HRP20050917B1 - Postupak za dobivanje kristaliniäśnog ciklesonida s definiranom veliäśinom äśestica - Google Patents

Postupak za dobivanje kristaliniäśnog ciklesonida s definiranom veliäśinom äśestica

Info

Publication number
HRP20050917B1
HRP20050917B1 HRP20050917AA HRP20050917A HRP20050917B1 HR P20050917 B1 HRP20050917 B1 HR P20050917B1 HR P20050917A A HRP20050917A A HR P20050917AA HR P20050917 A HRP20050917 A HR P20050917A HR P20050917 B1 HRP20050917 B1 HR P20050917B1
Authority
HR
Croatia
Prior art keywords
particle size
crystalline ciclesonide
pharmaceutical compositions
preparing crystalline
defined particle
Prior art date
Application number
HRP20050917AA
Other languages
English (en)
Inventor
Beate Schmidt
Stefan Kaupp
Ernst Sturm
Klaus Eistetter
Original Assignee
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33099298&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20050917(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of HRP20050917A2 publication Critical patent/HRP20050917A2/xx
Publication of HRP20050917B1 publication Critical patent/HRP20050917B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Izum se odnosi na nove postupke za dobivanje kristaliničnog ciklesonida s pogodnom veličinom čestica i raspodjelom veličine čestica i na njegovu upotrebu u proizvodnji farmaceutskih pripravaka, posebice za topikalnu upotrebu. Kristalinični ciklesonid dobiven novim postupkom ima povoljna aerodinamička svojstva, i može se dalje procesirati u inhalacijske farmaceutske pripravke ili farmaceutske pripravke za nazalnu primjenu, bez daljnje mehaničke mikronizacije.
HRP20050917AA 2003-03-27 2005-10-19 Postupak za dobivanje kristaliniäśnog ciklesonida s definiranom veliäśinom äśestica HRP20050917B1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03007007 2003-03-27
DE10314097 2003-03-27
PCT/EP2004/050373 WO2004085460A1 (en) 2003-03-27 2004-03-26 Process for preparing crystalline ciclesonide with defined particle size

Publications (2)

Publication Number Publication Date
HRP20050917A2 HRP20050917A2 (en) 2006-12-31
HRP20050917B1 true HRP20050917B1 (hr) 2014-02-14

Family

ID=33099298

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20050917AA HRP20050917B1 (hr) 2003-03-27 2005-10-19 Postupak za dobivanje kristaliniäśnog ciklesonida s definiranom veliäśinom äśestica

Country Status (28)

Country Link
US (1) US9422327B2 (hr)
EP (1) EP1611150B1 (hr)
JP (1) JP4746535B2 (hr)
KR (1) KR101102709B1 (hr)
AR (1) AR043579A1 (hr)
AT (1) ATE546459T1 (hr)
AU (1) AU2004224092B2 (hr)
BR (1) BRPI0408569B1 (hr)
CA (1) CA2519752C (hr)
CL (1) CL2004000636A1 (hr)
CY (1) CY1112970T1 (hr)
DK (1) DK1611150T3 (hr)
EA (1) EA011157B1 (hr)
ES (1) ES2382928T3 (hr)
HK (1) HK1088905A1 (hr)
HR (1) HRP20050917B1 (hr)
IL (1) IL170746A (hr)
MX (1) MXPA05010041A (hr)
MY (1) MY143936A (hr)
NO (1) NO331984B1 (hr)
NZ (1) NZ542827A (hr)
PE (1) PE20050388A1 (hr)
PL (1) PL1611150T3 (hr)
PT (1) PT1611150E (hr)
RS (1) RS52549B (hr)
SI (1) SI1611150T1 (hr)
TW (1) TWI328589B (hr)
WO (1) WO2004085460A1 (hr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
JP2009512733A (ja) * 2005-11-02 2009-03-26 シコール インコーポレイティド シクレソニドの改良された製造法
EP1904514A2 (en) * 2006-02-08 2008-04-02 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
NZ575549A (en) * 2006-09-19 2012-06-29 Cipla Ltd Processes for the preparation of ciclesonide and its crystal form
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
ES2401057T3 (es) * 2008-03-13 2013-04-16 Farmabios S.P.A. Procedimiento para la preparación de derivados de pregnano
WO2010054158A2 (en) * 2008-11-07 2010-05-14 Auspex Pharmaceuticals, Inc. Steroid modulators of glucocorticoid receptor
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
US10111957B2 (en) 2012-07-05 2018-10-30 Arven Ilac Snayi ve Ticaret A.S. Inhalation compositions comprising glucose anhydrous
WO2014007781A2 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions
US20150165037A1 (en) 2012-07-05 2015-06-18 Arven llac Sanayi Ve Ticaret A.S. Inhalation compositions comprising corticosteroid and sorbitol
PE20190622A1 (es) 2016-06-02 2019-04-26 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados del mismo
PL3658192T3 (pl) 2017-12-01 2021-10-18 Abbvie Inc. Agonista receptora glukokortykoidowego i jego immunokoniugaty

