HRP20040708A2 - Nicotinamide derivatives useful as pde4 inhibitors - Google Patents
Nicotinamide derivatives useful as pde4 inhibitorsInfo
- Publication number
- HRP20040708A2 HRP20040708A2 HR20040708A HRP20040708A HRP20040708A2 HR P20040708 A2 HRP20040708 A2 HR P20040708A2 HR 20040708 A HR20040708 A HR 20040708A HR P20040708 A HRP20040708 A HR P20040708A HR P20040708 A2 HRP20040708 A2 HR P20040708A2
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- alkyl
- group
- phenyl
- hydroxy
- Prior art date
Links
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- 230000037390 scarring Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- XIIOFHFUYBLOLW-UHFFFAOYSA-N selpercatinib Chemical compound OC(COC=1C=C(C=2N(C=1)N=CC=2C#N)C=1C=NC(=CC=1)N1CC2N(C(C1)C2)CC=1C=NC(=CC=1)OC)(C)C XIIOFHFUYBLOLW-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
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- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
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- 239000001587 sorbitan monostearate Substances 0.000 description 1
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- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
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- 239000004094 surface-active agent Substances 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
- 229950004351 telenzepine Drugs 0.000 description 1
- NZJKEPNCNBWESN-UHFFFAOYSA-N tert-butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound C1C(N)CC2CCC1N2C(=O)OC(C)(C)C NZJKEPNCNBWESN-UHFFFAOYSA-N 0.000 description 1
- LZRDHSFPLUWYAX-UHFFFAOYSA-N tert-butyl 4-aminopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(N)CC1 LZRDHSFPLUWYAX-UHFFFAOYSA-N 0.000 description 1
- RUPAXCPQAAOIPB-UHFFFAOYSA-N tert-butyl formate Chemical compound CC(C)(C)OC=O RUPAXCPQAAOIPB-UHFFFAOYSA-N 0.000 description 1
- NKTAICGRBGCICF-UHFFFAOYSA-N tert-butyl n-(4-azidocyclohexyl)carbamate Chemical compound CC(C)(C)OC(=O)NC1CCC(N=[N+]=[N-])CC1 NKTAICGRBGCICF-UHFFFAOYSA-N 0.000 description 1
- TVLSVTSCIHZHQO-UHFFFAOYSA-N tert-butyl n-[4-[(2-chloro-5-fluoropyridine-3-carbonyl)amino]cyclohexyl]carbamate Chemical compound C1CC(NC(=O)OC(C)(C)C)CCC1NC(=O)C1=CC(F)=CN=C1Cl TVLSVTSCIHZHQO-UHFFFAOYSA-N 0.000 description 1
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- 125000004055 thiomethyl group Chemical group [H]SC([H])([H])* 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 description 1
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- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0203196A GB0203196D0 (en) | 2002-02-11 | 2002-02-11 | Nicotinamide derivatives useful as pde4 inhibitors |
GB0220999A GB0220999D0 (en) | 2002-09-10 | 2002-09-10 | Nicotinamide derivatives useful as pde4 inhibitors |
GB0224453A GB0224453D0 (en) | 2002-10-21 | 2002-10-21 | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0227139A GB0227139D0 (en) | 2002-11-20 | 2002-11-20 | Nicotinamide derivatives useful as pde4 inhibitors |
PCT/IB2003/000439 WO2003068235A1 (en) | 2002-02-11 | 2003-02-03 | Nicotinamide derivatives useful as pde4 inhibitors |
Publications (1)
Publication Number | Publication Date |
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HRP20040708A2 true HRP20040708A2 (en) | 2005-06-30 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HR20040708A HRP20040708A2 (en) | 2002-02-11 | 2004-08-04 | Nicotinamide derivatives useful as pde4 inhibitors |
Country Status (33)
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US (3) | US6949573B2 (de) |
EP (1) | EP1476158B1 (de) |
