) 2009-10-26
SI1599469T1 (sl) 2006-10-31
PT1599469E (pt) 2006-10-31
EA200600879A1 (ru) 2006-10-27
IS8481A (is) 2006-05-24
NO20062509L (no) 2006-06-26
AR046611A1 (es) 2005-12-14
JP4533898B2 (ja) 2010-09-01
US8637555B2 (en) 2014-01-28
TNSN06150A1 (en) 2007-11-15
CA2539985C (en) 2010-02-16
JP2007509181A (ja) 2007-04-12
US20060217562A1 (en) 2006-09-28
MA28171A1 (fr) 2006-09-01
CA2539985A1 (en) 2005-05-19
ECSP066529A (es) 2006-10-10
CR8270A (es) 2006-10-06
CO5690551A2 (es) 2006-10-31

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