HRP20040370B1 - UPORABA (11ß, 17ß)-11-(1,3-BENZODIOKSOL-5-IL)-17-HIDROKSI-17-(1-PROPINIL)-ESTRA-4,9-DIEN-3-ONA U LIJEČENJU VELIKOG DEPRESIVNOG POREMEĆAJA - Google Patents

UPORABA (11ß, 17ß)-11-(1,3-BENZODIOKSOL-5-IL)-17-HIDROKSI-17-(1-PROPINIL)-ESTRA-4,9-DIEN-3-ONA U LIJEČENJU VELIKOG DEPRESIVNOG POREMEĆAJA

Info

Publication number
HRP20040370B1
HRP20040370B1 HRP20040370AA HRP20040370A HRP20040370B1 HR P20040370 B1 HRP20040370 B1 HR P20040370B1 HR P20040370A A HRP20040370A A HR P20040370AA HR P20040370 A HRP20040370 A HR P20040370A HR P20040370 B1 HRP20040370 B1 HR P20040370B1
Authority
HR
Croatia
Prior art keywords
estra
benzodioxol
dien
propynyl
hydroxy
Prior art date
Application number
HRP20040370AA
Other languages
English (en)
Inventor
Sennef Cornelis
Wijnand Mathys Marie Peeters Bernardus
Original Assignee
Pop Test Cortisol Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pop Test Cortisol Llc filed Critical Pop Test Cortisol Llc
Publication of HRP20040370A2 publication Critical patent/HRP20040370A2/hr
Publication of HRP20040370B1 publication Critical patent/HRP20040370B1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Uporaba (11?, 17?)-11-(1,3-benzodioksol-5-il)-17-hidroksi-17-(1-propinil)estra-4,9-dien-3-ona, naznačena time, da je za pripravljanje lijeka za liječenje pacijenta koji pati od velikog depresivnog poremećaja karakteriziranog time da pacijent ima razine kortizola u plazmi veće od 10?g/dl i spoj se primjenjuje u dnevnoj dozi od između 150 i 300 mg. Patent sadr·i jo® 1 patentni zahtjev.
HRP20040370AA 2001-10-26 2004-04-26 UPORABA (11ß, 17ß)-11-(1,3-BENZODIOKSOL-5-IL)-17-HIDROKSI-17-(1-PROPINIL)-ESTRA-4,9-DIEN-3-ONA U LIJEČENJU VELIKOG DEPRESIVNOG POREMEĆAJA HRP20040370B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01204072 2001-10-26
PCT/EP2002/011732 WO2003037354A1 (en) 2001-10-26 2002-10-21 USE OF (11β, 17β)-11-(1,3-BENZODIOXOL-5-YL)-17-HYDROXY-17-(1-PROPYNYL)-ESTRA-4,9-DIEN-3-ONE IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER

Publications (2)

Publication Number Publication Date
HRP20040370A2 HRP20040370A2 (en) 2004-08-31
HRP20040370B1 true HRP20040370B1 (hr) 2012-09-30

Family

ID=8181136

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20040370AA HRP20040370B1 (hr) 2001-10-26 2004-04-26 UPORABA (11ß, 17ß)-11-(1,3-BENZODIOKSOL-5-IL)-17-HIDROKSI-17-(1-PROPINIL)-ESTRA-4,9-DIEN-3-ONA U LIJEČENJU VELIKOG DEPRESIVNOG POREMEĆAJA

Country Status (27)

Country Link
US (1) US20040266863A1 (hr)
EP (2) EP1652526B1 (hr)
JP (1) JP4647909B2 (hr)
KR (1) KR20050038580A (hr)
CN (1) CN100531738C (hr)
AT (2) ATE420649T1 (hr)
AU (1) AU2002348996B2 (hr)
BR (1) BR0213466A (hr)
CA (1) CA2463446C (hr)
CY (1) CY1110173T1 (hr)
DE (2) DE60209248D1 (hr)
DK (1) DK1652526T3 (hr)
EC (1) ECSP045080A (hr)
ES (1) ES2319563T3 (hr)
HK (1) HK1087357A1 (hr)
HR (1) HRP20040370B1 (hr)
HU (1) HUP0500070A3 (hr)
IL (2) IL161248A0 (hr)
IS (1) IS2702B (hr)
MX (1) MXPA04003781A (hr)
NO (1) NO332978B1 (hr)
NZ (1) NZ532429A (hr)
PL (1) PL206687B1 (hr)
PT (1) PT1652526E (hr)
RU (1) RU2302245C2 (hr)
WO (1) WO2003037354A1 (hr)
ZA (1) ZA200403088B (hr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050080061A1 (en) * 2003-07-23 2005-04-14 Corcept Therapeutics, Inc. Antiglucocorticoid therapy for the prevention of neurological damage in premature infants
MX2007006045A (es) * 2004-11-19 2007-06-13 Organon Nv Combinacion farmaceutica que comprende inhibidor selectivo de reabsorcion de serotonina y antagonista del receptor de glucocorticoide para tratamiento de depresion.
AU2011236053B2 (en) * 2004-11-19 2014-06-26 Merck Sharpe & Dohme B.V. Drug combination comprising a selective serotonin reuptake inhibitor and a glucocorticoid receptor antagonist for the treatment of depression
JP2009535430A (ja) * 2006-05-02 2009-10-01 コーセプト セラピューティクス， インコーポレイテッド Ｉｌ−２を摂取している患者における抑うつを処置するためのグルココルチコイドレセプターｉｉアンタゴニストの使用
US8658128B2 (en) 2011-02-03 2014-02-25 Pop Test Cortisol Llc System and method for diagnosis and treatment
EP2699245A4 (en) * 2011-04-18 2014-12-10 Pop Test Cortisol Llc TREATMENT AGAINST HAIR LOSS
US8986677B2 (en) * 2012-07-30 2015-03-24 Pop Test Cortisol Llc Therapeutic compositions and methods