JP (1) | JP4583761B2 (de) |
KR (1) | KR100698982B1 (de) |
CN (1) | CN1652782A (de) |
AP (1) | AP2004003100A0 (de) |
AR (1) | AR038834A1 (de) |
AT (1) | ATE378049T1 (de) |
AU (1) | AU2003245711A1 (de) |
BR (1) | BR0307564A (de) |
CA (1) | CA2475712C (de) |
DE (1) | DE60317466T2 (de) |
EA (1) | EA008939B1 (de) |
EC (1) | ECSP045228A (de) |
ES (1) | ES2292988T3 (de) |
GE (1) | GEP20074055B (de) |
HN (1) | HN2003000064A (de) |
HR (1) | HRP20040708A2 (de) |
MA (1) | MA27174A1 (de) |
MX (1) | MXPA04007737A (de) |
MY (1) | MY135856A (de) |
NI (1) | NI200300025A (de) |
NO (1) | NO20043793L (de) |
NZ (1) | NZ534197A (de) |
OA (1) | OA12768A (de) |
PA (1) | PA8566401A1 (de) |
PE (1) | PE20030868A1 (de) |
PL (1) | PL372756A1 (de) |
RS (1) | RS70104A (de) |
TN (1) | TNSN04151A1 (de) |
TW (1) | TW200305419A (de) |
UY (1) | UY27659A1 (de) |
WO (1) | WO2003068235A1 (de) |
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US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
PL372756A1 (en) * | 2002-02-11 | 2005-08-08 | Pfizer Inc. | Nicotinamide derivatives useful as pde4 inhibitors |
US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
US20050186276A1 (en) * | 2003-07-17 | 2005-08-25 | Pfizer Inc | Pharmaceutical formulations |
GB0317484D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317472D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
US7132435B2 (en) | 2003-07-25 | 2006-11-07 | Pfizer Inc. | Compounds |
GB0317509D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317516D0 (en) | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317471D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Novel compounds |
US7378409B2 (en) | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
US20050142104A1 (en) * | 2003-11-06 | 2005-06-30 | Zeldis Jerome B. | Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders |
PE20060272A1 (es) * | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
TWI339578B (en) | 2004-10-29 | 2011-04-01 | Mitsubishi Tanabe Pharma Corp | Use of a pyridine compound for the preparation of a medicament for the treatment of skin lesions |
JP4874958B2 (ja) * | 2005-03-30 | 2012-02-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピリジン誘導体を含有する抗真菌剤 |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
US20080233188A1 (en) | 2005-09-12 | 2008-09-25 | Actelion Pharmaceuticals Ltd. | Stable Pharmaceutical Compositions Comprising a Pyrimidine - Sulfamide |
US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
RU2008122978A (ru) | 2005-11-09 | 2009-12-20 | Комбинаторкс, Инкорпорейтед (Us) | Способы, композиции и наборы для лечения медицинских состояний |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
ES2502527T3 (es) | 2008-05-27 | 2014-10-03 | Astrazeneca Ab | Derivados de fenoxipiridinilamida y su uso en el tratamiento de estados patológicos mediados por PDE4 |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8697691B2 (en) * | 2009-12-21 | 2014-04-15 | Vanderbilt University | Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same |
EP2804603A1 (de) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Betazellen-replikation für promoterverbindungen und verwendungsverfahren dafür |
JP6447500B2 (ja) * | 2013-08-08 | 2019-01-09 | 日本電気株式会社 | 二次電池用負極、その製造方法、およびそれを用いた二次電池 |
CA3105657A1 (en) * | 2018-07-09 | 2020-01-16 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting nav1.8 |
CN109674808A (zh) * | 2019-01-30 | 2019-04-26 | 四川大学 | β-烟酰胺单核苷酸或其前体在制备延缓肺衰老药物中的用途 |
CN114656371B (zh) * | 2020-09-14 | 2024-03-12 | 广州药本君安医药科技股份有限公司 | 1,4-环己二胺桥连化合物及在制备治疗糖代谢紊乱疾病的药物中的应用 |