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605517A (en) * 1983-10-29 1986-08-12 Sterling Drug Inc. Method of preparing steroid compounds of controlled particle size
DE19635498A1 (de) * 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung
WO2001000046A1 (de) * 1999-06-25 2001-01-04 Cognis Deutschland Gmbh Verwendung von nanoskaligen sterolen und sterolestern
WO2002038584A1 (en) * 2000-11-10 2002-05-16 Altana Pharma Ag Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation
US6482438B1 (en) * 1998-12-24 2002-11-19 Smithkline Beecham Corporation Apparatus and process for preparing crystalline particles

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003782A2 (en) 1988-10-05 1990-04-19 The Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE69012458T3 (de) 1989-05-31 2000-01-20 Fisons Plc Medikament und Inhalationsvorrichtung dafür.
GR1001529B (el) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
FR2668945B1 (fr) 1990-11-12 1993-02-19 Theramex Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus.
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
GB9306703D0 (en) 1993-03-31 1993-05-26 Fisons Plc Inhalation device
UA45311C2 (uk) * 1993-04-02 2002-04-15 Бік Гульден Ломберг Хеміше Фабрік Гмбх 16<font face="Symbol">a</font>,17-ЦИКЛОГЕКСИЛМЕТИЛЕНДІОКСИ-11<font face="Symbol">b</font>,21-ДИГІДРОКСИПРЕГНА-1,4-ДІЄН-3,20-ДІОН, СПОСІБ ЙОГО ОДЕРЖАННЯ, ЛІКАРСЬКИЙ ЗАСІБ
IL111194A (en) 1993-10-08 1998-02-08 Fisons Plc Process for the production of drug patramulations
CA2185015C (en) * 1994-03-09 2007-05-08 Beate Gutterer Novel silyl compounds and their use
DE19541689A1 (de) 1994-11-14 1996-05-15 Byk Gulden Lomberg Chem Fab Kombinationsarzneimittel
US6120752A (en) * 1997-05-21 2000-09-19 3M Innovative Properties Company Medicinal aerosol products containing formulations of ciclesonide and related steroids
GB9722285D0 (en) 1997-10-23 1997-12-17 Rhone Poulenc Rorer Ltd Inhalation device
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
WO2000006121A1 (de) * 1998-07-24 2000-02-10 Jago Research Ag Medizinische aerosolformulierungen
AR026073A1 (es) 1999-10-20 2002-12-26 Nycomed Gmbh Composicion farmaceutica acuosa que contiene ciclesonida
AR026072A1 (es) 1999-10-20 2002-12-26 Nycomed Gmbh Composicion farmaceutica que contiene ciclesonida para aplicacion a la mucosa

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605517A (en) * 1983-10-29 1986-08-12 Sterling Drug Inc. Method of preparing steroid compounds of controlled particle size
DE19635498A1 (de) * 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung
US6482438B1 (en) * 1998-12-24 2002-11-19 Smithkline Beecham Corporation Apparatus and process for preparing crystalline particles
WO2001000046A1 (de) * 1999-06-25 2001-01-04 Cognis Deutschland Gmbh Verwendung von nanoskaligen sterolen und sterolestern
WO2002038584A1 (en) * 2000-11-10 2002-05-16 Altana Pharma Ag Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation

Also Published As

Publication number Publication date
WO2004085460A8 (en) 2007-03-15
EA011157B1 (ru) 2009-02-27
ES2382928T3 (es) 2012-06-14
BRPI0408569A (pt) 2006-03-21
AU2004224092B2 (en) 2010-03-04
EP1611150A1 (en) 2006-01-04
US20060128954A1 (en) 2006-06-15
CL2004000636A1 (es) 2005-02-04
EP1611150B1 (en) 2012-02-22
CA2519752A1 (en) 2004-10-07
JP2006521332A (ja) 2006-09-21
HRP20050917A2 (en) 2006-12-31
MY143936A (en) 2011-07-29
NZ542827A (en) 2008-02-29
NO331984B1 (no) 2012-05-21
PT1611150E (pt) 2012-05-07
IL170746A (en) 2012-06-28
KR20050114250A (ko) 2005-12-05
PE20050388A1 (es) 2005-05-30
DK1611150T3 (da) 2012-05-14
RS52549B (en) 2013-04-30
PL1611150T3 (pl) 2012-07-31
TWI328589B (en) 2010-08-11
ATE546459T1 (de) 2012-03-15
WO2004085460A1 (en) 2004-10-07
EA200501391A1 (ru) 2006-06-30
US9422327B2 (en) 2016-08-23
JP4746535B2 (ja) 2011-08-10
KR101102709B1 (ko) 2012-01-05
AR043579A1 (es) 2005-08-03
RS20050704A (en) 2007-06-04
MXPA05010041A (es) 2005-11-17
IL170746A0 (en) 2009-02-11
HK1088905A1 (en) 2006-11-17
TW200418519A (en) 2004-10-01
AU2004224092A1 (en) 2004-10-07
BRPI0408569B1 (pt) 2017-08-29
SI1611150T1 (sl) 2012-06-29
NO20054835L (no) 2005-10-19
CA2519752C (en) 2012-05-29
CY1112970T1 (el) 2016-04-13

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A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: NYCOMED GMBH, DE

PNAN Change of the applicant name, address/residence

Owner name: TAKEDA GMBH, DE

B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: NYCOMED ASSET MANAGEMENT GMBH, DE

Owner name: NYCOMED GERMANY HOLDING GMBH, DE

Owner name: TAKEDA GMBH, DE

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