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814333A (en) * 1987-07-28 1989-03-21 The Trustees Of Dartmouth College Method for treatment of hypercortisolemic, depressed patients
EP0763541A1 (en) * 1995-08-17 1997-03-19 Akzo Nobel N.V. 11-(Substituted phenyl)-estra-4,9-diene derivatives
WO1999017779A1 (en) * 1997-10-06 1999-04-15 The Board Of Trustees Of Leland Stanford Jr. University Methods for treating psychosis associated with glucocorticoid related dysfunction
WO2002076390A2 (en) * 2001-03-23 2002-10-03 Corcept Therapeutics, Inc. Methods for treating stress disorders using glucocorticoid receptor-specific antagonists
WO2002096433A1 (en) * 2001-05-04 2002-12-05 Corcept Therapeutics, Inc. Methods for treating delirium using glucocorticoid receptor-specific antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19727772A1 (de) * 1997-06-30 1999-01-28 Forschungszentrum Juelich Gmbh Magnetflußsensor mit ringförmiger Sonde
IL160649A0 (en) * 2001-08-31 2004-07-25 Corcept Therapeutics Inc Methods for inhibiting cognitive deterioration in adults with down syndrome

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814333A (en) * 1987-07-28 1989-03-21 The Trustees Of Dartmouth College Method for treatment of hypercortisolemic, depressed patients
EP0763541A1 (en) * 1995-08-17 1997-03-19 Akzo Nobel N.V. 11-(Substituted phenyl)-estra-4,9-diene derivatives
WO1999017779A1 (en) * 1997-10-06 1999-04-15 The Board Of Trustees Of Leland Stanford Jr. University Methods for treating psychosis associated with glucocorticoid related dysfunction
WO2002076390A2 (en) * 2001-03-23 2002-10-03 Corcept Therapeutics, Inc. Methods for treating stress disorders using glucocorticoid receptor-specific antagonists
WO2002096433A1 (en) * 2001-05-04 2002-12-05 Corcept Therapeutics, Inc. Methods for treating delirium using glucocorticoid receptor-specific antagonists

Also Published As

Publication number Publication date
HUP0500070A2 (hu) 2005-04-28
ES2319563T3 (es) 2009-05-08
CA2463446A1 (en) 2003-05-08
CA2463446C (en) 2010-02-23
ATE420649T1 (de) 2009-01-15
IL161248A0 (en) 2004-09-27
BR0213466A (pt) 2004-11-09
CN100531738C (zh) 2009-08-26
NZ532429A (en) 2004-10-29
US20040266863A1 (en) 2004-12-30
RU2004116082A (ru) 2005-05-10
NO20041651L (no) 2004-04-23
RU2302245C2 (ru) 2007-07-10
KR20050038580A (ko) 2005-04-27
CY1110173T1 (el) 2015-01-14
EP1441739B1 (en) 2006-02-15
AU2002348996B2 (en) 2008-06-05
EP1652526B1 (en) 2009-01-14
DE60230936D1 (de) 2009-03-05
IS7204A (is) 2004-03-31
PL206687B1 (pl) 2010-09-30
MXPA04003781A (es) 2004-07-30
JP2005521637A (ja) 2005-07-21
EP1441739A1 (en) 2004-08-04
NO332978B1 (no) 2013-02-11
DE60209248D1 (de) 2006-04-20
JP4647909B2 (ja) 2011-03-09
ECSP045080A (es) 2004-06-28
PT1652526E (pt) 2009-02-06
IL161248A (en) 2010-12-30
HK1087357A1 (en) 2006-10-13
DK1652526T3 (da) 2009-05-18
WO2003037354A1 (en) 2003-05-08
CN1582153A (zh) 2005-02-16
PL369261A1 (en) 2005-04-18
HUP0500070A3 (en) 2012-09-28
ATE317700T1 (de) 2006-03-15
HRP20040370A2 (en) 2004-08-31
ZA200403088B (en) 2005-01-24
IS2702B (is) 2010-11-15
EP1652526A3 (en) 2006-08-02
EP1652526A2 (en) 2006-05-03

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: N.V. ORGANON, NL

PPPP Transfer of rights

Owner name: POP TEST CORTISOL LLC, US

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20121011

Year of fee payment: 11

PBON Lapse due to non-payment of renewal fee

Effective date: 20131021