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KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
YU49899A (sh) * | 1997-04-04 | 2002-09-19 | Pfizer Products Inc. | Nikotinamidni derivati |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
GB9924092D0 (en) * | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
KR20020072299A (ko) | 2000-01-31 | 2002-09-14 | 화이자 프로덕츠 인코포레이티드 | Pde4 이소자임의 선택적 억제제로서 유용한니코틴아미드 벤조접합된-헤테로사이클릴 유도체 |
GB0203193D0 (en) | 2002-02-11 | 2002-03-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
PL372756A1 (en) * | 2002-02-11 | 2005-08-08 | Pfizer Inc. | Nicotinamide derivatives useful as pde4 inhibitors |
AU2003201745A1 (en) | 2002-02-11 | 2003-09-04 | Pfizer Limited | Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases |
GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
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2003
- 2003-02-03 PL PL37275603A patent/PL372756A1/xx not_active Application Discontinuation
- 2003-02-03 NZ NZ534197A patent/NZ534197A/en unknown
- 2003-02-03 RS YUP70104 patent/RS70104A/sr unknown
- 2003-02-03 CN CNA038081865A patent/CN1652782A/zh active Pending
- 2003-02-03 BR BR0307564A patent/BR0307564A/pt not_active IP Right Cessation
- 2003-02-03 KR KR20047012338A patent/KR100698982B1/ko not_active IP Right Cessation
- 2003-02-03 EP EP20030739392 patent/EP1476158B1/de not_active Expired - Lifetime
- 2003-02-03 OA OA1200400207A patent/OA12768A/en unknown
- 2003-02-03 AT AT03739392T patent/ATE378049T1/de not_active IP Right Cessation
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- 2003-02-03 DE DE2003617466 patent/DE60317466T2/de not_active Expired - Lifetime
- 2003-02-03 JP JP2003567417A patent/JP4583761B2/ja not_active Expired - Fee Related
- 2003-02-03 MX MXPA04007737A patent/MXPA04007737A/es unknown
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- 2003-02-03 CA CA 2475712 patent/CA2475712C/en not_active Expired - Fee Related
- 2003-02-03 WO PCT/IB2003/000439 patent/WO2003068235A1/en active IP Right Grant
- 2003-02-03 EA EA200400892A patent/EA008939B1/ru unknown
- 2003-02-03 ES ES03739392T patent/ES2292988T3/es not_active Expired - Lifetime
- 2003-02-03 AU AU2003245711A patent/AU2003245711A1/en not_active Abandoned
- 2003-02-06 TW TW92102408A patent/TW200305419A/zh unknown
- 2003-02-06 US US10/361,062 patent/US6949573B2/en not_active Expired - Fee Related
- 2003-02-10 HN HN2003000064A patent/HN2003000064A/es unknown
- 2003-02-10 MY MYPI20030450 patent/MY135856A/en unknown
- 2003-02-10 AR ARP030100404 patent/AR038834A1/es unknown
- 2003-02-10 NI NI200300025A patent/NI200300025A/es unknown
- 2003-02-11 UY UY27659A patent/UY27659A1/es not_active Application Discontinuation
- 2003-02-11 PA PA8566401A patent/PA8566401A1/es unknown
- 2003-02-11 PE PE2003000151A patent/PE20030868A1/es not_active Application Discontinuation
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2004
- 2004-06-09 US US10/865,263 patent/US7060717B2/en not_active Expired - Fee Related
- 2004-08-03 MA MA27808A patent/MA27174A1/fr unknown
- 2004-08-04 HR HR20040708A patent/HRP20040708A2/hr not_active Application Discontinuation
- 2004-08-10 TN TNP2004000151A patent/TNSN04151A1/fr unknown
- 2004-08-11 EC ECSP045228 patent/ECSP045228A/es unknown
- 2004-09-10 NO NO20043793A patent/NO20043793L/no not_active Application Discontinuation
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2005
- 2005-09-16 US US11/229,395 patent/US20060014780A1/en not_active Abandoned
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