HRP20041075B1 - A process for the preparation of olanzapine and an intermediate therefor - Google Patents

A process for the preparation of olanzapine and an intermediate therefor

Info

Publication number
HRP20041075B1
HRP20041075B1 HR20041075A HRP20041075A HRP20041075B1 HR P20041075 B1 HRP20041075 B1 HR P20041075B1 HR 20041075 A HR20041075 A HR 20041075A HR P20041075 A HRP20041075 A HR P20041075A HR P20041075 B1 HRP20041075 B1 HR P20041075B1
Authority
HR
Croatia
Prior art keywords
preparation
olanzapine
intermediate therefor
therefor
benzodiazepine
Prior art date
Application number
HR20041075A
Other languages
English (en)
Croatian (hr)
Inventor
Majka Zbigniew
Stawinski Tomasz
Rechnio Justyna
Wieczorek Maciej
Original Assignee
Adamed Sp.Z.O.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29997625&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20041075(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adamed Sp.Z.O.O. filed Critical Adamed Sp.Z.O.O.
Publication of HRP20041075A2 publication Critical patent/HRP20041075A2/hr
Publication of HRP20041075B1 publication Critical patent/HRP20041075B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20041075A 2002-06-20 2004-11-17 A process for the preparation of olanzapine and an intermediate therefor HRP20041075B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL354642A PL199016B1 (pl) 2002-06-20 2002-06-20 Sposób wytwarzania olanzapiny
PCT/IB2003/002181 WO2004000847A1 (fr) 2002-06-20 2003-06-10 Procede de preparation d'olanzapine et intermediaire utilise

Publications (2)

Publication Number Publication Date
HRP20041075A2 HRP20041075A2 (en) 2005-02-28
HRP20041075B1 true HRP20041075B1 (en) 2008-05-31

Family

ID=29997625

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20041075A HRP20041075B1 (en) 2002-06-20 2004-11-17 A process for the preparation of olanzapine and an intermediate therefor

Country Status (17)

Country Link
EP (2) EP1513845B2 (fr)
CN (1) CN100338069C (fr)
AT (2) ATE373664T1 (fr)
AU (1) AU2003240167A1 (fr)
BR (1) BR0305100A (fr)
DE (2) DE60316047T2 (fr)
ES (2) ES2291644T5 (fr)
HR (1) HRP20041075B1 (fr)
MX (1) MXPA04012200A (fr)
NO (1) NO328873B1 (fr)
PL (1) PL199016B1 (fr)
PT (2) PT1513845E (fr)
RU (1) RU2005101324A (fr)
SI (2) SI1669359T1 (fr)
TN (1) TNSN04226A1 (fr)
UA (1) UA76616C2 (fr)
WO (1) WO2004000847A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1575962A1 (fr) 2002-12-24 2005-09-21 Teva Pharmaceutical Industries Limited Nouvelles formes cristallines d'olanzapine, procedes pour les preparer et procede pour preparer des formes cristallines d'olanzapine connues
EP1711503A1 (fr) * 2004-01-27 2006-10-18 Synthon B.V. Synthese de l'olanzapine, et intermediaires de celle-ci
AR047459A1 (es) 2004-01-27 2006-01-18 Synthon Bv Sales estables de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (olanzapina)
AR048272A1 (es) * 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
US8044196B2 (en) 2004-07-14 2011-10-25 Jubilant Organosys Limited Process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
PL198589B1 (pl) 2004-11-22 2008-06-30 Adamed Sp Z Oo Sposób wytwarzania N-demetyloolanzapiny
CN100383144C (zh) * 2006-09-11 2008-04-23 杭州盛美医药科技开发有限公司 一种奥氮平的中间体及其制备与应用
EP2292624A1 (fr) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Processus de purification d'olanzapine
CN102234285B (zh) * 2010-04-19 2013-06-12 江苏豪森药业股份有限公司 奥氮平的制备方法
CN102924470B (zh) * 2011-08-31 2014-12-03 江苏豪森药业股份有限公司 新颖的奥氮平的制备方法
CN102942573B (zh) * 2011-10-09 2015-03-25 连云港恒运医药科技有限公司 奥氮平的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1533235A (en) * 1974-11-26 1978-11-22 Lilly Industries Ltd Benzodiazepine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7306069A (fr) † 1973-05-02 1974-11-05
US4115568A (en) † 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
US5239071A (en) † 1989-11-21 1993-08-24 The B. F. Goodrich Company Process for methylating a hindered nitrogen atom in an inert non-aqueous solvent
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
DK55192D0 (da) † 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
US6348455B1 (en) 1998-11-23 2002-02-19 Sepracor Inc. Desmetylolanzapine compositions and methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1533235A (en) * 1974-11-26 1978-11-22 Lilly Industries Ltd Benzodiazepine derivatives

Also Published As

Publication number Publication date
EP1513845B2 (fr) 2010-11-03
ATE371660T1 (de) 2007-09-15
CN100338069C (zh) 2007-09-19
CN1662543A (zh) 2005-08-31
DE60316439D1 (de) 2007-10-31
MXPA04012200A (es) 2005-08-26
NO20040658L (no) 2004-02-13
SI1513845T1 (sl) 2007-12-31
PT1513845E (pt) 2007-11-21
PT1669359E (pt) 2007-10-16
DE60316047D1 (de) 2007-10-11
BR0305100A (pt) 2004-09-28
EP1513845B1 (fr) 2007-09-19
ES2289730T3 (es) 2008-02-01
PL354642A1 (en) 2003-12-29
UA76616C2 (en) 2006-08-15
AU2003240167A1 (en) 2004-01-06
WO2004000847A1 (fr) 2003-12-31
DE60316047T2 (de) 2008-05-21
DE60316439T3 (de) 2011-05-05
ATE373664T1 (de) 2007-10-15
ES2291644T3 (es) 2008-03-01
ES2291644T5 (es) 2011-02-15
EP1669359B1 (fr) 2007-08-29
EP1669359A1 (fr) 2006-06-14
NO328873B1 (no) 2010-06-07
SI1669359T1 (sl) 2007-12-31
SI1513845T2 (sl) 2011-01-31
EP1513845A1 (fr) 2005-03-16
DE60316439T2 (de) 2008-07-31
TNSN04226A1 (en) 2007-03-12
HRP20041075A2 (en) 2005-02-28
RU2005101324A (ru) 2005-08-10
PL199016B1 (pl) 2008-08-29

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